Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner
Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and c...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ema Pristi Yunita [verfasserIn] Puji Astuti Nur Hidayanti [verfasserIn] Cholid Tri Tjahjono [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Indonesisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Jurnal Manajemen dan Pelayanan Farmasi - Universitas Gadjah Mada, 2019, 10(2020), 3, Seite 186-194 |
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| Übergeordnetes Werk: |
volume:10 ; year:2020 ; number:3 ; pages:186-194 |
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Link aufrufen |
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| DOI / URN: |
10.22146/jmpf.53312 |
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| Katalog-ID: |
DOAJ023531568 |
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| 520 | |a Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. | ||
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10.22146/jmpf.53312 doi (DE-627)DOAJ023531568 (DE-599)DOAJd9a36cbbaad74dfb84733c6a60f510f7 DE-627 ger DE-627 rakwb ind RS1-441 Ema Pristi Yunita verfasserin aut Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. aspirin dosis-rendah bun kreatinin serum penyakit jantung koroner Pharmacy and materia medica Puji Astuti Nur Hidayanti verfasserin aut Cholid Tri Tjahjono verfasserin aut In Jurnal Manajemen dan Pelayanan Farmasi Universitas Gadjah Mada, 2019 10(2020), 3, Seite 186-194 (DE-627)1760603716 24432946 nnns volume:10 year:2020 number:3 pages:186-194 https://doi.org/10.22146/jmpf.53312 kostenfrei https://doaj.org/article/d9a36cbbaad74dfb84733c6a60f510f7 kostenfrei https://jurnal.ugm.ac.id/jmpf/article/view/53312 kostenfrei https://doaj.org/toc/2088-8139 Journal toc kostenfrei https://doaj.org/toc/2443-2946 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 10 2020 3 186-194 |
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10.22146/jmpf.53312 doi (DE-627)DOAJ023531568 (DE-599)DOAJd9a36cbbaad74dfb84733c6a60f510f7 DE-627 ger DE-627 rakwb ind RS1-441 Ema Pristi Yunita verfasserin aut Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. aspirin dosis-rendah bun kreatinin serum penyakit jantung koroner Pharmacy and materia medica Puji Astuti Nur Hidayanti verfasserin aut Cholid Tri Tjahjono verfasserin aut In Jurnal Manajemen dan Pelayanan Farmasi Universitas Gadjah Mada, 2019 10(2020), 3, Seite 186-194 (DE-627)1760603716 24432946 nnns volume:10 year:2020 number:3 pages:186-194 https://doi.org/10.22146/jmpf.53312 kostenfrei https://doaj.org/article/d9a36cbbaad74dfb84733c6a60f510f7 kostenfrei https://jurnal.ugm.ac.id/jmpf/article/view/53312 kostenfrei https://doaj.org/toc/2088-8139 Journal toc kostenfrei https://doaj.org/toc/2443-2946 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 10 2020 3 186-194 |
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10.22146/jmpf.53312 doi (DE-627)DOAJ023531568 (DE-599)DOAJd9a36cbbaad74dfb84733c6a60f510f7 DE-627 ger DE-627 rakwb ind RS1-441 Ema Pristi Yunita verfasserin aut Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. aspirin dosis-rendah bun kreatinin serum penyakit jantung koroner Pharmacy and materia medica Puji Astuti Nur Hidayanti verfasserin aut Cholid Tri Tjahjono verfasserin aut In Jurnal Manajemen dan Pelayanan Farmasi Universitas Gadjah Mada, 2019 10(2020), 3, Seite 186-194 (DE-627)1760603716 24432946 nnns volume:10 year:2020 number:3 pages:186-194 https://doi.org/10.22146/jmpf.53312 kostenfrei https://doaj.org/article/d9a36cbbaad74dfb84733c6a60f510f7 kostenfrei https://jurnal.ugm.ac.id/jmpf/article/view/53312 kostenfrei https://doaj.org/toc/2088-8139 Journal toc kostenfrei https://doaj.org/toc/2443-2946 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 10 2020 3 186-194 |
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10.22146/jmpf.53312 doi (DE-627)DOAJ023531568 (DE-599)DOAJd9a36cbbaad74dfb84733c6a60f510f7 DE-627 ger DE-627 rakwb ind RS1-441 Ema Pristi Yunita verfasserin aut Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. aspirin dosis-rendah bun kreatinin serum penyakit jantung koroner Pharmacy and materia medica Puji Astuti Nur Hidayanti verfasserin aut Cholid Tri Tjahjono verfasserin aut In Jurnal Manajemen dan Pelayanan Farmasi Universitas Gadjah Mada, 2019 10(2020), 3, Seite 186-194 (DE-627)1760603716 24432946 nnns volume:10 year:2020 number:3 pages:186-194 https://doi.org/10.22146/jmpf.53312 kostenfrei https://doaj.org/article/d9a36cbbaad74dfb84733c6a60f510f7 kostenfrei https://jurnal.ugm.ac.id/jmpf/article/view/53312 kostenfrei https://doaj.org/toc/2088-8139 Journal toc kostenfrei https://doaj.org/toc/2443-2946 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 10 2020 3 186-194 |
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10.22146/jmpf.53312 doi (DE-627)DOAJ023531568 (DE-599)DOAJd9a36cbbaad74dfb84733c6a60f510f7 DE-627 ger DE-627 rakwb ind RS1-441 Ema Pristi Yunita verfasserin aut Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. aspirin dosis-rendah bun kreatinin serum penyakit jantung koroner Pharmacy and materia medica Puji Astuti Nur Hidayanti verfasserin aut Cholid Tri Tjahjono verfasserin aut In Jurnal Manajemen dan Pelayanan Farmasi Universitas Gadjah Mada, 2019 10(2020), 3, Seite 186-194 (DE-627)1760603716 24432946 nnns volume:10 year:2020 number:3 pages:186-194 https://doi.org/10.22146/jmpf.53312 kostenfrei https://doaj.org/article/d9a36cbbaad74dfb84733c6a60f510f7 kostenfrei https://jurnal.ugm.ac.id/jmpf/article/view/53312 kostenfrei https://doaj.org/toc/2088-8139 Journal toc kostenfrei https://doaj.org/toc/2443-2946 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 10 2020 3 186-194 |
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The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. 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Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner |
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Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. |
| abstractGer |
Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. |
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Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p < 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p < 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN. |
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