In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<

In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secr...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Dahae Lee [verfasserIn] Jun Yeon Park [verfasserIn] Sanghyun Lee [verfasserIn] Ki Sung Kang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	α-Glucosidase Insulin ERK PI3K AKT

Übergeordnetes Werk:	In: Processes - MDPI AG, 2013, 9(2021), 483, p 483
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:483, p 483

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pr9030483

Katalog-ID:	DOAJ024008419

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245	1	0	\|a In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<
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allfields	10.3390/pr9030483 doi (DE-627)DOAJ024008419 (DE-599)DOAJ8ff830a10285456e9c8db9e120c2c01d DE-627 ger DE-627 rakwb eng TP1-1185 QD1-999 Dahae Lee verfasserin aut In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance. <i<Salicornia herbacea</i< α-Glucosidase Insulin ERK PI3K AKT Chemical technology Chemistry Jun Yeon Park verfasserin aut Sanghyun Lee verfasserin aut Ki Sung Kang verfasserin aut In Processes MDPI AG, 2013 9(2021), 483, p 483 (DE-627)750371439 (DE-600)2720994-5 22279717 nnns volume:9 year:2021 number:483, p 483 https://doi.org/10.3390/pr9030483 kostenfrei https://doaj.org/article/8ff830a10285456e9c8db9e120c2c01d kostenfrei https://www.mdpi.com/2227-9717/9/3/483 kostenfrei https://doaj.org/toc/2227-9717 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 483, p 483
spelling	10.3390/pr9030483 doi (DE-627)DOAJ024008419 (DE-599)DOAJ8ff830a10285456e9c8db9e120c2c01d DE-627 ger DE-627 rakwb eng TP1-1185 QD1-999 Dahae Lee verfasserin aut In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance. <i<Salicornia herbacea</i< α-Glucosidase Insulin ERK PI3K AKT Chemical technology Chemistry Jun Yeon Park verfasserin aut Sanghyun Lee verfasserin aut Ki Sung Kang verfasserin aut In Processes MDPI AG, 2013 9(2021), 483, p 483 (DE-627)750371439 (DE-600)2720994-5 22279717 nnns volume:9 year:2021 number:483, p 483 https://doi.org/10.3390/pr9030483 kostenfrei https://doaj.org/article/8ff830a10285456e9c8db9e120c2c01d kostenfrei https://www.mdpi.com/2227-9717/9/3/483 kostenfrei https://doaj.org/toc/2227-9717 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 483, p 483
allfields_unstemmed	10.3390/pr9030483 doi (DE-627)DOAJ024008419 (DE-599)DOAJ8ff830a10285456e9c8db9e120c2c01d DE-627 ger DE-627 rakwb eng TP1-1185 QD1-999 Dahae Lee verfasserin aut In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance. <i<Salicornia herbacea</i< α-Glucosidase Insulin ERK PI3K AKT Chemical technology Chemistry Jun Yeon Park verfasserin aut Sanghyun Lee verfasserin aut Ki Sung Kang verfasserin aut In Processes MDPI AG, 2013 9(2021), 483, p 483 (DE-627)750371439 (DE-600)2720994-5 22279717 nnns volume:9 year:2021 number:483, p 483 https://doi.org/10.3390/pr9030483 kostenfrei https://doaj.org/article/8ff830a10285456e9c8db9e120c2c01d kostenfrei https://www.mdpi.com/2227-9717/9/3/483 kostenfrei https://doaj.org/toc/2227-9717 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 483, p 483
allfieldsGer	10.3390/pr9030483 doi (DE-627)DOAJ024008419 (DE-599)DOAJ8ff830a10285456e9c8db9e120c2c01d DE-627 ger DE-627 rakwb eng TP1-1185 QD1-999 Dahae Lee verfasserin aut In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance. <i<Salicornia herbacea</i< α-Glucosidase Insulin ERK PI3K AKT Chemical technology Chemistry Jun Yeon Park verfasserin aut Sanghyun Lee verfasserin aut Ki Sung Kang verfasserin aut In Processes MDPI AG, 2013 9(2021), 483, p 483 (DE-627)750371439 (DE-600)2720994-5 22279717 nnns volume:9 year:2021 number:483, p 483 https://doi.org/10.3390/pr9030483 kostenfrei https://doaj.org/article/8ff830a10285456e9c8db9e120c2c01d kostenfrei https://www.mdpi.com/2227-9717/9/3/483 kostenfrei https://doaj.org/toc/2227-9717 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 483, p 483
allfieldsSound	10.3390/pr9030483 doi (DE-627)DOAJ024008419 (DE-599)DOAJ8ff830a10285456e9c8db9e120c2c01d DE-627 ger DE-627 rakwb eng TP1-1185 QD1-999 Dahae Lee verfasserin aut In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance. <i<Salicornia herbacea</i< α-Glucosidase Insulin ERK PI3K AKT Chemical technology Chemistry Jun Yeon Park verfasserin aut Sanghyun Lee verfasserin aut Ki Sung Kang verfasserin aut In Processes MDPI AG, 2013 9(2021), 483, p 483 (DE-627)750371439 (DE-600)2720994-5 22279717 nnns volume:9 year:2021 number:483, p 483 https://doi.org/10.3390/pr9030483 kostenfrei https://doaj.org/article/8ff830a10285456e9c8db9e120c2c01d kostenfrei https://www.mdpi.com/2227-9717/9/3/483 kostenfrei https://doaj.org/toc/2227-9717 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 483, p 483
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callnumber-first	T - Technology
author	Dahae Lee
spellingShingle	Dahae Lee misc TP1-1185 misc QD1-999 misc <i<Salicornia herbacea</i< misc α-Glucosidase misc Insulin misc ERK misc PI3K misc AKT misc Chemical technology misc Chemistry In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<
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topic_title	TP1-1185 QD1-999 In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i< <i<Salicornia herbacea</i< α-Glucosidase Insulin ERK PI3K AKT
topic	misc TP1-1185 misc QD1-999 misc <i<Salicornia herbacea</i< misc α-Glucosidase misc Insulin misc ERK misc PI3K misc AKT misc Chemical technology misc Chemistry
topic_unstemmed	misc TP1-1185 misc QD1-999 misc <i<Salicornia herbacea</i< misc α-Glucosidase misc Insulin misc ERK misc PI3K misc AKT misc Chemical technology misc Chemistry
topic_browse	misc TP1-1185 misc QD1-999 misc <i<Salicornia herbacea</i< misc α-Glucosidase misc Insulin misc ERK misc PI3K misc AKT misc Chemical technology misc Chemistry
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title	In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<
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title_full	In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<
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author_browse	Dahae Lee Jun Yeon Park Sanghyun Lee Ki Sung Kang
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title_sort	in vitro studies to assess the α-glucosidase inhibitory activity and insulin secretion effect of isorhamnetin 3-<i<o</i<-glucoside and quercetin 3-<i<o</i<-glucoside isolated from <i<salicornia herbacea</i<
callnumber	TP1-1185
title_auth	In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<
abstract	In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance.
abstractGer	In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance.
abstract_unstemmed	In this study, we examined the effect of ethanolic extract of <i<Salicornia herbacea</i< (ESH), isorhamnetin 3-<i<O</i<-glucoside (I3G), quercetin 3-<i<O</i<-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance.
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container_issue	483, p 483
title_short	In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<
url	https://doi.org/10.3390/pr9030483 https://doaj.org/article/8ff830a10285456e9c8db9e120c2c01d https://www.mdpi.com/2227-9717/9/3/483 https://doaj.org/toc/2227-9717
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A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC<sub<50</sub< value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. 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In Vitro Studies to Assess the α-Glucosidase Inhibitory Activity and Insulin Secretion Effect of Isorhamnetin 3-<i<O</i<-Glucoside and Quercetin 3-<i<O</i<-Glucoside Isolated from <i<Salicornia herbacea</i<

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