Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer

Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort...
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Autor*in:	Tong Liu [verfasserIn] Qingsong Zhang [verfasserIn] Yiming Wang [verfasserIn] Xiangming Ma [verfasserIn] Qi Zhang [verfasserIn] Mengmeng Song [verfasserIn] Liying Cao [verfasserIn] Hanping Shi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Insulin resistance Marker Colorectal cancer Prospective Cohort

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 22(2022), 1, Seite 11
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12885-022-10100-w

Katalog-ID:	DOAJ022911405

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520			\|a Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
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allfields	10.1186/s12885-022-10100-w doi (DE-627)DOAJ022911405 (DE-599)DOAJe348129b4362421faa98791ee84333c9 DE-627 ger DE-627 rakwb eng RC254-282 Tong Liu verfasserin aut Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China. Insulin resistance Marker Colorectal cancer Prospective Cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingsong Zhang verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Qi Zhang verfasserin aut Mengmeng Song verfasserin aut Liying Cao verfasserin aut Hanping Shi verfasserin aut In BMC Cancer BMC, 2003 22(2022), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:22 year:2022 number:1 pages:11 https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/article/e348129b4362421faa98791ee84333c9 kostenfrei https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 11
spelling	10.1186/s12885-022-10100-w doi (DE-627)DOAJ022911405 (DE-599)DOAJe348129b4362421faa98791ee84333c9 DE-627 ger DE-627 rakwb eng RC254-282 Tong Liu verfasserin aut Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China. Insulin resistance Marker Colorectal cancer Prospective Cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingsong Zhang verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Qi Zhang verfasserin aut Mengmeng Song verfasserin aut Liying Cao verfasserin aut Hanping Shi verfasserin aut In BMC Cancer BMC, 2003 22(2022), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:22 year:2022 number:1 pages:11 https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/article/e348129b4362421faa98791ee84333c9 kostenfrei https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 11
allfields_unstemmed	10.1186/s12885-022-10100-w doi (DE-627)DOAJ022911405 (DE-599)DOAJe348129b4362421faa98791ee84333c9 DE-627 ger DE-627 rakwb eng RC254-282 Tong Liu verfasserin aut Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China. Insulin resistance Marker Colorectal cancer Prospective Cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingsong Zhang verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Qi Zhang verfasserin aut Mengmeng Song verfasserin aut Liying Cao verfasserin aut Hanping Shi verfasserin aut In BMC Cancer BMC, 2003 22(2022), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:22 year:2022 number:1 pages:11 https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/article/e348129b4362421faa98791ee84333c9 kostenfrei https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 11
allfieldsGer	10.1186/s12885-022-10100-w doi (DE-627)DOAJ022911405 (DE-599)DOAJe348129b4362421faa98791ee84333c9 DE-627 ger DE-627 rakwb eng RC254-282 Tong Liu verfasserin aut Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China. Insulin resistance Marker Colorectal cancer Prospective Cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingsong Zhang verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Qi Zhang verfasserin aut Mengmeng Song verfasserin aut Liying Cao verfasserin aut Hanping Shi verfasserin aut In BMC Cancer BMC, 2003 22(2022), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:22 year:2022 number:1 pages:11 https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/article/e348129b4362421faa98791ee84333c9 kostenfrei https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 11
allfieldsSound	10.1186/s12885-022-10100-w doi (DE-627)DOAJ022911405 (DE-599)DOAJe348129b4362421faa98791ee84333c9 DE-627 ger DE-627 rakwb eng RC254-282 Tong Liu verfasserin aut Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China. Insulin resistance Marker Colorectal cancer Prospective Cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingsong Zhang verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Qi Zhang verfasserin aut Mengmeng Song verfasserin aut Liying Cao verfasserin aut Hanping Shi verfasserin aut In BMC Cancer BMC, 2003 22(2022), 1, Seite 11 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:22 year:2022 number:1 pages:11 https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/article/e348129b4362421faa98791ee84333c9 kostenfrei https://doi.org/10.1186/s12885-022-10100-w kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 11
language	English
source	In BMC Cancer 22(2022), 1, Seite 11 volume:22 year:2022 number:1 pages:11
sourceStr	In BMC Cancer 22(2022), 1, Seite 11 volume:22 year:2022 number:1 pages:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Insulin resistance Marker Colorectal cancer Prospective Cohort Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	BMC Cancer
authorswithroles_txt_mv	Tong Liu @@aut@@ Qingsong Zhang @@aut@@ Yiming Wang @@aut@@ Xiangming Ma @@aut@@ Qi Zhang @@aut@@ Mengmeng Song @@aut@@ Liying Cao @@aut@@ Hanping Shi @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	326643710
id	DOAJ022911405
language_de	englisch
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Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. 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callnumber-first	R - Medicine
author	Tong Liu
spellingShingle	Tong Liu misc RC254-282 misc Insulin resistance misc Marker misc Colorectal cancer misc Prospective misc Cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer
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topic_title	RC254-282 Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer Insulin resistance Marker Colorectal cancer Prospective Cohort
topic	misc RC254-282 misc Insulin resistance misc Marker misc Colorectal cancer misc Prospective misc Cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Insulin resistance misc Marker misc Colorectal cancer misc Prospective misc Cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Insulin resistance misc Marker misc Colorectal cancer misc Prospective misc Cohort misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer
ctrlnum	(DE-627)DOAJ022911405 (DE-599)DOAJe348129b4362421faa98791ee84333c9
title_full	Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer
author_sort	Tong Liu
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author_browse	Tong Liu Qingsong Zhang Yiming Wang Xiangming Ma Qi Zhang Mengmeng Song Liying Cao Hanping Shi
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title_sort	association between the tyg index and tg/hdl-c ratio as insulin resistance markers and the risk of colorectal cancer
callnumber	RC254-282
title_auth	Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer
abstract	Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
abstractGer	Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
abstract_unstemmed	Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
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title_short	Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer
url	https://doi.org/10.1186/s12885-022-10100-w https://doaj.org/article/e348129b4362421faa98791ee84333c9 https://doaj.org/toc/1471-2407
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Association between the TyG index and TG/HDL-C ratio as insulin resistance markers and the risk of colorectal cancer

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