Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis
Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revea...
Ausführliche Beschreibung
Autor*in: |
Amrullah Shidiki [verfasserIn] Ashish Vyas [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy |
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Übergeordnetes Werk: |
In: Biomedical and Biotechnology Research Journal - Wolters Kluwer Medknow Publications, 2019, 6(2022), 1, Seite 66-72 |
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Übergeordnetes Werk: |
volume:6 ; year:2022 ; number:1 ; pages:66-72 |
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Link aufrufen |
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DOI / URN: |
10.4103/bbrj.bbrj_139_21 |
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Katalog-ID: |
DOAJ021238510 |
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520 | |a Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. | ||
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10.4103/bbrj.bbrj_139_21 doi (DE-627)DOAJ021238510 (DE-599)DOAJe65d1968059847fab9933b981e825d23 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Amrullah Shidiki verfasserin aut Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy methicillin-resistant staphylococcus aureus syzygium cumini Biotechnology Ashish Vyas verfasserin aut In Biomedical and Biotechnology Research Journal Wolters Kluwer Medknow Publications, 2019 6(2022), 1, Seite 66-72 (DE-627)1666372854 25889842 nnns volume:6 year:2022 number:1 pages:66-72 https://doi.org/10.4103/bbrj.bbrj_139_21 kostenfrei https://doaj.org/article/e65d1968059847fab9933b981e825d23 kostenfrei http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=1;spage=66;epage=72;aulast=Shidiki kostenfrei https://doaj.org/toc/2588-9834 Journal toc kostenfrei https://doaj.org/toc/2588-9842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1 66-72 |
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10.4103/bbrj.bbrj_139_21 doi (DE-627)DOAJ021238510 (DE-599)DOAJe65d1968059847fab9933b981e825d23 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Amrullah Shidiki verfasserin aut Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy methicillin-resistant staphylococcus aureus syzygium cumini Biotechnology Ashish Vyas verfasserin aut In Biomedical and Biotechnology Research Journal Wolters Kluwer Medknow Publications, 2019 6(2022), 1, Seite 66-72 (DE-627)1666372854 25889842 nnns volume:6 year:2022 number:1 pages:66-72 https://doi.org/10.4103/bbrj.bbrj_139_21 kostenfrei https://doaj.org/article/e65d1968059847fab9933b981e825d23 kostenfrei http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=1;spage=66;epage=72;aulast=Shidiki kostenfrei https://doaj.org/toc/2588-9834 Journal toc kostenfrei https://doaj.org/toc/2588-9842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1 66-72 |
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10.4103/bbrj.bbrj_139_21 doi (DE-627)DOAJ021238510 (DE-599)DOAJe65d1968059847fab9933b981e825d23 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Amrullah Shidiki verfasserin aut Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy methicillin-resistant staphylococcus aureus syzygium cumini Biotechnology Ashish Vyas verfasserin aut In Biomedical and Biotechnology Research Journal Wolters Kluwer Medknow Publications, 2019 6(2022), 1, Seite 66-72 (DE-627)1666372854 25889842 nnns volume:6 year:2022 number:1 pages:66-72 https://doi.org/10.4103/bbrj.bbrj_139_21 kostenfrei https://doaj.org/article/e65d1968059847fab9933b981e825d23 kostenfrei http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=1;spage=66;epage=72;aulast=Shidiki kostenfrei https://doaj.org/toc/2588-9834 Journal toc kostenfrei https://doaj.org/toc/2588-9842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1 66-72 |
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10.4103/bbrj.bbrj_139_21 doi (DE-627)DOAJ021238510 (DE-599)DOAJe65d1968059847fab9933b981e825d23 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Amrullah Shidiki verfasserin aut Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy methicillin-resistant staphylococcus aureus syzygium cumini Biotechnology Ashish Vyas verfasserin aut In Biomedical and Biotechnology Research Journal Wolters Kluwer Medknow Publications, 2019 6(2022), 1, Seite 66-72 (DE-627)1666372854 25889842 nnns volume:6 year:2022 number:1 pages:66-72 https://doi.org/10.4103/bbrj.bbrj_139_21 kostenfrei https://doaj.org/article/e65d1968059847fab9933b981e825d23 kostenfrei http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=1;spage=66;epage=72;aulast=Shidiki kostenfrei https://doaj.org/toc/2588-9834 Journal toc kostenfrei https://doaj.org/toc/2588-9842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1 66-72 |
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10.4103/bbrj.bbrj_139_21 doi (DE-627)DOAJ021238510 (DE-599)DOAJe65d1968059847fab9933b981e825d23 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Amrullah Shidiki verfasserin aut Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy methicillin-resistant staphylococcus aureus syzygium cumini Biotechnology Ashish Vyas verfasserin aut In Biomedical and Biotechnology Research Journal Wolters Kluwer Medknow Publications, 2019 6(2022), 1, Seite 66-72 (DE-627)1666372854 25889842 nnns volume:6 year:2022 number:1 pages:66-72 https://doi.org/10.4103/bbrj.bbrj_139_21 kostenfrei https://doaj.org/article/e65d1968059847fab9933b981e825d23 kostenfrei http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=1;spage=66;epage=72;aulast=Shidiki kostenfrei https://doaj.org/toc/2588-9834 Journal toc kostenfrei https://doaj.org/toc/2588-9842 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2022 1 66-72 |
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TP248.13-248.65 Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis constitutive clindamycin-resistant staphylococcus aureus inducible clindamycin resistant staphylococcus aureus liquid chromatography mass spectroscopy methicillin-resistant staphylococcus aureus syzygium cumini |
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Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis |
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evaluation of antibacterial potential of syzygium cumini against methicillin-resistant staphylococcus aureus and macrolide-lincosamide-streptogramin b strains of staphylococcus aureus and its liquid chromatography mass spectroscopy analysis |
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Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis |
abstract |
Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. |
abstractGer |
Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. |
abstract_unstemmed |
Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. |
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Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis |
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https://doi.org/10.4103/bbrj.bbrj_139_21 https://doaj.org/article/e65d1968059847fab9933b981e825d23 http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=1;spage=66;epage=72;aulast=Shidiki https://doaj.org/toc/2588-9834 https://doaj.org/toc/2588-9842 |
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An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. 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