Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance

Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Amaia Mentxaka [verfasserIn] Javier Gómez-Ambrosi [verfasserIn] Beatriz Ramírez [verfasserIn] Amaia Rodríguez [verfasserIn] Sara Becerril [verfasserIn] Gabriela Neira [verfasserIn] Víctor Valentí [verfasserIn] Rafael Moncada [verfasserIn] Camilo Silva [verfasserIn] Xabier Unamuno [verfasserIn] Javier A. Cienfuegos [verfasserIn] Javier Escalada [verfasserIn] Gema Frühbeck [verfasserIn] Victoria Catalán [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 14(2022), 20, p 4372
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:20, p 4372

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu14204372

Katalog-ID:	DOAJ021638209

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allfields	10.3390/nu14204372 doi (DE-627)DOAJ021638209 (DE-599)DOAJ225cf5ebebea4da09e2ddf1f7f7cb155 DE-627 ger DE-627 rakwb eng TX341-641 Amaia Mentxaka verfasserin aut Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity. NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages Nutrition. Foods and food supply Javier Gómez-Ambrosi verfasserin aut Beatriz Ramírez verfasserin aut Amaia Rodríguez verfasserin aut Sara Becerril verfasserin aut Gabriela Neira verfasserin aut Víctor Valentí verfasserin aut Rafael Moncada verfasserin aut Camilo Silva verfasserin aut Xabier Unamuno verfasserin aut Javier A. Cienfuegos verfasserin aut Javier Escalada verfasserin aut Gema Frühbeck verfasserin aut Victoria Catalán verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 20, p 4372 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:20, p 4372 https://doi.org/10.3390/nu14204372 kostenfrei https://doaj.org/article/225cf5ebebea4da09e2ddf1f7f7cb155 kostenfrei https://www.mdpi.com/2072-6643/14/20/4372 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 20, p 4372
spelling	10.3390/nu14204372 doi (DE-627)DOAJ021638209 (DE-599)DOAJ225cf5ebebea4da09e2ddf1f7f7cb155 DE-627 ger DE-627 rakwb eng TX341-641 Amaia Mentxaka verfasserin aut Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity. NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages Nutrition. Foods and food supply Javier Gómez-Ambrosi verfasserin aut Beatriz Ramírez verfasserin aut Amaia Rodríguez verfasserin aut Sara Becerril verfasserin aut Gabriela Neira verfasserin aut Víctor Valentí verfasserin aut Rafael Moncada verfasserin aut Camilo Silva verfasserin aut Xabier Unamuno verfasserin aut Javier A. Cienfuegos verfasserin aut Javier Escalada verfasserin aut Gema Frühbeck verfasserin aut Victoria Catalán verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 20, p 4372 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:20, p 4372 https://doi.org/10.3390/nu14204372 kostenfrei https://doaj.org/article/225cf5ebebea4da09e2ddf1f7f7cb155 kostenfrei https://www.mdpi.com/2072-6643/14/20/4372 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 20, p 4372
allfields_unstemmed	10.3390/nu14204372 doi (DE-627)DOAJ021638209 (DE-599)DOAJ225cf5ebebea4da09e2ddf1f7f7cb155 DE-627 ger DE-627 rakwb eng TX341-641 Amaia Mentxaka verfasserin aut Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity. NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages Nutrition. Foods and food supply Javier Gómez-Ambrosi verfasserin aut Beatriz Ramírez verfasserin aut Amaia Rodríguez verfasserin aut Sara Becerril verfasserin aut Gabriela Neira verfasserin aut Víctor Valentí verfasserin aut Rafael Moncada verfasserin aut Camilo Silva verfasserin aut Xabier Unamuno verfasserin aut Javier A. Cienfuegos verfasserin aut Javier Escalada verfasserin aut Gema Frühbeck verfasserin aut Victoria Catalán verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 20, p 4372 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:20, p 4372 https://doi.org/10.3390/nu14204372 kostenfrei https://doaj.org/article/225cf5ebebea4da09e2ddf1f7f7cb155 kostenfrei https://www.mdpi.com/2072-6643/14/20/4372 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 20, p 4372
allfieldsGer	10.3390/nu14204372 doi (DE-627)DOAJ021638209 (DE-599)DOAJ225cf5ebebea4da09e2ddf1f7f7cb155 DE-627 ger DE-627 rakwb eng TX341-641 Amaia Mentxaka verfasserin aut Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity. NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages Nutrition. Foods and food supply Javier Gómez-Ambrosi verfasserin aut Beatriz Ramírez verfasserin aut Amaia Rodríguez verfasserin aut Sara Becerril verfasserin aut Gabriela Neira verfasserin aut Víctor Valentí verfasserin aut Rafael Moncada verfasserin aut Camilo Silva verfasserin aut Xabier Unamuno verfasserin aut Javier A. Cienfuegos verfasserin aut Javier Escalada verfasserin aut Gema Frühbeck verfasserin aut Victoria Catalán verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 20, p 4372 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:20, p 4372 https://doi.org/10.3390/nu14204372 kostenfrei https://doaj.org/article/225cf5ebebea4da09e2ddf1f7f7cb155 kostenfrei https://www.mdpi.com/2072-6643/14/20/4372 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 20, p 4372
allfieldsSound	10.3390/nu14204372 doi (DE-627)DOAJ021638209 (DE-599)DOAJ225cf5ebebea4da09e2ddf1f7f7cb155 DE-627 ger DE-627 rakwb eng TX341-641 Amaia Mentxaka verfasserin aut Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity. NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages Nutrition. Foods and food supply Javier Gómez-Ambrosi verfasserin aut Beatriz Ramírez verfasserin aut Amaia Rodríguez verfasserin aut Sara Becerril verfasserin aut Gabriela Neira verfasserin aut Víctor Valentí verfasserin aut Rafael Moncada verfasserin aut Camilo Silva verfasserin aut Xabier Unamuno verfasserin aut Javier A. Cienfuegos verfasserin aut Javier Escalada verfasserin aut Gema Frühbeck verfasserin aut Victoria Catalán verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 20, p 4372 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:20, p 4372 https://doi.org/10.3390/nu14204372 kostenfrei https://doaj.org/article/225cf5ebebea4da09e2ddf1f7f7cb155 kostenfrei https://www.mdpi.com/2072-6643/14/20/4372 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 20, p 4372
language	English
source	In Nutrients 14(2022), 20, p 4372 volume:14 year:2022 number:20, p 4372
sourceStr	In Nutrients 14(2022), 20, p 4372 volume:14 year:2022 number:20, p 4372
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Nutrients
authorswithroles_txt_mv	Amaia Mentxaka @@aut@@ Javier Gómez-Ambrosi @@aut@@ Beatriz Ramírez @@aut@@ Amaia Rodríguez @@aut@@ Sara Becerril @@aut@@ Gabriela Neira @@aut@@ Víctor Valentí @@aut@@ Rafael Moncada @@aut@@ Camilo Silva @@aut@@ Xabier Unamuno @@aut@@ Javier A. Cienfuegos @@aut@@ Javier Escalada @@aut@@ Gema Frühbeck @@aut@@ Victoria Catalán @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	610604155
id	DOAJ021638209
language_de	englisch
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We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. 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callnumber-first	T - Technology
author	Amaia Mentxaka
spellingShingle	Amaia Mentxaka misc TX341-641 misc NTN-1 misc NEO-1 misc weight loss misc Roux-en-Y gastric bypass misc caloric restriction misc macrophages misc Nutrition. Foods and food supply Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
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topic_title	TX341-641 Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance NTN-1 NEO-1 weight loss Roux-en-Y gastric bypass caloric restriction macrophages
topic	misc TX341-641 misc NTN-1 misc NEO-1 misc weight loss misc Roux-en-Y gastric bypass misc caloric restriction misc macrophages misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc NTN-1 misc NEO-1 misc weight loss misc Roux-en-Y gastric bypass misc caloric restriction misc macrophages misc Nutrition. Foods and food supply
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title	Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
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title_full	Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
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author_browse	Amaia Mentxaka Javier Gómez-Ambrosi Beatriz Ramírez Amaia Rodríguez Sara Becerril Gabriela Neira Víctor Valentí Rafael Moncada Camilo Silva Xabier Unamuno Javier A. Cienfuegos Javier Escalada Gema Frühbeck Victoria Catalán
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title_sort	netrin-1 promotes visceral adipose tissue inflammation in obesity and is associated with insulin resistance
callnumber	TX341-641
title_auth	Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
abstract	Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity.
abstractGer	Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity.
abstract_unstemmed	Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. We aimed to determine the impact of NTN-1 on obesity and obesity-associated type 2 diabetes, as well as its role in visceral adipose tissue (VAT) inflammation. A total of 91 subjects were enrolled in this case-control study. Circulating levels of NTN-1 and its receptor neogenin (NEO)-1 were determined before and after weight loss achieved by caloric restriction and bariatric surgery. mRNA levels of <i<NTN1</i< and <i<NEO1</i< were assessed in human VAT, liver, and peripheral blood mononuclear cells. In vitro studies in human visceral adipocytes and human monocytic leukemia cells (THP-1)-derived macrophages were performed to analyze the impact of inflammation-related mediators on the gene expression levels of <i<NTN1</i< and its receptor <i<NEO1</i< as well as the effect of NTN-1 on inflammation. Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. Collectively, these findings suggest that NTN-1 regulates VAT chronic inflammation and insulin resistance in obesity.
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title_short	Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
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Increased (<i<p</i< < 0.001) circulating concentrations of NTN-1 in obesity decreased (<i<p</i< < 0.05) after diet-induced weight loss being also associated with a reduction in glucose (<i<p</i< < 0.01) and insulin levels (<i<p</i< < 0.05). Gene expression levels of <i<NTN1</i< and <i<NEO1</i< were upregulated (<i<p</i< < 0.05) in the VAT from patients with obesity with the highest expression in the stromovascular fraction cells compared with mature adipocytes (<i<p</i< < 0.01). <i<NTN1</i< expression levels were enhanced (<i<p</i< < 0.01) under hypoxia and by inflammatory factors in both adipocytes and macrophages. Adipocyte-conditioned media strongly upregulated (<i<p</i< < 0.001) the mRNA levels of <i<NTN1</i< in macrophages. The treatment of adipocytes with NTN-1 promoted the upregulation (<i<p</i< < 0.05) of pro-inflammatory and chemotactic molecules as well as its receptor <i<NEO1</i<. 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Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance

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