Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series

Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 202...
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Autor*in:	Nicola Fazio [verfasserIn] Patrick Maisonneuve [verfasserIn] Francesca Spada [verfasserIn] Lorenzo Gervaso [verfasserIn] Chiara Alessandra Cella [verfasserIn] Marta Pozzari [verfasserIn] Dario Zerini [verfasserIn] Eleonora Pisa [verfasserIn] Caterina Fumagalli [verfasserIn] Massimo Barberis [verfasserIn] Alice Laffi [verfasserIn] Chiara Maria Grana C. [verfasserIn] Gianmarco Orsolini [verfasserIn] Pierpaolo Prestianni [verfasserIn] Guido Bonomo [verfasserIn] Luigi Funicelli [verfasserIn] Emilio Bertani [verfasserIn] Paola Queirolo [verfasserIn] Davide Ravizza [verfasserIn] Manila Rubino [verfasserIn] Giulio Tosti [verfasserIn] Elisabetta Pennacchioli [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 19, p 4777
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:19, p 4777

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14194777

Katalog-ID:	DOAJ021306559

Internformat


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520			\|a Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data.
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allfields	10.3390/cancers14194777 doi (DE-627)DOAJ021306559 (DE-599)DOAJb54ad553cf6e45ee9c4b8fe47482e104 DE-627 ger DE-627 rakwb eng RC254-282 Nicola Fazio verfasserin aut Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data. Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV Neoplasms. Tumors. Oncology. Including cancer and carcinogens Patrick Maisonneuve verfasserin aut Francesca Spada verfasserin aut Lorenzo Gervaso verfasserin aut Chiara Alessandra Cella verfasserin aut Marta Pozzari verfasserin aut Dario Zerini verfasserin aut Eleonora Pisa verfasserin aut Caterina Fumagalli verfasserin aut Massimo Barberis verfasserin aut Alice Laffi verfasserin aut Chiara Maria Grana C. verfasserin aut Gianmarco Orsolini verfasserin aut Pierpaolo Prestianni verfasserin aut Guido Bonomo verfasserin aut Luigi Funicelli verfasserin aut Emilio Bertani verfasserin aut Paola Queirolo verfasserin aut Davide Ravizza verfasserin aut Manila Rubino verfasserin aut Giulio Tosti verfasserin aut Elisabetta Pennacchioli verfasserin aut In Cancers MDPI AG, 2010 14(2022), 19, p 4777 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:19, p 4777 https://doi.org/10.3390/cancers14194777 kostenfrei https://doaj.org/article/b54ad553cf6e45ee9c4b8fe47482e104 kostenfrei https://www.mdpi.com/2072-6694/14/19/4777 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 19, p 4777
spelling	10.3390/cancers14194777 doi (DE-627)DOAJ021306559 (DE-599)DOAJb54ad553cf6e45ee9c4b8fe47482e104 DE-627 ger DE-627 rakwb eng RC254-282 Nicola Fazio verfasserin aut Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data. Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV Neoplasms. Tumors. Oncology. Including cancer and carcinogens Patrick Maisonneuve verfasserin aut Francesca Spada verfasserin aut Lorenzo Gervaso verfasserin aut Chiara Alessandra Cella verfasserin aut Marta Pozzari verfasserin aut Dario Zerini verfasserin aut Eleonora Pisa verfasserin aut Caterina Fumagalli verfasserin aut Massimo Barberis verfasserin aut Alice Laffi verfasserin aut Chiara Maria Grana C. verfasserin aut Gianmarco Orsolini verfasserin aut Pierpaolo Prestianni verfasserin aut Guido Bonomo verfasserin aut Luigi Funicelli verfasserin aut Emilio Bertani verfasserin aut Paola Queirolo verfasserin aut Davide Ravizza verfasserin aut Manila Rubino verfasserin aut Giulio Tosti verfasserin aut Elisabetta Pennacchioli verfasserin aut In Cancers MDPI AG, 2010 14(2022), 19, p 4777 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:19, p 4777 https://doi.org/10.3390/cancers14194777 kostenfrei https://doaj.org/article/b54ad553cf6e45ee9c4b8fe47482e104 kostenfrei https://www.mdpi.com/2072-6694/14/19/4777 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 19, p 4777
allfields_unstemmed	10.3390/cancers14194777 doi (DE-627)DOAJ021306559 (DE-599)DOAJb54ad553cf6e45ee9c4b8fe47482e104 DE-627 ger DE-627 rakwb eng RC254-282 Nicola Fazio verfasserin aut Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data. Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV Neoplasms. Tumors. Oncology. Including cancer and carcinogens Patrick Maisonneuve verfasserin aut Francesca Spada verfasserin aut Lorenzo Gervaso verfasserin aut Chiara Alessandra Cella verfasserin aut Marta Pozzari verfasserin aut Dario Zerini verfasserin aut Eleonora Pisa verfasserin aut Caterina Fumagalli verfasserin aut Massimo Barberis verfasserin aut Alice Laffi verfasserin aut Chiara Maria Grana C. verfasserin aut Gianmarco Orsolini verfasserin aut Pierpaolo Prestianni verfasserin aut Guido Bonomo verfasserin aut Luigi Funicelli verfasserin aut Emilio Bertani verfasserin aut Paola Queirolo verfasserin aut Davide Ravizza verfasserin aut Manila Rubino verfasserin aut Giulio Tosti verfasserin aut Elisabetta Pennacchioli verfasserin aut In Cancers MDPI AG, 2010 14(2022), 19, p 4777 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:19, p 4777 https://doi.org/10.3390/cancers14194777 kostenfrei https://doaj.org/article/b54ad553cf6e45ee9c4b8fe47482e104 kostenfrei https://www.mdpi.com/2072-6694/14/19/4777 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 19, p 4777
allfieldsGer	10.3390/cancers14194777 doi (DE-627)DOAJ021306559 (DE-599)DOAJb54ad553cf6e45ee9c4b8fe47482e104 DE-627 ger DE-627 rakwb eng RC254-282 Nicola Fazio verfasserin aut Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data. Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV Neoplasms. Tumors. Oncology. Including cancer and carcinogens Patrick Maisonneuve verfasserin aut Francesca Spada verfasserin aut Lorenzo Gervaso verfasserin aut Chiara Alessandra Cella verfasserin aut Marta Pozzari verfasserin aut Dario Zerini verfasserin aut Eleonora Pisa verfasserin aut Caterina Fumagalli verfasserin aut Massimo Barberis verfasserin aut Alice Laffi verfasserin aut Chiara Maria Grana C. verfasserin aut Gianmarco Orsolini verfasserin aut Pierpaolo Prestianni verfasserin aut Guido Bonomo verfasserin aut Luigi Funicelli verfasserin aut Emilio Bertani verfasserin aut Paola Queirolo verfasserin aut Davide Ravizza verfasserin aut Manila Rubino verfasserin aut Giulio Tosti verfasserin aut Elisabetta Pennacchioli verfasserin aut In Cancers MDPI AG, 2010 14(2022), 19, p 4777 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:19, p 4777 https://doi.org/10.3390/cancers14194777 kostenfrei https://doaj.org/article/b54ad553cf6e45ee9c4b8fe47482e104 kostenfrei https://www.mdpi.com/2072-6694/14/19/4777 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 19, p 4777
allfieldsSound	10.3390/cancers14194777 doi (DE-627)DOAJ021306559 (DE-599)DOAJb54ad553cf6e45ee9c4b8fe47482e104 DE-627 ger DE-627 rakwb eng RC254-282 Nicola Fazio verfasserin aut Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data. Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV Neoplasms. Tumors. Oncology. Including cancer and carcinogens Patrick Maisonneuve verfasserin aut Francesca Spada verfasserin aut Lorenzo Gervaso verfasserin aut Chiara Alessandra Cella verfasserin aut Marta Pozzari verfasserin aut Dario Zerini verfasserin aut Eleonora Pisa verfasserin aut Caterina Fumagalli verfasserin aut Massimo Barberis verfasserin aut Alice Laffi verfasserin aut Chiara Maria Grana C. verfasserin aut Gianmarco Orsolini verfasserin aut Pierpaolo Prestianni verfasserin aut Guido Bonomo verfasserin aut Luigi Funicelli verfasserin aut Emilio Bertani verfasserin aut Paola Queirolo verfasserin aut Davide Ravizza verfasserin aut Manila Rubino verfasserin aut Giulio Tosti verfasserin aut Elisabetta Pennacchioli verfasserin aut In Cancers MDPI AG, 2010 14(2022), 19, p 4777 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:19, p 4777 https://doi.org/10.3390/cancers14194777 kostenfrei https://doaj.org/article/b54ad553cf6e45ee9c4b8fe47482e104 kostenfrei https://www.mdpi.com/2072-6694/14/19/4777 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 19, p 4777
language	English
source	In Cancers 14(2022), 19, p 4777 volume:14 year:2022 number:19, p 4777
sourceStr	In Cancers 14(2022), 19, p 4777 volume:14 year:2022 number:19, p 4777
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Nicola Fazio @@aut@@ Patrick Maisonneuve @@aut@@ Francesca Spada @@aut@@ Lorenzo Gervaso @@aut@@ Chiara Alessandra Cella @@aut@@ Marta Pozzari @@aut@@ Dario Zerini @@aut@@ Eleonora Pisa @@aut@@ Caterina Fumagalli @@aut@@ Massimo Barberis @@aut@@ Alice Laffi @@aut@@ Chiara Maria Grana C. @@aut@@ Gianmarco Orsolini @@aut@@ Pierpaolo Prestianni @@aut@@ Guido Bonomo @@aut@@ Luigi Funicelli @@aut@@ Emilio Bertani @@aut@@ Paola Queirolo @@aut@@ Davide Ravizza @@aut@@ Manila Rubino @@aut@@ Giulio Tosti @@aut@@ Elisabetta Pennacchioli @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ021306559
language_de	englisch
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callnumber-first	R - Medicine
author	Nicola Fazio
spellingShingle	Nicola Fazio misc RC254-282 misc Merkel cell carcinoma misc unknown primary misc Merkel cell polyoma virus misc MCC misc CUP misc MCPyV misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series
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topic_title	RC254-282 Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series Merkel cell carcinoma unknown primary Merkel cell polyoma virus MCC CUP MCPyV
topic	misc RC254-282 misc Merkel cell carcinoma misc unknown primary misc Merkel cell polyoma virus misc MCC misc CUP misc MCPyV misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Merkel cell carcinoma misc unknown primary misc Merkel cell polyoma virus misc MCC misc CUP misc MCPyV misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Merkel cell carcinoma misc unknown primary misc Merkel cell polyoma virus misc MCC misc CUP misc MCPyV misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series
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title_full	Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series
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title_sort	nodal merkel cell carcinoma with unknown primary site and no distant metastasis: a single-center series
callnumber	RC254-282
title_auth	Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series
abstract	Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data.
abstractGer	Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data.
abstract_unstemmed	Merkel cell carcinoma (MCC) is a very rare and aggressive neuroendocrine carcinoma originating from Merkel cells, typically with a skin nodule; however, it exceptionally presents with only a basin lymph node localization, with neither a cutaneous primary site nor distant metastases. From 1996 to 2020, among patients with histologically confirmed MCC managed at a neuroendocrine neoplasm-referral center, we selected those with an exclusive nodal basin, no distant metastasis, and an unknown primary site defined by cross-sectional and physical examination. A total of 55 out of 310 patients fulfilled the selection criteria. The median age was 64 years and the majority were males. Inguinal lymph-nodes were the most common anatomic site. With a median follow-up of 4.3 years, the 5-year relapse-free survival (RFS) rate was 56.6 (95% CI 42.0–68.8%) and the 5-year cancer specific survival (CSS) rate was 68.5 (95% CI 52.8–79.9%) for the whole population. The 36 patients (65.5%) undergoing lymphadenectomy (LND) + radiotherapy (RT) ± chemotherapy had a 5-year RFS rate of 87.2% (95% CI 65.5–95.7%) and a 5-year CSS rate of 90.5% (95% CI 67.0–97.5), which were better than those receiving LND alone. In a multivariable analysis, the survival benefit for LND + RT remained significant. Results from one of the largest single-center series of nMCC-UP suggest that a curative approach including RT can be effective, similar to what is observed for stage IIIB MCC. Multicentric studies with homogenous populations should be carried out in this controversial clinical entity, to minimize the risk of biases and provide robust data.
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container_issue	19, p 4777
title_short	Nodal Merkel Cell Carcinoma with Unknown Primary Site and No Distant Metastasis: A Single-Center Series
url	https://doi.org/10.3390/cancers14194777 https://doaj.org/article/b54ad553cf6e45ee9c4b8fe47482e104 https://www.mdpi.com/2072-6694/14/19/4777 https://doaj.org/toc/2072-6694
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