Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract
Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1...
Ausführliche Beschreibung
Autor*in: |
Caitlín Ní Chasaide [verfasserIn] Kingston H.G. Mills [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Vaccines - MDPI AG, 2013, 8(2020), 4, p 621 |
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Übergeordnetes Werk: |
volume:8 ; year:2020 ; number:4, p 621 |
Links: |
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DOI / URN: |
10.3390/vaccines8040621 |
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Katalog-ID: |
DOAJ023824271 |
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520 | |a Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1 and Th17 responses are integral to protective immunity induced by previous infection with <i<B. pertussis</i< and immunization with whole cell pertussis (wP) vaccines. Mucosal Th17 cells, IL-17 and secretory IgA (sIgA) are particularly important in generating sustained sterilizing immunity in the nasal cavity. Current aP vaccines induce potent IgG and Th2-skewed T cell responses but are less effective at generating Th1 and Th17 responses and fail to prime respiratory tissue-resident memory T (T<sub<RM</sub<) cells, that maintain long-term immunity at mucosal sites. In contrast, a live attenuated pertussis vaccine, pertussis outer membrane vesicle (OMV) vaccines or aP vaccines formulated with novel adjuvants do induce cellular immune responses in the respiratory tract, especially when delivered by the intranasal route. An increased understanding of the mechanisms of sustained protective immunity, especially the role of respiratory T<sub<RM</sub< cells, will facilitate the development of next generation pertussis vaccines that not only protect against pertussis disease, but prevent nasal colonization and transmission of <i<B. pertussis</i<. | ||
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10.3390/vaccines8040621 doi (DE-627)DOAJ023824271 (DE-599)DOAJ910c31d7febc42f792ef6fe68fd291d1 DE-627 ger DE-627 rakwb eng Caitlín Ní Chasaide verfasserin aut Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1 and Th17 responses are integral to protective immunity induced by previous infection with <i<B. pertussis</i< and immunization with whole cell pertussis (wP) vaccines. Mucosal Th17 cells, IL-17 and secretory IgA (sIgA) are particularly important in generating sustained sterilizing immunity in the nasal cavity. Current aP vaccines induce potent IgG and Th2-skewed T cell responses but are less effective at generating Th1 and Th17 responses and fail to prime respiratory tissue-resident memory T (T<sub<RM</sub<) cells, that maintain long-term immunity at mucosal sites. In contrast, a live attenuated pertussis vaccine, pertussis outer membrane vesicle (OMV) vaccines or aP vaccines formulated with novel adjuvants do induce cellular immune responses in the respiratory tract, especially when delivered by the intranasal route. An increased understanding of the mechanisms of sustained protective immunity, especially the role of respiratory T<sub<RM</sub< cells, will facilitate the development of next generation pertussis vaccines that not only protect against pertussis disease, but prevent nasal colonization and transmission of <i<B. pertussis</i<. <i<Bordetella pertussis</i< pertussis vaccine T cells Th1 cells Th17 cells memory T cells Medicine R Kingston H.G. Mills verfasserin aut In Vaccines MDPI AG, 2013 8(2020), 4, p 621 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:8 year:2020 number:4, p 621 https://doi.org/10.3390/vaccines8040621 kostenfrei https://doaj.org/article/910c31d7febc42f792ef6fe68fd291d1 kostenfrei https://www.mdpi.com/2076-393X/8/4/621 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 4, p 621 |
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10.3390/vaccines8040621 doi (DE-627)DOAJ023824271 (DE-599)DOAJ910c31d7febc42f792ef6fe68fd291d1 DE-627 ger DE-627 rakwb eng Caitlín Ní Chasaide verfasserin aut Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1 and Th17 responses are integral to protective immunity induced by previous infection with <i<B. pertussis</i< and immunization with whole cell pertussis (wP) vaccines. Mucosal Th17 cells, IL-17 and secretory IgA (sIgA) are particularly important in generating sustained sterilizing immunity in the nasal cavity. Current aP vaccines induce potent IgG and Th2-skewed T cell responses but are less effective at generating Th1 and Th17 responses and fail to prime respiratory tissue-resident memory T (T<sub<RM</sub<) cells, that maintain long-term immunity at mucosal sites. In contrast, a live attenuated pertussis vaccine, pertussis outer membrane vesicle (OMV) vaccines or aP vaccines formulated with novel adjuvants do induce cellular immune responses in the respiratory tract, especially when delivered by the intranasal route. An increased understanding of the mechanisms of sustained protective immunity, especially the role of respiratory T<sub<RM</sub< cells, will facilitate the development of next generation pertussis vaccines that not only protect against pertussis disease, but prevent nasal colonization and transmission of <i<B. pertussis</i<. <i<Bordetella pertussis</i< pertussis vaccine T cells Th1 cells Th17 cells memory T cells Medicine R Kingston H.G. Mills verfasserin aut In Vaccines MDPI AG, 2013 8(2020), 4, p 621 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:8 year:2020 number:4, p 621 https://doi.org/10.3390/vaccines8040621 kostenfrei https://doaj.org/article/910c31d7febc42f792ef6fe68fd291d1 kostenfrei https://www.mdpi.com/2076-393X/8/4/621 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 4, p 621 |
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Caitlín Ní Chasaide misc <i<Bordetella pertussis</i< misc pertussis vaccine misc T cells misc Th1 cells misc Th17 cells misc memory T cells misc Medicine misc R Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract |
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Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract <i<Bordetella pertussis</i< pertussis vaccine T cells Th1 cells Th17 cells memory T cells |
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Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract |
abstract |
Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1 and Th17 responses are integral to protective immunity induced by previous infection with <i<B. pertussis</i< and immunization with whole cell pertussis (wP) vaccines. Mucosal Th17 cells, IL-17 and secretory IgA (sIgA) are particularly important in generating sustained sterilizing immunity in the nasal cavity. Current aP vaccines induce potent IgG and Th2-skewed T cell responses but are less effective at generating Th1 and Th17 responses and fail to prime respiratory tissue-resident memory T (T<sub<RM</sub<) cells, that maintain long-term immunity at mucosal sites. In contrast, a live attenuated pertussis vaccine, pertussis outer membrane vesicle (OMV) vaccines or aP vaccines formulated with novel adjuvants do induce cellular immune responses in the respiratory tract, especially when delivered by the intranasal route. An increased understanding of the mechanisms of sustained protective immunity, especially the role of respiratory T<sub<RM</sub< cells, will facilitate the development of next generation pertussis vaccines that not only protect against pertussis disease, but prevent nasal colonization and transmission of <i<B. pertussis</i<. |
abstractGer |
Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1 and Th17 responses are integral to protective immunity induced by previous infection with <i<B. pertussis</i< and immunization with whole cell pertussis (wP) vaccines. Mucosal Th17 cells, IL-17 and secretory IgA (sIgA) are particularly important in generating sustained sterilizing immunity in the nasal cavity. Current aP vaccines induce potent IgG and Th2-skewed T cell responses but are less effective at generating Th1 and Th17 responses and fail to prime respiratory tissue-resident memory T (T<sub<RM</sub<) cells, that maintain long-term immunity at mucosal sites. In contrast, a live attenuated pertussis vaccine, pertussis outer membrane vesicle (OMV) vaccines or aP vaccines formulated with novel adjuvants do induce cellular immune responses in the respiratory tract, especially when delivered by the intranasal route. An increased understanding of the mechanisms of sustained protective immunity, especially the role of respiratory T<sub<RM</sub< cells, will facilitate the development of next generation pertussis vaccines that not only protect against pertussis disease, but prevent nasal colonization and transmission of <i<B. pertussis</i<. |
abstract_unstemmed |
Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with <i<Bordetella pertussis</i<. Studies in mouse and baboon models have demonstrated that Th1 and Th17 responses are integral to protective immunity induced by previous infection with <i<B. pertussis</i< and immunization with whole cell pertussis (wP) vaccines. Mucosal Th17 cells, IL-17 and secretory IgA (sIgA) are particularly important in generating sustained sterilizing immunity in the nasal cavity. Current aP vaccines induce potent IgG and Th2-skewed T cell responses but are less effective at generating Th1 and Th17 responses and fail to prime respiratory tissue-resident memory T (T<sub<RM</sub<) cells, that maintain long-term immunity at mucosal sites. In contrast, a live attenuated pertussis vaccine, pertussis outer membrane vesicle (OMV) vaccines or aP vaccines formulated with novel adjuvants do induce cellular immune responses in the respiratory tract, especially when delivered by the intranasal route. An increased understanding of the mechanisms of sustained protective immunity, especially the role of respiratory T<sub<RM</sub< cells, will facilitate the development of next generation pertussis vaccines that not only protect against pertussis disease, but prevent nasal colonization and transmission of <i<B. pertussis</i<. |
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Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract |
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