Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC

Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Method...
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Autor*in:	Zhonghao Wang [verfasserIn] Bei Lu [verfasserIn] Lixin Sun [verfasserIn] Xi Yan [verfasserIn] Jinzhi Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Metastasis Lymph node Small cell lung cancer Survival

Übergeordnetes Werk:	In: Cancer Cell International - BMC, 2003, 18(2018), 1, Seite 10
Übergeordnetes Werk:	volume:18 ; year:2018 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12935-018-0653-5

Katalog-ID:	DOAJ021217580

Internformat


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520			\|a Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC.
650		4	\|a Metastasis
650		4	\|a Lymph node
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700	0		\|a Jinzhi Xu \|e verfasserin \|4 aut
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allfields	10.1186/s12935-018-0653-5 doi (DE-627)DOAJ021217580 (DE-599)DOAJ66a2f41caaf94b63a3495f66c8b8a3b5 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Zhonghao Wang verfasserin aut Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC. Metastasis Lymph node Small cell lung cancer Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Bei Lu verfasserin aut Lixin Sun verfasserin aut Xi Yan verfasserin aut Jinzhi Xu verfasserin aut In Cancer Cell International BMC, 2003 18(2018), 1, Seite 10 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:18 year:2018 number:1 pages:10 https://doi.org/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/article/66a2f41caaf94b63a3495f66c8b8a3b5 kostenfrei http://link.springer.com/article/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 10
spelling	10.1186/s12935-018-0653-5 doi (DE-627)DOAJ021217580 (DE-599)DOAJ66a2f41caaf94b63a3495f66c8b8a3b5 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Zhonghao Wang verfasserin aut Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC. Metastasis Lymph node Small cell lung cancer Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Bei Lu verfasserin aut Lixin Sun verfasserin aut Xi Yan verfasserin aut Jinzhi Xu verfasserin aut In Cancer Cell International BMC, 2003 18(2018), 1, Seite 10 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:18 year:2018 number:1 pages:10 https://doi.org/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/article/66a2f41caaf94b63a3495f66c8b8a3b5 kostenfrei http://link.springer.com/article/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 10
allfields_unstemmed	10.1186/s12935-018-0653-5 doi (DE-627)DOAJ021217580 (DE-599)DOAJ66a2f41caaf94b63a3495f66c8b8a3b5 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Zhonghao Wang verfasserin aut Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC. Metastasis Lymph node Small cell lung cancer Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Bei Lu verfasserin aut Lixin Sun verfasserin aut Xi Yan verfasserin aut Jinzhi Xu verfasserin aut In Cancer Cell International BMC, 2003 18(2018), 1, Seite 10 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:18 year:2018 number:1 pages:10 https://doi.org/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/article/66a2f41caaf94b63a3495f66c8b8a3b5 kostenfrei http://link.springer.com/article/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 10
allfieldsGer	10.1186/s12935-018-0653-5 doi (DE-627)DOAJ021217580 (DE-599)DOAJ66a2f41caaf94b63a3495f66c8b8a3b5 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Zhonghao Wang verfasserin aut Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC. Metastasis Lymph node Small cell lung cancer Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Bei Lu verfasserin aut Lixin Sun verfasserin aut Xi Yan verfasserin aut Jinzhi Xu verfasserin aut In Cancer Cell International BMC, 2003 18(2018), 1, Seite 10 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:18 year:2018 number:1 pages:10 https://doi.org/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/article/66a2f41caaf94b63a3495f66c8b8a3b5 kostenfrei http://link.springer.com/article/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 10
allfieldsSound	10.1186/s12935-018-0653-5 doi (DE-627)DOAJ021217580 (DE-599)DOAJ66a2f41caaf94b63a3495f66c8b8a3b5 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Zhonghao Wang verfasserin aut Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC. Metastasis Lymph node Small cell lung cancer Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Bei Lu verfasserin aut Lixin Sun verfasserin aut Xi Yan verfasserin aut Jinzhi Xu verfasserin aut In Cancer Cell International BMC, 2003 18(2018), 1, Seite 10 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:18 year:2018 number:1 pages:10 https://doi.org/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/article/66a2f41caaf94b63a3495f66c8b8a3b5 kostenfrei http://link.springer.com/article/10.1186/s12935-018-0653-5 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 10
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source	In Cancer Cell International 18(2018), 1, Seite 10 volume:18 year:2018 number:1 pages:10
sourceStr	In Cancer Cell International 18(2018), 1, Seite 10 volume:18 year:2018 number:1 pages:10
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topic_facet	Metastasis Lymph node Small cell lung cancer Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology
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container_title	Cancer Cell International
authorswithroles_txt_mv	Zhonghao Wang @@aut@@ Bei Lu @@aut@@ Lixin Sun @@aut@@ Xi Yan @@aut@@ Jinzhi Xu @@aut@@
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callnumber-first	R - Medicine
author	Zhonghao Wang
spellingShingle	Zhonghao Wang misc RC254-282 misc QH573-671 misc Metastasis misc Lymph node misc Small cell lung cancer misc Survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
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topic_title	RC254-282 QH573-671 Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC Metastasis Lymph node Small cell lung cancer Survival
topic	misc RC254-282 misc QH573-671 misc Metastasis misc Lymph node misc Small cell lung cancer misc Survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
topic_unstemmed	misc RC254-282 misc QH573-671 misc Metastasis misc Lymph node misc Small cell lung cancer misc Survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
topic_browse	misc RC254-282 misc QH573-671 misc Metastasis misc Lymph node misc Small cell lung cancer misc Survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
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title	Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
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title_full	Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
author_sort	Zhonghao Wang
journal	Cancer Cell International
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author_browse	Zhonghao Wang Bei Lu Lixin Sun Xi Yan Jinzhi Xu
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title_sort	identification of candidate genes or micrornas associated with the lymph node metastasis of sclc
callnumber	RC254-282
title_auth	Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
abstract	Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC.
abstractGer	Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC.
abstract_unstemmed	Abstract Background Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated with the lymph node metastasis of SCLC. Methods The DEGs between the metastasis and cancer groups were identified, and GO functional and KEGG pathway enrichment analyses for these DEGs were implemented. Subsequently, the protein–protein interaction network and subnetwork of module were constructed. Then the regulatory networks based on miRNAs, transcription factors (TFs) and target DEGs were constructed. Ultimately, the survival analysis for DEGs was performed to obtain the DEGs related to the survival of SCLC. Results Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis. GRM8 was attracted to the G-protein coupled receptor signaling pathway. Besides, miR-126 was identified in the miRNAs-TFs-target regulatory network. GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC.
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title_short	Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC
url	https://doi.org/10.1186/s12935-018-0653-5 https://doaj.org/article/66a2f41caaf94b63a3495f66c8b8a3b5 http://link.springer.com/article/10.1186/s12935-018-0653-5 https://doaj.org/toc/1475-2867
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author2	Bei Lu Lixin Sun Xi Yan Jinzhi Xu
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up_date	2024-07-03T19:36:06.614Z
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GRM8 and DACH1 were all regulated by miR-126. In particular, GSR and HCP5 were correlated with survival of SCLC patients. Conclusion MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Metastasis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lymph node</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Small cell lung cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Survival</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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Identification of candidate genes or microRNAs associated with the lymph node metastasis of SCLC

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