Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great p...
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Gespeichert in:

Autor*in:	Saeid Kargozar [verfasserIn] Sara Hooshmand [verfasserIn] Seyede Atefe Hosseini [verfasserIn] Sara Gorgani [verfasserIn] Farzad Kermani [verfasserIn] Francesco Baino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	bioactive glasses (BGs) oxidative stress free radicals tissue engineering wound healing

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 27(2022), 19, p 6642
Übergeordnetes Werk:	volume:27 ; year:2022 ; number:19, p 6642

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules27196642

Katalog-ID:	DOAJ021283664

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language	English
source	In Molecules 27(2022), 19, p 6642 volume:27 year:2022 number:19, p 6642
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spellingShingle	Saeid Kargozar misc QD241-441 misc bioactive glasses (BGs) misc oxidative stress misc free radicals misc tissue engineering misc wound healing misc Organic chemistry Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies
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topic_title	QD241-441 Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies bioactive glasses (BGs) oxidative stress free radicals tissue engineering wound healing
topic	misc QD241-441 misc bioactive glasses (BGs) misc oxidative stress misc free radicals misc tissue engineering misc wound healing misc Organic chemistry
topic_unstemmed	misc QD241-441 misc bioactive glasses (BGs) misc oxidative stress misc free radicals misc tissue engineering misc wound healing misc Organic chemistry
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title	Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies
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title_sort	antioxidant effects of bioactive glasses (bgs) and their significance in tissue engineering strategies
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title_auth	Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies
abstract	Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.
abstractGer	Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.
abstract_unstemmed	Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.
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title_short	Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies
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Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies

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