The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia

The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection le...
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Gespeichert in:

Autor*in:	Ahmed El-Shamy [verfasserIn] Andrea D. Branch [verfasserIn] Thomas D. Schiano [verfasserIn] Peter D. Gorevic [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2018.01001

Katalog-ID:	DOAJ021345112

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520			\|a The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation.
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spelling	10.3389/fimmu.2018.01001 doi (DE-627)DOAJ021345112 (DE-599)DOAJd050bd540f6548ea85282dde1f2b9ff7 DE-627 ger DE-627 rakwb eng RC581-607 Ahmed El-Shamy verfasserin aut The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation. liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia Immunologic diseases. Allergy Ahmed El-Shamy verfasserin aut Andrea D. Branch verfasserin aut Thomas D. Schiano verfasserin aut Peter D. Gorevic verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 9(2018) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:9 year:2018 https://doi.org/10.3389/fimmu.2018.01001 kostenfrei https://doaj.org/article/d050bd540f6548ea85282dde1f2b9ff7 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2018.01001/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfields_unstemmed	10.3389/fimmu.2018.01001 doi (DE-627)DOAJ021345112 (DE-599)DOAJd050bd540f6548ea85282dde1f2b9ff7 DE-627 ger DE-627 rakwb eng RC581-607 Ahmed El-Shamy verfasserin aut The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation. liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia Immunologic diseases. Allergy Ahmed El-Shamy verfasserin aut Andrea D. Branch verfasserin aut Thomas D. Schiano verfasserin aut Peter D. Gorevic verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 9(2018) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:9 year:2018 https://doi.org/10.3389/fimmu.2018.01001 kostenfrei https://doaj.org/article/d050bd540f6548ea85282dde1f2b9ff7 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2018.01001/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsGer	10.3389/fimmu.2018.01001 doi (DE-627)DOAJ021345112 (DE-599)DOAJd050bd540f6548ea85282dde1f2b9ff7 DE-627 ger DE-627 rakwb eng RC581-607 Ahmed El-Shamy verfasserin aut The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation. liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia Immunologic diseases. Allergy Ahmed El-Shamy verfasserin aut Andrea D. Branch verfasserin aut Thomas D. Schiano verfasserin aut Peter D. Gorevic verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 9(2018) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:9 year:2018 https://doi.org/10.3389/fimmu.2018.01001 kostenfrei https://doaj.org/article/d050bd540f6548ea85282dde1f2b9ff7 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2018.01001/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsSound	10.3389/fimmu.2018.01001 doi (DE-627)DOAJ021345112 (DE-599)DOAJd050bd540f6548ea85282dde1f2b9ff7 DE-627 ger DE-627 rakwb eng RC581-607 Ahmed El-Shamy verfasserin aut The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation. liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia Immunologic diseases. Allergy Ahmed El-Shamy verfasserin aut Andrea D. Branch verfasserin aut Thomas D. Schiano verfasserin aut Peter D. Gorevic verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 9(2018) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:9 year:2018 https://doi.org/10.3389/fimmu.2018.01001 kostenfrei https://doaj.org/article/d050bd540f6548ea85282dde1f2b9ff7 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2018.01001/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
language	English
source	In Frontiers in Immunology 9(2018) volume:9 year:2018
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topic_facet	liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Ahmed El-Shamy @@aut@@ Andrea D. Branch @@aut@@ Thomas D. Schiano @@aut@@ Peter D. Gorevic @@aut@@
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callnumber-first	R - Medicine
author	Ahmed El-Shamy
spellingShingle	Ahmed El-Shamy misc RC581-607 misc liver misc hepatitis C virus misc complement misc C1q misc gC1qR misc mixed cryoglobulinemia misc Immunologic diseases. Allergy The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia
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topic_title	RC581-607 The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia liver hepatitis C virus complement C1q gC1qR mixed cryoglobulinemia
topic	misc RC581-607 misc liver misc hepatitis C virus misc complement misc C1q misc gC1qR misc mixed cryoglobulinemia misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc liver misc hepatitis C virus misc complement misc C1q misc gC1qR misc mixed cryoglobulinemia misc Immunologic diseases. Allergy
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title	The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia
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title_sort	complement system and c1q in chronic hepatitis c virus infection and mixed cryoglobulinemia
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title_auth	The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia
abstract	The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation.
abstractGer	The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation.
abstract_unstemmed	The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation.
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title_short	The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia
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up_date	2024-07-03T20:20:01.347Z
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