Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants
Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOA...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
EFSA Panel on Contaminants in the Food Chain (CONTAM) [verfasserIn] Dieter Schrenk [verfasserIn] Margherita Bignami [verfasserIn] Laurent Bodin [verfasserIn] James Kevin Chipman [verfasserIn] Jesús del Mazo [verfasserIn] Bettina Grasl‐Kraupp [verfasserIn] Christer Hogstrand [verfasserIn] Jean‐Charles Leblanc [verfasserIn] Elsa Nielsen [verfasserIn] Evangelia Ntzani [verfasserIn] Annette Petersen [verfasserIn] Salomon Sand [verfasserIn] Tanja Schwerdtle [verfasserIn] Christiane Vleminckx [verfasserIn] Heather Wallace [verfasserIn] Sven Daenicke [verfasserIn] Carlo Stefano Nebbia [verfasserIn] Isabelle P Oswald [verfasserIn] Elena Rovesti [verfasserIn] Hans Steinkellner [verfasserIn] Laurentius (Ron) Hoogenboom [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: EFSA Journal - Wiley, 2018, 20(2022), 9, Seite n/a-n/a |
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| Übergeordnetes Werk: |
volume:20 ; year:2022 ; number:9 ; pages:n/a-n/a |
| Links: |
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| DOI / URN: |
10.2903/j.efsa.2022.7564 |
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| Katalog-ID: |
DOAJ022183701 |
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| 520 | |a Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. | ||
| 650 | 4 | |a T‐2 toxin | |
| 650 | 4 | |a HT‐2 toxin | |
| 650 | 4 | |a animal health | |
| 650 | 4 | |a feed | |
| 650 | 4 | |a exposure | |
| 650 | 4 | |a toxicity | |
| 653 | 0 | |a Nutrition. Foods and food supply | |
| 653 | 0 | |a Chemical technology | |
| 700 | 0 | |a Dieter Schrenk |e verfasserin |4 aut | |
| 700 | 0 | |a Margherita Bignami |e verfasserin |4 aut | |
| 700 | 0 | |a Laurent Bodin |e verfasserin |4 aut | |
| 700 | 0 | |a James Kevin Chipman |e verfasserin |4 aut | |
| 700 | 0 | |a Jesús del Mazo |e verfasserin |4 aut | |
| 700 | 0 | |a Bettina Grasl‐Kraupp |e verfasserin |4 aut | |
| 700 | 0 | |a Christer Hogstrand |e verfasserin |4 aut | |
| 700 | 0 | |a Jean‐Charles Leblanc |e verfasserin |4 aut | |
| 700 | 0 | |a Elsa Nielsen |e verfasserin |4 aut | |
| 700 | 0 | |a Evangelia Ntzani |e verfasserin |4 aut | |
| 700 | 0 | |a Annette Petersen |e verfasserin |4 aut | |
| 700 | 0 | |a Salomon Sand |e verfasserin |4 aut | |
| 700 | 0 | |a Tanja Schwerdtle |e verfasserin |4 aut | |
| 700 | 0 | |a Christiane Vleminckx |e verfasserin |4 aut | |
| 700 | 0 | |a Heather Wallace |e verfasserin |4 aut | |
| 700 | 0 | |a Sven Daenicke |e verfasserin |4 aut | |
| 700 | 0 | |a Carlo Stefano Nebbia |e verfasserin |4 aut | |
| 700 | 0 | |a Isabelle P Oswald |e verfasserin |4 aut | |
| 700 | 0 | |a Elena Rovesti |e verfasserin |4 aut | |
| 700 | 0 | |a Hans Steinkellner |e verfasserin |4 aut | |
| 700 | 0 | |a Laurentius (Ron) Hoogenboom |e verfasserin |4 aut | |
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10.2903/j.efsa.2022.7564 doi (DE-627)DOAJ022183701 (DE-599)DOAJ478ae5adcf954bc1839db5e70fed8cd2 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. T‐2 toxin HT‐2 toxin animal health feed exposure toxicity Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman verfasserin aut Jesús del Mazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Daenicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 20(2022), 9, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:20 year:2022 number:9 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/article/478ae5adcf954bc1839db5e70fed8cd2 kostenfrei https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 9 n/a-n/a |
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10.2903/j.efsa.2022.7564 doi (DE-627)DOAJ022183701 (DE-599)DOAJ478ae5adcf954bc1839db5e70fed8cd2 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. T‐2 toxin HT‐2 toxin animal health feed exposure toxicity Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman verfasserin aut Jesús del Mazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Daenicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 20(2022), 9, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:20 year:2022 number:9 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/article/478ae5adcf954bc1839db5e70fed8cd2 kostenfrei https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 9 n/a-n/a |
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10.2903/j.efsa.2022.7564 doi (DE-627)DOAJ022183701 (DE-599)DOAJ478ae5adcf954bc1839db5e70fed8cd2 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. T‐2 toxin HT‐2 toxin animal health feed exposure toxicity Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman verfasserin aut Jesús del Mazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Daenicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 20(2022), 9, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:20 year:2022 number:9 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/article/478ae5adcf954bc1839db5e70fed8cd2 kostenfrei https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 9 n/a-n/a |
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10.2903/j.efsa.2022.7564 doi (DE-627)DOAJ022183701 (DE-599)DOAJ478ae5adcf954bc1839db5e70fed8cd2 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. T‐2 toxin HT‐2 toxin animal health feed exposure toxicity Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman verfasserin aut Jesús del Mazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Daenicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 20(2022), 9, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:20 year:2022 number:9 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/article/478ae5adcf954bc1839db5e70fed8cd2 kostenfrei https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 9 n/a-n/a |
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10.2903/j.efsa.2022.7564 doi (DE-627)DOAJ022183701 (DE-599)DOAJ478ae5adcf954bc1839db5e70fed8cd2 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Contaminants in the Food Chain (CONTAM) verfasserin aut Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. T‐2 toxin HT‐2 toxin animal health feed exposure toxicity Nutrition. Foods and food supply Chemical technology Dieter Schrenk verfasserin aut Margherita Bignami verfasserin aut Laurent Bodin verfasserin aut James Kevin Chipman verfasserin aut Jesús del Mazo verfasserin aut Bettina Grasl‐Kraupp verfasserin aut Christer Hogstrand verfasserin aut Jean‐Charles Leblanc verfasserin aut Elsa Nielsen verfasserin aut Evangelia Ntzani verfasserin aut Annette Petersen verfasserin aut Salomon Sand verfasserin aut Tanja Schwerdtle verfasserin aut Christiane Vleminckx verfasserin aut Heather Wallace verfasserin aut Sven Daenicke verfasserin aut Carlo Stefano Nebbia verfasserin aut Isabelle P Oswald verfasserin aut Elena Rovesti verfasserin aut Hans Steinkellner verfasserin aut Laurentius (Ron) Hoogenboom verfasserin aut In EFSA Journal Wiley, 2018 20(2022), 9, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:20 year:2022 number:9 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/article/478ae5adcf954bc1839db5e70fed8cd2 kostenfrei https://doi.org/10.2903/j.efsa.2022.7564 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 9 n/a-n/a |
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EFSA Panel on Contaminants in the Food Chain (CONTAM) @@aut@@ Dieter Schrenk @@aut@@ Margherita Bignami @@aut@@ Laurent Bodin @@aut@@ James Kevin Chipman @@aut@@ Jesús del Mazo @@aut@@ Bettina Grasl‐Kraupp @@aut@@ Christer Hogstrand @@aut@@ Jean‐Charles Leblanc @@aut@@ Elsa Nielsen @@aut@@ Evangelia Ntzani @@aut@@ Annette Petersen @@aut@@ Salomon Sand @@aut@@ Tanja Schwerdtle @@aut@@ Christiane Vleminckx @@aut@@ Heather Wallace @@aut@@ Sven Daenicke @@aut@@ Carlo Stefano Nebbia @@aut@@ Isabelle P Oswald @@aut@@ Elena Rovesti @@aut@@ Hans Steinkellner @@aut@@ Laurentius (Ron) Hoogenboom @@aut@@ |
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No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. 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EFSA Panel on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús del Mazo Bettina Grasl‐Kraupp Christer Hogstrand Jean‐Charles Leblanc Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Sven Daenicke Carlo Stefano Nebbia Isabelle P Oswald Elena Rovesti Hans Steinkellner Laurentius (Ron) Hoogenboom |
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Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants |
| abstract |
Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. |
| abstractGer |
Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. |
| abstract_unstemmed |
Abstract In 2011, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of T‐2 (T2) and HT‐2 (HT2) toxin in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. In ruminants a LOAEL was established for the sum of T2 and HT2 of 0.3 mg/kg body weight (bw) per day, based on studies with calves and lambs. The CONTAM Panel noted that the effects observed in nutritionally challenged heifers and ewes give rise to the assumption that rumen detoxification of T2 may not always be complete and therefore effective to prevent adverse effects in ruminants. However, the limited data on the effects of T2 on adult ruminants did not allow a conclusion. The European Commission requested EFSA to review the information regarding the toxicity of T2 and HT2 for ruminants and to revise, if necessary, the established Reference Point (RP). Adverse effect levels of 0.001 and 0.01 mg T2/kg bw per day for, respectively, sheep and cows, were derived from case studies, estimated to correspond to feed concentrations of 0.035 mg T2/kg for sheep and 0.6 mg T2/kg for cows. RPs for adverse animal health effects of 0.01 mg/kg feed for sheep and 0.2 mg/kg feed for cows were established. For goats, the RP for cows was selected, in the absence of data that they are more sensitive. Based on high exposure estimates performed in the 2017 EFSA Scientific Report, the risk of adverse health effects of feeds containing T2 and HT2 was considered low for dairy cows, fattening beef, cereal beef and lactating sheep. For milking goats, a comparison performed between dietary exposure and the RP derived for bovines, also indicates a low risk for adverse health effects. |
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| container_issue |
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| title_short |
Assessment of information as regards the toxicity of T‐2 and HT‐2 toxin for ruminants |
| url |
https://doi.org/10.2903/j.efsa.2022.7564 https://doaj.org/article/478ae5adcf954bc1839db5e70fed8cd2 https://doaj.org/toc/1831-4732 |
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Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús del Mazo Bettina Grasl‐Kraupp Christer Hogstrand Jean‐Charles Leblanc Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Sven Daenicke Carlo Stefano Nebbia Isabelle P Oswald Elena Rovesti Hans Steinkellner Laurentius (Ron) Hoogenboom |
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Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús del Mazo Bettina Grasl‐Kraupp Christer Hogstrand Jean‐Charles Leblanc Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Tanja Schwerdtle Christiane Vleminckx Heather Wallace Sven Daenicke Carlo Stefano Nebbia Isabelle P Oswald Elena Rovesti Hans Steinkellner Laurentius (Ron) Hoogenboom |
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10.2903/j.efsa.2022.7564 |
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2024-07-04T00:33:18.803Z |
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| score |
7.4013853 |