A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S

Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shifeng Qiu [verfasserIn] Zhuhua Sun [verfasserIn] Xinzhong Li [verfasserIn] Jianyong Li [verfasserIn] Xiaobo Huang [verfasserIn] Menghui Liu [verfasserIn] Jianping Bin [verfasserIn] Yulin Liao [verfasserIn] Jiancheng Xiu [verfasserIn] Daogang Zha [verfasserIn] Yumei Xue [verfasserIn] Lichun Wang [verfasserIn] Yuegang Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis

Übergeordnetes Werk:	In: Frontiers in Cardiovascular Medicine - Frontiers Media S.A., 2015, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcvm.2022.868634

Katalog-ID:	DOAJ021365342

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245	1	2	\|a A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S
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520			\|a Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure.
650		4	\|a radiofrequency ablation
650		4	\|a electrocardiogram
650		4	\|a V2S
650		4	\|a angle
650		4	\|a ventricular outflow tract arrhythmias
650		4	\|a cardiac long-axis
653		0	\|a Diseases of the circulatory (Cardiovascular) system
700	0		\|a Shifeng Qiu \|e verfasserin \|4 aut
700	0		\|a Shifeng Qiu \|e verfasserin \|4 aut
700	0		\|a Zhuhua Sun \|e verfasserin \|4 aut
700	0		\|a Xinzhong Li \|e verfasserin \|4 aut
700	0		\|a Xinzhong Li \|e verfasserin \|4 aut
700	0		\|a Xinzhong Li \|e verfasserin \|4 aut
700	0		\|a Jianyong Li \|e verfasserin \|4 aut
700	0		\|a Jianyong Li \|e verfasserin \|4 aut
700	0		\|a Jianyong Li \|e verfasserin \|4 aut
700	0		\|a Xiaobo Huang \|e verfasserin \|4 aut
700	0		\|a Xiaobo Huang \|e verfasserin \|4 aut
700	0		\|a Xiaobo Huang \|e verfasserin \|4 aut
700	0		\|a Menghui Liu \|e verfasserin \|4 aut
700	0		\|a Menghui Liu \|e verfasserin \|4 aut
700	0		\|a Jianping Bin \|e verfasserin \|4 aut
700	0		\|a Jianping Bin \|e verfasserin \|4 aut
700	0		\|a Jianping Bin \|e verfasserin \|4 aut
700	0		\|a Yulin Liao \|e verfasserin \|4 aut
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700	0		\|a Jiancheng Xiu \|e verfasserin \|4 aut
700	0		\|a Jiancheng Xiu \|e verfasserin \|4 aut
700	0		\|a Jiancheng Xiu \|e verfasserin \|4 aut
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700	0		\|a Yumei Xue \|e verfasserin \|4 aut
700	0		\|a Yumei Xue \|e verfasserin \|4 aut
700	0		\|a Lichun Wang \|e verfasserin \|4 aut
700	0		\|a Lichun Wang \|e verfasserin \|4 aut
700	0		\|a Yuegang Wang \|e verfasserin \|4 aut
700	0		\|a Yuegang Wang \|e verfasserin \|4 aut
700	0		\|a Yuegang Wang \|e verfasserin \|4 aut
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allfields	10.3389/fcvm.2022.868634 doi (DE-627)DOAJ021365342 (DE-599)DOAJea365c1f9dc34bf081c4cf7c988a5342 DE-627 ger DE-627 rakwb eng RC666-701 Shifeng Qiu verfasserin aut A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure. radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis Diseases of the circulatory (Cardiovascular) system Shifeng Qiu verfasserin aut Shifeng Qiu verfasserin aut Zhuhua Sun verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Menghui Liu verfasserin aut Menghui Liu verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Yumei Xue verfasserin aut Yumei Xue verfasserin aut Lichun Wang verfasserin aut Lichun Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.868634 kostenfrei https://doaj.org/article/ea365c1f9dc34bf081c4cf7c988a5342 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.868634/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
spelling	10.3389/fcvm.2022.868634 doi (DE-627)DOAJ021365342 (DE-599)DOAJea365c1f9dc34bf081c4cf7c988a5342 DE-627 ger DE-627 rakwb eng RC666-701 Shifeng Qiu verfasserin aut A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure. radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis Diseases of the circulatory (Cardiovascular) system Shifeng Qiu verfasserin aut Shifeng Qiu verfasserin aut Zhuhua Sun verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Menghui Liu verfasserin aut Menghui Liu verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Yumei Xue verfasserin aut Yumei Xue verfasserin aut Lichun Wang verfasserin aut Lichun Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.868634 kostenfrei https://doaj.org/article/ea365c1f9dc34bf081c4cf7c988a5342 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.868634/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfields_unstemmed	10.3389/fcvm.2022.868634 doi (DE-627)DOAJ021365342 (DE-599)DOAJea365c1f9dc34bf081c4cf7c988a5342 DE-627 ger DE-627 rakwb eng RC666-701 Shifeng Qiu verfasserin aut A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure. radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis Diseases of the circulatory (Cardiovascular) system Shifeng Qiu verfasserin aut Shifeng Qiu verfasserin aut Zhuhua Sun verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Menghui Liu verfasserin aut Menghui Liu verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Yumei Xue verfasserin aut Yumei Xue verfasserin aut Lichun Wang verfasserin aut Lichun Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.868634 kostenfrei https://doaj.org/article/ea365c1f9dc34bf081c4cf7c988a5342 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.868634/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsGer	10.3389/fcvm.2022.868634 doi (DE-627)DOAJ021365342 (DE-599)DOAJea365c1f9dc34bf081c4cf7c988a5342 DE-627 ger DE-627 rakwb eng RC666-701 Shifeng Qiu verfasserin aut A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure. radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis Diseases of the circulatory (Cardiovascular) system Shifeng Qiu verfasserin aut Shifeng Qiu verfasserin aut Zhuhua Sun verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Menghui Liu verfasserin aut Menghui Liu verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Yumei Xue verfasserin aut Yumei Xue verfasserin aut Lichun Wang verfasserin aut Lichun Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.868634 kostenfrei https://doaj.org/article/ea365c1f9dc34bf081c4cf7c988a5342 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.868634/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsSound	10.3389/fcvm.2022.868634 doi (DE-627)DOAJ021365342 (DE-599)DOAJea365c1f9dc34bf081c4cf7c988a5342 DE-627 ger DE-627 rakwb eng RC666-701 Shifeng Qiu verfasserin aut A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure. radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis Diseases of the circulatory (Cardiovascular) system Shifeng Qiu verfasserin aut Shifeng Qiu verfasserin aut Zhuhua Sun verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Xinzhong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Jianyong Li verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Xiaobo Huang verfasserin aut Menghui Liu verfasserin aut Menghui Liu verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Jianping Bin verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Yulin Liao verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Jiancheng Xiu verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Daogang Zha verfasserin aut Yumei Xue verfasserin aut Yumei Xue verfasserin aut Lichun Wang verfasserin aut Lichun Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut Yuegang Wang verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.868634 kostenfrei https://doaj.org/article/ea365c1f9dc34bf081c4cf7c988a5342 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.868634/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
language	English
source	In Frontiers in Cardiovascular Medicine 9(2022) volume:9 year:2022
sourceStr	In Frontiers in Cardiovascular Medicine 9(2022) volume:9 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis Diseases of the circulatory (Cardiovascular) system
isfreeaccess_bool	true
container_title	Frontiers in Cardiovascular Medicine
authorswithroles_txt_mv	Shifeng Qiu @@aut@@ Zhuhua Sun @@aut@@ Xinzhong Li @@aut@@ Jianyong Li @@aut@@ Xiaobo Huang @@aut@@ Menghui Liu @@aut@@ Jianping Bin @@aut@@ Yulin Liao @@aut@@ Jiancheng Xiu @@aut@@ Daogang Zha @@aut@@ Yumei Xue @@aut@@ Lichun Wang @@aut@@ Yuegang Wang @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	793951607
id	DOAJ021365342
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ021365342</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307045655.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fcvm.2022.868634</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ021365342</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJea365c1f9dc34bf081c4cf7c988a5342</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC666-701</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Shifeng Qiu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P &lt; 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P &lt; 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P &lt; 0.016); TZ index: 0.858 (P &lt; 0.001); V1-2 SRd: 0.876 (P &lt; 0.001); V3 transition: 0.651 (P &lt; 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. 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callnumber-first	R - Medicine
author	Shifeng Qiu
spellingShingle	Shifeng Qiu misc RC666-701 misc radiofrequency ablation misc electrocardiogram misc V2S misc angle misc ventricular outflow tract arrhythmias misc cardiac long-axis misc Diseases of the circulatory (Cardiovascular) system A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S
authorStr	Shifeng Qiu
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topic_title	RC666-701 A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S radiofrequency ablation electrocardiogram V2S angle ventricular outflow tract arrhythmias cardiac long-axis
topic	misc RC666-701 misc radiofrequency ablation misc electrocardiogram misc V2S misc angle misc ventricular outflow tract arrhythmias misc cardiac long-axis misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc radiofrequency ablation misc electrocardiogram misc V2S misc angle misc ventricular outflow tract arrhythmias misc cardiac long-axis misc Diseases of the circulatory (Cardiovascular) system
topic_browse	misc RC666-701 misc radiofrequency ablation misc electrocardiogram misc V2S misc angle misc ventricular outflow tract arrhythmias misc cardiac long-axis misc Diseases of the circulatory (Cardiovascular) system
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title	A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S
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title_full	A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S
author_sort	Shifeng Qiu
journal	Frontiers in Cardiovascular Medicine
journalStr	Frontiers in Cardiovascular Medicine
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author_browse	Shifeng Qiu Zhuhua Sun Xinzhong Li Jianyong Li Xiaobo Huang Menghui Liu Jianping Bin Yulin Liao Jiancheng Xiu Daogang Zha Yumei Xue Lichun Wang Yuegang Wang
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author-letter	Shifeng Qiu
doi_str_mv	10.3389/fcvm.2022.868634
author2-role	verfasserin
title_sort	novel and effective ecg method to differentiate right from left ventricular outflow tract arrhythmias: angle-corrected v2s
callnumber	RC666-701
title_auth	A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S
abstract	Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure.
abstractGer	Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure.
abstract_unstemmed	Background and aimsStandard 12-lead electrocardiogram (ECG) patterns combined with the anatomical cardiac long-axis angle revealed by chest X-ray can prevent the influence of cardiac rotation, physical shape, and lead position, so it may be an ideal means to predict the origin of the outflow tract (OT) ventricular arrhythmias (OTVAs) for ablation procedures. The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P < 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P < 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P < 0.016); TZ index: 0.858 (P < 0.001); V1-2 SRd: 0.876 (P < 0.001); V3 transition: 0.651 (P < 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. It could help decrease ablation duration and radiation exposure.
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title_short	A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S
url	https://doi.org/10.3389/fcvm.2022.868634 https://doaj.org/article/ea365c1f9dc34bf081c4cf7c988a5342 https://www.frontiersin.org/articles/10.3389/fcvm.2022.868634/full https://doaj.org/toc/2297-055X
remote_bool	true
author2	Shifeng Qiu Zhuhua Sun Xinzhong Li Jianyong Li Xiaobo Huang Menghui Liu Jianping Bin Yulin Liao Jiancheng Xiu Daogang Zha Yumei Xue Lichun Wang Yuegang Wang
author2Str	Shifeng Qiu Zhuhua Sun Xinzhong Li Jianyong Li Xiaobo Huang Menghui Liu Jianping Bin Yulin Liao Jiancheng Xiu Daogang Zha Yumei Xue Lichun Wang Yuegang Wang
ppnlink	793951607
callnumber-subject	RC - Internal Medicine
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isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3389/fcvm.2022.868634
callnumber-a	RC666-701
up_date	2024-07-03T20:27:18.936Z
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The study explores the value of this strategy in identifying the origin of OTVA.MethodsThis study was conducted using a retrospective cohort and a prospective cohort of consecutive patients at two centers. The anatomical cardiac long-axis angle was calculated by measuring the angle between the cardiac long-axis (a line joining the apex to the midpoint of the mitral annulus) and the horizontal plane on a chest X-ray. The V2S angle was calculated as the V2S amplitude times the angle. We ultimately enrolled 147 patients with symptomatic OTVAs who underwent successful radiofrequency catheter ablation (RFCA) (98 women (66.7%); mean age 46.9 ± 14.7 years; 126 right ventricular OT (RVOT) origins, 21 left ventricular OT (LVOT) origins) as a development cohort. The new algorithm was validated in 48 prospective patients (12 men (25.0%); mean age 48.0 ± 15.8 years; 36 RVOT, 12 LVOT origins).ResultsPatients with RVOT VAs had greater V2S, long-axis angle, and V2S angle than patients with LVOT VA (all P &lt; 0.001). The cut-off V2S angle obtained by receiver operating characteristic (ROC) curve analysis was 58.28 mV° for the prediction of RVOT origin (sensitivity: 85.7%; specificity: 95.2%; positive predictive value: 99.1%; negative predictive value: 52.6%). The AUC achieved using the V2S angle was 0.888 (P &lt; 0.001), which was the highest among all indexes (V2S/V3R: 0.887 (P &lt; 0.016); TZ index: 0.858 (P &lt; 0.001); V1-2 SRd: 0.876 (P &lt; 0.001); V3 transition: 0.651 (P &lt; 0.001)). In the prospective cohort, the V2S angle had a high overall accuracy of 93.8% and decreased the procedure time (P = 0.002).ConclusionV2S angle can be a novel measure that can be used to accurately differentiate RVOT from LVOT origins. 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A novel and effective ECG method to differentiate right from left ventricular outflow tract arrhythmias: Angle-corrected V2S

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