Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos

Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac...
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Gespeichert in:

Autor*in:	Jaeho Yoon [verfasserIn] Vijay Kumar [verfasserIn] Ravi Shankar Goutam [verfasserIn] Sung-Chan Kim [verfasserIn] Soochul Park [verfasserIn] Unjoo Lee [verfasserIn] Jaebong Kim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Bmp Wnt-PCP gastrulation Disheveled daam1

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 11(2021), 1, p 44
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:1, p 44

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells11010044

Katalog-ID:	DOAJ023448504

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520			\|a Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression.
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allfields	10.3390/cells11010044 doi (DE-627)DOAJ023448504 (DE-599)DOAJ63183c3f503e4016abba2ead8d01962d DE-627 ger DE-627 rakwb eng QH573-671 Jaeho Yoon verfasserin aut Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression. Bmp Wnt-PCP gastrulation <i<Xarhgef3.2</i< Disheveled daam1 Cytology Vijay Kumar verfasserin aut Ravi Shankar Goutam verfasserin aut Sung-Chan Kim verfasserin aut Soochul Park verfasserin aut Unjoo Lee verfasserin aut Jaebong Kim verfasserin aut In Cells MDPI AG, 2012 11(2021), 1, p 44 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2021 number:1, p 44 https://doi.org/10.3390/cells11010044 kostenfrei https://doaj.org/article/63183c3f503e4016abba2ead8d01962d kostenfrei https://www.mdpi.com/2073-4409/11/1/44 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 44
spelling	10.3390/cells11010044 doi (DE-627)DOAJ023448504 (DE-599)DOAJ63183c3f503e4016abba2ead8d01962d DE-627 ger DE-627 rakwb eng QH573-671 Jaeho Yoon verfasserin aut Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression. Bmp Wnt-PCP gastrulation <i<Xarhgef3.2</i< Disheveled daam1 Cytology Vijay Kumar verfasserin aut Ravi Shankar Goutam verfasserin aut Sung-Chan Kim verfasserin aut Soochul Park verfasserin aut Unjoo Lee verfasserin aut Jaebong Kim verfasserin aut In Cells MDPI AG, 2012 11(2021), 1, p 44 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2021 number:1, p 44 https://doi.org/10.3390/cells11010044 kostenfrei https://doaj.org/article/63183c3f503e4016abba2ead8d01962d kostenfrei https://www.mdpi.com/2073-4409/11/1/44 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 44
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allfieldsGer	10.3390/cells11010044 doi (DE-627)DOAJ023448504 (DE-599)DOAJ63183c3f503e4016abba2ead8d01962d DE-627 ger DE-627 rakwb eng QH573-671 Jaeho Yoon verfasserin aut Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression. Bmp Wnt-PCP gastrulation <i<Xarhgef3.2</i< Disheveled daam1 Cytology Vijay Kumar verfasserin aut Ravi Shankar Goutam verfasserin aut Sung-Chan Kim verfasserin aut Soochul Park verfasserin aut Unjoo Lee verfasserin aut Jaebong Kim verfasserin aut In Cells MDPI AG, 2012 11(2021), 1, p 44 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2021 number:1, p 44 https://doi.org/10.3390/cells11010044 kostenfrei https://doaj.org/article/63183c3f503e4016abba2ead8d01962d kostenfrei https://www.mdpi.com/2073-4409/11/1/44 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 44
allfieldsSound	10.3390/cells11010044 doi (DE-627)DOAJ023448504 (DE-599)DOAJ63183c3f503e4016abba2ead8d01962d DE-627 ger DE-627 rakwb eng QH573-671 Jaeho Yoon verfasserin aut Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression. Bmp Wnt-PCP gastrulation <i<Xarhgef3.2</i< Disheveled daam1 Cytology Vijay Kumar verfasserin aut Ravi Shankar Goutam verfasserin aut Sung-Chan Kim verfasserin aut Soochul Park verfasserin aut Unjoo Lee verfasserin aut Jaebong Kim verfasserin aut In Cells MDPI AG, 2012 11(2021), 1, p 44 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2021 number:1, p 44 https://doi.org/10.3390/cells11010044 kostenfrei https://doaj.org/article/63183c3f503e4016abba2ead8d01962d kostenfrei https://www.mdpi.com/2073-4409/11/1/44 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 44
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authorswithroles_txt_mv	Jaeho Yoon @@aut@@ Vijay Kumar @@aut@@ Ravi Shankar Goutam @@aut@@ Sung-Chan Kim @@aut@@ Soochul Park @@aut@@ Unjoo Lee @@aut@@ Jaebong Kim @@aut@@
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author	Jaeho Yoon
spellingShingle	Jaeho Yoon misc QH573-671 misc Bmp misc Wnt-PCP misc gastrulation misc <i<Xarhgef3.2</i< misc Disheveled misc daam1 misc Cytology Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos
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topic_title	QH573-671 Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos Bmp Wnt-PCP gastrulation <i<Xarhgef3.2</i< Disheveled daam1
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title	Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos
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title_full	Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos
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title_sort	bmp signal gradient modulates convergent cell movement via <i<xarhgef3.2</i< during gastrulation of <i<xenopus</i< embryos
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title_auth	Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos
abstract	Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression.
abstractGer	Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression.
abstract_unstemmed	Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of <i<Xenopus</i< Arhgef3.2 (Rho guanine nucleotide exchange factor) was negatively regulated by Bmp signaling. We also showed that overexpression or knockdown of <i<Xarhgef3.2</i< caused gastrulation defects. Interestingly, Xarhgef3.2 controlled gastrulation cell movements through interacting with Disheveled (Dsh2) and Dsh2-associated activator of morphogenesis 1 (Daam1). Our results suggest that Bmp gradient affects gastrulation cell movement (CE) via negative regulation of <i<Xarhgef3.2</i< expression.
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title_short	Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos
url	https://doi.org/10.3390/cells11010044 https://doaj.org/article/63183c3f503e4016abba2ead8d01962d https://www.mdpi.com/2073-4409/11/1/44 https://doaj.org/toc/2073-4409
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up_date	2024-07-03T17:40:03.183Z
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Bmp Signal Gradient Modulates Convergent Cell Movement via <i<Xarhgef3.2</i< during Gastrulation of <i<Xenopus</i< Embryos

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