Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future

Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory responses results in age-specif...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Simone S. Schüller [verfasserIn] Boris W. Kramer [verfasserIn] Eduardo Villamor [verfasserIn] Andreas Spittler [verfasserIn] Angelika Berger [verfasserIn] Ofer Levy [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	neonatal sepsis preterm infant adjuvant sepsis therapy immunomodulation pentoxifylline lactoferrin

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 6(2018)
Übergeordnetes Werk:	volume:6 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2018.00199

Katalog-ID:	DOAJ024024341

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allfieldsSound	10.3389/fped.2018.00199 doi (DE-627)DOAJ024024341 (DE-599)DOAJc21d9c755ae74e96802a566002516c81 DE-627 ger DE-627 rakwb eng RJ1-570 Simone S. Schüller verfasserin aut Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory responses results in age-specific inflammatory and protective immune response to infection. This review first provides an overview of the neonatal immune system, then covers current mainstream, and experimental preventive and adjuvant therapies in neonatal sepsis. We also discuss how the distinct physiology of the perinatal period shapes early life immune responses and review strategies to reduce neonatal sepsis-related morbidity and mortality. A summary of studies that characterize immune ontogeny and neonatal sepsis is presented, followed by discussion of clinical trials assessing interventions such as breast milk, lactoferrin, probiotics, and pentoxifylline. Finally, we critically appraise future treatment options such as stem cell therapy, other antimicrobial protein and peptides, and targeting of pattern recognition receptors in an effort to prevent and/or treat sepsis in this highly vulnerable neonatal population. neonatal sepsis preterm infant adjuvant sepsis therapy immunomodulation pentoxifylline lactoferrin Pediatrics Simone S. Schüller verfasserin aut Simone S. Schüller verfasserin aut Boris W. Kramer verfasserin aut Boris W. Kramer verfasserin aut Eduardo Villamor verfasserin aut Eduardo Villamor verfasserin aut Andreas Spittler verfasserin aut Angelika Berger verfasserin aut Ofer Levy verfasserin aut Ofer Levy verfasserin aut Ofer Levy verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 6(2018) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:6 year:2018 https://doi.org/10.3389/fped.2018.00199 kostenfrei https://doaj.org/article/c21d9c755ae74e96802a566002516c81 kostenfrei https://www.frontiersin.org/article/10.3389/fped.2018.00199/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018
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container_title	Frontiers in Pediatrics
authorswithroles_txt_mv	Simone S. Schüller @@aut@@ Boris W. Kramer @@aut@@ Eduardo Villamor @@aut@@ Andreas Spittler @@aut@@ Angelika Berger @@aut@@ Ofer Levy @@aut@@
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callnumber-first	R - Medicine
author	Simone S. Schüller
spellingShingle	Simone S. Schüller misc RJ1-570 misc neonatal sepsis misc preterm infant misc adjuvant sepsis therapy misc immunomodulation misc pentoxifylline misc lactoferrin misc Pediatrics Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
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topic	misc RJ1-570 misc neonatal sepsis misc preterm infant misc adjuvant sepsis therapy misc immunomodulation misc pentoxifylline misc lactoferrin misc Pediatrics
topic_unstemmed	misc RJ1-570 misc neonatal sepsis misc preterm infant misc adjuvant sepsis therapy misc immunomodulation misc pentoxifylline misc lactoferrin misc Pediatrics
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title	Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
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title_sort	immunomodulation to prevent or treat neonatal sepsis: past, present, and future
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title_auth	Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
abstract	Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory responses results in age-specific inflammatory and protective immune response to infection. This review first provides an overview of the neonatal immune system, then covers current mainstream, and experimental preventive and adjuvant therapies in neonatal sepsis. We also discuss how the distinct physiology of the perinatal period shapes early life immune responses and review strategies to reduce neonatal sepsis-related morbidity and mortality. A summary of studies that characterize immune ontogeny and neonatal sepsis is presented, followed by discussion of clinical trials assessing interventions such as breast milk, lactoferrin, probiotics, and pentoxifylline. Finally, we critically appraise future treatment options such as stem cell therapy, other antimicrobial protein and peptides, and targeting of pattern recognition receptors in an effort to prevent and/or treat sepsis in this highly vulnerable neonatal population.
abstractGer	Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory responses results in age-specific inflammatory and protective immune response to infection. This review first provides an overview of the neonatal immune system, then covers current mainstream, and experimental preventive and adjuvant therapies in neonatal sepsis. We also discuss how the distinct physiology of the perinatal period shapes early life immune responses and review strategies to reduce neonatal sepsis-related morbidity and mortality. A summary of studies that characterize immune ontogeny and neonatal sepsis is presented, followed by discussion of clinical trials assessing interventions such as breast milk, lactoferrin, probiotics, and pentoxifylline. Finally, we critically appraise future treatment options such as stem cell therapy, other antimicrobial protein and peptides, and targeting of pattern recognition receptors in an effort to prevent and/or treat sepsis in this highly vulnerable neonatal population.
abstract_unstemmed	Despite continued advances in neonatal medicine, sepsis remains a leading cause of death worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates varies markedly from that in older children and adults, and distinct acute inflammatory responses results in age-specific inflammatory and protective immune response to infection. This review first provides an overview of the neonatal immune system, then covers current mainstream, and experimental preventive and adjuvant therapies in neonatal sepsis. We also discuss how the distinct physiology of the perinatal period shapes early life immune responses and review strategies to reduce neonatal sepsis-related morbidity and mortality. A summary of studies that characterize immune ontogeny and neonatal sepsis is presented, followed by discussion of clinical trials assessing interventions such as breast milk, lactoferrin, probiotics, and pentoxifylline. Finally, we critically appraise future treatment options such as stem cell therapy, other antimicrobial protein and peptides, and targeting of pattern recognition receptors in an effort to prevent and/or treat sepsis in this highly vulnerable neonatal population.
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title_short	Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
url	https://doi.org/10.3389/fped.2018.00199 https://doaj.org/article/c21d9c755ae74e96802a566002516c81 https://www.frontiersin.org/article/10.3389/fped.2018.00199/full https://doaj.org/toc/2296-2360
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