Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma
AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hai-Dong Huang [verfasserIn] Li-Yang Li [verfasserIn] Ying Guo [verfasserIn] Xing Zhao [verfasserIn] Jing-Jia Kang [verfasserIn] Di Guan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Guoji Yanke Zazhi - Press of International Journal of Ophthalmology (IJO PRESS), 2017, 13(2013), 7, Seite 1314-1316 |
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| Übergeordnetes Werk: |
volume:13 ; year:2013 ; number:7 ; pages:1314-1316 |
| Links: |
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| DOI / URN: |
10.3980/j.issn.1672-5123.2013.07.04 |
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| Katalog-ID: |
DOAJ022911138 |
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| 520 | |a AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. | ||
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10.3980/j.issn.1672-5123.2013.07.04 doi (DE-627)DOAJ022911138 (DE-599)DOAJ0cce8167ef874780842651574a38b227 DE-627 ger DE-627 rakwb eng RE1-994 Hai-Dong Huang verfasserin aut Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. <i<Pax6</i< gene retinoblastoma expression Ophthalmology Li-Yang Li verfasserin aut Ying Guo verfasserin aut Xing Zhao verfasserin aut Jing-Jia Kang verfasserin aut Di Guan verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 13(2013), 7, Seite 1314-1316 (DE-627)1680946854 16725123 nnns volume:13 year:2013 number:7 pages:1314-1316 https://doi.org/10.3980/j.issn.1672-5123.2013.07.04 kostenfrei https://doaj.org/article/0cce8167ef874780842651574a38b227 kostenfrei http://www.ies.net.cn/cn_publish/2013/7/201307004.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_2817 AR 13 2013 7 1314-1316 |
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10.3980/j.issn.1672-5123.2013.07.04 doi (DE-627)DOAJ022911138 (DE-599)DOAJ0cce8167ef874780842651574a38b227 DE-627 ger DE-627 rakwb eng RE1-994 Hai-Dong Huang verfasserin aut Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. <i<Pax6</i< gene retinoblastoma expression Ophthalmology Li-Yang Li verfasserin aut Ying Guo verfasserin aut Xing Zhao verfasserin aut Jing-Jia Kang verfasserin aut Di Guan verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 13(2013), 7, Seite 1314-1316 (DE-627)1680946854 16725123 nnns volume:13 year:2013 number:7 pages:1314-1316 https://doi.org/10.3980/j.issn.1672-5123.2013.07.04 kostenfrei https://doaj.org/article/0cce8167ef874780842651574a38b227 kostenfrei http://www.ies.net.cn/cn_publish/2013/7/201307004.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_2817 AR 13 2013 7 1314-1316 |
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10.3980/j.issn.1672-5123.2013.07.04 doi (DE-627)DOAJ022911138 (DE-599)DOAJ0cce8167ef874780842651574a38b227 DE-627 ger DE-627 rakwb eng RE1-994 Hai-Dong Huang verfasserin aut Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. <i<Pax6</i< gene retinoblastoma expression Ophthalmology Li-Yang Li verfasserin aut Ying Guo verfasserin aut Xing Zhao verfasserin aut Jing-Jia Kang verfasserin aut Di Guan verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 13(2013), 7, Seite 1314-1316 (DE-627)1680946854 16725123 nnns volume:13 year:2013 number:7 pages:1314-1316 https://doi.org/10.3980/j.issn.1672-5123.2013.07.04 kostenfrei https://doaj.org/article/0cce8167ef874780842651574a38b227 kostenfrei http://www.ies.net.cn/cn_publish/2013/7/201307004.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_2817 AR 13 2013 7 1314-1316 |
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10.3980/j.issn.1672-5123.2013.07.04 doi (DE-627)DOAJ022911138 (DE-599)DOAJ0cce8167ef874780842651574a38b227 DE-627 ger DE-627 rakwb eng RE1-994 Hai-Dong Huang verfasserin aut Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. <i<Pax6</i< gene retinoblastoma expression Ophthalmology Li-Yang Li verfasserin aut Ying Guo verfasserin aut Xing Zhao verfasserin aut Jing-Jia Kang verfasserin aut Di Guan verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 13(2013), 7, Seite 1314-1316 (DE-627)1680946854 16725123 nnns volume:13 year:2013 number:7 pages:1314-1316 https://doi.org/10.3980/j.issn.1672-5123.2013.07.04 kostenfrei https://doaj.org/article/0cce8167ef874780842651574a38b227 kostenfrei http://www.ies.net.cn/cn_publish/2013/7/201307004.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_2817 AR 13 2013 7 1314-1316 |
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10.3980/j.issn.1672-5123.2013.07.04 doi (DE-627)DOAJ022911138 (DE-599)DOAJ0cce8167ef874780842651574a38b227 DE-627 ger DE-627 rakwb eng RE1-994 Hai-Dong Huang verfasserin aut Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. <i<Pax6</i< gene retinoblastoma expression Ophthalmology Li-Yang Li verfasserin aut Ying Guo verfasserin aut Xing Zhao verfasserin aut Jing-Jia Kang verfasserin aut Di Guan verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 13(2013), 7, Seite 1314-1316 (DE-627)1680946854 16725123 nnns volume:13 year:2013 number:7 pages:1314-1316 https://doi.org/10.3980/j.issn.1672-5123.2013.07.04 kostenfrei https://doaj.org/article/0cce8167ef874780842651574a38b227 kostenfrei http://www.ies.net.cn/cn_publish/2013/7/201307004.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_2817 AR 13 2013 7 1314-1316 |
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Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. 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Expression and clinical significance of <i<Pax6</i< gene in retinoblastoma |
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AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. |
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AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. |
| abstract_unstemmed |
AIM: To discuss the expression and clinical significance of <i<Pax6 </i<gene in retinoblastoma(Rb). <p<METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i<Pax6</i< protein and <i<Pax6 </i<mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i<Pax6</i< gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i<Pax6</i< gene in Rb were discussed. <p<RESULTS: In the observation group, average value of mRNA expression of <i<Pax6</i< gene was 0.99±0.03; average value of <i<Pax6</i< gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i<P</i<<0.05). <p<CONCLUSION: Abnormal expression of <i<Pax6</i< gene is likely to accelerate the occurrence of Rb. |
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