Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients

Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiat...
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Autor*in:	Carlos Fernández-Pereira [verfasserIn] Maria Aránzazu Penedo [verfasserIn] Tania Rivera-Baltanas [verfasserIn] Rafael Fernández-Martínez [verfasserIn] Saida Ortolano [verfasserIn] José Manuel Olivares [verfasserIn] Roberto Carlos Agís-Balboa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 17, p 9591
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:17, p 9591

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23179591

Katalog-ID:	DOAJ023692901

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allfields	10.3390/ijms23179591 doi (DE-627)DOAJ023692901 (DE-599)DOAJ0718afc756cb4126a217442ea731b504 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients. insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanas verfasserin aut Rafael Fernández-Martínez verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9591 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9591 https://doi.org/10.3390/ijms23179591 kostenfrei https://doaj.org/article/0718afc756cb4126a217442ea731b504 kostenfrei https://www.mdpi.com/1422-0067/23/17/9591 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9591
spelling	10.3390/ijms23179591 doi (DE-627)DOAJ023692901 (DE-599)DOAJ0718afc756cb4126a217442ea731b504 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients. insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanas verfasserin aut Rafael Fernández-Martínez verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9591 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9591 https://doi.org/10.3390/ijms23179591 kostenfrei https://doaj.org/article/0718afc756cb4126a217442ea731b504 kostenfrei https://www.mdpi.com/1422-0067/23/17/9591 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9591
allfields_unstemmed	10.3390/ijms23179591 doi (DE-627)DOAJ023692901 (DE-599)DOAJ0718afc756cb4126a217442ea731b504 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients. insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanas verfasserin aut Rafael Fernández-Martínez verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9591 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9591 https://doi.org/10.3390/ijms23179591 kostenfrei https://doaj.org/article/0718afc756cb4126a217442ea731b504 kostenfrei https://www.mdpi.com/1422-0067/23/17/9591 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9591
allfieldsGer	10.3390/ijms23179591 doi (DE-627)DOAJ023692901 (DE-599)DOAJ0718afc756cb4126a217442ea731b504 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients. insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanas verfasserin aut Rafael Fernández-Martínez verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9591 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9591 https://doi.org/10.3390/ijms23179591 kostenfrei https://doaj.org/article/0718afc756cb4126a217442ea731b504 kostenfrei https://www.mdpi.com/1422-0067/23/17/9591 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9591
allfieldsSound	10.3390/ijms23179591 doi (DE-627)DOAJ023692901 (DE-599)DOAJ0718afc756cb4126a217442ea731b504 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Carlos Fernández-Pereira verfasserin aut Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients. insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve Biology (General) Chemistry Maria Aránzazu Penedo verfasserin aut Tania Rivera-Baltanas verfasserin aut Rafael Fernández-Martínez verfasserin aut Saida Ortolano verfasserin aut José Manuel Olivares verfasserin aut Roberto Carlos Agís-Balboa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 17, p 9591 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:17, p 9591 https://doi.org/10.3390/ijms23179591 kostenfrei https://doaj.org/article/0718afc756cb4126a217442ea731b504 kostenfrei https://www.mdpi.com/1422-0067/23/17/9591 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 17, p 9591
language	English
source	In International Journal of Molecular Sciences 23(2022), 17, p 9591 volume:23 year:2022 number:17, p 9591
sourceStr	In International Journal of Molecular Sciences 23(2022), 17, p 9591 volume:23 year:2022 number:17, p 9591
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Carlos Fernández-Pereira @@aut@@ Maria Aránzazu Penedo @@aut@@ Tania Rivera-Baltanas @@aut@@ Rafael Fernández-Martínez @@aut@@ Saida Ortolano @@aut@@ José Manuel Olivares @@aut@@ Roberto Carlos Agís-Balboa @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ023692901
language_de	englisch
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callnumber-first	Q - Science
author	Carlos Fernández-Pereira
spellingShingle	Carlos Fernández-Pereira misc QH301-705.5 misc QD1-999 misc insulin-like growth factor (IGF-2) misc insulin-like growth factor binding protein 7 (IGFBP-7) misc schizophrenia (SZ) misc first episode (FE) misc drug-naïve misc Biology (General) misc Chemistry Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients
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topic_title	QH301-705.5 QD1-999 Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients insulin-like growth factor (IGF-2) insulin-like growth factor binding protein 7 (IGFBP-7) schizophrenia (SZ) first episode (FE) drug-naïve
topic	misc QH301-705.5 misc QD1-999 misc insulin-like growth factor (IGF-2) misc insulin-like growth factor binding protein 7 (IGFBP-7) misc schizophrenia (SZ) misc first episode (FE) misc drug-naïve misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc insulin-like growth factor (IGF-2) misc insulin-like growth factor binding protein 7 (IGFBP-7) misc schizophrenia (SZ) misc first episode (FE) misc drug-naïve misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc insulin-like growth factor (IGF-2) misc insulin-like growth factor binding protein 7 (IGFBP-7) misc schizophrenia (SZ) misc first episode (FE) misc drug-naïve misc Biology (General) misc Chemistry
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title	Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients
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title_full	Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients
author_sort	Carlos Fernández-Pereira
journal	International Journal of Molecular Sciences
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author_browse	Carlos Fernández-Pereira Maria Aránzazu Penedo Tania Rivera-Baltanas Rafael Fernández-Martínez Saida Ortolano José Manuel Olivares Roberto Carlos Agís-Balboa
container_volume	23
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title_sort	insulin-like growth factor 2 (igf-2) and insulin-like growth factor binding protein 7 (igfbp-7) are upregulated after atypical antipsychotics in spanish schizophrenia patients
callnumber	QH301-705.5
title_auth	Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients
abstract	Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients.
abstractGer	Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients.
abstract_unstemmed	Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients.
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title_short	Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients
url	https://doi.org/10.3390/ijms23179591 https://doaj.org/article/0718afc756cb4126a217442ea731b504 https://www.mdpi.com/1422-0067/23/17/9591 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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