Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe...
Ausführliche Beschreibung
Autor*in: |
Lukasz Jaskiewicz [verfasserIn] Karolina Hejne [verfasserIn] Blazej Szostak [verfasserIn] Karolina Osowiecka [verfasserIn] Mariusz T. Skowronski [verfasserIn] Ewa Lepiarczyk [verfasserIn] Anna Doboszynska [verfasserIn] Marta Majewska [verfasserIn] Pawel Kordowitzki [verfasserIn] Agnieszka Skowronska [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 19, p 5954 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:19, p 5954 |
Links: |
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DOI / URN: |
10.3390/jcm11195954 |
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Katalog-ID: |
DOAJ021328331 |
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10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954 |
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10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954 |
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10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954 |
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10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954 |
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10.3390/jcm11195954 doi (DE-627)DOAJ021328331 (DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad DE-627 ger DE-627 rakwb eng Lukasz Jaskiewicz verfasserin aut Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. AQP3 AQP4 aquaporin lung cancer NSCLC adenocarcinoma Medicine R Karolina Hejne verfasserin aut Blazej Szostak verfasserin aut Karolina Osowiecka verfasserin aut Mariusz T. Skowronski verfasserin aut Ewa Lepiarczyk verfasserin aut Anna Doboszynska verfasserin aut Marta Majewska verfasserin aut Pawel Kordowitzki verfasserin aut Agnieszka Skowronska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 19, p 5954 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:19, p 5954 https://doi.org/10.3390/jcm11195954 kostenfrei https://doaj.org/article/0a837c68b215401a86ce4c39ac6fd4ad kostenfrei https://www.mdpi.com/2077-0383/11/19/5954 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 19, p 5954 |
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Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies |
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Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. |
abstractGer |
Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. |
abstract_unstemmed |
Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ021328331</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414184340.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/jcm11195954</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ021328331</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ0a837c68b215401a86ce4c39ac6fd4ad</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Lukasz Jaskiewicz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (<i<p</i< = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (<i<p</i< < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (<i<p</i< < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (<i<p</i< = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">AQP3</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">AQP4</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">aquaporin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lung cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NSCLC</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">adenocarcinoma</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karolina Hejne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Blazej Szostak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karolina Osowiecka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariusz T. 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