The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre

Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pratibha Kale [verfasserIn] Vikas Khillan [verfasserIn] Pradheer Gupta [verfasserIn] Shiv Kumar Sarin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis

Übergeordnetes Werk:	In: Journal of Clinical and Diagnostic Research - JCDR Research and Publications Private Limited, 2009, 12(2018), 9, Seite DC07-DC10
Übergeordnetes Werk:	volume:12 ; year:2018 ; number:9 ; pages:DC07-DC10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.7860/JCDR/2018/36773.11976

Katalog-ID:	DOAJ023118458

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245	1	4	\|a The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
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520			\|a Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues.
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allfields	10.7860/JCDR/2018/36773.11976 doi (DE-627)DOAJ023118458 (DE-599)DOAJa7315430884e41068da823bc59a089d4 DE-627 ger DE-627 rakwb eng Pratibha Kale verfasserin aut The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues. diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis Medicine R Vikas Khillan verfasserin aut Pradheer Gupta verfasserin aut Shiv Kumar Sarin verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 12(2018), 9, Seite DC07-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:12 year:2018 number:9 pages:DC07-DC10 https://doi.org/10.7860/JCDR/2018/36773.11976 kostenfrei https://doaj.org/article/a7315430884e41068da823bc59a089d4 kostenfrei https://jcdr.net/articles/PDF/11976/36773_CE[Ra]_F(Sh)_PF1(AGAK)_PFA(AK)_PB(AG_OM)_PN(SS).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 9 DC07-DC10
spelling	10.7860/JCDR/2018/36773.11976 doi (DE-627)DOAJ023118458 (DE-599)DOAJa7315430884e41068da823bc59a089d4 DE-627 ger DE-627 rakwb eng Pratibha Kale verfasserin aut The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues. diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis Medicine R Vikas Khillan verfasserin aut Pradheer Gupta verfasserin aut Shiv Kumar Sarin verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 12(2018), 9, Seite DC07-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:12 year:2018 number:9 pages:DC07-DC10 https://doi.org/10.7860/JCDR/2018/36773.11976 kostenfrei https://doaj.org/article/a7315430884e41068da823bc59a089d4 kostenfrei https://jcdr.net/articles/PDF/11976/36773_CE[Ra]_F(Sh)_PF1(AGAK)_PFA(AK)_PB(AG_OM)_PN(SS).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 9 DC07-DC10
allfields_unstemmed	10.7860/JCDR/2018/36773.11976 doi (DE-627)DOAJ023118458 (DE-599)DOAJa7315430884e41068da823bc59a089d4 DE-627 ger DE-627 rakwb eng Pratibha Kale verfasserin aut The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues. diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis Medicine R Vikas Khillan verfasserin aut Pradheer Gupta verfasserin aut Shiv Kumar Sarin verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 12(2018), 9, Seite DC07-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:12 year:2018 number:9 pages:DC07-DC10 https://doi.org/10.7860/JCDR/2018/36773.11976 kostenfrei https://doaj.org/article/a7315430884e41068da823bc59a089d4 kostenfrei https://jcdr.net/articles/PDF/11976/36773_CE[Ra]_F(Sh)_PF1(AGAK)_PFA(AK)_PB(AG_OM)_PN(SS).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 9 DC07-DC10
allfieldsGer	10.7860/JCDR/2018/36773.11976 doi (DE-627)DOAJ023118458 (DE-599)DOAJa7315430884e41068da823bc59a089d4 DE-627 ger DE-627 rakwb eng Pratibha Kale verfasserin aut The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues. diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis Medicine R Vikas Khillan verfasserin aut Pradheer Gupta verfasserin aut Shiv Kumar Sarin verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 12(2018), 9, Seite DC07-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:12 year:2018 number:9 pages:DC07-DC10 https://doi.org/10.7860/JCDR/2018/36773.11976 kostenfrei https://doaj.org/article/a7315430884e41068da823bc59a089d4 kostenfrei https://jcdr.net/articles/PDF/11976/36773_CE[Ra]_F(Sh)_PF1(AGAK)_PFA(AK)_PB(AG_OM)_PN(SS).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 9 DC07-DC10
allfieldsSound	10.7860/JCDR/2018/36773.11976 doi (DE-627)DOAJ023118458 (DE-599)DOAJa7315430884e41068da823bc59a089d4 DE-627 ger DE-627 rakwb eng Pratibha Kale verfasserin aut The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues. diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis Medicine R Vikas Khillan verfasserin aut Pradheer Gupta verfasserin aut Shiv Kumar Sarin verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 12(2018), 9, Seite DC07-DC10 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:12 year:2018 number:9 pages:DC07-DC10 https://doi.org/10.7860/JCDR/2018/36773.11976 kostenfrei https://doaj.org/article/a7315430884e41068da823bc59a089d4 kostenfrei https://jcdr.net/articles/PDF/11976/36773_CE[Ra]_F(Sh)_PF1(AGAK)_PFA(AK)_PB(AG_OM)_PN(SS).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 9 DC07-DC10
language	English
source	In Journal of Clinical and Diagnostic Research 12(2018), 9, Seite DC07-DC10 volume:12 year:2018 number:9 pages:DC07-DC10
sourceStr	In Journal of Clinical and Diagnostic Research 12(2018), 9, Seite DC07-DC10 volume:12 year:2018 number:9 pages:DC07-DC10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis Medicine R
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container_title	Journal of Clinical and Diagnostic Research
authorswithroles_txt_mv	Pratibha Kale @@aut@@ Vikas Khillan @@aut@@ Pradheer Gupta @@aut@@ Shiv Kumar Sarin @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	789478048
id	DOAJ023118458
language_de	englisch
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Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. 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author	Pratibha Kale
spellingShingle	Pratibha Kale misc diagnosis misc extra-pulmonary tuberculosis misc mycobacteria other than tuberculosis misc Medicine misc R The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
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topic_title	The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre diagnosis extra-pulmonary tuberculosis mycobacteria other than tuberculosis
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title	The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
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title_full	The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
author_sort	Pratibha Kale
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author_browse	Pratibha Kale Vikas Khillan Pradheer Gupta Shiv Kumar Sarin
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doi_str_mv	10.7860/JCDR/2018/36773.11976
author2-role	verfasserin
title_sort	prevalence and profile of mycobacterial infections in liver diseases from tertiary care hepatobiliary centre
title_auth	The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
abstract	Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues.
abstractGer	Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues.
abstract_unstemmed	Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic characteristics, profile of mycobacterial infection and comparison of diagnostic methods in liver diseases. Materials and Methods: We studied liver disease patients from January 2012 to December 2016, screened for Tuberculosis (TB) if having fever, cough for <2 weeks, haemoptysis, unexplained weight loss, increasing ascites, unresponsive to diuretics, unexplained bowel symptoms, radiological lesions and past or family history of TB. TB diagnosed if there is: (i) histological caseating granulomas; (ii) smear Acid Fast Bacilli; (AFB) positivity; (iii) growth on Mycobacterial Growth Indicator Tube (MGIT) culture; or (iv) positive quantitative polymerase chain reaction for Mycobacterium tuberculosis (MTB qPCR). Mycobacteria other than tuberculosis (MOTT) were identified by negative MPT64 assay. Results: Of the 118/816 positive samples, 31/260 (11.92%) were pulmonary and 87/556 (15.65%) were extra-pulmonary TB (EPTB). There was a male preponderance (66.1%), median age 53 years in pulmonary and 37 years in EPTB. Thirty two samples (27.11%) were smear positive, low in EPTB 13/87 (14.9%) as compared to 19/31 (61.2%) pulmonary. MGIT was positive in 108/118 (91.52%) and 97/118 (82.2%) were MTB qPCR positive. MTB was isolated from all pulmonary samples and 72/87 (82.75%) of EPTB. MOTT was identified in 15/118(12.71%). Sensitivity and specificity of MTB qPCR was 90.3% and 100% respectively in pulmonary and 76.6% and 97.9% respectively in EPTB. Conclusion: There is predominance of smear negative, EPTB and MOTT in liver diseases. MGIT culture and TB PCR have additive advantage over either test alone. MOTT should be ruled out in all cases as treatment varies. High index of suspicion and good screening methods are needed to identify TB and MOTT owing to similar presentation and anti-tubercular drug toxicity issues.
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title_short	The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
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