Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis

Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been prop...
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Autor*in:	Laura Massarenti [verfasserIn] Christian Enevold [verfasserIn] Dres Damgaard [verfasserIn] Peter Riis Hansen [verfasserIn] Morten Frisch [verfasserIn] Niels Ødum [verfasserIn] Søren Jacobsen [verfasserIn] Claus Henrik Nielsen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 17, p 9536
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:17, p 9536

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23179536

Katalog-ID:	DOAJ023685506

Internformat


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520			\|a Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA.
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Indexfelder

author_variant	l m lm c e ce d d dd p r h prh m f mf n ø nø s j sj c h n chn
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allfields	10.3390/ijms23179536 doi (DE-627)DOAJ023685506 (DE-599)DOAJe604a690c6634b06a6d32194c2293e1e DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Massarenti verfasserin aut Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA. rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis Biology (General) Chemistry Christian Enevold verfasserin aut Dres Damgaard verfasserin aut Peter Riis Hansen verfasserin aut Morten Frisch verfasserin aut Niels Ødum verfasserin aut Søren Jacobsen verfasserin aut Claus Henrik Nielsen verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9536 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9536 https://doi.org/10.3390/ijms23179536 kostenfrei https://doaj.org/article/e604a690c6634b06a6d32194c2293e1e kostenfrei https://www.mdpi.com/1422-0067/23/17/9536 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9536
spelling	10.3390/ijms23179536 doi (DE-627)DOAJ023685506 (DE-599)DOAJe604a690c6634b06a6d32194c2293e1e DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Massarenti verfasserin aut Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA. rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis Biology (General) Chemistry Christian Enevold verfasserin aut Dres Damgaard verfasserin aut Peter Riis Hansen verfasserin aut Morten Frisch verfasserin aut Niels Ødum verfasserin aut Søren Jacobsen verfasserin aut Claus Henrik Nielsen verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9536 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9536 https://doi.org/10.3390/ijms23179536 kostenfrei https://doaj.org/article/e604a690c6634b06a6d32194c2293e1e kostenfrei https://www.mdpi.com/1422-0067/23/17/9536 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9536
allfields_unstemmed	10.3390/ijms23179536 doi (DE-627)DOAJ023685506 (DE-599)DOAJe604a690c6634b06a6d32194c2293e1e DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Massarenti verfasserin aut Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA. rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis Biology (General) Chemistry Christian Enevold verfasserin aut Dres Damgaard verfasserin aut Peter Riis Hansen verfasserin aut Morten Frisch verfasserin aut Niels Ødum verfasserin aut Søren Jacobsen verfasserin aut Claus Henrik Nielsen verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9536 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9536 https://doi.org/10.3390/ijms23179536 kostenfrei https://doaj.org/article/e604a690c6634b06a6d32194c2293e1e kostenfrei https://www.mdpi.com/1422-0067/23/17/9536 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9536
allfieldsGer	10.3390/ijms23179536 doi (DE-627)DOAJ023685506 (DE-599)DOAJe604a690c6634b06a6d32194c2293e1e DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Massarenti verfasserin aut Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA. rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis Biology (General) Chemistry Christian Enevold verfasserin aut Dres Damgaard verfasserin aut Peter Riis Hansen verfasserin aut Morten Frisch verfasserin aut Niels Ødum verfasserin aut Søren Jacobsen verfasserin aut Claus Henrik Nielsen verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9536 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9536 https://doi.org/10.3390/ijms23179536 kostenfrei https://doaj.org/article/e604a690c6634b06a6d32194c2293e1e kostenfrei https://www.mdpi.com/1422-0067/23/17/9536 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9536
allfieldsSound	10.3390/ijms23179536 doi (DE-627)DOAJ023685506 (DE-599)DOAJe604a690c6634b06a6d32194c2293e1e DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Laura Massarenti verfasserin aut Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA. rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis Biology (General) Chemistry Christian Enevold verfasserin aut Dres Damgaard verfasserin aut Peter Riis Hansen verfasserin aut Morten Frisch verfasserin aut Niels Ødum verfasserin aut Søren Jacobsen verfasserin aut Claus Henrik Nielsen verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9536 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9536 https://doi.org/10.3390/ijms23179536 kostenfrei https://doaj.org/article/e604a690c6634b06a6d32194c2293e1e kostenfrei https://www.mdpi.com/1422-0067/23/17/9536 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9536
language	English
source	In International Journal of Molecular Sciences 23(2022), 17, p 9536 volume:23 year:2022 number:17, p 9536
sourceStr	In International Journal of Molecular Sciences 23(2022), 17, p 9536 volume:23 year:2022 number:17, p 9536
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Laura Massarenti @@aut@@ Christian Enevold @@aut@@ Dres Damgaard @@aut@@ Peter Riis Hansen @@aut@@ Morten Frisch @@aut@@ Niels Ødum @@aut@@ Søren Jacobsen @@aut@@ Claus Henrik Nielsen @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ023685506
language_de	englisch
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callnumber-first	Q - Science
author	Laura Massarenti
spellingShingle	Laura Massarenti misc QH301-705.5 misc QD1-999 misc rheumatoid arthritis misc peptidylarginine deiminases misc anti-citrullinated protein antibodies (ACPAs) misc single nucleotide polymorphism misc periodontitis misc Biology (General) misc Chemistry Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
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topic_title	QH301-705.5 QD1-999 Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis rheumatoid arthritis peptidylarginine deiminases anti-citrullinated protein antibodies (ACPAs) single nucleotide polymorphism periodontitis
topic	misc QH301-705.5 misc QD1-999 misc rheumatoid arthritis misc peptidylarginine deiminases misc anti-citrullinated protein antibodies (ACPAs) misc single nucleotide polymorphism misc periodontitis misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc rheumatoid arthritis misc peptidylarginine deiminases misc anti-citrullinated protein antibodies (ACPAs) misc single nucleotide polymorphism misc periodontitis misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc rheumatoid arthritis misc peptidylarginine deiminases misc anti-citrullinated protein antibodies (ACPAs) misc single nucleotide polymorphism misc periodontitis misc Biology (General) misc Chemistry
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title	Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
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title_full	Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
author_sort	Laura Massarenti
journal	International Journal of Molecular Sciences
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author_browse	Laura Massarenti Christian Enevold Dres Damgaard Peter Riis Hansen Morten Frisch Niels Ødum Søren Jacobsen Claus Henrik Nielsen
container_volume	23
class	QH301-705.5 QD1-999
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author-letter	Laura Massarenti
doi_str_mv	10.3390/ijms23179536
author2-role	verfasserin
title_sort	peptidylarginine deiminase 2 gene polymorphisms in subjects with periodontitis predispose to rheumatoid arthritis
callnumber	QH301-705.5
title_auth	Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
abstract	Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA.
abstractGer	Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA.
abstract_unstemmed	Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from <i<Porphyromonas gingivalis</i< has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is influenced by single nucleotide polymorphisms (SNPs) in the genes encoding PAD2 and PAD4 that catalyze aberrant citrullination in RA and often are overexpressed in inflamed gingival connective tissue in subjects with periodontitis. The study included 137 RA patients and 161 controls with self-reported periodontitis. Periodontitis onset preceded RA onset by 13 years on average and was not associated with any of the SNPs investigated. In subjects with periodontitis, carriage of the minor alleles of rs2057094 and rs2235912 in <i<PADI2</i< significantly increased the risk of RA (odds ratios 1.42 [<i<p</i< = 0.03] and 1.48 [<i<p</i< = 0.02], respectively), and this effect was driven by the anti-CCP-negative RA patients. The minor alleles of these SNPs only increased risk of anti-CCP-positive RA in individuals with periodontitis and a history of smoking. These data suggest that individuals with periodontitis carrying the minor alleles of SNPs rs2057094, rs2076616 and rs2235912 in <i<PADI2</i< may be at increased risk of RA.
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container_issue	17, p 9536
title_short	Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
url	https://doi.org/10.3390/ijms23179536 https://doaj.org/article/e604a690c6634b06a6d32194c2293e1e https://www.mdpi.com/1422-0067/23/17/9536 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T18:56:31.671Z
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Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis

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