Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells

Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extrac...
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Autor*in:	Nhung Quynh Do [verfasserIn] Shengdao Zheng [verfasserIn] Sarang Oh [verfasserIn] Quynh T. N. Nguyen [verfasserIn] Minzhe Fang [verfasserIn] Minseon Kim [verfasserIn] Junhui Choi [verfasserIn] Myeong-Ju Kim [verfasserIn] Jeehaeng Jeong [verfasserIn] Tae-Hoo Yi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 11(2021), 1, p 104
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:1, p 104

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox11010104

Katalog-ID:	DOAJ023370769

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allfields	10.3390/antiox11010104 doi (DE-627)DOAJ023370769 (DE-599)DOAJ3065739b56a94b6e8025412b657fd778 DE-627 ger DE-627 rakwb eng RM1-950 Nhung Quynh Do verfasserin aut Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment. camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells Therapeutics. Pharmacology Shengdao Zheng verfasserin aut Sarang Oh verfasserin aut Quynh T. N. Nguyen verfasserin aut Minzhe Fang verfasserin aut Minseon Kim verfasserin aut Junhui Choi verfasserin aut Myeong-Ju Kim verfasserin aut Jeehaeng Jeong verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 11(2021), 1, p 104 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2021 number:1, p 104 https://doi.org/10.3390/antiox11010104 kostenfrei https://doaj.org/article/3065739b56a94b6e8025412b657fd778 kostenfrei https://www.mdpi.com/2076-3921/11/1/104 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 104
spelling	10.3390/antiox11010104 doi (DE-627)DOAJ023370769 (DE-599)DOAJ3065739b56a94b6e8025412b657fd778 DE-627 ger DE-627 rakwb eng RM1-950 Nhung Quynh Do verfasserin aut Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment. camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells Therapeutics. Pharmacology Shengdao Zheng verfasserin aut Sarang Oh verfasserin aut Quynh T. N. Nguyen verfasserin aut Minzhe Fang verfasserin aut Minseon Kim verfasserin aut Junhui Choi verfasserin aut Myeong-Ju Kim verfasserin aut Jeehaeng Jeong verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 11(2021), 1, p 104 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2021 number:1, p 104 https://doi.org/10.3390/antiox11010104 kostenfrei https://doaj.org/article/3065739b56a94b6e8025412b657fd778 kostenfrei https://www.mdpi.com/2076-3921/11/1/104 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 104
allfields_unstemmed	10.3390/antiox11010104 doi (DE-627)DOAJ023370769 (DE-599)DOAJ3065739b56a94b6e8025412b657fd778 DE-627 ger DE-627 rakwb eng RM1-950 Nhung Quynh Do verfasserin aut Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment. camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells Therapeutics. Pharmacology Shengdao Zheng verfasserin aut Sarang Oh verfasserin aut Quynh T. N. Nguyen verfasserin aut Minzhe Fang verfasserin aut Minseon Kim verfasserin aut Junhui Choi verfasserin aut Myeong-Ju Kim verfasserin aut Jeehaeng Jeong verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 11(2021), 1, p 104 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2021 number:1, p 104 https://doi.org/10.3390/antiox11010104 kostenfrei https://doaj.org/article/3065739b56a94b6e8025412b657fd778 kostenfrei https://www.mdpi.com/2076-3921/11/1/104 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 104
allfieldsGer	10.3390/antiox11010104 doi (DE-627)DOAJ023370769 (DE-599)DOAJ3065739b56a94b6e8025412b657fd778 DE-627 ger DE-627 rakwb eng RM1-950 Nhung Quynh Do verfasserin aut Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment. camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells Therapeutics. Pharmacology Shengdao Zheng verfasserin aut Sarang Oh verfasserin aut Quynh T. N. Nguyen verfasserin aut Minzhe Fang verfasserin aut Minseon Kim verfasserin aut Junhui Choi verfasserin aut Myeong-Ju Kim verfasserin aut Jeehaeng Jeong verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 11(2021), 1, p 104 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2021 number:1, p 104 https://doi.org/10.3390/antiox11010104 kostenfrei https://doaj.org/article/3065739b56a94b6e8025412b657fd778 kostenfrei https://www.mdpi.com/2076-3921/11/1/104 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 104
allfieldsSound	10.3390/antiox11010104 doi (DE-627)DOAJ023370769 (DE-599)DOAJ3065739b56a94b6e8025412b657fd778 DE-627 ger DE-627 rakwb eng RM1-950 Nhung Quynh Do verfasserin aut Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment. camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells Therapeutics. Pharmacology Shengdao Zheng verfasserin aut Sarang Oh verfasserin aut Quynh T. N. Nguyen verfasserin aut Minzhe Fang verfasserin aut Minseon Kim verfasserin aut Junhui Choi verfasserin aut Myeong-Ju Kim verfasserin aut Jeehaeng Jeong verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 11(2021), 1, p 104 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2021 number:1, p 104 https://doi.org/10.3390/antiox11010104 kostenfrei https://doaj.org/article/3065739b56a94b6e8025412b657fd778 kostenfrei https://www.mdpi.com/2076-3921/11/1/104 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 104
language	English
source	In Antioxidants 11(2021), 1, p 104 volume:11 year:2021 number:1, p 104
sourceStr	In Antioxidants 11(2021), 1, p 104 volume:11 year:2021 number:1, p 104
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topic_facet	camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells Therapeutics. Pharmacology
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container_title	Antioxidants
authorswithroles_txt_mv	Nhung Quynh Do @@aut@@ Shengdao Zheng @@aut@@ Sarang Oh @@aut@@ Quynh T. N. Nguyen @@aut@@ Minzhe Fang @@aut@@ Minseon Kim @@aut@@ Junhui Choi @@aut@@ Myeong-Ju Kim @@aut@@ Jeehaeng Jeong @@aut@@ Tae-Hoo Yi @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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topic_title	RM1-950 Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells camu-camu fruit extract anti-allergic effect histamine H1 receptor histamine H4 receptor histidine decarboxylase RBL-2H3 cells
topic	misc RM1-950 misc camu-camu fruit extract misc anti-allergic effect misc histamine H1 receptor misc histamine H4 receptor misc histidine decarboxylase misc RBL-2H3 cells misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc camu-camu fruit extract misc anti-allergic effect misc histamine H1 receptor misc histamine H4 receptor misc histidine decarboxylase misc RBL-2H3 cells misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc camu-camu fruit extract misc anti-allergic effect misc histamine H1 receptor misc histamine H4 receptor misc histidine decarboxylase misc RBL-2H3 cells misc Therapeutics. Pharmacology
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title	Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells
ctrlnum	(DE-627)DOAJ023370769 (DE-599)DOAJ3065739b56a94b6e8025412b657fd778
title_full	Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells
author_sort	Nhung Quynh Do
journal	Antioxidants
journalStr	Antioxidants
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author_browse	Nhung Quynh Do Shengdao Zheng Sarang Oh Quynh T. N. Nguyen Minzhe Fang Minseon Kim Junhui Choi Myeong-Ju Kim Jeehaeng Jeong Tae-Hoo Yi
container_volume	11
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author-letter	Nhung Quynh Do
doi_str_mv	10.3390/antiox11010104
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title_sort	anti-allergic effects of <i<myrciaria dubia</i< (camu-camu) fruit extract by inhibiting histamine h1 and h4 receptors and histidine decarboxylase in rbl-2h3 cells
callnumber	RM1-950
title_auth	Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells
abstract	Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment.
abstractGer	Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment.
abstract_unstemmed	Although <i<Myrciaria dubia</i< (camu-camu) has been shown to exert anti-oxidant and anti-inflammatory effects in both in vitro and in vivo studies, its use in allergic responses has not been elucidated. In the present study, the anti-allergic effect of 70% ethanol camu-camu fruit extract was tested on calcium ionophore (A23187)-induced allergies in RBL-2H3 cells. The RBL-2H3 cells were induced with 100 nM A23187 for 6 h, followed by a 1 h camu-camu fruit extract treatment. A23187 sanitization exacerbated mast cell degranulation; however, camu-camu fruit extract decreased the release of histamine and β-hexosaminidase, which are considered as key biomarkers in cell degranulation. Camu-camu fruit extract inhibited cell exocytosis by regulating the calcium/nuclear factor of activated T cell (NFAT) signaling. By downregulating the activation of mitogen-activated protein kinase (MAPK) signaling, camu-camu fruit extract hindered the activation of both histamine H1 and H4 receptors and inhibited histidine decarboxylase (HDC) expression by mediating its transcription factors KLF4/SP1 and GATA2/MITF. In A23187-induced ROS overproduction, camu-camu fruit extract activated nuclear factor erythroid-2-related factor 2 (Nrf2) to protect mast cells against A23187-induced oxidative stress. These findings indicate that camu-camu fruit extract can be developed to act as a mast cell stabilizer and an anti-histamine. This work also “opens the door” to new investigations using natural products to achieve breakthroughs in allergic disorder treatment.
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title_short	Anti-Allergic Effects of <i<Myrciaria dubia</i< (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells
url	https://doi.org/10.3390/antiox11010104 https://doaj.org/article/3065739b56a94b6e8025412b657fd778 https://www.mdpi.com/2076-3921/11/1/104 https://doaj.org/toc/2076-3921
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author2	Shengdao Zheng Sarang Oh Quynh T. N. Nguyen Minzhe Fang Minseon Kim Junhui Choi Myeong-Ju Kim Jeehaeng Jeong Tae-Hoo Yi
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