Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici

The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can...
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Autor*in:	Kurt H. Lamour [verfasserIn] Joann Mudge [verfasserIn] Daniel Gobena [verfasserIn] Oscar P. Hurtado-Gonzales [verfasserIn] Jeremy Schmutz [verfasserIn] Alan Kuo [verfasserIn] Neil A. Miller [verfasserIn] Brandon J. Rice [verfasserIn] Sylvain Raffaele [verfasserIn] Liliana M. Cano [verfasserIn] Arvind K. Bharti [verfasserIn] Ryan S. Donahoo [verfasserIn] Sabra Finley [verfasserIn] Edgar Huitema [verfasserIn] Jon Hulvey [verfasserIn] Darren Platt [verfasserIn] Asaf Salamov [verfasserIn] Alon Savidor [verfasserIn] Rahul Sharma [verfasserIn] Remco Stam [verfasserIn] Dylan Storey [verfasserIn] Marco Thines [verfasserIn] Joe Win [verfasserIn] Brian J. Haas [verfasserIn] Darrell L. Dinwiddie [verfasserIn] Jerry Jenkins [verfasserIn] James R. Knight [verfasserIn] Jason P. Affourtit [verfasserIn] Cliff S. Han [verfasserIn] Olga Chertkov [verfasserIn] Erika A. Lindquist [verfasserIn] Chris Detter [verfasserIn] Igor V. Grigoriev [verfasserIn] Sophien Kamoun [verfasserIn] Stephen F. Kingsmore [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	In: Molecular Plant-Microbe Interactions - The American Phytopathological Society, 2021, 25(2012), 10, Seite 1350-1360
Übergeordnetes Werk:	volume:25 ; year:2012 ; number:10 ; pages:1350-1360

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1094/MPMI-02-12-0028-R

Katalog-ID:	DOAJ022676198

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520			\|a The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici.
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allfields	10.1094/MPMI-02-12-0028-R doi (DE-627)DOAJ022676198 (DE-599)DOAJ122d1955f18e4063abf5a5e27542151c DE-627 ger DE-627 rakwb eng QR1-502 QK1-989 Kurt H. Lamour verfasserin aut Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici. Microbiology Botany Joann Mudge verfasserin aut Daniel Gobena verfasserin aut Oscar P. Hurtado-Gonzales verfasserin aut Jeremy Schmutz verfasserin aut Alan Kuo verfasserin aut Neil A. Miller verfasserin aut Brandon J. Rice verfasserin aut Sylvain Raffaele verfasserin aut Liliana M. Cano verfasserin aut Arvind K. Bharti verfasserin aut Ryan S. Donahoo verfasserin aut Sabra Finley verfasserin aut Edgar Huitema verfasserin aut Jon Hulvey verfasserin aut Darren Platt verfasserin aut Asaf Salamov verfasserin aut Alon Savidor verfasserin aut Rahul Sharma verfasserin aut Remco Stam verfasserin aut Dylan Storey verfasserin aut Marco Thines verfasserin aut Joe Win verfasserin aut Brian J. Haas verfasserin aut Darrell L. Dinwiddie verfasserin aut Jerry Jenkins verfasserin aut James R. Knight verfasserin aut Jason P. Affourtit verfasserin aut Cliff S. Han verfasserin aut Olga Chertkov verfasserin aut Erika A. Lindquist verfasserin aut Chris Detter verfasserin aut Igor V. Grigoriev verfasserin aut Sophien Kamoun verfasserin aut Stephen F. Kingsmore verfasserin aut In Molecular Plant-Microbe Interactions The American Phytopathological Society, 2021 25(2012), 10, Seite 1350-1360 (DE-627)325568367 (DE-600)2037108-1 19437706 nnns volume:25 year:2012 number:10 pages:1350-1360 https://doi.org/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/article/122d1955f18e4063abf5a5e27542151c kostenfrei https://apsjournals.apsnet.org/doi/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/toc/0894-0282 Journal toc kostenfrei https://doaj.org/toc/1943-7706 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 25 2012 10 1350-1360
spelling	10.1094/MPMI-02-12-0028-R doi (DE-627)DOAJ022676198 (DE-599)DOAJ122d1955f18e4063abf5a5e27542151c DE-627 ger DE-627 rakwb eng QR1-502 QK1-989 Kurt H. Lamour verfasserin aut Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici. Microbiology Botany Joann Mudge verfasserin aut Daniel Gobena verfasserin aut Oscar P. Hurtado-Gonzales verfasserin aut Jeremy Schmutz verfasserin aut Alan Kuo verfasserin aut Neil A. Miller verfasserin aut Brandon J. Rice verfasserin aut Sylvain Raffaele verfasserin aut Liliana M. Cano verfasserin aut Arvind K. Bharti verfasserin aut Ryan S. Donahoo verfasserin aut Sabra Finley verfasserin aut Edgar Huitema verfasserin aut Jon Hulvey verfasserin aut Darren Platt verfasserin aut Asaf Salamov verfasserin aut Alon Savidor verfasserin aut Rahul Sharma verfasserin aut Remco Stam verfasserin aut Dylan Storey verfasserin aut Marco Thines verfasserin aut Joe Win verfasserin aut Brian J. Haas verfasserin aut Darrell L. Dinwiddie verfasserin aut Jerry Jenkins verfasserin aut James R. Knight verfasserin aut Jason P. Affourtit verfasserin aut Cliff S. Han verfasserin aut Olga Chertkov verfasserin aut Erika A. Lindquist verfasserin aut Chris Detter verfasserin aut Igor V. Grigoriev verfasserin aut Sophien Kamoun verfasserin aut Stephen F. Kingsmore verfasserin aut In Molecular Plant-Microbe Interactions The American Phytopathological Society, 2021 25(2012), 10, Seite 1350-1360 (DE-627)325568367 (DE-600)2037108-1 19437706 nnns volume:25 year:2012 number:10 pages:1350-1360 https://doi.org/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/article/122d1955f18e4063abf5a5e27542151c kostenfrei https://apsjournals.apsnet.org/doi/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/toc/0894-0282 Journal toc kostenfrei https://doaj.org/toc/1943-7706 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 25 2012 10 1350-1360
allfields_unstemmed	10.1094/MPMI-02-12-0028-R doi (DE-627)DOAJ022676198 (DE-599)DOAJ122d1955f18e4063abf5a5e27542151c DE-627 ger DE-627 rakwb eng QR1-502 QK1-989 Kurt H. Lamour verfasserin aut Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici. Microbiology Botany Joann Mudge verfasserin aut Daniel Gobena verfasserin aut Oscar P. Hurtado-Gonzales verfasserin aut Jeremy Schmutz verfasserin aut Alan Kuo verfasserin aut Neil A. Miller verfasserin aut Brandon J. Rice verfasserin aut Sylvain Raffaele verfasserin aut Liliana M. Cano verfasserin aut Arvind K. Bharti verfasserin aut Ryan S. Donahoo verfasserin aut Sabra Finley verfasserin aut Edgar Huitema verfasserin aut Jon Hulvey verfasserin aut Darren Platt verfasserin aut Asaf Salamov verfasserin aut Alon Savidor verfasserin aut Rahul Sharma verfasserin aut Remco Stam verfasserin aut Dylan Storey verfasserin aut Marco Thines verfasserin aut Joe Win verfasserin aut Brian J. Haas verfasserin aut Darrell L. Dinwiddie verfasserin aut Jerry Jenkins verfasserin aut James R. Knight verfasserin aut Jason P. Affourtit verfasserin aut Cliff S. Han verfasserin aut Olga Chertkov verfasserin aut Erika A. Lindquist verfasserin aut Chris Detter verfasserin aut Igor V. Grigoriev verfasserin aut Sophien Kamoun verfasserin aut Stephen F. Kingsmore verfasserin aut In Molecular Plant-Microbe Interactions The American Phytopathological Society, 2021 25(2012), 10, Seite 1350-1360 (DE-627)325568367 (DE-600)2037108-1 19437706 nnns volume:25 year:2012 number:10 pages:1350-1360 https://doi.org/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/article/122d1955f18e4063abf5a5e27542151c kostenfrei https://apsjournals.apsnet.org/doi/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/toc/0894-0282 Journal toc kostenfrei https://doaj.org/toc/1943-7706 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 25 2012 10 1350-1360
allfieldsGer	10.1094/MPMI-02-12-0028-R doi (DE-627)DOAJ022676198 (DE-599)DOAJ122d1955f18e4063abf5a5e27542151c DE-627 ger DE-627 rakwb eng QR1-502 QK1-989 Kurt H. Lamour verfasserin aut Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici. Microbiology Botany Joann Mudge verfasserin aut Daniel Gobena verfasserin aut Oscar P. Hurtado-Gonzales verfasserin aut Jeremy Schmutz verfasserin aut Alan Kuo verfasserin aut Neil A. Miller verfasserin aut Brandon J. Rice verfasserin aut Sylvain Raffaele verfasserin aut Liliana M. Cano verfasserin aut Arvind K. Bharti verfasserin aut Ryan S. Donahoo verfasserin aut Sabra Finley verfasserin aut Edgar Huitema verfasserin aut Jon Hulvey verfasserin aut Darren Platt verfasserin aut Asaf Salamov verfasserin aut Alon Savidor verfasserin aut Rahul Sharma verfasserin aut Remco Stam verfasserin aut Dylan Storey verfasserin aut Marco Thines verfasserin aut Joe Win verfasserin aut Brian J. Haas verfasserin aut Darrell L. Dinwiddie verfasserin aut Jerry Jenkins verfasserin aut James R. Knight verfasserin aut Jason P. Affourtit verfasserin aut Cliff S. Han verfasserin aut Olga Chertkov verfasserin aut Erika A. Lindquist verfasserin aut Chris Detter verfasserin aut Igor V. Grigoriev verfasserin aut Sophien Kamoun verfasserin aut Stephen F. Kingsmore verfasserin aut In Molecular Plant-Microbe Interactions The American Phytopathological Society, 2021 25(2012), 10, Seite 1350-1360 (DE-627)325568367 (DE-600)2037108-1 19437706 nnns volume:25 year:2012 number:10 pages:1350-1360 https://doi.org/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/article/122d1955f18e4063abf5a5e27542151c kostenfrei https://apsjournals.apsnet.org/doi/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/toc/0894-0282 Journal toc kostenfrei https://doaj.org/toc/1943-7706 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 25 2012 10 1350-1360
allfieldsSound	10.1094/MPMI-02-12-0028-R doi (DE-627)DOAJ022676198 (DE-599)DOAJ122d1955f18e4063abf5a5e27542151c DE-627 ger DE-627 rakwb eng QR1-502 QK1-989 Kurt H. Lamour verfasserin aut Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici. Microbiology Botany Joann Mudge verfasserin aut Daniel Gobena verfasserin aut Oscar P. Hurtado-Gonzales verfasserin aut Jeremy Schmutz verfasserin aut Alan Kuo verfasserin aut Neil A. Miller verfasserin aut Brandon J. Rice verfasserin aut Sylvain Raffaele verfasserin aut Liliana M. Cano verfasserin aut Arvind K. Bharti verfasserin aut Ryan S. Donahoo verfasserin aut Sabra Finley verfasserin aut Edgar Huitema verfasserin aut Jon Hulvey verfasserin aut Darren Platt verfasserin aut Asaf Salamov verfasserin aut Alon Savidor verfasserin aut Rahul Sharma verfasserin aut Remco Stam verfasserin aut Dylan Storey verfasserin aut Marco Thines verfasserin aut Joe Win verfasserin aut Brian J. Haas verfasserin aut Darrell L. Dinwiddie verfasserin aut Jerry Jenkins verfasserin aut James R. Knight verfasserin aut Jason P. Affourtit verfasserin aut Cliff S. Han verfasserin aut Olga Chertkov verfasserin aut Erika A. Lindquist verfasserin aut Chris Detter verfasserin aut Igor V. Grigoriev verfasserin aut Sophien Kamoun verfasserin aut Stephen F. Kingsmore verfasserin aut In Molecular Plant-Microbe Interactions The American Phytopathological Society, 2021 25(2012), 10, Seite 1350-1360 (DE-627)325568367 (DE-600)2037108-1 19437706 nnns volume:25 year:2012 number:10 pages:1350-1360 https://doi.org/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/article/122d1955f18e4063abf5a5e27542151c kostenfrei https://apsjournals.apsnet.org/doi/10.1094/MPMI-02-12-0028-R kostenfrei https://doaj.org/toc/0894-0282 Journal toc kostenfrei https://doaj.org/toc/1943-7706 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 25 2012 10 1350-1360
language	English
source	In Molecular Plant-Microbe Interactions 25(2012), 10, Seite 1350-1360 volume:25 year:2012 number:10 pages:1350-1360
sourceStr	In Molecular Plant-Microbe Interactions 25(2012), 10, Seite 1350-1360 volume:25 year:2012 number:10 pages:1350-1360
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Microbiology Botany
isfreeaccess_bool	true
container_title	Molecular Plant-Microbe Interactions
authorswithroles_txt_mv	Kurt H. Lamour @@aut@@ Joann Mudge @@aut@@ Daniel Gobena @@aut@@ Oscar P. Hurtado-Gonzales @@aut@@ Jeremy Schmutz @@aut@@ Alan Kuo @@aut@@ Neil A. Miller @@aut@@ Brandon J. Rice @@aut@@ Sylvain Raffaele @@aut@@ Liliana M. Cano @@aut@@ Arvind K. Bharti @@aut@@ Ryan S. Donahoo @@aut@@ Sabra Finley @@aut@@ Edgar Huitema @@aut@@ Jon Hulvey @@aut@@ Darren Platt @@aut@@ Asaf Salamov @@aut@@ Alon Savidor @@aut@@ Rahul Sharma @@aut@@ Remco Stam @@aut@@ Dylan Storey @@aut@@ Marco Thines @@aut@@ Joe Win @@aut@@ Brian J. Haas @@aut@@ Darrell L. Dinwiddie @@aut@@ Jerry Jenkins @@aut@@ James R. Knight @@aut@@ Jason P. Affourtit @@aut@@ Cliff S. Han @@aut@@ Olga Chertkov @@aut@@ Erika A. Lindquist @@aut@@ Chris Detter @@aut@@ Igor V. Grigoriev @@aut@@ Sophien Kamoun @@aut@@ Stephen F. Kingsmore @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	325568367
id	DOAJ022676198
language_de	englisch
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callnumber-first	Q - Science
author	Kurt H. Lamour
spellingShingle	Kurt H. Lamour misc QR1-502 misc QK1-989 misc Microbiology misc Botany Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
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topic_title	QR1-502 QK1-989 Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
topic	misc QR1-502 misc QK1-989 misc Microbiology misc Botany
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title	Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
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title_full	Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
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title_sort	genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen phytophthora capsici
callnumber	QR1-502
title_auth	Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
abstract	The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici.
abstractGer	The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici.
abstract_unstemmed	The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting <30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici.
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title_short	Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici
url	https://doi.org/10.1094/MPMI-02-12-0028-R https://doaj.org/article/122d1955f18e4063abf5a5e27542151c https://apsjournals.apsnet.org/doi/10.1094/MPMI-02-12-0028-R https://doaj.org/toc/0894-0282 https://doaj.org/toc/1943-7706
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author2	Joann Mudge Daniel Gobena Oscar P. Hurtado-Gonzales Jeremy Schmutz Alan Kuo Neil A. Miller Brandon J. Rice Sylvain Raffaele Liliana M. Cano Arvind K. Bharti Ryan S. Donahoo Sabra Finley Edgar Huitema Jon Hulvey Darren Platt Asaf Salamov Alon Savidor Rahul Sharma Remco Stam Dylan Storey Marco Thines Joe Win Brian J. Haas Darrell L. Dinwiddie Jerry Jenkins James R. Knight Jason P. Affourtit Cliff S. Han Olga Chertkov Erika A. Lindquist Chris Detter Igor V. Grigoriev Sophien Kamoun Stephen F. Kingsmore
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Genome Sequencing and Mapping Reveal Loss of Heterozygosity as a Mechanism for Rapid Adaptation in the Vegetable Pathogen Phytophthora capsici

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