Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients

Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, ph...
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Autor*in:	Katarzyna Waszczuk [verfasserIn] Jolanta Kucharska-Mazur [verfasserIn] Ernest Tyburski [verfasserIn] Katarzyna Rek-Owodziń [verfasserIn] Piotr Plichta [verfasserIn] Krzysztof Rudkowski [verfasserIn] Piotr Podwalski [verfasserIn] Tomasz Grąźlewski [verfasserIn] Monika Mak [verfasserIn] Błażej Misiak [verfasserIn] Anna Michalczyk [verfasserIn] Maciej Tarnowski [verfasserIn] Katarzyna Sielatycka [verfasserIn] Angelika Szczęśniak [verfasserIn] Karolina Łuczkowska [verfasserIn] Barbara Dołęgowska [verfasserIn] Marta Budkowska [verfasserIn] Mariusz Z. Ratajczak [verfasserIn] Jerzy Samochowiec [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 19(2022), 6001, p 6001
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:6001, p 6001

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph19106001

Katalog-ID:	DOAJ022498346

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520			\|a Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed.
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allfields	10.3390/ijerph19106001 doi (DE-627)DOAJ022498346 (DE-599)DOAJ0ece63aac9794f369642bbe83d0d0b8f DE-627 ger DE-627 rakwb eng Katarzyna Waszczuk verfasserin aut Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed. stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR Medicine R Jolanta Kucharska-Mazur verfasserin aut Ernest Tyburski verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Krzysztof Rudkowski verfasserin aut Piotr Podwalski verfasserin aut Tomasz Grąźlewski verfasserin aut Monika Mak verfasserin aut Błażej Misiak verfasserin aut Anna Michalczyk verfasserin aut Maciej Tarnowski verfasserin aut Katarzyna Sielatycka verfasserin aut Angelika Szczęśniak verfasserin aut Karolina Łuczkowska verfasserin aut Barbara Dołęgowska verfasserin aut Marta Budkowska verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jerzy Samochowiec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 6001, p 6001 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:6001, p 6001 https://doi.org/10.3390/ijerph19106001 kostenfrei https://doaj.org/article/0ece63aac9794f369642bbe83d0d0b8f kostenfrei https://www.mdpi.com/1660-4601/19/10/6001 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 6001, p 6001
spelling	10.3390/ijerph19106001 doi (DE-627)DOAJ022498346 (DE-599)DOAJ0ece63aac9794f369642bbe83d0d0b8f DE-627 ger DE-627 rakwb eng Katarzyna Waszczuk verfasserin aut Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed. stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR Medicine R Jolanta Kucharska-Mazur verfasserin aut Ernest Tyburski verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Krzysztof Rudkowski verfasserin aut Piotr Podwalski verfasserin aut Tomasz Grąźlewski verfasserin aut Monika Mak verfasserin aut Błażej Misiak verfasserin aut Anna Michalczyk verfasserin aut Maciej Tarnowski verfasserin aut Katarzyna Sielatycka verfasserin aut Angelika Szczęśniak verfasserin aut Karolina Łuczkowska verfasserin aut Barbara Dołęgowska verfasserin aut Marta Budkowska verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jerzy Samochowiec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 6001, p 6001 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:6001, p 6001 https://doi.org/10.3390/ijerph19106001 kostenfrei https://doaj.org/article/0ece63aac9794f369642bbe83d0d0b8f kostenfrei https://www.mdpi.com/1660-4601/19/10/6001 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 6001, p 6001
allfields_unstemmed	10.3390/ijerph19106001 doi (DE-627)DOAJ022498346 (DE-599)DOAJ0ece63aac9794f369642bbe83d0d0b8f DE-627 ger DE-627 rakwb eng Katarzyna Waszczuk verfasserin aut Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed. stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR Medicine R Jolanta Kucharska-Mazur verfasserin aut Ernest Tyburski verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Krzysztof Rudkowski verfasserin aut Piotr Podwalski verfasserin aut Tomasz Grąźlewski verfasserin aut Monika Mak verfasserin aut Błażej Misiak verfasserin aut Anna Michalczyk verfasserin aut Maciej Tarnowski verfasserin aut Katarzyna Sielatycka verfasserin aut Angelika Szczęśniak verfasserin aut Karolina Łuczkowska verfasserin aut Barbara Dołęgowska verfasserin aut Marta Budkowska verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jerzy Samochowiec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 6001, p 6001 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:6001, p 6001 https://doi.org/10.3390/ijerph19106001 kostenfrei https://doaj.org/article/0ece63aac9794f369642bbe83d0d0b8f kostenfrei https://www.mdpi.com/1660-4601/19/10/6001 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 6001, p 6001
allfieldsGer	10.3390/ijerph19106001 doi (DE-627)DOAJ022498346 (DE-599)DOAJ0ece63aac9794f369642bbe83d0d0b8f DE-627 ger DE-627 rakwb eng Katarzyna Waszczuk verfasserin aut Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed. stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR Medicine R Jolanta Kucharska-Mazur verfasserin aut Ernest Tyburski verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Krzysztof Rudkowski verfasserin aut Piotr Podwalski verfasserin aut Tomasz Grąźlewski verfasserin aut Monika Mak verfasserin aut Błażej Misiak verfasserin aut Anna Michalczyk verfasserin aut Maciej Tarnowski verfasserin aut Katarzyna Sielatycka verfasserin aut Angelika Szczęśniak verfasserin aut Karolina Łuczkowska verfasserin aut Barbara Dołęgowska verfasserin aut Marta Budkowska verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jerzy Samochowiec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 6001, p 6001 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:6001, p 6001 https://doi.org/10.3390/ijerph19106001 kostenfrei https://doaj.org/article/0ece63aac9794f369642bbe83d0d0b8f kostenfrei https://www.mdpi.com/1660-4601/19/10/6001 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 6001, p 6001
allfieldsSound	10.3390/ijerph19106001 doi (DE-627)DOAJ022498346 (DE-599)DOAJ0ece63aac9794f369642bbe83d0d0b8f DE-627 ger DE-627 rakwb eng Katarzyna Waszczuk verfasserin aut Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed. stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR Medicine R Jolanta Kucharska-Mazur verfasserin aut Ernest Tyburski verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Krzysztof Rudkowski verfasserin aut Piotr Podwalski verfasserin aut Tomasz Grąźlewski verfasserin aut Monika Mak verfasserin aut Błażej Misiak verfasserin aut Anna Michalczyk verfasserin aut Maciej Tarnowski verfasserin aut Katarzyna Sielatycka verfasserin aut Angelika Szczęśniak verfasserin aut Karolina Łuczkowska verfasserin aut Barbara Dołęgowska verfasserin aut Marta Budkowska verfasserin aut Mariusz Z. Ratajczak verfasserin aut Jerzy Samochowiec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 6001, p 6001 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:6001, p 6001 https://doi.org/10.3390/ijerph19106001 kostenfrei https://doaj.org/article/0ece63aac9794f369642bbe83d0d0b8f kostenfrei https://www.mdpi.com/1660-4601/19/10/6001 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 6001, p 6001
language	English
source	In International Journal of Environmental Research and Public Health 19(2022), 6001, p 6001 volume:19 year:2022 number:6001, p 6001
sourceStr	In International Journal of Environmental Research and Public Health 19(2022), 6001, p 6001 volume:19 year:2022 number:6001, p 6001
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR Medicine R
isfreeaccess_bool	true
container_title	International Journal of Environmental Research and Public Health
authorswithroles_txt_mv	Katarzyna Waszczuk @@aut@@ Jolanta Kucharska-Mazur @@aut@@ Ernest Tyburski @@aut@@ Katarzyna Rek-Owodziń @@aut@@ Piotr Plichta @@aut@@ Krzysztof Rudkowski @@aut@@ Piotr Podwalski @@aut@@ Tomasz Grąźlewski @@aut@@ Monika Mak @@aut@@ Błażej Misiak @@aut@@ Anna Michalczyk @@aut@@ Maciej Tarnowski @@aut@@ Katarzyna Sielatycka @@aut@@ Angelika Szczęśniak @@aut@@ Karolina Łuczkowska @@aut@@ Barbara Dołęgowska @@aut@@ Marta Budkowska @@aut@@ Mariusz Z. Ratajczak @@aut@@ Jerzy Samochowiec @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	477992463
id	DOAJ022498346
language_de	englisch
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author	Katarzyna Waszczuk
spellingShingle	Katarzyna Waszczuk misc stem cells misc HSCs misc VSELs misc embryonic stem cells misc high-risk psychosis misc UHR misc Medicine misc R Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients
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topic_title	Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients stem cells HSCs VSELs embryonic stem cells high-risk psychosis UHR
topic	misc stem cells misc HSCs misc VSELs misc embryonic stem cells misc high-risk psychosis misc UHR misc Medicine misc R
topic_unstemmed	misc stem cells misc HSCs misc VSELs misc embryonic stem cells misc high-risk psychosis misc UHR misc Medicine misc R
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title	Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients
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title_full	Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients
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author_browse	Katarzyna Waszczuk Jolanta Kucharska-Mazur Ernest Tyburski Katarzyna Rek-Owodziń Piotr Plichta Krzysztof Rudkowski Piotr Podwalski Tomasz Grąźlewski Monika Mak Błażej Misiak Anna Michalczyk Maciej Tarnowski Katarzyna Sielatycka Angelika Szczęśniak Karolina Łuczkowska Barbara Dołęgowska Marta Budkowska Mariusz Z. Ratajczak Jerzy Samochowiec
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title_sort	psychopathology and stem cell mobilization in ultra-high risk of psychosis and first-episode psychosis patients
title_auth	Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients
abstract	Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed.
abstractGer	Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed.
abstract_unstemmed	Although regenerative and inflammatory processes are involved in the etiopathogenesis of many psychiatric disorders, their roles are poorly understood. We investigate the potential role of stem cells (SC) and factors influencing the trafficking thereof, such as complement cascade (CC) components, phospholipid substrates, and chemokines, in the etiology of schizophrenia. We measured sphingosine-1-phosphate (S1P), stromal-derived factor 1 (SDF-1), and CC cleavage fragments (C3a, C5a, and C5b-C9; also known as the membrane attack complex) in the peripheral blood of 49 unrelated patients: 9 patients with ultra-high risk of psychosis (UHR), 22 patients with first-episode psychosis (FEP), and 18 healthy controls (HC). When compared with the HC group, the UHR and FEP groups had higher levels of C3a. We found no significant differences in hematopoietic SC, very small embryonic-like stem cell (VSEL), C5a, S1P, or SDF-1 levels in the UHR and FEP groups. However, among FEP patients, there was a significant positive correlation between VSELs (CD133+) and negative symptoms. These preliminary findings support the role of the immune system and regenerative processes in the etiology of schizophrenia. To establish the relevance of SC and other factors affecting the trafficking thereof as potential biomarkers of schizophrenia, more studies on larger groups of individuals from across the disease spectrum are needed.
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title_short	Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients
url	https://doi.org/10.3390/ijerph19106001 https://doaj.org/article/0ece63aac9794f369642bbe83d0d0b8f https://www.mdpi.com/1660-4601/19/10/6001 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601
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author2	Jolanta Kucharska-Mazur Ernest Tyburski Katarzyna Rek-Owodziń Piotr Plichta Krzysztof Rudkowski Piotr Podwalski Tomasz Grąźlewski Monika Mak Błażej Misiak Anna Michalczyk Maciej Tarnowski Katarzyna Sielatycka Angelika Szczęśniak Karolina Łuczkowska Barbara Dołęgowska Marta Budkowska Mariusz Z. Ratajczak Jerzy Samochowiec
author2Str	Jolanta Kucharska-Mazur Ernest Tyburski Katarzyna Rek-Owodziń Piotr Plichta Krzysztof Rudkowski Piotr Podwalski Tomasz Grąźlewski Monika Mak Błażej Misiak Anna Michalczyk Maciej Tarnowski Katarzyna Sielatycka Angelika Szczęśniak Karolina Łuczkowska Barbara Dołęgowska Marta Budkowska Mariusz Z. Ratajczak Jerzy Samochowiec
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up_date	2024-07-04T01:46:37.488Z
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Psychopathology and Stem Cell Mobilization in Ultra-High Risk of Psychosis and First-Episode Psychosis Patients

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