Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster

Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic tran...
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Autor*in:	Anna A. Feitzinger [verfasserIn] Anthony Le [verfasserIn] Ammon Thompson [verfasserIn] Mehnoor Haseeb [verfasserIn] Mohan Koumar Murugesan [verfasserIn] Austin M. Tang [verfasserIn] Susan E. Lott [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation

Übergeordnetes Werk:	In: BMC Genomics - BMC, 2003, 23(2022), 1, Seite 14
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12864-022-08839-4

Katalog-ID:	DOAJ023547480

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520			\|a Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.
650		4	\|a Early embryonic development
650		4	\|a Maternal gene expression
650		4	\|a Early zygotic gene expression
650		4	\|a Expression variation
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700	0		\|a Ammon Thompson \|e verfasserin \|4 aut
700	0		\|a Mehnoor Haseeb \|e verfasserin \|4 aut
700	0		\|a Mohan Koumar Murugesan \|e verfasserin \|4 aut
700	0		\|a Austin M. Tang \|e verfasserin \|4 aut
700	0		\|a Susan E. Lott \|e verfasserin \|4 aut
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allfields	10.1186/s12864-022-08839-4 doi (DE-627)DOAJ023547480 (DE-599)DOAJ89f94e6cdae54e73b85f51b036edb52e DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Anna A. Feitzinger verfasserin aut Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world. Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation Biotechnology Genetics Anthony Le verfasserin aut Ammon Thompson verfasserin aut Mehnoor Haseeb verfasserin aut Mohan Koumar Murugesan verfasserin aut Austin M. Tang verfasserin aut Susan E. Lott verfasserin aut In BMC Genomics BMC, 2003 23(2022), 1, Seite 14 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:23 year:2022 number:1 pages:14 https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/article/89f94e6cdae54e73b85f51b036edb52e kostenfrei https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 14
spelling	10.1186/s12864-022-08839-4 doi (DE-627)DOAJ023547480 (DE-599)DOAJ89f94e6cdae54e73b85f51b036edb52e DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Anna A. Feitzinger verfasserin aut Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world. Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation Biotechnology Genetics Anthony Le verfasserin aut Ammon Thompson verfasserin aut Mehnoor Haseeb verfasserin aut Mohan Koumar Murugesan verfasserin aut Austin M. Tang verfasserin aut Susan E. Lott verfasserin aut In BMC Genomics BMC, 2003 23(2022), 1, Seite 14 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:23 year:2022 number:1 pages:14 https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/article/89f94e6cdae54e73b85f51b036edb52e kostenfrei https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 14
allfields_unstemmed	10.1186/s12864-022-08839-4 doi (DE-627)DOAJ023547480 (DE-599)DOAJ89f94e6cdae54e73b85f51b036edb52e DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Anna A. Feitzinger verfasserin aut Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world. Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation Biotechnology Genetics Anthony Le verfasserin aut Ammon Thompson verfasserin aut Mehnoor Haseeb verfasserin aut Mohan Koumar Murugesan verfasserin aut Austin M. Tang verfasserin aut Susan E. Lott verfasserin aut In BMC Genomics BMC, 2003 23(2022), 1, Seite 14 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:23 year:2022 number:1 pages:14 https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/article/89f94e6cdae54e73b85f51b036edb52e kostenfrei https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 14
allfieldsGer	10.1186/s12864-022-08839-4 doi (DE-627)DOAJ023547480 (DE-599)DOAJ89f94e6cdae54e73b85f51b036edb52e DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Anna A. Feitzinger verfasserin aut Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world. Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation Biotechnology Genetics Anthony Le verfasserin aut Ammon Thompson verfasserin aut Mehnoor Haseeb verfasserin aut Mohan Koumar Murugesan verfasserin aut Austin M. Tang verfasserin aut Susan E. Lott verfasserin aut In BMC Genomics BMC, 2003 23(2022), 1, Seite 14 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:23 year:2022 number:1 pages:14 https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/article/89f94e6cdae54e73b85f51b036edb52e kostenfrei https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 14
allfieldsSound	10.1186/s12864-022-08839-4 doi (DE-627)DOAJ023547480 (DE-599)DOAJ89f94e6cdae54e73b85f51b036edb52e DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Anna A. Feitzinger verfasserin aut Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world. Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation Biotechnology Genetics Anthony Le verfasserin aut Ammon Thompson verfasserin aut Mehnoor Haseeb verfasserin aut Mohan Koumar Murugesan verfasserin aut Austin M. Tang verfasserin aut Susan E. Lott verfasserin aut In BMC Genomics BMC, 2003 23(2022), 1, Seite 14 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:23 year:2022 number:1 pages:14 https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/article/89f94e6cdae54e73b85f51b036edb52e kostenfrei https://doi.org/10.1186/s12864-022-08839-4 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 14
language	English
source	In BMC Genomics 23(2022), 1, Seite 14 volume:23 year:2022 number:1 pages:14
sourceStr	In BMC Genomics 23(2022), 1, Seite 14 volume:23 year:2022 number:1 pages:14
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation Biotechnology Genetics
isfreeaccess_bool	true
container_title	BMC Genomics
authorswithroles_txt_mv	Anna A. Feitzinger @@aut@@ Anthony Le @@aut@@ Ammon Thompson @@aut@@ Mehnoor Haseeb @@aut@@ Mohan Koumar Murugesan @@aut@@ Austin M. Tang @@aut@@ Susan E. Lott @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	326644954
id	DOAJ023547480
language_de	englisch
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Feitzinger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Early embryonic development</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Maternal gene expression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Early zygotic gene expression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Expression variation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biotechnology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Genetics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anthony Le</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ammon Thompson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mehnoor Haseeb</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohan Koumar Murugesan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Austin M. 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callnumber-first	T - Technology
author	Anna A. Feitzinger
spellingShingle	Anna A. Feitzinger misc TP248.13-248.65 misc QH426-470 misc Early embryonic development misc Maternal gene expression misc Early zygotic gene expression misc Expression variation misc Biotechnology misc Genetics Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
authorStr	Anna A. Feitzinger
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topic_title	TP248.13-248.65 QH426-470 Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster Early embryonic development Maternal gene expression Early zygotic gene expression Expression variation
topic	misc TP248.13-248.65 misc QH426-470 misc Early embryonic development misc Maternal gene expression misc Early zygotic gene expression misc Expression variation misc Biotechnology misc Genetics
topic_unstemmed	misc TP248.13-248.65 misc QH426-470 misc Early embryonic development misc Maternal gene expression misc Early zygotic gene expression misc Expression variation misc Biotechnology misc Genetics
topic_browse	misc TP248.13-248.65 misc QH426-470 misc Early embryonic development misc Maternal gene expression misc Early zygotic gene expression misc Expression variation misc Biotechnology misc Genetics
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title	Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
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title_full	Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
author_sort	Anna A. Feitzinger
journal	BMC Genomics
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author_browse	Anna A. Feitzinger Anthony Le Ammon Thompson Mehnoor Haseeb Mohan Koumar Murugesan Austin M. Tang Susan E. Lott
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class	TP248.13-248.65 QH426-470
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author-letter	Anna A. Feitzinger
doi_str_mv	10.1186/s12864-022-08839-4
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title_sort	natural variation in the maternal and zygotic mrna complements of the early embryo in drosophila melanogaster
callnumber	TP248.13-248.65
title_auth	Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
abstract	Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.
abstractGer	Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.
abstract_unstemmed	Abstract Background Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Recently, it has been shown that the expression of maternal and zygotic transcripts have evolved in the Drosophila genus over the course of 50 million years. However, the extent of natural variation of maternal and zygotic transcripts within a species has yet to be determined. We asked how the maternal and zygotic pools of mRNA vary within and between populations of D. melanogaster. In order to maximize sampling of genetic diversity, African lines of D. melanogaster originating from Zambia as well as DGRP lines originating from North America were chosen for transcriptomic analysis. Results Generally, we find that maternal transcripts are more highly conserved, and zygotic transcripts evolve at a higher rate. We find that there is more within-population variation in transcript abundance than between populations and that expression variation is highest post- MZT between African lines. Conclusions Determining the natural variation of gene expression surrounding the MZT in natural populations of D. melanogaster gives insight into the extent of how a tightly regulated process may vary within a species, the extent of developmental constraint at both stages and on both the maternal and zygotic genomes, and reveals expression changes allowing this species to adapt as it spread across the world.
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title_short	Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
url	https://doi.org/10.1186/s12864-022-08839-4 https://doaj.org/article/89f94e6cdae54e73b85f51b036edb52e https://doaj.org/toc/1471-2164
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author2	Anthony Le Ammon Thompson Mehnoor Haseeb Mohan Koumar Murugesan Austin M. Tang Susan E. Lott
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up_date	2024-07-03T18:12:30.251Z
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Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster

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