The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis

Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screeni...
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Gespeichert in:

Autor*in:	Ling Liu [verfasserIn] Junjie Lang [verfasserIn] Yuelong Jin [verfasserIn] Yan Chen [verfasserIn] Weiwei Chang [verfasserIn] Yingshui Yao [verfasserIn] Jiegen Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Gastroenterology Research and Practice - Hindawi Limited, 2008, (2019)
Übergeordnetes Werk:	year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1155/2019/7087232

Katalog-ID:	DOAJ022748601

Internformat


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520			\|a Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified.
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700	0		\|a Weiwei Chang \|e verfasserin \|4 aut
700	0		\|a Yingshui Yao \|e verfasserin \|4 aut
700	0		\|a Jiegen Yu \|e verfasserin \|4 aut
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allfields	10.1155/2019/7087232 doi (DE-627)DOAJ022748601 (DE-599)DOAJ3a6a71588df24e2baf670394356a7364 DE-627 ger DE-627 rakwb eng RC799-869 Ling Liu verfasserin aut The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified. Diseases of the digestive system. Gastroenterology Junjie Lang verfasserin aut Yuelong Jin verfasserin aut Yan Chen verfasserin aut Weiwei Chang verfasserin aut Yingshui Yao verfasserin aut Jiegen Yu verfasserin aut In Gastroenterology Research and Practice Hindawi Limited, 2008 (2019) (DE-627)571608647 (DE-600)2435460-0 1687630X nnns year:2019 https://doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/article/3a6a71588df24e2baf670394356a7364 kostenfrei http://dx.doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/toc/1687-6121 Journal toc kostenfrei https://doaj.org/toc/1687-630X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
spelling	10.1155/2019/7087232 doi (DE-627)DOAJ022748601 (DE-599)DOAJ3a6a71588df24e2baf670394356a7364 DE-627 ger DE-627 rakwb eng RC799-869 Ling Liu verfasserin aut The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified. Diseases of the digestive system. Gastroenterology Junjie Lang verfasserin aut Yuelong Jin verfasserin aut Yan Chen verfasserin aut Weiwei Chang verfasserin aut Yingshui Yao verfasserin aut Jiegen Yu verfasserin aut In Gastroenterology Research and Practice Hindawi Limited, 2008 (2019) (DE-627)571608647 (DE-600)2435460-0 1687630X nnns year:2019 https://doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/article/3a6a71588df24e2baf670394356a7364 kostenfrei http://dx.doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/toc/1687-6121 Journal toc kostenfrei https://doaj.org/toc/1687-630X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
allfields_unstemmed	10.1155/2019/7087232 doi (DE-627)DOAJ022748601 (DE-599)DOAJ3a6a71588df24e2baf670394356a7364 DE-627 ger DE-627 rakwb eng RC799-869 Ling Liu verfasserin aut The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified. Diseases of the digestive system. Gastroenterology Junjie Lang verfasserin aut Yuelong Jin verfasserin aut Yan Chen verfasserin aut Weiwei Chang verfasserin aut Yingshui Yao verfasserin aut Jiegen Yu verfasserin aut In Gastroenterology Research and Practice Hindawi Limited, 2008 (2019) (DE-627)571608647 (DE-600)2435460-0 1687630X nnns year:2019 https://doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/article/3a6a71588df24e2baf670394356a7364 kostenfrei http://dx.doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/toc/1687-6121 Journal toc kostenfrei https://doaj.org/toc/1687-630X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
allfieldsGer	10.1155/2019/7087232 doi (DE-627)DOAJ022748601 (DE-599)DOAJ3a6a71588df24e2baf670394356a7364 DE-627 ger DE-627 rakwb eng RC799-869 Ling Liu verfasserin aut The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified. Diseases of the digestive system. Gastroenterology Junjie Lang verfasserin aut Yuelong Jin verfasserin aut Yan Chen verfasserin aut Weiwei Chang verfasserin aut Yingshui Yao verfasserin aut Jiegen Yu verfasserin aut In Gastroenterology Research and Practice Hindawi Limited, 2008 (2019) (DE-627)571608647 (DE-600)2435460-0 1687630X nnns year:2019 https://doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/article/3a6a71588df24e2baf670394356a7364 kostenfrei http://dx.doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/toc/1687-6121 Journal toc kostenfrei https://doaj.org/toc/1687-630X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
allfieldsSound	10.1155/2019/7087232 doi (DE-627)DOAJ022748601 (DE-599)DOAJ3a6a71588df24e2baf670394356a7364 DE-627 ger DE-627 rakwb eng RC799-869 Ling Liu verfasserin aut The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified. Diseases of the digestive system. Gastroenterology Junjie Lang verfasserin aut Yuelong Jin verfasserin aut Yan Chen verfasserin aut Weiwei Chang verfasserin aut Yingshui Yao verfasserin aut Jiegen Yu verfasserin aut In Gastroenterology Research and Practice Hindawi Limited, 2008 (2019) (DE-627)571608647 (DE-600)2435460-0 1687630X nnns year:2019 https://doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/article/3a6a71588df24e2baf670394356a7364 kostenfrei http://dx.doi.org/10.1155/2019/7087232 kostenfrei https://doaj.org/toc/1687-6121 Journal toc kostenfrei https://doaj.org/toc/1687-630X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019
language	English
source	In Gastroenterology Research and Practice (2019) year:2019
sourceStr	In Gastroenterology Research and Practice (2019) year:2019
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the digestive system. Gastroenterology
isfreeaccess_bool	true
container_title	Gastroenterology Research and Practice
authorswithroles_txt_mv	Ling Liu @@aut@@ Junjie Lang @@aut@@ Yuelong Jin @@aut@@ Yan Chen @@aut@@ Weiwei Chang @@aut@@ Yingshui Yao @@aut@@ Jiegen Yu @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	571608647
id	DOAJ022748601
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ022748601</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307061058.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1155/2019/7087232</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ022748601</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3a6a71588df24e2baf670394356a7364</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC799-869</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Ling Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the digestive system. 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callnumber-first	R - Medicine
author	Ling Liu
spellingShingle	Ling Liu misc RC799-869 misc Diseases of the digestive system. Gastroenterology The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
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topic_title	RC799-869 The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
topic	misc RC799-869 misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc Diseases of the digestive system. Gastroenterology
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title	The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
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title_full	The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
author_sort	Ling Liu
journal	Gastroenterology Research and Practice
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author_browse	Ling Liu Junjie Lang Yuelong Jin Yan Chen Weiwei Chang Yingshui Yao Jiegen Yu
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title_sort	value of pepsinogen in gc screening: a systematic review and meta-analysis
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title_auth	The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
abstract	Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified.
abstractGer	Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified.
abstract_unstemmed	Background. The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified.
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title_short	The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
url	https://doi.org/10.1155/2019/7087232 https://doaj.org/article/3a6a71588df24e2baf670394356a7364 http://dx.doi.org/10.1155/2019/7087232 https://doaj.org/toc/1687-6121 https://doaj.org/toc/1687-630X
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The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray. This is not applicable to a wide range of screening capabilities due to the lack of operability. This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC. Methods. PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC. Articles were searched from January 2003 to January 2018. Two reviewers independently screened the literature according to specified inclusion and exclusion criteria. The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry. The meta-analysis (MA) was performed using Meta-DiSc 1.4 software. Stata 12.0 software was used to assess publication bias. Results. A total of 19 studies were finally included from a total of 169,009 cases. The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively. The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01). The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468. Conclusions. Serum PG provides medium levels of sensitivity and specificity for GC assessment. To be used in a clinical setting, further high-quality research must be performed and verified.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the digestive system. 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The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis

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