Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit)
Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring sys...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Celalettin Ustun [verfasserIn] Elizabeth Morgan [verfasserIn] Erica E. M. Moodie [verfasserIn] Sheeja Pullarkat [verfasserIn] Cecilia Yeung [verfasserIn] Sigurd Broesby‐Olsen [verfasserIn] Robert Ohgami [verfasserIn] Young Kim [verfasserIn] Wolfgang Sperr [verfasserIn] Hanne Vestergaard [verfasserIn] Dong Chen [verfasserIn] Philip M. Kluin [verfasserIn] Michelle Dolan [verfasserIn] Krzysztof Mrózek [verfasserIn] David Czuchlewski [verfasserIn] Hans‐Peter Horny [verfasserIn] Tracy I. George [verfasserIn] Thomas Kielsgaard Kristensen [verfasserIn] Nam K. Ku [verfasserIn] Cecilia Arana Yi [verfasserIn] Michael Boe Møller [verfasserIn] Guido Marcucci [verfasserIn] Linda Baughn [verfasserIn] Ana‐Iris Schiefer [verfasserIn] J. R. Hilberink [verfasserIn] Vinod Pullarkat [verfasserIn] Ryan Shanley [verfasserIn] Jessica Kohlschmidt [verfasserIn] Janie Coulombe [verfasserIn] Amandeep Salhotra [verfasserIn] Lori Soma [verfasserIn] Christina Cho [verfasserIn] Michael A. Linden [verfasserIn] Cem Akin [verfasserIn] Jason Gotlib [verfasserIn] Gregor Hoermann [verfasserIn] Jason Hornick [verfasserIn] Ryo Nakamura [verfasserIn] Joachim Deeg [verfasserIn] Clara D. Bloomfield [verfasserIn] Daniel Weisdorf [verfasserIn] Mark R. Litzow [verfasserIn] Peter Valent [verfasserIn] Gerwin Huls [verfasserIn] Miguel‐Angel Perales [verfasserIn] Gautam Borthakur [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Übergeordnetes Werk: |
In: Cancer Medicine - Wiley, 2012, 7(2018), 9, Seite 4447-4455 |
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| Übergeordnetes Werk: |
volume:7 ; year:2018 ; number:9 ; pages:4447-4455 |
| Links: |
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| DOI / URN: |
10.1002/cam4.1733 |
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| Katalog-ID: |
DOAJ023164182 |
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| 100 | 0 | |a Celalettin Ustun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) |
| 264 | 1 | |c 2018 | |
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| 520 | |a Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). | ||
| 650 | 4 | |a acute myeloid leukemia | |
| 650 | 4 | |a core‐binding factor | |
| 650 | 4 | |a disease‐free survival | |
| 650 | 4 | |a KIT mutation | |
| 650 | 4 | |a predictive value | |
| 650 | 4 | |a relapse | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Elizabeth Morgan |e verfasserin |4 aut | |
| 700 | 0 | |a Erica E. M. Moodie |e verfasserin |4 aut | |
| 700 | 0 | |a Sheeja Pullarkat |e verfasserin |4 aut | |
| 700 | 0 | |a Cecilia Yeung |e verfasserin |4 aut | |
| 700 | 0 | |a Sigurd Broesby‐Olsen |e verfasserin |4 aut | |
| 700 | 0 | |a Robert Ohgami |e verfasserin |4 aut | |
| 700 | 0 | |a Young Kim |e verfasserin |4 aut | |
| 700 | 0 | |a Wolfgang Sperr |e verfasserin |4 aut | |
| 700 | 0 | |a Hanne Vestergaard |e verfasserin |4 aut | |
| 700 | 0 | |a Dong Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Philip M. Kluin |e verfasserin |4 aut | |
| 700 | 0 | |a Michelle Dolan |e verfasserin |4 aut | |
| 700 | 0 | |a Krzysztof Mrózek |e verfasserin |4 aut | |
| 700 | 0 | |a David Czuchlewski |e verfasserin |4 aut | |
| 700 | 0 | |a Hans‐Peter Horny |e verfasserin |4 aut | |
| 700 | 0 | |a Tracy I. George |e verfasserin |4 aut | |
| 700 | 0 | |a Thomas Kielsgaard Kristensen |e verfasserin |4 aut | |
| 700 | 0 | |a Nam K. Ku |e verfasserin |4 aut | |
| 700 | 0 | |a Cecilia Arana Yi |e verfasserin |4 aut | |
| 700 | 0 | |a Michael Boe Møller |e verfasserin |4 aut | |
| 700 | 0 | |a Guido Marcucci |e verfasserin |4 aut | |
| 700 | 0 | |a Linda Baughn |e verfasserin |4 aut | |
| 700 | 0 | |a Ana‐Iris Schiefer |e verfasserin |4 aut | |
| 700 | 0 | |a J. R. Hilberink |e verfasserin |4 aut | |
| 700 | 0 | |a Vinod Pullarkat |e verfasserin |4 aut | |
| 700 | 0 | |a Ryan Shanley |e verfasserin |4 aut | |
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| 700 | 0 | |a Amandeep Salhotra |e verfasserin |4 aut | |
| 700 | 0 | |a Lori Soma |e verfasserin |4 aut | |
| 700 | 0 | |a Christina Cho |e verfasserin |4 aut | |
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| 700 | 0 | |a Cem Akin |e verfasserin |4 aut | |
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| 700 | 0 | |a Peter Valent |e verfasserin |4 aut | |
| 700 | 0 | |a Gerwin Huls |e verfasserin |4 aut | |
| 700 | 0 | |a Miguel‐Angel Perales |e verfasserin |4 aut | |
| 700 | 0 | |a Gautam Borthakur |e verfasserin |4 aut | |
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10.1002/cam4.1733 doi (DE-627)DOAJ023164182 (DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c DE-627 ger DE-627 rakwb eng RC254-282 Celalettin Ustun verfasserin aut Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elizabeth Morgan verfasserin aut Erica E. M. Moodie verfasserin aut Sheeja Pullarkat verfasserin aut Cecilia Yeung verfasserin aut Sigurd Broesby‐Olsen verfasserin aut Robert Ohgami verfasserin aut Young Kim verfasserin aut Wolfgang Sperr verfasserin aut Hanne Vestergaard verfasserin aut Dong Chen verfasserin aut Philip M. Kluin verfasserin aut Michelle Dolan verfasserin aut Krzysztof Mrózek verfasserin aut David Czuchlewski verfasserin aut Hans‐Peter Horny verfasserin aut Tracy I. George verfasserin aut Thomas Kielsgaard Kristensen verfasserin aut Nam K. Ku verfasserin aut Cecilia Arana Yi verfasserin aut Michael Boe Møller verfasserin aut Guido Marcucci verfasserin aut Linda Baughn verfasserin aut Ana‐Iris Schiefer verfasserin aut J. R. Hilberink verfasserin aut Vinod Pullarkat verfasserin aut Ryan Shanley verfasserin aut Jessica Kohlschmidt verfasserin aut Janie Coulombe verfasserin aut Amandeep Salhotra verfasserin aut Lori Soma verfasserin aut Christina Cho verfasserin aut Michael A. Linden verfasserin aut Cem Akin verfasserin aut Jason Gotlib verfasserin aut Gregor Hoermann verfasserin aut Jason Hornick verfasserin aut Ryo Nakamura verfasserin aut Joachim Deeg verfasserin aut Clara D. Bloomfield verfasserin aut Daniel Weisdorf verfasserin aut Mark R. Litzow verfasserin aut Peter Valent verfasserin aut Gerwin Huls verfasserin aut Miguel‐Angel Perales verfasserin aut Gautam Borthakur verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 9, Seite 4447-4455 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:9 pages:4447-4455 https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/article/094eb1a2e98b464ea81e0fe6a9fdcc3c kostenfrei https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 9 4447-4455 |
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10.1002/cam4.1733 doi (DE-627)DOAJ023164182 (DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c DE-627 ger DE-627 rakwb eng RC254-282 Celalettin Ustun verfasserin aut Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elizabeth Morgan verfasserin aut Erica E. M. Moodie verfasserin aut Sheeja Pullarkat verfasserin aut Cecilia Yeung verfasserin aut Sigurd Broesby‐Olsen verfasserin aut Robert Ohgami verfasserin aut Young Kim verfasserin aut Wolfgang Sperr verfasserin aut Hanne Vestergaard verfasserin aut Dong Chen verfasserin aut Philip M. Kluin verfasserin aut Michelle Dolan verfasserin aut Krzysztof Mrózek verfasserin aut David Czuchlewski verfasserin aut Hans‐Peter Horny verfasserin aut Tracy I. George verfasserin aut Thomas Kielsgaard Kristensen verfasserin aut Nam K. Ku verfasserin aut Cecilia Arana Yi verfasserin aut Michael Boe Møller verfasserin aut Guido Marcucci verfasserin aut Linda Baughn verfasserin aut Ana‐Iris Schiefer verfasserin aut J. R. Hilberink verfasserin aut Vinod Pullarkat verfasserin aut Ryan Shanley verfasserin aut Jessica Kohlschmidt verfasserin aut Janie Coulombe verfasserin aut Amandeep Salhotra verfasserin aut Lori Soma verfasserin aut Christina Cho verfasserin aut Michael A. Linden verfasserin aut Cem Akin verfasserin aut Jason Gotlib verfasserin aut Gregor Hoermann verfasserin aut Jason Hornick verfasserin aut Ryo Nakamura verfasserin aut Joachim Deeg verfasserin aut Clara D. Bloomfield verfasserin aut Daniel Weisdorf verfasserin aut Mark R. Litzow verfasserin aut Peter Valent verfasserin aut Gerwin Huls verfasserin aut Miguel‐Angel Perales verfasserin aut Gautam Borthakur verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 9, Seite 4447-4455 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:9 pages:4447-4455 https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/article/094eb1a2e98b464ea81e0fe6a9fdcc3c kostenfrei https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 9 4447-4455 |
| allfields_unstemmed |
10.1002/cam4.1733 doi (DE-627)DOAJ023164182 (DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c DE-627 ger DE-627 rakwb eng RC254-282 Celalettin Ustun verfasserin aut Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elizabeth Morgan verfasserin aut Erica E. M. Moodie verfasserin aut Sheeja Pullarkat verfasserin aut Cecilia Yeung verfasserin aut Sigurd Broesby‐Olsen verfasserin aut Robert Ohgami verfasserin aut Young Kim verfasserin aut Wolfgang Sperr verfasserin aut Hanne Vestergaard verfasserin aut Dong Chen verfasserin aut Philip M. Kluin verfasserin aut Michelle Dolan verfasserin aut Krzysztof Mrózek verfasserin aut David Czuchlewski verfasserin aut Hans‐Peter Horny verfasserin aut Tracy I. George verfasserin aut Thomas Kielsgaard Kristensen verfasserin aut Nam K. Ku verfasserin aut Cecilia Arana Yi verfasserin aut Michael Boe Møller verfasserin aut Guido Marcucci verfasserin aut Linda Baughn verfasserin aut Ana‐Iris Schiefer verfasserin aut J. R. Hilberink verfasserin aut Vinod Pullarkat verfasserin aut Ryan Shanley verfasserin aut Jessica Kohlschmidt verfasserin aut Janie Coulombe verfasserin aut Amandeep Salhotra verfasserin aut Lori Soma verfasserin aut Christina Cho verfasserin aut Michael A. Linden verfasserin aut Cem Akin verfasserin aut Jason Gotlib verfasserin aut Gregor Hoermann verfasserin aut Jason Hornick verfasserin aut Ryo Nakamura verfasserin aut Joachim Deeg verfasserin aut Clara D. Bloomfield verfasserin aut Daniel Weisdorf verfasserin aut Mark R. Litzow verfasserin aut Peter Valent verfasserin aut Gerwin Huls verfasserin aut Miguel‐Angel Perales verfasserin aut Gautam Borthakur verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 9, Seite 4447-4455 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:9 pages:4447-4455 https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/article/094eb1a2e98b464ea81e0fe6a9fdcc3c kostenfrei https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 9 4447-4455 |
| allfieldsGer |
10.1002/cam4.1733 doi (DE-627)DOAJ023164182 (DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c DE-627 ger DE-627 rakwb eng RC254-282 Celalettin Ustun verfasserin aut Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elizabeth Morgan verfasserin aut Erica E. M. Moodie verfasserin aut Sheeja Pullarkat verfasserin aut Cecilia Yeung verfasserin aut Sigurd Broesby‐Olsen verfasserin aut Robert Ohgami verfasserin aut Young Kim verfasserin aut Wolfgang Sperr verfasserin aut Hanne Vestergaard verfasserin aut Dong Chen verfasserin aut Philip M. Kluin verfasserin aut Michelle Dolan verfasserin aut Krzysztof Mrózek verfasserin aut David Czuchlewski verfasserin aut Hans‐Peter Horny verfasserin aut Tracy I. George verfasserin aut Thomas Kielsgaard Kristensen verfasserin aut Nam K. Ku verfasserin aut Cecilia Arana Yi verfasserin aut Michael Boe Møller verfasserin aut Guido Marcucci verfasserin aut Linda Baughn verfasserin aut Ana‐Iris Schiefer verfasserin aut J. R. Hilberink verfasserin aut Vinod Pullarkat verfasserin aut Ryan Shanley verfasserin aut Jessica Kohlschmidt verfasserin aut Janie Coulombe verfasserin aut Amandeep Salhotra verfasserin aut Lori Soma verfasserin aut Christina Cho verfasserin aut Michael A. Linden verfasserin aut Cem Akin verfasserin aut Jason Gotlib verfasserin aut Gregor Hoermann verfasserin aut Jason Hornick verfasserin aut Ryo Nakamura verfasserin aut Joachim Deeg verfasserin aut Clara D. Bloomfield verfasserin aut Daniel Weisdorf verfasserin aut Mark R. Litzow verfasserin aut Peter Valent verfasserin aut Gerwin Huls verfasserin aut Miguel‐Angel Perales verfasserin aut Gautam Borthakur verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 9, Seite 4447-4455 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:9 pages:4447-4455 https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/article/094eb1a2e98b464ea81e0fe6a9fdcc3c kostenfrei https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 9 4447-4455 |
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10.1002/cam4.1733 doi (DE-627)DOAJ023164182 (DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c DE-627 ger DE-627 rakwb eng RC254-282 Celalettin Ustun verfasserin aut Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elizabeth Morgan verfasserin aut Erica E. M. Moodie verfasserin aut Sheeja Pullarkat verfasserin aut Cecilia Yeung verfasserin aut Sigurd Broesby‐Olsen verfasserin aut Robert Ohgami verfasserin aut Young Kim verfasserin aut Wolfgang Sperr verfasserin aut Hanne Vestergaard verfasserin aut Dong Chen verfasserin aut Philip M. Kluin verfasserin aut Michelle Dolan verfasserin aut Krzysztof Mrózek verfasserin aut David Czuchlewski verfasserin aut Hans‐Peter Horny verfasserin aut Tracy I. George verfasserin aut Thomas Kielsgaard Kristensen verfasserin aut Nam K. Ku verfasserin aut Cecilia Arana Yi verfasserin aut Michael Boe Møller verfasserin aut Guido Marcucci verfasserin aut Linda Baughn verfasserin aut Ana‐Iris Schiefer verfasserin aut J. R. Hilberink verfasserin aut Vinod Pullarkat verfasserin aut Ryan Shanley verfasserin aut Jessica Kohlschmidt verfasserin aut Janie Coulombe verfasserin aut Amandeep Salhotra verfasserin aut Lori Soma verfasserin aut Christina Cho verfasserin aut Michael A. Linden verfasserin aut Cem Akin verfasserin aut Jason Gotlib verfasserin aut Gregor Hoermann verfasserin aut Jason Hornick verfasserin aut Ryo Nakamura verfasserin aut Joachim Deeg verfasserin aut Clara D. Bloomfield verfasserin aut Daniel Weisdorf verfasserin aut Mark R. Litzow verfasserin aut Peter Valent verfasserin aut Gerwin Huls verfasserin aut Miguel‐Angel Perales verfasserin aut Gautam Borthakur verfasserin aut In Cancer Medicine Wiley, 2012 7(2018), 9, Seite 4447-4455 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:7 year:2018 number:9 pages:4447-4455 https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/article/094eb1a2e98b464ea81e0fe6a9fdcc3c kostenfrei https://doi.org/10.1002/cam4.1733 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 9 4447-4455 |
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In Cancer Medicine 7(2018), 9, Seite 4447-4455 volume:7 year:2018 number:9 pages:4447-4455 |
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acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Celalettin Ustun @@aut@@ Elizabeth Morgan @@aut@@ Erica E. M. Moodie @@aut@@ Sheeja Pullarkat @@aut@@ Cecilia Yeung @@aut@@ Sigurd Broesby‐Olsen @@aut@@ Robert Ohgami @@aut@@ Young Kim @@aut@@ Wolfgang Sperr @@aut@@ Hanne Vestergaard @@aut@@ Dong Chen @@aut@@ Philip M. Kluin @@aut@@ Michelle Dolan @@aut@@ Krzysztof Mrózek @@aut@@ David Czuchlewski @@aut@@ Hans‐Peter Horny @@aut@@ Tracy I. George @@aut@@ Thomas Kielsgaard Kristensen @@aut@@ Nam K. Ku @@aut@@ Cecilia Arana Yi @@aut@@ Michael Boe Møller @@aut@@ Guido Marcucci @@aut@@ Linda Baughn @@aut@@ Ana‐Iris Schiefer @@aut@@ J. R. Hilberink @@aut@@ Vinod Pullarkat @@aut@@ Ryan Shanley @@aut@@ Jessica Kohlschmidt @@aut@@ Janie Coulombe @@aut@@ Amandeep Salhotra @@aut@@ Lori Soma @@aut@@ Christina Cho @@aut@@ Michael A. Linden @@aut@@ Cem Akin @@aut@@ Jason Gotlib @@aut@@ Gregor Hoermann @@aut@@ Jason Hornick @@aut@@ Ryo Nakamura @@aut@@ Joachim Deeg @@aut@@ Clara D. Bloomfield @@aut@@ Daniel Weisdorf @@aut@@ Mark R. Litzow @@aut@@ Peter Valent @@aut@@ Gerwin Huls @@aut@@ Miguel‐Angel Perales @@aut@@ Gautam Borthakur @@aut@@ |
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2018-01-01T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ023164182</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503000832.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/cam4.1733</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ023164182</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Celalettin Ustun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">acute myeloid leukemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">core‐binding factor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">disease‐free survival</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">KIT mutation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">predictive value</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">relapse</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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Celalettin Ustun misc RC254-282 misc acute myeloid leukemia misc core‐binding factor misc disease‐free survival misc KIT mutation misc predictive value misc relapse misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) |
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RC254-282 Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) acute myeloid leukemia core‐binding factor disease‐free survival KIT mutation predictive value relapse |
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misc RC254-282 misc acute myeloid leukemia misc core‐binding factor misc disease‐free survival misc KIT mutation misc predictive value misc relapse misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) |
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Celalettin Ustun Elizabeth Morgan Erica E. M. Moodie Sheeja Pullarkat Cecilia Yeung Sigurd Broesby‐Olsen Robert Ohgami Young Kim Wolfgang Sperr Hanne Vestergaard Dong Chen Philip M. Kluin Michelle Dolan Krzysztof Mrózek David Czuchlewski Hans‐Peter Horny Tracy I. George Thomas Kielsgaard Kristensen Nam K. Ku Cecilia Arana Yi Michael Boe Møller Guido Marcucci Linda Baughn Ana‐Iris Schiefer J. R. Hilberink Vinod Pullarkat Ryan Shanley Jessica Kohlschmidt Janie Coulombe Amandeep Salhotra Lori Soma Christina Cho Michael A. Linden Cem Akin Jason Gotlib Gregor Hoermann Jason Hornick Ryo Nakamura Joachim Deeg Clara D. Bloomfield Daniel Weisdorf Mark R. Litzow Peter Valent Gerwin Huls Miguel‐Angel Perales Gautam Borthakur |
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core‐binding factor acute myeloid leukemia with t(8;21): risk factors and a novel scoring system (i‐cbfit) |
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RC254-282 |
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Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) |
| abstract |
Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). |
| abstractGer |
Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). |
| abstract_unstemmed |
Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score). |
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Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit) |
| url |
https://doi.org/10.1002/cam4.1733 https://doaj.org/article/094eb1a2e98b464ea81e0fe6a9fdcc3c https://doaj.org/toc/2045-7634 |
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Elizabeth Morgan Erica E. M. Moodie Sheeja Pullarkat Cecilia Yeung Sigurd Broesby‐Olsen Robert Ohgami Young Kim Wolfgang Sperr Hanne Vestergaard Dong Chen Philip M. Kluin Michelle Dolan Krzysztof Mrózek David Czuchlewski Hans‐Peter Horny Tracy I. George Thomas Kielsgaard Kristensen Nam K. Ku Cecilia Arana Yi Michael Boe Møller Guido Marcucci Linda Baughn Ana‐Iris Schiefer J. R. Hilberink Vinod Pullarkat Ryan Shanley Jessica Kohlschmidt Janie Coulombe Amandeep Salhotra Lori Soma Christina Cho Michael A. Linden Cem Akin Jason Gotlib Gregor Hoermann Jason Hornick Ryo Nakamura Joachim Deeg Clara D. Bloomfield Daniel Weisdorf Mark R. Litzow Peter Valent Gerwin Huls Miguel‐Angel Perales Gautam Borthakur |
| author2Str |
Elizabeth Morgan Erica E. M. Moodie Sheeja Pullarkat Cecilia Yeung Sigurd Broesby‐Olsen Robert Ohgami Young Kim Wolfgang Sperr Hanne Vestergaard Dong Chen Philip M. Kluin Michelle Dolan Krzysztof Mrózek David Czuchlewski Hans‐Peter Horny Tracy I. George Thomas Kielsgaard Kristensen Nam K. Ku Cecilia Arana Yi Michael Boe Møller Guido Marcucci Linda Baughn Ana‐Iris Schiefer J. R. Hilberink Vinod Pullarkat Ryan Shanley Jessica Kohlschmidt Janie Coulombe Amandeep Salhotra Lori Soma Christina Cho Michael A. Linden Cem Akin Jason Gotlib Gregor Hoermann Jason Hornick Ryo Nakamura Joachim Deeg Clara D. Bloomfield Daniel Weisdorf Mark R. Litzow Peter Valent Gerwin Huls Miguel‐Angel Perales Gautam Borthakur |
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71860153X |
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RC - Internal Medicine |
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c |
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true |
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false |
| doi_str |
10.1002/cam4.1733 |
| callnumber-a |
RC254-282 |
| up_date |
2024-07-03T16:05:33.415Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ023164182</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503000832.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/cam4.1733</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ023164182</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ094eb1a2e98b464ea81e0fe6a9fdcc3c</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Celalettin Ustun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Core‐binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I‐CBFit)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Although the prognosis of core‐binding factor (CBF) acute myeloid leukemia (AML) is better than other subtypes of AML, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (alloHCT). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse. Methods Eleven centers in the US and Europe evaluated 247 patients with t(8;21)(q22;q22). Results Complete remission (CR) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received alloHCT. The median disease‐free (DFS) and overall (OS) survival were 20.8 and 31.2 months, respectively. Age, KIT D816V mutated (11.3%) or nontested (36.4%) compared with KIT D816V wild type (52.5%), high white blood cell counts (WBC), and pseudodiploidy compared with hyper‐ or hypodiploidy were included in a scoring system (named I‐CBFit). DFS rate at 2 years was 76% for patients with a low‐risk I‐CBFit score compared with 36% for those with a high‐risk I‐CBFit score (P < 0.0001). Low‐ vs high‐risk OS at 2 years was 89% vs 51% (P < 0.0001). Conclusions I‐CBFit composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom alloHCT is not need in CR1 (ie, patients with a low‐risk I‐CBFit score).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">acute myeloid leukemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">core‐binding factor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">disease‐free survival</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">KIT mutation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">predictive value</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">relapse</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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| score |
7.401267 |