Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment
The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demon...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Eugenio De Corso [verfasserIn] Stefano Settimi [verfasserIn] Claudio Montuori [verfasserIn] Marco Corbò [verfasserIn] Giulio Cesare Passali [verfasserIn] Davide Paolo Porru [verfasserIn] Simone Lo Verde [verfasserIn] Camilla Spanu [verfasserIn] Daniele Penazzi [verfasserIn] Giuseppe Alberto Di Bella [verfasserIn] Eleonora Nucera [verfasserIn] Matteo Bonini [verfasserIn] Gaetano Paludetti [verfasserIn] Jacopo Galli [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 10, p 2684 |
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| Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:10, p 2684 |
| Links: |
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| DOI / URN: |
10.3390/jcm11102684 |
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DOAJ022505261 |
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10.3390/jcm11102684 doi (DE-627)DOAJ022505261 (DE-599)DOAJ3c6969dc61ff4764926effbe649cdef8 DE-627 ger DE-627 rakwb eng Eugenio De Corso verfasserin aut Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. chronic rhinosinusitis with nasal polyps type-2 inflammation asthma biologics dupilumab real life Medicine R Stefano Settimi verfasserin aut Claudio Montuori verfasserin aut Marco Corbò verfasserin aut Giulio Cesare Passali verfasserin aut Davide Paolo Porru verfasserin aut Simone Lo Verde verfasserin aut Camilla Spanu verfasserin aut Daniele Penazzi verfasserin aut Giuseppe Alberto Di Bella verfasserin aut Eleonora Nucera verfasserin aut Matteo Bonini verfasserin aut Gaetano Paludetti verfasserin aut Jacopo Galli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 10, p 2684 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:10, p 2684 https://doi.org/10.3390/jcm11102684 kostenfrei https://doaj.org/article/3c6969dc61ff4764926effbe649cdef8 kostenfrei https://www.mdpi.com/2077-0383/11/10/2684 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 2684 |
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10.3390/jcm11102684 doi (DE-627)DOAJ022505261 (DE-599)DOAJ3c6969dc61ff4764926effbe649cdef8 DE-627 ger DE-627 rakwb eng Eugenio De Corso verfasserin aut Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. chronic rhinosinusitis with nasal polyps type-2 inflammation asthma biologics dupilumab real life Medicine R Stefano Settimi verfasserin aut Claudio Montuori verfasserin aut Marco Corbò verfasserin aut Giulio Cesare Passali verfasserin aut Davide Paolo Porru verfasserin aut Simone Lo Verde verfasserin aut Camilla Spanu verfasserin aut Daniele Penazzi verfasserin aut Giuseppe Alberto Di Bella verfasserin aut Eleonora Nucera verfasserin aut Matteo Bonini verfasserin aut Gaetano Paludetti verfasserin aut Jacopo Galli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 10, p 2684 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:10, p 2684 https://doi.org/10.3390/jcm11102684 kostenfrei https://doaj.org/article/3c6969dc61ff4764926effbe649cdef8 kostenfrei https://www.mdpi.com/2077-0383/11/10/2684 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 2684 |
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10.3390/jcm11102684 doi (DE-627)DOAJ022505261 (DE-599)DOAJ3c6969dc61ff4764926effbe649cdef8 DE-627 ger DE-627 rakwb eng Eugenio De Corso verfasserin aut Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. chronic rhinosinusitis with nasal polyps type-2 inflammation asthma biologics dupilumab real life Medicine R Stefano Settimi verfasserin aut Claudio Montuori verfasserin aut Marco Corbò verfasserin aut Giulio Cesare Passali verfasserin aut Davide Paolo Porru verfasserin aut Simone Lo Verde verfasserin aut Camilla Spanu verfasserin aut Daniele Penazzi verfasserin aut Giuseppe Alberto Di Bella verfasserin aut Eleonora Nucera verfasserin aut Matteo Bonini verfasserin aut Gaetano Paludetti verfasserin aut Jacopo Galli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 10, p 2684 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:10, p 2684 https://doi.org/10.3390/jcm11102684 kostenfrei https://doaj.org/article/3c6969dc61ff4764926effbe649cdef8 kostenfrei https://www.mdpi.com/2077-0383/11/10/2684 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 2684 |
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10.3390/jcm11102684 doi (DE-627)DOAJ022505261 (DE-599)DOAJ3c6969dc61ff4764926effbe649cdef8 DE-627 ger DE-627 rakwb eng Eugenio De Corso verfasserin aut Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. chronic rhinosinusitis with nasal polyps type-2 inflammation asthma biologics dupilumab real life Medicine R Stefano Settimi verfasserin aut Claudio Montuori verfasserin aut Marco Corbò verfasserin aut Giulio Cesare Passali verfasserin aut Davide Paolo Porru verfasserin aut Simone Lo Verde verfasserin aut Camilla Spanu verfasserin aut Daniele Penazzi verfasserin aut Giuseppe Alberto Di Bella verfasserin aut Eleonora Nucera verfasserin aut Matteo Bonini verfasserin aut Gaetano Paludetti verfasserin aut Jacopo Galli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 10, p 2684 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:10, p 2684 https://doi.org/10.3390/jcm11102684 kostenfrei https://doaj.org/article/3c6969dc61ff4764926effbe649cdef8 kostenfrei https://www.mdpi.com/2077-0383/11/10/2684 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 2684 |
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10.3390/jcm11102684 doi (DE-627)DOAJ022505261 (DE-599)DOAJ3c6969dc61ff4764926effbe649cdef8 DE-627 ger DE-627 rakwb eng Eugenio De Corso verfasserin aut Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. chronic rhinosinusitis with nasal polyps type-2 inflammation asthma biologics dupilumab real life Medicine R Stefano Settimi verfasserin aut Claudio Montuori verfasserin aut Marco Corbò verfasserin aut Giulio Cesare Passali verfasserin aut Davide Paolo Porru verfasserin aut Simone Lo Verde verfasserin aut Camilla Spanu verfasserin aut Daniele Penazzi verfasserin aut Giuseppe Alberto Di Bella verfasserin aut Eleonora Nucera verfasserin aut Matteo Bonini verfasserin aut Gaetano Paludetti verfasserin aut Jacopo Galli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 10, p 2684 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:10, p 2684 https://doi.org/10.3390/jcm11102684 kostenfrei https://doaj.org/article/3c6969dc61ff4764926effbe649cdef8 kostenfrei https://www.mdpi.com/2077-0383/11/10/2684 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 2684 |
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Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment |
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The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. |
| abstractGer |
The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. |
| abstract_unstemmed |
The aim of this study was to evaluate the efficacy of dupilumab in the treatment of severe uncontrolled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), with or without asthma as add-on therapy with intra-nasal corticosteroids in a real-life setting over the first year of treatment. Our data demonstrated that subcutaneous 300 mg dupilumab administered at home via a pre-filled auto-injector every two weeks, based on indications set by the Italian Medicines Agency, was rapidly effective in reducing the size of polyps, decreasing symptoms of disease, improving quality of life, and recovering olfaction. Significant improvement was observed after only 15 days of treatment, and it progressively increased at 6 and 12 months. Dupilumab was also effective in reducing the local nasal eosinophilic infiltrate, in decreasing the need for surgery and/or oral corticosteroids, and in improving control of associated comorbidities such as chronic eosinophilic otitis media and bronchial asthma. After 12 months of treatment, 96.5% of patients had a moderate/excellent response. From our data, it was evident that there was a group of patients that showed a very early response within one month of therapy, another group with early response within six months from baseline, and a last group that improved later within 12 months. The results of this study support the use of dupilumab as an effective option in the current standard of care for patients affected by severe uncontrolled CRSwNP. |
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| container_issue |
10, p 2684 |
| title_short |
Effectiveness of Dupilumab in the Treatment of Patients with Severe Uncontrolled CRSwNP: A “Real-Life” Observational Study in the First Year of Treatment |
| url |
https://doi.org/10.3390/jcm11102684 https://doaj.org/article/3c6969dc61ff4764926effbe649cdef8 https://www.mdpi.com/2077-0383/11/10/2684 https://doaj.org/toc/2077-0383 |
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| author2 |
Stefano Settimi Claudio Montuori Marco Corbò Giulio Cesare Passali Davide Paolo Porru Simone Lo Verde Camilla Spanu Daniele Penazzi Giuseppe Alberto Di Bella Eleonora Nucera Matteo Bonini Gaetano Paludetti Jacopo Galli |
| author2Str |
Stefano Settimi Claudio Montuori Marco Corbò Giulio Cesare Passali Davide Paolo Porru Simone Lo Verde Camilla Spanu Daniele Penazzi Giuseppe Alberto Di Bella Eleonora Nucera Matteo Bonini Gaetano Paludetti Jacopo Galli |
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| doi_str |
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| up_date |
2024-07-04T01:48:14.410Z |
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