Characterization of prostate cancer detected at repeat biopsy

<p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Saito Mitsuru [verfasserIn] Narita Shintaro [verfasserIn] Inoue Takamitsu [verfasserIn] Kumazawa Teruaki [verfasserIn] Tsuchiya Norihiko [verfasserIn] Yuasa Takeshi [verfasserIn] Horikawa Yohei [verfasserIn] Satoh Shigeru [verfasserIn] Habuchi Tomonori [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: BMC Urology - BMC, 2003, 8(2008), 1, p 14
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1, p 14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2490-8-14

Katalog-ID:	DOAJ021743150

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p<
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allfields	10.1186/1471-2490-8-14 doi (DE-627)DOAJ021743150 (DE-599)DOAJb89827d6c8b6466aa8638e6b5d9c7105 DE-627 ger DE-627 rakwb eng RC870-923 Saito Mitsuru verfasserin aut Characterization of prostate cancer detected at repeat biopsy 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p< Diseases of the genitourinary system. Urology Narita Shintaro verfasserin aut Inoue Takamitsu verfasserin aut Kumazawa Teruaki verfasserin aut Tsuchiya Norihiko verfasserin aut Yuasa Takeshi verfasserin aut Horikawa Yohei verfasserin aut Satoh Shigeru verfasserin aut Habuchi Tomonori verfasserin aut In BMC Urology BMC, 2003 8(2008), 1, p 14 (DE-627)335488811 (DE-600)2059857-9 14712490 nnns volume:8 year:2008 number:1, p 14 https://doi.org/10.1186/1471-2490-8-14 kostenfrei https://doaj.org/article/b89827d6c8b6466aa8638e6b5d9c7105 kostenfrei http://www.biomedcentral.com/1471-2490/8/14 kostenfrei https://doaj.org/toc/1471-2490 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 14
spelling	10.1186/1471-2490-8-14 doi (DE-627)DOAJ021743150 (DE-599)DOAJb89827d6c8b6466aa8638e6b5d9c7105 DE-627 ger DE-627 rakwb eng RC870-923 Saito Mitsuru verfasserin aut Characterization of prostate cancer detected at repeat biopsy 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p< Diseases of the genitourinary system. Urology Narita Shintaro verfasserin aut Inoue Takamitsu verfasserin aut Kumazawa Teruaki verfasserin aut Tsuchiya Norihiko verfasserin aut Yuasa Takeshi verfasserin aut Horikawa Yohei verfasserin aut Satoh Shigeru verfasserin aut Habuchi Tomonori verfasserin aut In BMC Urology BMC, 2003 8(2008), 1, p 14 (DE-627)335488811 (DE-600)2059857-9 14712490 nnns volume:8 year:2008 number:1, p 14 https://doi.org/10.1186/1471-2490-8-14 kostenfrei https://doaj.org/article/b89827d6c8b6466aa8638e6b5d9c7105 kostenfrei http://www.biomedcentral.com/1471-2490/8/14 kostenfrei https://doaj.org/toc/1471-2490 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 14
allfields_unstemmed	10.1186/1471-2490-8-14 doi (DE-627)DOAJ021743150 (DE-599)DOAJb89827d6c8b6466aa8638e6b5d9c7105 DE-627 ger DE-627 rakwb eng RC870-923 Saito Mitsuru verfasserin aut Characterization of prostate cancer detected at repeat biopsy 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p< Diseases of the genitourinary system. Urology Narita Shintaro verfasserin aut Inoue Takamitsu verfasserin aut Kumazawa Teruaki verfasserin aut Tsuchiya Norihiko verfasserin aut Yuasa Takeshi verfasserin aut Horikawa Yohei verfasserin aut Satoh Shigeru verfasserin aut Habuchi Tomonori verfasserin aut In BMC Urology BMC, 2003 8(2008), 1, p 14 (DE-627)335488811 (DE-600)2059857-9 14712490 nnns volume:8 year:2008 number:1, p 14 https://doi.org/10.1186/1471-2490-8-14 kostenfrei https://doaj.org/article/b89827d6c8b6466aa8638e6b5d9c7105 kostenfrei http://www.biomedcentral.com/1471-2490/8/14 kostenfrei https://doaj.org/toc/1471-2490 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 14
allfieldsGer	10.1186/1471-2490-8-14 doi (DE-627)DOAJ021743150 (DE-599)DOAJb89827d6c8b6466aa8638e6b5d9c7105 DE-627 ger DE-627 rakwb eng RC870-923 Saito Mitsuru verfasserin aut Characterization of prostate cancer detected at repeat biopsy 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p< Diseases of the genitourinary system. Urology Narita Shintaro verfasserin aut Inoue Takamitsu verfasserin aut Kumazawa Teruaki verfasserin aut Tsuchiya Norihiko verfasserin aut Yuasa Takeshi verfasserin aut Horikawa Yohei verfasserin aut Satoh Shigeru verfasserin aut Habuchi Tomonori verfasserin aut In BMC Urology BMC, 2003 8(2008), 1, p 14 (DE-627)335488811 (DE-600)2059857-9 14712490 nnns volume:8 year:2008 number:1, p 14 https://doi.org/10.1186/1471-2490-8-14 kostenfrei https://doaj.org/article/b89827d6c8b6466aa8638e6b5d9c7105 kostenfrei http://www.biomedcentral.com/1471-2490/8/14 kostenfrei https://doaj.org/toc/1471-2490 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 14
allfieldsSound	10.1186/1471-2490-8-14 doi (DE-627)DOAJ021743150 (DE-599)DOAJb89827d6c8b6466aa8638e6b5d9c7105 DE-627 ger DE-627 rakwb eng RC870-923 Saito Mitsuru verfasserin aut Characterization of prostate cancer detected at repeat biopsy 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p< Diseases of the genitourinary system. Urology Narita Shintaro verfasserin aut Inoue Takamitsu verfasserin aut Kumazawa Teruaki verfasserin aut Tsuchiya Norihiko verfasserin aut Yuasa Takeshi verfasserin aut Horikawa Yohei verfasserin aut Satoh Shigeru verfasserin aut Habuchi Tomonori verfasserin aut In BMC Urology BMC, 2003 8(2008), 1, p 14 (DE-627)335488811 (DE-600)2059857-9 14712490 nnns volume:8 year:2008 number:1, p 14 https://doi.org/10.1186/1471-2490-8-14 kostenfrei https://doaj.org/article/b89827d6c8b6466aa8638e6b5d9c7105 kostenfrei http://www.biomedcentral.com/1471-2490/8/14 kostenfrei https://doaj.org/toc/1471-2490 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 14
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authorswithroles_txt_mv	Saito Mitsuru @@aut@@ Narita Shintaro @@aut@@ Inoue Takamitsu @@aut@@ Kumazawa Teruaki @@aut@@ Tsuchiya Norihiko @@aut@@ Yuasa Takeshi @@aut@@ Horikawa Yohei @@aut@@ Satoh Shigeru @@aut@@ Habuchi Tomonori @@aut@@
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callnumber-first	R - Medicine
author	Saito Mitsuru
spellingShingle	Saito Mitsuru misc RC870-923 misc Diseases of the genitourinary system. Urology Characterization of prostate cancer detected at repeat biopsy
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topic_title	RC870-923 Characterization of prostate cancer detected at repeat biopsy
topic	misc RC870-923 misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Diseases of the genitourinary system. Urology
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title	Characterization of prostate cancer detected at repeat biopsy
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title_full	Characterization of prostate cancer detected at repeat biopsy
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author_browse	Saito Mitsuru Narita Shintaro Inoue Takamitsu Kumazawa Teruaki Tsuchiya Norihiko Yuasa Takeshi Horikawa Yohei Satoh Shigeru Habuchi Tomonori
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author-letter	Saito Mitsuru
doi_str_mv	10.1186/1471-2490-8-14
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title_sort	characterization of prostate cancer detected at repeat biopsy
callnumber	RC870-923
title_auth	Characterization of prostate cancer detected at repeat biopsy
abstract	<p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The aim of this study was to investigate the characteristics of prostate cancer patients who were diagnosed at repeat biopsy and compare them to non-cancerous patients or patients who were diagnosed at initial biopsy.</p< <p<Methods</p< <p<We carried out a retrospective analysis of clinical and pathological data from 576 patients, which included data on the period of time from radical prostatectomy to biochemical failure.</p< <p<Results</p< <p<Cancer was diagnosed in 191 (33%) of 576 patients at initial biopsy and in 23 (18%) of 127 patients who underwent a repeat biopsy. Cut-off values of 0.80 and 0.30 for prostate specific antigen velocity (PSAV) and prostate specific antigen density (PSAD), respectively, were determined using ROC curve analysis. Based on these values, PSAV and PSAD were able to predict 94% (46 of 49) of negative repeat biopsies, indicating that these patients had undergone unnecessary repeat biopsies. Although the patients who were diagnosed at repeat biopsy had a higher rate of organ-confined tumor than those who were diagnosed at initial biopsy (73% and 44%, respectively; <it<P </it<= 0.041), there were no differences in the recurrence rate or the duration of biochemical failure-free survival between the two groups.</p< <p<Conclusion</p< <p<PSAV and PSAD may be useful indicators of the results of repeat biopsies. Although prostate cancer that was diagnosed at repeat biopsy was associated with a more favorable pathological profile, it was not associated with a better outcome after radical prostatectomy.</p<
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title_short	Characterization of prostate cancer detected at repeat biopsy
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author2	Narita Shintaro Inoue Takamitsu Kumazawa Teruaki Tsuchiya Norihiko Yuasa Takeshi Horikawa Yohei Satoh Shigeru Habuchi Tomonori
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up_date	2024-07-03T22:34:33.076Z
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