Does the KIR2DS5 gene protect from some human diseases?
BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compar...
Ausführliche Beschreibung
Autor*in: |
Izabela Nowak [verfasserIn] Edyta Majorczyk [verfasserIn] Andrzej Wiśniewski [verfasserIn] Andrzej Pawlik [verfasserIn] Maria Magott-Procelewska [verfasserIn] Ewa Passowicz-Muszyńska [verfasserIn] Jacek Malejczyk [verfasserIn] Rafał Płoski [verfasserIn] Sebastian Giebel [verfasserIn] Ewa Barcz [verfasserIn] Aleksandra Zoń-Giebel [verfasserIn] Andrzej Malinowski [verfasserIn] Henryk Tchórzewski [verfasserIn] Arkadiusz Chlebicki [verfasserIn] Wioleta Łuszczek [verfasserIn] Maciej Kurpisz [verfasserIn] Marian Gryboś [verfasserIn] Jacek Wilczyński [verfasserIn] Piotr Wiland [verfasserIn] David Senitzer [verfasserIn] Ji-Yao Sun [verfasserIn] Renata Jankowska [verfasserIn] Marian Klinger [verfasserIn] Piotr Kuśnierczyk [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2010 |
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Übergeordnetes Werk: |
In: PLoS ONE - Public Library of Science (PLoS), 2007, 5(2010), 8, p e12381 |
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Übergeordnetes Werk: |
volume:5 ; year:2010 ; number:8, p e12381 |
Links: |
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DOI / URN: |
10.1371/journal.pone.0012381 |
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Katalog-ID: |
DOAJ023176261 |
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245 | 1 | 0 | |a Does the KIR2DS5 gene protect from some human diseases? |
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520 | |a BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. | ||
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700 | 0 | |a Edyta Majorczyk |e verfasserin |4 aut | |
700 | 0 | |a Andrzej Wiśniewski |e verfasserin |4 aut | |
700 | 0 | |a Andrzej Pawlik |e verfasserin |4 aut | |
700 | 0 | |a Maria Magott-Procelewska |e verfasserin |4 aut | |
700 | 0 | |a Ewa Passowicz-Muszyńska |e verfasserin |4 aut | |
700 | 0 | |a Jacek Malejczyk |e verfasserin |4 aut | |
700 | 0 | |a Rafał Płoski |e verfasserin |4 aut | |
700 | 0 | |a Sebastian Giebel |e verfasserin |4 aut | |
700 | 0 | |a Ewa Barcz |e verfasserin |4 aut | |
700 | 0 | |a Aleksandra Zoń-Giebel |e verfasserin |4 aut | |
700 | 0 | |a Andrzej Malinowski |e verfasserin |4 aut | |
700 | 0 | |a Henryk Tchórzewski |e verfasserin |4 aut | |
700 | 0 | |a Arkadiusz Chlebicki |e verfasserin |4 aut | |
700 | 0 | |a Wioleta Łuszczek |e verfasserin |4 aut | |
700 | 0 | |a Maciej Kurpisz |e verfasserin |4 aut | |
700 | 0 | |a Marian Gryboś |e verfasserin |4 aut | |
700 | 0 | |a Jacek Wilczyński |e verfasserin |4 aut | |
700 | 0 | |a Piotr Wiland |e verfasserin |4 aut | |
700 | 0 | |a David Senitzer |e verfasserin |4 aut | |
700 | 0 | |a Ji-Yao Sun |e verfasserin |4 aut | |
700 | 0 | |a Renata Jankowska |e verfasserin |4 aut | |
700 | 0 | |a Marian Klinger |e verfasserin |4 aut | |
700 | 0 | |a Piotr Kuśnierczyk |e verfasserin |4 aut | |
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10.1371/journal.pone.0012381 doi (DE-627)DOAJ023176261 (DE-599)DOAJ7f7c47daf72f4b119cbddb562bc283c5 DE-627 ger DE-627 rakwb eng Izabela Nowak verfasserin aut Does the KIR2DS5 gene protect from some human diseases? 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. Medicine R Science Q Edyta Majorczyk verfasserin aut Andrzej Wiśniewski verfasserin aut Andrzej Pawlik verfasserin aut Maria Magott-Procelewska verfasserin aut Ewa Passowicz-Muszyńska verfasserin aut Jacek Malejczyk verfasserin aut Rafał Płoski verfasserin aut Sebastian Giebel verfasserin aut Ewa Barcz verfasserin aut Aleksandra Zoń-Giebel verfasserin aut Andrzej Malinowski verfasserin aut Henryk Tchórzewski verfasserin aut Arkadiusz Chlebicki verfasserin aut Wioleta Łuszczek verfasserin aut Maciej Kurpisz verfasserin aut Marian Gryboś verfasserin aut Jacek Wilczyński verfasserin aut Piotr Wiland verfasserin aut David Senitzer verfasserin aut Ji-Yao Sun verfasserin aut Renata Jankowska verfasserin aut Marian Klinger verfasserin aut Piotr Kuśnierczyk verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 5(2010), 8, p e12381 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:5 year:2010 number:8, p e12381 https://doi.org/10.1371/journal.pone.0012381 kostenfrei https://doaj.org/article/7f7c47daf72f4b119cbddb562bc283c5 kostenfrei http://europepmc.org/articles/PMC2928722?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 8, p e12381 |
spelling |
10.1371/journal.pone.0012381 doi (DE-627)DOAJ023176261 (DE-599)DOAJ7f7c47daf72f4b119cbddb562bc283c5 DE-627 ger DE-627 rakwb eng Izabela Nowak verfasserin aut Does the KIR2DS5 gene protect from some human diseases? 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. Medicine R Science Q Edyta Majorczyk verfasserin aut Andrzej Wiśniewski verfasserin aut Andrzej Pawlik verfasserin aut Maria Magott-Procelewska verfasserin aut Ewa Passowicz-Muszyńska verfasserin aut Jacek Malejczyk verfasserin aut Rafał Płoski verfasserin aut Sebastian Giebel verfasserin aut Ewa Barcz verfasserin aut Aleksandra Zoń-Giebel verfasserin aut Andrzej Malinowski verfasserin aut Henryk Tchórzewski verfasserin aut Arkadiusz Chlebicki verfasserin aut Wioleta Łuszczek verfasserin aut Maciej Kurpisz verfasserin aut Marian Gryboś verfasserin aut Jacek Wilczyński verfasserin aut Piotr Wiland verfasserin aut David Senitzer verfasserin aut Ji-Yao Sun verfasserin aut Renata Jankowska verfasserin aut Marian Klinger verfasserin aut Piotr Kuśnierczyk verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 5(2010), 8, p e12381 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:5 year:2010 number:8, p e12381 https://doi.org/10.1371/journal.pone.0012381 kostenfrei https://doaj.org/article/7f7c47daf72f4b119cbddb562bc283c5 kostenfrei http://europepmc.org/articles/PMC2928722?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 8, p e12381 |
allfields_unstemmed |
10.1371/journal.pone.0012381 doi (DE-627)DOAJ023176261 (DE-599)DOAJ7f7c47daf72f4b119cbddb562bc283c5 DE-627 ger DE-627 rakwb eng Izabela Nowak verfasserin aut Does the KIR2DS5 gene protect from some human diseases? 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. Medicine R Science Q Edyta Majorczyk verfasserin aut Andrzej Wiśniewski verfasserin aut Andrzej Pawlik verfasserin aut Maria Magott-Procelewska verfasserin aut Ewa Passowicz-Muszyńska verfasserin aut Jacek Malejczyk verfasserin aut Rafał Płoski verfasserin aut Sebastian Giebel verfasserin aut Ewa Barcz verfasserin aut Aleksandra Zoń-Giebel verfasserin aut Andrzej Malinowski verfasserin aut Henryk Tchórzewski verfasserin aut Arkadiusz Chlebicki verfasserin aut Wioleta Łuszczek verfasserin aut Maciej Kurpisz verfasserin aut Marian Gryboś verfasserin aut Jacek Wilczyński verfasserin aut Piotr Wiland verfasserin aut David Senitzer verfasserin aut Ji-Yao Sun verfasserin aut Renata Jankowska verfasserin aut Marian Klinger verfasserin aut Piotr Kuśnierczyk verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 5(2010), 8, p e12381 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:5 year:2010 number:8, p e12381 https://doi.org/10.1371/journal.pone.0012381 kostenfrei https://doaj.org/article/7f7c47daf72f4b119cbddb562bc283c5 kostenfrei http://europepmc.org/articles/PMC2928722?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 8, p e12381 |
allfieldsGer |
10.1371/journal.pone.0012381 doi (DE-627)DOAJ023176261 (DE-599)DOAJ7f7c47daf72f4b119cbddb562bc283c5 DE-627 ger DE-627 rakwb eng Izabela Nowak verfasserin aut Does the KIR2DS5 gene protect from some human diseases? 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. Medicine R Science Q Edyta Majorczyk verfasserin aut Andrzej Wiśniewski verfasserin aut Andrzej Pawlik verfasserin aut Maria Magott-Procelewska verfasserin aut Ewa Passowicz-Muszyńska verfasserin aut Jacek Malejczyk verfasserin aut Rafał Płoski verfasserin aut Sebastian Giebel verfasserin aut Ewa Barcz verfasserin aut Aleksandra Zoń-Giebel verfasserin aut Andrzej Malinowski verfasserin aut Henryk Tchórzewski verfasserin aut Arkadiusz Chlebicki verfasserin aut Wioleta Łuszczek verfasserin aut Maciej Kurpisz verfasserin aut Marian Gryboś verfasserin aut Jacek Wilczyński verfasserin aut Piotr Wiland verfasserin aut David Senitzer verfasserin aut Ji-Yao Sun verfasserin aut Renata Jankowska verfasserin aut Marian Klinger verfasserin aut Piotr Kuśnierczyk verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 5(2010), 8, p e12381 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:5 year:2010 number:8, p e12381 https://doi.org/10.1371/journal.pone.0012381 kostenfrei https://doaj.org/article/7f7c47daf72f4b119cbddb562bc283c5 kostenfrei http://europepmc.org/articles/PMC2928722?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 8, p e12381 |
allfieldsSound |
10.1371/journal.pone.0012381 doi (DE-627)DOAJ023176261 (DE-599)DOAJ7f7c47daf72f4b119cbddb562bc283c5 DE-627 ger DE-627 rakwb eng Izabela Nowak verfasserin aut Does the KIR2DS5 gene protect from some human diseases? 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. Medicine R Science Q Edyta Majorczyk verfasserin aut Andrzej Wiśniewski verfasserin aut Andrzej Pawlik verfasserin aut Maria Magott-Procelewska verfasserin aut Ewa Passowicz-Muszyńska verfasserin aut Jacek Malejczyk verfasserin aut Rafał Płoski verfasserin aut Sebastian Giebel verfasserin aut Ewa Barcz verfasserin aut Aleksandra Zoń-Giebel verfasserin aut Andrzej Malinowski verfasserin aut Henryk Tchórzewski verfasserin aut Arkadiusz Chlebicki verfasserin aut Wioleta Łuszczek verfasserin aut Maciej Kurpisz verfasserin aut Marian Gryboś verfasserin aut Jacek Wilczyński verfasserin aut Piotr Wiland verfasserin aut David Senitzer verfasserin aut Ji-Yao Sun verfasserin aut Renata Jankowska verfasserin aut Marian Klinger verfasserin aut Piotr Kuśnierczyk verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 5(2010), 8, p e12381 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:5 year:2010 number:8, p e12381 https://doi.org/10.1371/journal.pone.0012381 kostenfrei https://doaj.org/article/7f7c47daf72f4b119cbddb562bc283c5 kostenfrei http://europepmc.org/articles/PMC2928722?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 8, p e12381 |
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Izabela Nowak @@aut@@ Edyta Majorczyk @@aut@@ Andrzej Wiśniewski @@aut@@ Andrzej Pawlik @@aut@@ Maria Magott-Procelewska @@aut@@ Ewa Passowicz-Muszyńska @@aut@@ Jacek Malejczyk @@aut@@ Rafał Płoski @@aut@@ Sebastian Giebel @@aut@@ Ewa Barcz @@aut@@ Aleksandra Zoń-Giebel @@aut@@ Andrzej Malinowski @@aut@@ Henryk Tchórzewski @@aut@@ Arkadiusz Chlebicki @@aut@@ Wioleta Łuszczek @@aut@@ Maciej Kurpisz @@aut@@ Marian Gryboś @@aut@@ Jacek Wilczyński @@aut@@ Piotr Wiland @@aut@@ David Senitzer @@aut@@ Ji-Yao Sun @@aut@@ Renata Jankowska @@aut@@ Marian Klinger @@aut@@ Piotr Kuśnierczyk @@aut@@ |
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It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Science</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Q</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edyta Majorczyk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrzej Wiśniewski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrzej Pawlik</subfield><subfield code="e">verfasserin</subfield><subfield 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does the kir2ds5 gene protect from some human diseases? |
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Does the KIR2DS5 gene protect from some human diseases? |
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BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. |
abstractGer |
BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. |
abstract_unstemmed |
BACKGROUND: KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. METHODOLOGY/PRINCIPAL FINDINGS: In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p<0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37). CONCLUSIONS/SIGNIFICANCE: Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. |
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container_issue |
8, p e12381 |
title_short |
Does the KIR2DS5 gene protect from some human diseases? |
url |
https://doi.org/10.1371/journal.pone.0012381 https://doaj.org/article/7f7c47daf72f4b119cbddb562bc283c5 http://europepmc.org/articles/PMC2928722?pdf=render https://doaj.org/toc/1932-6203 |
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author2 |
Edyta Majorczyk Andrzej Wiśniewski Andrzej Pawlik Maria Magott-Procelewska Ewa Passowicz-Muszyńska Jacek Malejczyk Rafał Płoski Sebastian Giebel Ewa Barcz Aleksandra Zoń-Giebel Andrzej Malinowski Henryk Tchórzewski Arkadiusz Chlebicki Wioleta Łuszczek Maciej Kurpisz Marian Gryboś Jacek Wilczyński Piotr Wiland David Senitzer Ji-Yao Sun Renata Jankowska Marian Klinger Piotr Kuśnierczyk |
author2Str |
Edyta Majorczyk Andrzej Wiśniewski Andrzej Pawlik Maria Magott-Procelewska Ewa Passowicz-Muszyńska Jacek Malejczyk Rafał Płoski Sebastian Giebel Ewa Barcz Aleksandra Zoń-Giebel Andrzej Malinowski Henryk Tchórzewski Arkadiusz Chlebicki Wioleta Łuszczek Maciej Kurpisz Marian Gryboś Jacek Wilczyński Piotr Wiland David Senitzer Ji-Yao Sun Renata Jankowska Marian Klinger Piotr Kuśnierczyk |
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up_date |
2024-07-03T16:09:59.210Z |
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|
score |
7.400717 |