Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases

Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-p...
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Autor*in:	Mohammad Amir Mishan [verfasserIn] Mozhgan Rezaei Kanavi [verfasserIn] Koorosh Shahpasand [verfasserIn] Hamid Ahmadieh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Microtubule-associated Protein Neurodegenerative Disorders Tau Ocular Neurons

Übergeordnetes Werk:	In: Journal of Ophthalmic & Vision Research - Knowledge E, 2009, 14(2019), Seite 491-505
Übergeordnetes Werk:	volume:14 ; year:2019 ; pages:491-505

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.18502/jovr.v14i4.5459

Katalog-ID:	DOAJ022275622

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spelling	10.18502/jovr.v14i4.5459 doi (DE-627)DOAJ022275622 (DE-599)DOAJ1b2e6787bf8f4cc8b5ac6499c5539b54 DE-627 ger DE-627 rakwb eng RE1-994 Mohammad Amir Mishan verfasserin aut Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders. Microtubule-associated Protein Neurodegenerative Disorders Tau Ocular Neurons Ophthalmology Mozhgan Rezaei Kanavi verfasserin aut Koorosh Shahpasand verfasserin aut Hamid Ahmadieh verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 14(2019), Seite 491-505 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:14 year:2019 pages:491-505 https://doi.org/10.18502/jovr.v14i4.5459 kostenfrei https://doaj.org/article/1b2e6787bf8f4cc8b5ac6499c5539b54 kostenfrei https://doi.org/10.18502/jovr.v14i4.5459 kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 491-505
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allfieldsSound	10.18502/jovr.v14i4.5459 doi (DE-627)DOAJ022275622 (DE-599)DOAJ1b2e6787bf8f4cc8b5ac6499c5539b54 DE-627 ger DE-627 rakwb eng RE1-994 Mohammad Amir Mishan verfasserin aut Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders. Microtubule-associated Protein Neurodegenerative Disorders Tau Ocular Neurons Ophthalmology Mozhgan Rezaei Kanavi verfasserin aut Koorosh Shahpasand verfasserin aut Hamid Ahmadieh verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 14(2019), Seite 491-505 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:14 year:2019 pages:491-505 https://doi.org/10.18502/jovr.v14i4.5459 kostenfrei https://doaj.org/article/1b2e6787bf8f4cc8b5ac6499c5539b54 kostenfrei https://doi.org/10.18502/jovr.v14i4.5459 kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 491-505
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source	In Journal of Ophthalmic & Vision Research 14(2019), Seite 491-505 volume:14 year:2019 pages:491-505
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topic_facet	Microtubule-associated Protein Neurodegenerative Disorders Tau Ocular Neurons Ophthalmology
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callnumber-first	R - Medicine
author	Mohammad Amir Mishan
spellingShingle	Mohammad Amir Mishan misc RE1-994 misc Microtubule-associated Protein misc Neurodegenerative Disorders misc Tau misc Ocular Neurons misc Ophthalmology Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
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topic_title	RE1-994 Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases Microtubule-associated Protein Neurodegenerative Disorders Tau Ocular Neurons
topic	misc RE1-994 misc Microtubule-associated Protein misc Neurodegenerative Disorders misc Tau misc Ocular Neurons misc Ophthalmology
topic_unstemmed	misc RE1-994 misc Microtubule-associated Protein misc Neurodegenerative Disorders misc Tau misc Ocular Neurons misc Ophthalmology
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title	Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
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title_full	Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
author_sort	Mohammad Amir Mishan
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title_sort	pathogenic tau protein species: promising therapeutic targets for ocular neurodegenerative diseases
callnumber	RE1-994
title_auth	Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
abstract	Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders.
abstractGer	Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders.
abstract_unstemmed	Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders.
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title_short	Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
url	https://doi.org/10.18502/jovr.v14i4.5459 https://doaj.org/article/1b2e6787bf8f4cc8b5ac6499c5539b54 https://doaj.org/toc/2008-322X
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up_date	2024-07-04T00:54:43.857Z
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Nicht das Richtige dabei?