Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters
BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investi...
Ausführliche Beschreibung
Autor*in: |
Mattia Pagnoni [verfasserIn] David Meier [verfasserIn] Adrian Luca [verfasserIn] Stephane Fournier [verfasserIn] Farhang Aminfar [verfasserIn] Pascale Gentil [verfasserIn] Christelle Haddad [verfasserIn] Giulia Domenichini [verfasserIn] Mathieu Le Bloa [verfasserIn] Claudia Herrera-Siklody [verfasserIn] Stephane Cook [verfasserIn] Jean-Jacques Goy [verfasserIn] Christan Roguelov [verfasserIn] Grégoire Girod [verfasserIn] Vladimir Rubimbura [verfasserIn] Marion Dupré [verfasserIn] Eric Eeckhout [verfasserIn] Etienne Pruvot [verfasserIn] Olivier Muller [verfasserIn] Patrizio Pascale [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) |
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Übergeordnetes Werk: |
In: Frontiers in Cardiovascular Medicine - Frontiers Media S.A., 2015, 9(2022) |
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Übergeordnetes Werk: |
volume:9 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fcvm.2022.910693 |
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Katalog-ID: |
DOAJ021175381 |
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245 | 1 | 0 | |a Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters |
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520 | |a BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. | ||
650 | 4 | |a electrophysiological study (EPS) | |
650 | 4 | |a trans-catheter aortic valve replacement (TAVR) | |
650 | 4 | |a atrioventricular block (AV block) | |
650 | 4 | |a HV interval | |
650 | 4 | |a PR interval | |
653 | 0 | |a Diseases of the circulatory (Cardiovascular) system | |
700 | 0 | |a David Meier |e verfasserin |4 aut | |
700 | 0 | |a Adrian Luca |e verfasserin |4 aut | |
700 | 0 | |a Stephane Fournier |e verfasserin |4 aut | |
700 | 0 | |a Stephane Fournier |e verfasserin |4 aut | |
700 | 0 | |a Farhang Aminfar |e verfasserin |4 aut | |
700 | 0 | |a Pascale Gentil |e verfasserin |4 aut | |
700 | 0 | |a Christelle Haddad |e verfasserin |4 aut | |
700 | 0 | |a Christelle Haddad |e verfasserin |4 aut | |
700 | 0 | |a Giulia Domenichini |e verfasserin |4 aut | |
700 | 0 | |a Mathieu Le Bloa |e verfasserin |4 aut | |
700 | 0 | |a Claudia Herrera-Siklody |e verfasserin |4 aut | |
700 | 0 | |a Stephane Cook |e verfasserin |4 aut | |
700 | 0 | |a Stephane Cook |e verfasserin |4 aut | |
700 | 0 | |a Jean-Jacques Goy |e verfasserin |4 aut | |
700 | 0 | |a Jean-Jacques Goy |e verfasserin |4 aut | |
700 | 0 | |a Christan Roguelov |e verfasserin |4 aut | |
700 | 0 | |a Grégoire Girod |e verfasserin |4 aut | |
700 | 0 | |a Vladimir Rubimbura |e verfasserin |4 aut | |
700 | 0 | |a Marion Dupré |e verfasserin |4 aut | |
700 | 0 | |a Eric Eeckhout |e verfasserin |4 aut | |
700 | 0 | |a Etienne Pruvot |e verfasserin |4 aut | |
700 | 0 | |a Olivier Muller |e verfasserin |4 aut | |
700 | 0 | |a Patrizio Pascale |e verfasserin |4 aut | |
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10.3389/fcvm.2022.910693 doi (DE-627)DOAJ021175381 (DE-599)DOAJ1e7f6f5f2578400a814e83c70d8fc0df DE-627 ger DE-627 rakwb eng RC666-701 Mattia Pagnoni verfasserin aut Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) atrioventricular block (AV block) HV interval PR interval Diseases of the circulatory (Cardiovascular) system David Meier verfasserin aut Adrian Luca verfasserin aut Stephane Fournier verfasserin aut Stephane Fournier verfasserin aut Farhang Aminfar verfasserin aut Pascale Gentil verfasserin aut Christelle Haddad verfasserin aut Christelle Haddad verfasserin aut Giulia Domenichini verfasserin aut Mathieu Le Bloa verfasserin aut Claudia Herrera-Siklody verfasserin aut Stephane Cook verfasserin aut Stephane Cook verfasserin aut Jean-Jacques Goy verfasserin aut Jean-Jacques Goy verfasserin aut Christan Roguelov verfasserin aut Grégoire Girod verfasserin aut Vladimir Rubimbura verfasserin aut Marion Dupré verfasserin aut Eric Eeckhout verfasserin aut Etienne Pruvot verfasserin aut Olivier Muller verfasserin aut Patrizio Pascale verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.910693 kostenfrei https://doaj.org/article/1e7f6f5f2578400a814e83c70d8fc0df kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.910693/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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10.3389/fcvm.2022.910693 doi (DE-627)DOAJ021175381 (DE-599)DOAJ1e7f6f5f2578400a814e83c70d8fc0df DE-627 ger DE-627 rakwb eng RC666-701 Mattia Pagnoni verfasserin aut Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) atrioventricular block (AV block) HV interval PR interval Diseases of the circulatory (Cardiovascular) system David Meier verfasserin aut Adrian Luca verfasserin aut Stephane Fournier verfasserin aut Stephane Fournier verfasserin aut Farhang Aminfar verfasserin aut Pascale Gentil verfasserin aut Christelle Haddad verfasserin aut Christelle Haddad verfasserin aut Giulia Domenichini verfasserin aut Mathieu Le Bloa verfasserin aut Claudia Herrera-Siklody verfasserin aut Stephane Cook verfasserin aut Stephane Cook verfasserin aut Jean-Jacques Goy verfasserin aut Jean-Jacques Goy verfasserin aut Christan Roguelov verfasserin aut Grégoire Girod verfasserin aut Vladimir Rubimbura verfasserin aut Marion Dupré verfasserin aut Eric Eeckhout verfasserin aut Etienne Pruvot verfasserin aut Olivier Muller verfasserin aut Patrizio Pascale verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.910693 kostenfrei https://doaj.org/article/1e7f6f5f2578400a814e83c70d8fc0df kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.910693/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
allfields_unstemmed |
10.3389/fcvm.2022.910693 doi (DE-627)DOAJ021175381 (DE-599)DOAJ1e7f6f5f2578400a814e83c70d8fc0df DE-627 ger DE-627 rakwb eng RC666-701 Mattia Pagnoni verfasserin aut Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) atrioventricular block (AV block) HV interval PR interval Diseases of the circulatory (Cardiovascular) system David Meier verfasserin aut Adrian Luca verfasserin aut Stephane Fournier verfasserin aut Stephane Fournier verfasserin aut Farhang Aminfar verfasserin aut Pascale Gentil verfasserin aut Christelle Haddad verfasserin aut Christelle Haddad verfasserin aut Giulia Domenichini verfasserin aut Mathieu Le Bloa verfasserin aut Claudia Herrera-Siklody verfasserin aut Stephane Cook verfasserin aut Stephane Cook verfasserin aut Jean-Jacques Goy verfasserin aut Jean-Jacques Goy verfasserin aut Christan Roguelov verfasserin aut Grégoire Girod verfasserin aut Vladimir Rubimbura verfasserin aut Marion Dupré verfasserin aut Eric Eeckhout verfasserin aut Etienne Pruvot verfasserin aut Olivier Muller verfasserin aut Patrizio Pascale verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.910693 kostenfrei https://doaj.org/article/1e7f6f5f2578400a814e83c70d8fc0df kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.910693/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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10.3389/fcvm.2022.910693 doi (DE-627)DOAJ021175381 (DE-599)DOAJ1e7f6f5f2578400a814e83c70d8fc0df DE-627 ger DE-627 rakwb eng RC666-701 Mattia Pagnoni verfasserin aut Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) atrioventricular block (AV block) HV interval PR interval Diseases of the circulatory (Cardiovascular) system David Meier verfasserin aut Adrian Luca verfasserin aut Stephane Fournier verfasserin aut Stephane Fournier verfasserin aut Farhang Aminfar verfasserin aut Pascale Gentil verfasserin aut Christelle Haddad verfasserin aut Christelle Haddad verfasserin aut Giulia Domenichini verfasserin aut Mathieu Le Bloa verfasserin aut Claudia Herrera-Siklody verfasserin aut Stephane Cook verfasserin aut Stephane Cook verfasserin aut Jean-Jacques Goy verfasserin aut Jean-Jacques Goy verfasserin aut Christan Roguelov verfasserin aut Grégoire Girod verfasserin aut Vladimir Rubimbura verfasserin aut Marion Dupré verfasserin aut Eric Eeckhout verfasserin aut Etienne Pruvot verfasserin aut Olivier Muller verfasserin aut Patrizio Pascale verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.910693 kostenfrei https://doaj.org/article/1e7f6f5f2578400a814e83c70d8fc0df kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.910693/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
allfieldsSound |
10.3389/fcvm.2022.910693 doi (DE-627)DOAJ021175381 (DE-599)DOAJ1e7f6f5f2578400a814e83c70d8fc0df DE-627 ger DE-627 rakwb eng RC666-701 Mattia Pagnoni verfasserin aut Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) atrioventricular block (AV block) HV interval PR interval Diseases of the circulatory (Cardiovascular) system David Meier verfasserin aut Adrian Luca verfasserin aut Stephane Fournier verfasserin aut Stephane Fournier verfasserin aut Farhang Aminfar verfasserin aut Pascale Gentil verfasserin aut Christelle Haddad verfasserin aut Christelle Haddad verfasserin aut Giulia Domenichini verfasserin aut Mathieu Le Bloa verfasserin aut Claudia Herrera-Siklody verfasserin aut Stephane Cook verfasserin aut Stephane Cook verfasserin aut Jean-Jacques Goy verfasserin aut Jean-Jacques Goy verfasserin aut Christan Roguelov verfasserin aut Grégoire Girod verfasserin aut Vladimir Rubimbura verfasserin aut Marion Dupré verfasserin aut Eric Eeckhout verfasserin aut Etienne Pruvot verfasserin aut Olivier Muller verfasserin aut Patrizio Pascale verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.910693 kostenfrei https://doaj.org/article/1e7f6f5f2578400a814e83c70d8fc0df kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.910693/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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Mattia Pagnoni @@aut@@ David Meier @@aut@@ Adrian Luca @@aut@@ Stephane Fournier @@aut@@ Farhang Aminfar @@aut@@ Pascale Gentil @@aut@@ Christelle Haddad @@aut@@ Giulia Domenichini @@aut@@ Mathieu Le Bloa @@aut@@ Claudia Herrera-Siklody @@aut@@ Stephane Cook @@aut@@ Jean-Jacques Goy @@aut@@ Christan Roguelov @@aut@@ Grégoire Girod @@aut@@ Vladimir Rubimbura @@aut@@ Marion Dupré @@aut@@ Eric Eeckhout @@aut@@ Etienne Pruvot @@aut@@ Olivier Muller @@aut@@ Patrizio Pascale @@aut@@ |
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However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval &gt; 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval &gt; 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p &lt; 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV &gt; 55 ms (AUC = 0.804 and 0.769, respectively; p &lt; 0.001). 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Mattia Pagnoni misc RC666-701 misc electrophysiological study (EPS) misc trans-catheter aortic valve replacement (TAVR) misc atrioventricular block (AV block) misc HV interval misc PR interval misc Diseases of the circulatory (Cardiovascular) system Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters |
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RC666-701 Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters electrophysiological study (EPS) trans-catheter aortic valve replacement (TAVR) atrioventricular block (AV block) HV interval PR interval |
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Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters |
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Mattia Pagnoni David Meier Adrian Luca Stephane Fournier Farhang Aminfar Pascale Gentil Christelle Haddad Giulia Domenichini Mathieu Le Bloa Claudia Herrera-Siklody Stephane Cook Jean-Jacques Goy Christan Roguelov Grégoire Girod Vladimir Rubimbura Marion Dupré Eric Eeckhout Etienne Pruvot Olivier Muller Patrizio Pascale |
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yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: the pr interval matters |
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Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters |
abstract |
BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. |
abstractGer |
BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. |
abstract_unstemmed |
BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.Materials and methodsConsecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval > 55 ms.ResultsAmong 61 patients, 28 (46%) had an HV interval > 55 ms after TAVR. Post-TAVR PR interval and ΔPR (PR-post–pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 ± 38 vs. 228 ± 34 ms, p < 0.001, ΔPR: 10 ± 30 vs. 34 ± 23 ms, p = 0.001), while no difference was found in QRS duration. PR and ΔPR intervals both effectively discriminated patients with HV > 55 ms (AUC = 0.804 and 0.769, respectively; p < 0.001). A PR > 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. ΔPR ≥ 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR > 200 ms or ΔPR ≥ 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1/3 of exams.ConclusionPR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes. |
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Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters |
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