Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy

<p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhang Rui [verfasserIn] Zhao Liancheng [verfasserIn] Liang Lirong [verfasserIn] Xie Gaoqiang [verfasserIn] Wu Yangfeng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient

Übergeordnetes Werk:	In: Lipids in Health and Disease - BMC, 2003, 11(2012), 1, p 59
Übergeordnetes Werk:	volume:11 ; year:2012 ; number:1, p 59

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1476-511X-11-59

Katalog-ID:	DOAJ023870990

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p<
650		4	\|a Dyslipidemia
650		4	\|a Lipid-lowering treatment
650		4	\|a Goal attainment
650		4	\|a Gender disparity
650		4	\|a Patient
653		0	\|a Nutritional diseases. Deficiency diseases
700	0		\|a Zhao Liancheng \|e verfasserin \|4 aut
700	0		\|a Liang Lirong \|e verfasserin \|4 aut
700	0		\|a Xie Gaoqiang \|e verfasserin \|4 aut
700	0		\|a Wu Yangfeng \|e verfasserin \|4 aut
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allfields	10.1186/1476-511X-11-59 doi (DE-627)DOAJ023870990 (DE-599)DOAJ9bf402a121d5489398117c281b36994c DE-627 ger DE-627 rakwb eng RC620-627 Zhang Rui verfasserin aut Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p< Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient Nutritional diseases. Deficiency diseases Zhao Liancheng verfasserin aut Liang Lirong verfasserin aut Xie Gaoqiang verfasserin aut Wu Yangfeng verfasserin aut In Lipids in Health and Disease BMC, 2003 11(2012), 1, p 59 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:11 year:2012 number:1, p 59 https://doi.org/10.1186/1476-511X-11-59 kostenfrei https://doaj.org/article/9bf402a121d5489398117c281b36994c kostenfrei http://www.lipidworld.com/content/11/1/59 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1, p 59
spelling	10.1186/1476-511X-11-59 doi (DE-627)DOAJ023870990 (DE-599)DOAJ9bf402a121d5489398117c281b36994c DE-627 ger DE-627 rakwb eng RC620-627 Zhang Rui verfasserin aut Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p< Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient Nutritional diseases. Deficiency diseases Zhao Liancheng verfasserin aut Liang Lirong verfasserin aut Xie Gaoqiang verfasserin aut Wu Yangfeng verfasserin aut In Lipids in Health and Disease BMC, 2003 11(2012), 1, p 59 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:11 year:2012 number:1, p 59 https://doi.org/10.1186/1476-511X-11-59 kostenfrei https://doaj.org/article/9bf402a121d5489398117c281b36994c kostenfrei http://www.lipidworld.com/content/11/1/59 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1, p 59
allfields_unstemmed	10.1186/1476-511X-11-59 doi (DE-627)DOAJ023870990 (DE-599)DOAJ9bf402a121d5489398117c281b36994c DE-627 ger DE-627 rakwb eng RC620-627 Zhang Rui verfasserin aut Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p< Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient Nutritional diseases. Deficiency diseases Zhao Liancheng verfasserin aut Liang Lirong verfasserin aut Xie Gaoqiang verfasserin aut Wu Yangfeng verfasserin aut In Lipids in Health and Disease BMC, 2003 11(2012), 1, p 59 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:11 year:2012 number:1, p 59 https://doi.org/10.1186/1476-511X-11-59 kostenfrei https://doaj.org/article/9bf402a121d5489398117c281b36994c kostenfrei http://www.lipidworld.com/content/11/1/59 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1, p 59
allfieldsGer	10.1186/1476-511X-11-59 doi (DE-627)DOAJ023870990 (DE-599)DOAJ9bf402a121d5489398117c281b36994c DE-627 ger DE-627 rakwb eng RC620-627 Zhang Rui verfasserin aut Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p< Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient Nutritional diseases. Deficiency diseases Zhao Liancheng verfasserin aut Liang Lirong verfasserin aut Xie Gaoqiang verfasserin aut Wu Yangfeng verfasserin aut In Lipids in Health and Disease BMC, 2003 11(2012), 1, p 59 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:11 year:2012 number:1, p 59 https://doi.org/10.1186/1476-511X-11-59 kostenfrei https://doaj.org/article/9bf402a121d5489398117c281b36994c kostenfrei http://www.lipidworld.com/content/11/1/59 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1, p 59
allfieldsSound	10.1186/1476-511X-11-59 doi (DE-627)DOAJ023870990 (DE-599)DOAJ9bf402a121d5489398117c281b36994c DE-627 ger DE-627 rakwb eng RC620-627 Zhang Rui verfasserin aut Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p< Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient Nutritional diseases. Deficiency diseases Zhao Liancheng verfasserin aut Liang Lirong verfasserin aut Xie Gaoqiang verfasserin aut Wu Yangfeng verfasserin aut In Lipids in Health and Disease BMC, 2003 11(2012), 1, p 59 (DE-627)355987694 (DE-600)2091381-3 1476511X nnns volume:11 year:2012 number:1, p 59 https://doi.org/10.1186/1476-511X-11-59 kostenfrei https://doaj.org/article/9bf402a121d5489398117c281b36994c kostenfrei http://www.lipidworld.com/content/11/1/59 kostenfrei https://doaj.org/toc/1476-511X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1, p 59
language	English
source	In Lipids in Health and Disease 11(2012), 1, p 59 volume:11 year:2012 number:1, p 59
sourceStr	In Lipids in Health and Disease 11(2012), 1, p 59 volume:11 year:2012 number:1, p 59
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient Nutritional diseases. Deficiency diseases
isfreeaccess_bool	true
container_title	Lipids in Health and Disease
authorswithroles_txt_mv	Zhang Rui @@aut@@ Zhao Liancheng @@aut@@ Liang Lirong @@aut@@ Xie Gaoqiang @@aut@@ Wu Yangfeng @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	355987694
id	DOAJ023870990
language_de	englisch
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Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dyslipidemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lipid-lowering treatment</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Goal attainment</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gender disparity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Patient</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutritional diseases. 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callnumber-first	R - Medicine
author	Zhang Rui
spellingShingle	Zhang Rui misc RC620-627 misc Dyslipidemia misc Lipid-lowering treatment misc Goal attainment misc Gender disparity misc Patient misc Nutritional diseases. Deficiency diseases Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy
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topic_title	RC620-627 Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy Dyslipidemia Lipid-lowering treatment Goal attainment Gender disparity Patient
topic	misc RC620-627 misc Dyslipidemia misc Lipid-lowering treatment misc Goal attainment misc Gender disparity misc Patient misc Nutritional diseases. Deficiency diseases
topic_unstemmed	misc RC620-627 misc Dyslipidemia misc Lipid-lowering treatment misc Goal attainment misc Gender disparity misc Patient misc Nutritional diseases. Deficiency diseases
topic_browse	misc RC620-627 misc Dyslipidemia misc Lipid-lowering treatment misc Goal attainment misc Gender disparity misc Patient misc Nutritional diseases. Deficiency diseases
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title	Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy
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title_full	Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy
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author_browse	Zhang Rui Zhao Liancheng Liang Lirong Xie Gaoqiang Wu Yangfeng
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title_sort	factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in chinese patients with statin therapy
callnumber	RC620-627
title_auth	Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy
abstract	<p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.</p< <p<Objectives</p< <p<To elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.</p< <p<Methods</p< <p<We used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.</p< <p<Results</p< <p<A total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p<
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title_short	Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy
url	https://doi.org/10.1186/1476-511X-11-59 https://doaj.org/article/9bf402a121d5489398117c281b36994c http://www.lipidworld.com/content/11/1/59 https://doaj.org/toc/1476-511X
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Approximately 50% of the gender disparity remained unexplained by these factors.</p< <p<Conclusions</p< <p<Although nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.</p<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dyslipidemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lipid-lowering treatment</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Goal attainment</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gender disparity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Patient</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutritional diseases. 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Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy

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