Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes

<p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rouy Zoé [verfasserIn] Vacherie Benoit [verfasserIn] Jarraud Sophie [verfasserIn] Rusniok Christophe [verfasserIn] Gomez-Valero Laura [verfasserIn] Barbe Valerie [verfasserIn] Medigue Claudine [verfasserIn] Etienne Jerome [verfasserIn] Buchrieser Carmen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Übergeordnetes Werk:	In: BMC Genomics - BMC, 2003, 12(2011), 1, p 536
Übergeordnetes Werk:	volume:12 ; year:2011 ; number:1, p 536

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2164-12-536

Katalog-ID:	DOAJ022107134

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p<
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allfields	10.1186/1471-2164-12-536 doi (DE-627)DOAJ022107134 (DE-599)DOAJfdb762cf1b34497681aa5584c1c06385 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Rouy Zoé verfasserin aut Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p< Biotechnology Genetics Vacherie Benoit verfasserin aut Jarraud Sophie verfasserin aut Rusniok Christophe verfasserin aut Gomez-Valero Laura verfasserin aut Barbe Valerie verfasserin aut Medigue Claudine verfasserin aut Etienne Jerome verfasserin aut Buchrieser Carmen verfasserin aut In BMC Genomics BMC, 2003 12(2011), 1, p 536 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:12 year:2011 number:1, p 536 https://doi.org/10.1186/1471-2164-12-536 kostenfrei https://doaj.org/article/fdb762cf1b34497681aa5584c1c06385 kostenfrei http://www.biomedcentral.com/1471-2164/12/536 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2011 1, p 536
spelling	10.1186/1471-2164-12-536 doi (DE-627)DOAJ022107134 (DE-599)DOAJfdb762cf1b34497681aa5584c1c06385 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Rouy Zoé verfasserin aut Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p< Biotechnology Genetics Vacherie Benoit verfasserin aut Jarraud Sophie verfasserin aut Rusniok Christophe verfasserin aut Gomez-Valero Laura verfasserin aut Barbe Valerie verfasserin aut Medigue Claudine verfasserin aut Etienne Jerome verfasserin aut Buchrieser Carmen verfasserin aut In BMC Genomics BMC, 2003 12(2011), 1, p 536 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:12 year:2011 number:1, p 536 https://doi.org/10.1186/1471-2164-12-536 kostenfrei https://doaj.org/article/fdb762cf1b34497681aa5584c1c06385 kostenfrei http://www.biomedcentral.com/1471-2164/12/536 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2011 1, p 536
allfields_unstemmed	10.1186/1471-2164-12-536 doi (DE-627)DOAJ022107134 (DE-599)DOAJfdb762cf1b34497681aa5584c1c06385 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Rouy Zoé verfasserin aut Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p< Biotechnology Genetics Vacherie Benoit verfasserin aut Jarraud Sophie verfasserin aut Rusniok Christophe verfasserin aut Gomez-Valero Laura verfasserin aut Barbe Valerie verfasserin aut Medigue Claudine verfasserin aut Etienne Jerome verfasserin aut Buchrieser Carmen verfasserin aut In BMC Genomics BMC, 2003 12(2011), 1, p 536 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:12 year:2011 number:1, p 536 https://doi.org/10.1186/1471-2164-12-536 kostenfrei https://doaj.org/article/fdb762cf1b34497681aa5584c1c06385 kostenfrei http://www.biomedcentral.com/1471-2164/12/536 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2011 1, p 536
allfieldsGer	10.1186/1471-2164-12-536 doi (DE-627)DOAJ022107134 (DE-599)DOAJfdb762cf1b34497681aa5584c1c06385 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Rouy Zoé verfasserin aut Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p< Biotechnology Genetics Vacherie Benoit verfasserin aut Jarraud Sophie verfasserin aut Rusniok Christophe verfasserin aut Gomez-Valero Laura verfasserin aut Barbe Valerie verfasserin aut Medigue Claudine verfasserin aut Etienne Jerome verfasserin aut Buchrieser Carmen verfasserin aut In BMC Genomics BMC, 2003 12(2011), 1, p 536 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:12 year:2011 number:1, p 536 https://doi.org/10.1186/1471-2164-12-536 kostenfrei https://doaj.org/article/fdb762cf1b34497681aa5584c1c06385 kostenfrei http://www.biomedcentral.com/1471-2164/12/536 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2011 1, p 536
allfieldsSound	10.1186/1471-2164-12-536 doi (DE-627)DOAJ022107134 (DE-599)DOAJfdb762cf1b34497681aa5584c1c06385 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Rouy Zoé verfasserin aut Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p< Biotechnology Genetics Vacherie Benoit verfasserin aut Jarraud Sophie verfasserin aut Rusniok Christophe verfasserin aut Gomez-Valero Laura verfasserin aut Barbe Valerie verfasserin aut Medigue Claudine verfasserin aut Etienne Jerome verfasserin aut Buchrieser Carmen verfasserin aut In BMC Genomics BMC, 2003 12(2011), 1, p 536 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:12 year:2011 number:1, p 536 https://doi.org/10.1186/1471-2164-12-536 kostenfrei https://doaj.org/article/fdb762cf1b34497681aa5584c1c06385 kostenfrei http://www.biomedcentral.com/1471-2164/12/536 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2011 1, p 536
language	English
source	In BMC Genomics 12(2011), 1, p 536 volume:12 year:2011 number:1, p 536
sourceStr	In BMC Genomics 12(2011), 1, p 536 volume:12 year:2011 number:1, p 536
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biotechnology Genetics
isfreeaccess_bool	true
container_title	BMC Genomics
authorswithroles_txt_mv	Rouy Zoé @@aut@@ Vacherie Benoit @@aut@@ Jarraud Sophie @@aut@@ Rusniok Christophe @@aut@@ Gomez-Valero Laura @@aut@@ Barbe Valerie @@aut@@ Medigue Claudine @@aut@@ Etienne Jerome @@aut@@ Buchrieser Carmen @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	326644954
id	DOAJ022107134
language_de	englisch
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callnumber-first	T - Technology
author	Rouy Zoé
spellingShingle	Rouy Zoé misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes
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topic_title	TP248.13-248.65 QH426-470 Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes
topic	misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics
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title	Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes
ctrlnum	(DE-627)DOAJ022107134 (DE-599)DOAJfdb762cf1b34497681aa5584c1c06385
title_full	Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes
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author_browse	Rouy Zoé Vacherie Benoit Jarraud Sophie Rusniok Christophe Gomez-Valero Laura Barbe Valerie Medigue Claudine Etienne Jerome Buchrieser Carmen
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title_sort	extensive recombination events and horizontal gene transfer shaped the <it<legionella pneumophila </it<genomes
callnumber	TP248.13-248.65
title_auth	Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes
abstract	<p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<<it<Legionella pneumophila </it<is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of <it<Legionella </it<species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely <it<L. pneumophila </it<Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.</p< <p<Results</p< <p<We show that <it<L. pneumophila </it<Sg1 has a highly conserved and syntenic core genome that comprises the many eukaryotic like proteins and a conserved repertoire of over 200 Dot/Icm type IV secreted substrates. However, recombination events and horizontal gene transfer are frequent. In particular the analyses of the distribution of nucleotide polymorphisms suggests that large chromosomal fragments of over 200 kbs are exchanged between <it<L. pneumophila </it<strains and contribute to the genome dynamics in the natural population. The many secretion systems present might be implicated in exchange of these fragments by conjugal transfer. Plasmids also play a role in genome diversification and are exchanged among strains and circulate between different <it<Legionella </it<species.</p< <p<Conclusion</p< <p<Horizontal gene transfer among bacteria and from eukaryotes to <it<L. pneumophila </it<as well as recombination between strains allows different clones to evolve into predominant disease clones and others to replace them subsequently within relatively short periods of time.</p<
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title_short	Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes
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Extensive recombination events and horizontal gene transfer shaped the <it<Legionella pneumophila </it<genomes

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