Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies

Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe...
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Autor*in:	Lukasz Jaskiewicz [verfasserIn] Karolina Hejne [verfasserIn] Blazej Szostak [verfasserIn] Karolina Osowiecka [verfasserIn] Mariusz T. Skowronski [verfasserIn] Ewa Lepiarczyk [verfasserIn] Anna Doboszynska [verfasserIn] Marta Majewska [verfasserIn] Pawel Kordowitzki [verfasserIn] Agnieszka Skowronska [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 19, p 5954
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:19, p 5954

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm11195954

Katalog-ID:	DOAJ021328331

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allfields	10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954
spelling	10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954
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allfieldsGer	10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954
allfieldsSound	10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954
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author	Lukasz Jaskiewicz
spellingShingle	Lukasz Jaskiewicz misc AQP3 misc AQP4 misc aquaporin misc lung cancer misc NSCLC misc adenocarcinoma misc Medicine misc R Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
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topic_title	Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma
topic	misc AQP3 misc AQP4 misc aquaporin misc lung cancer misc NSCLC misc adenocarcinoma misc Medicine misc R
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title	Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
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author_browse	Lukasz Jaskiewicz Karolina Hejne Blazej Szostak Karolina Osowiecka Mariusz T. Skowronski Ewa Lepiarczyk Anna Doboszynska Marta Majewska Pawel Kordowitzki Agnieszka Skowronska
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title_sort	expression profiles of aqp3 and aqp4 in lung adenocarcinoma samples generated via bronchoscopic biopsies
title_auth	Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
abstract	Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients.
abstractGer	Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients.
abstract_unstemmed	Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients.
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title_short	Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
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Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). 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Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies

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