Effects of transcranial direct current stimulation (tDCS) on consolidation of fear memory
It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applie...
Ausführliche Beschreibung
Autor*in: |
Manish eAsthana [verfasserIn] Katharina eNueckel [verfasserIn] Andreas eMühlberger [verfasserIn] Dorothea eNeueder [verfasserIn] Thomas ePolak [verfasserIn] Katharina eDomschke [verfasserIn] Jürgen eDeckert [verfasserIn] Martin J. Herrmann [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2013 |
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Schlagwörter: |
transcranial direct current stimulation (tDCS) dorsolateral prefrontal cortex (DLPFC) |
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Übergeordnetes Werk: |
In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 4(2013) |
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Übergeordnetes Werk: |
volume:4 ; year:2013 |
Links: |
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DOI / URN: |
10.3389/fpsyt.2013.00107 |
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Katalog-ID: |
DOAJ02139427X |
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520 | |a It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. | ||
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10.3389/fpsyt.2013.00107 doi (DE-627)DOAJ02139427X (DE-599)DOAJ8e5abe2c577f4670b91e8cc1e39c5ae6 DE-627 ger DE-627 rakwb eng RC435-571 Manish eAsthana verfasserin aut Effects of transcranial direct current stimulation (tDCS) on consolidation of fear memory 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. Fear conditioning transcranial direct current stimulation (tDCS) dorsolateral prefrontal cortex (DLPFC) skin conductance response (SCR) fear memory consolidation Psychiatry Katharina eNueckel verfasserin aut Andreas eMühlberger verfasserin aut Dorothea eNeueder verfasserin aut Thomas ePolak verfasserin aut Katharina eDomschke verfasserin aut Jürgen eDeckert verfasserin aut Martin J. Herrmann verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 4(2013) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:4 year:2013 https://doi.org/10.3389/fpsyt.2013.00107 kostenfrei https://doaj.org/article/8e5abe2c577f4670b91e8cc1e39c5ae6 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00107/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 |
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10.3389/fpsyt.2013.00107 doi (DE-627)DOAJ02139427X (DE-599)DOAJ8e5abe2c577f4670b91e8cc1e39c5ae6 DE-627 ger DE-627 rakwb eng RC435-571 Manish eAsthana verfasserin aut Effects of transcranial direct current stimulation (tDCS) on consolidation of fear memory 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. Fear conditioning transcranial direct current stimulation (tDCS) dorsolateral prefrontal cortex (DLPFC) skin conductance response (SCR) fear memory consolidation Psychiatry Katharina eNueckel verfasserin aut Andreas eMühlberger verfasserin aut Dorothea eNeueder verfasserin aut Thomas ePolak verfasserin aut Katharina eDomschke verfasserin aut Jürgen eDeckert verfasserin aut Martin J. Herrmann verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 4(2013) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:4 year:2013 https://doi.org/10.3389/fpsyt.2013.00107 kostenfrei https://doaj.org/article/8e5abe2c577f4670b91e8cc1e39c5ae6 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00107/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 |
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Manish eAsthana misc RC435-571 misc Fear conditioning misc transcranial direct current stimulation (tDCS) misc dorsolateral prefrontal cortex (DLPFC) misc skin conductance response (SCR) misc fear memory consolidation misc Psychiatry Effects of transcranial direct current stimulation (tDCS) on consolidation of fear memory |
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Effects of transcranial direct current stimulation (tDCS) on consolidation of fear memory |
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It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. |
abstractGer |
It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. |
abstract_unstemmed |
It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. |
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Effects of transcranial direct current stimulation (tDCS) on consolidation of fear memory |
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This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm; in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 minutes after fear conditioning. The effect of fear conditioning and consolidation (24 hours later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. 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