Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma

IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-t...
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Autor*in:	Domenica Lorusso [verfasserIn] Romano Danesi [verfasserIn] Laura Deborah Locati [verfasserIn] Gianluca Masi [verfasserIn] Ugo De Giorgi [verfasserIn] Angiolo Gadducci [verfasserIn] Sandro Pignata [verfasserIn] Sabbatini Roberto [verfasserIn] Antonella Savarese [verfasserIn] Giorgio Valabrega [verfasserIn] Claudio Zamagni [verfasserIn] Nicoletta Colombo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 12(2022)
Übergeordnetes Werk:	volume:12 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2022.979519

Katalog-ID:	DOAJ023366273

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520			\|a IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care.
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allfields	10.3389/fonc.2022.979519 doi (DE-627)DOAJ023366273 (DE-599)DOAJ3326d4a85d0b488b9f8013eaaad98244 DE-627 ger DE-627 rakwb eng RC254-282 Domenica Lorusso verfasserin aut Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care. lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Domenica Lorusso verfasserin aut Romano Danesi verfasserin aut Laura Deborah Locati verfasserin aut Laura Deborah Locati verfasserin aut Gianluca Masi verfasserin aut Gianluca Masi verfasserin aut Ugo De Giorgi verfasserin aut Angiolo Gadducci verfasserin aut Sandro Pignata verfasserin aut Sabbatini Roberto verfasserin aut Antonella Savarese verfasserin aut Giorgio Valabrega verfasserin aut Claudio Zamagni verfasserin aut Nicoletta Colombo verfasserin aut Nicoletta Colombo verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.979519 kostenfrei https://doaj.org/article/3326d4a85d0b488b9f8013eaaad98244 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.979519/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022
spelling	10.3389/fonc.2022.979519 doi (DE-627)DOAJ023366273 (DE-599)DOAJ3326d4a85d0b488b9f8013eaaad98244 DE-627 ger DE-627 rakwb eng RC254-282 Domenica Lorusso verfasserin aut Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care. lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Domenica Lorusso verfasserin aut Romano Danesi verfasserin aut Laura Deborah Locati verfasserin aut Laura Deborah Locati verfasserin aut Gianluca Masi verfasserin aut Gianluca Masi verfasserin aut Ugo De Giorgi verfasserin aut Angiolo Gadducci verfasserin aut Sandro Pignata verfasserin aut Sabbatini Roberto verfasserin aut Antonella Savarese verfasserin aut Giorgio Valabrega verfasserin aut Claudio Zamagni verfasserin aut Nicoletta Colombo verfasserin aut Nicoletta Colombo verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.979519 kostenfrei https://doaj.org/article/3326d4a85d0b488b9f8013eaaad98244 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.979519/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022
allfields_unstemmed	10.3389/fonc.2022.979519 doi (DE-627)DOAJ023366273 (DE-599)DOAJ3326d4a85d0b488b9f8013eaaad98244 DE-627 ger DE-627 rakwb eng RC254-282 Domenica Lorusso verfasserin aut Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care. lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Domenica Lorusso verfasserin aut Romano Danesi verfasserin aut Laura Deborah Locati verfasserin aut Laura Deborah Locati verfasserin aut Gianluca Masi verfasserin aut Gianluca Masi verfasserin aut Ugo De Giorgi verfasserin aut Angiolo Gadducci verfasserin aut Sandro Pignata verfasserin aut Sabbatini Roberto verfasserin aut Antonella Savarese verfasserin aut Giorgio Valabrega verfasserin aut Claudio Zamagni verfasserin aut Nicoletta Colombo verfasserin aut Nicoletta Colombo verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.979519 kostenfrei https://doaj.org/article/3326d4a85d0b488b9f8013eaaad98244 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.979519/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022
allfieldsGer	10.3389/fonc.2022.979519 doi (DE-627)DOAJ023366273 (DE-599)DOAJ3326d4a85d0b488b9f8013eaaad98244 DE-627 ger DE-627 rakwb eng RC254-282 Domenica Lorusso verfasserin aut Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care. lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Domenica Lorusso verfasserin aut Romano Danesi verfasserin aut Laura Deborah Locati verfasserin aut Laura Deborah Locati verfasserin aut Gianluca Masi verfasserin aut Gianluca Masi verfasserin aut Ugo De Giorgi verfasserin aut Angiolo Gadducci verfasserin aut Sandro Pignata verfasserin aut Sabbatini Roberto verfasserin aut Antonella Savarese verfasserin aut Giorgio Valabrega verfasserin aut Claudio Zamagni verfasserin aut Nicoletta Colombo verfasserin aut Nicoletta Colombo verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.979519 kostenfrei https://doaj.org/article/3326d4a85d0b488b9f8013eaaad98244 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.979519/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022
allfieldsSound	10.3389/fonc.2022.979519 doi (DE-627)DOAJ023366273 (DE-599)DOAJ3326d4a85d0b488b9f8013eaaad98244 DE-627 ger DE-627 rakwb eng RC254-282 Domenica Lorusso verfasserin aut Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care. lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response Neoplasms. Tumors. Oncology. Including cancer and carcinogens Domenica Lorusso verfasserin aut Romano Danesi verfasserin aut Laura Deborah Locati verfasserin aut Laura Deborah Locati verfasserin aut Gianluca Masi verfasserin aut Gianluca Masi verfasserin aut Ugo De Giorgi verfasserin aut Angiolo Gadducci verfasserin aut Sandro Pignata verfasserin aut Sabbatini Roberto verfasserin aut Antonella Savarese verfasserin aut Giorgio Valabrega verfasserin aut Claudio Zamagni verfasserin aut Nicoletta Colombo verfasserin aut Nicoletta Colombo verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 12(2022) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:12 year:2022 https://doi.org/10.3389/fonc.2022.979519 kostenfrei https://doaj.org/article/3326d4a85d0b488b9f8013eaaad98244 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2022.979519/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022
language	English
source	In Frontiers in Oncology 12(2022) volume:12 year:2022
sourceStr	In Frontiers in Oncology 12(2022) volume:12 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Frontiers in Oncology
authorswithroles_txt_mv	Domenica Lorusso @@aut@@ Romano Danesi @@aut@@ Laura Deborah Locati @@aut@@ Gianluca Masi @@aut@@ Ugo De Giorgi @@aut@@ Angiolo Gadducci @@aut@@ Sandro Pignata @@aut@@ Sabbatini Roberto @@aut@@ Antonella Savarese @@aut@@ Giorgio Valabrega @@aut@@ Claudio Zamagni @@aut@@ Nicoletta Colombo @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	684965518
id	DOAJ023366273
language_de	englisch
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callnumber-first	R - Medicine
author	Domenica Lorusso
spellingShingle	Domenica Lorusso misc RC254-282 misc lenvatinib misc pembrolizumab misc endometrial cancer misc tyrosine kinase inhibitor misc immune response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma
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topic_title	RC254-282 Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma lenvatinib pembrolizumab endometrial cancer tyrosine kinase inhibitor immune response
topic	misc RC254-282 misc lenvatinib misc pembrolizumab misc endometrial cancer misc tyrosine kinase inhibitor misc immune response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc lenvatinib misc pembrolizumab misc endometrial cancer misc tyrosine kinase inhibitor misc immune response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc lenvatinib misc pembrolizumab misc endometrial cancer misc tyrosine kinase inhibitor misc immune response misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma
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title_full	Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma
author_sort	Domenica Lorusso
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author_browse	Domenica Lorusso Romano Danesi Laura Deborah Locati Gianluca Masi Ugo De Giorgi Angiolo Gadducci Sandro Pignata Sabbatini Roberto Antonella Savarese Giorgio Valabrega Claudio Zamagni Nicoletta Colombo
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title_sort	optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma
callnumber	RC254-282
title_auth	Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma
abstract	IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care.
abstractGer	IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care.
abstract_unstemmed	IntroductionThe combination of lenvatinib plus pembrolizumab demonstrated a relevant clinical benefit in patients with endometrial carcinoma. The safety profile was consistent with the established profiles of each drug in monotherapy, with the most frequent adverse events being hypertension, an on-target effect, hypothyroidism, diarrhea, nausea, vomiting, loss of appetite, fatigue, and weight loss.Areas coveredWe first review the rationale based on the combination of a VEGFR inhibitor and an immune checkpoint inhibitor, highlighting the main pharmacokinetic and pharmacodynamic features of lenvatinib. Next, we focus on the common adverse events associated with lenvatinib and guide how to optimally prevent, detect, and manage them, while minimizing interruptions during lenvatinib treatment.DiscussionThe side effects profile of lenvatinib is very well known, being similar across different tumor types. Most toxicities can be preventable. An appropriate, proactive, and thorough management of lenvatinib toxicities during treatment is required to maximize potential lenvatinib efficacy. Adverse events should be detected as early as possible, by both carefully monitoring the patient from lenvatinib initiation and preventing their occurrence. Patients should be followed also during treatment as some adverse events, e.g., cardiac dysfunction might appear later. Increased awareness on risk to benefit ratio among clinicians would be helpful to avoid dose interruptions or discontinuation of lenvatinib, with preferring other medical interventions and supportive care.
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title_short	Optimizing the use of lenvatinib in combination with pembrolizumab in patients with advanced endometrial carcinoma
url	https://doi.org/10.3389/fonc.2022.979519 https://doaj.org/article/3326d4a85d0b488b9f8013eaaad98244 https://www.frontiersin.org/articles/10.3389/fonc.2022.979519/full https://doaj.org/toc/2234-943X
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author2	Domenica Lorusso Romano Danesi Laura Deborah Locati Gianluca Masi Ugo De Giorgi Angiolo Gadducci Sandro Pignata Sabbatini Roberto Antonella Savarese Giorgio Valabrega Claudio Zamagni Nicoletta Colombo
author2Str	Domenica Lorusso Romano Danesi Laura Deborah Locati Gianluca Masi Ugo De Giorgi Angiolo Gadducci Sandro Pignata Sabbatini Roberto Antonella Savarese Giorgio Valabrega Claudio Zamagni Nicoletta Colombo
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up_date	2024-07-03T17:12:04.530Z
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