Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal

Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related...
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Autor*in:	Adrià Ramírez Mena [verfasserIn] Ndeye Fatou Ngom [verfasserIn] Judicaël Tine [verfasserIn] Kine Ndiaye [verfasserIn] Louise Fortes [verfasserIn] Ousseynou Ndiaye [verfasserIn] Maguette Fall [verfasserIn] Assietou Gaye [verfasserIn] Daye Ka [verfasserIn] Moussa Seydi [verfasserIn] Gilles Wandeler [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	hepatitis B liver fibrosis HIV hepatitis B viral load Senegal

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 14(2022), 8, p 1614
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:8, p 1614

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v14081614

Katalog-ID:	DOAJ024130591

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520			\|a Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.
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allfields	10.3390/v14081614 doi (DE-627)DOAJ024130591 (DE-599)DOAJbbc9cd418b1e4c47b7170f247afbdc9b DE-627 ger DE-627 rakwb eng QR1-502 Adrià Ramírez Mena verfasserin aut Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters. hepatitis B liver fibrosis HIV hepatitis B viral load Senegal Microbiology Ndeye Fatou Ngom verfasserin aut Judicaël Tine verfasserin aut Kine Ndiaye verfasserin aut Louise Fortes verfasserin aut Ousseynou Ndiaye verfasserin aut Maguette Fall verfasserin aut Assietou Gaye verfasserin aut Daye Ka verfasserin aut Moussa Seydi verfasserin aut Gilles Wandeler verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1614 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1614 https://doi.org/10.3390/v14081614 kostenfrei https://doaj.org/article/bbc9cd418b1e4c47b7170f247afbdc9b kostenfrei https://www.mdpi.com/1999-4915/14/8/1614 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1614
spelling	10.3390/v14081614 doi (DE-627)DOAJ024130591 (DE-599)DOAJbbc9cd418b1e4c47b7170f247afbdc9b DE-627 ger DE-627 rakwb eng QR1-502 Adrià Ramírez Mena verfasserin aut Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters. hepatitis B liver fibrosis HIV hepatitis B viral load Senegal Microbiology Ndeye Fatou Ngom verfasserin aut Judicaël Tine verfasserin aut Kine Ndiaye verfasserin aut Louise Fortes verfasserin aut Ousseynou Ndiaye verfasserin aut Maguette Fall verfasserin aut Assietou Gaye verfasserin aut Daye Ka verfasserin aut Moussa Seydi verfasserin aut Gilles Wandeler verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1614 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1614 https://doi.org/10.3390/v14081614 kostenfrei https://doaj.org/article/bbc9cd418b1e4c47b7170f247afbdc9b kostenfrei https://www.mdpi.com/1999-4915/14/8/1614 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1614
allfields_unstemmed	10.3390/v14081614 doi (DE-627)DOAJ024130591 (DE-599)DOAJbbc9cd418b1e4c47b7170f247afbdc9b DE-627 ger DE-627 rakwb eng QR1-502 Adrià Ramírez Mena verfasserin aut Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters. hepatitis B liver fibrosis HIV hepatitis B viral load Senegal Microbiology Ndeye Fatou Ngom verfasserin aut Judicaël Tine verfasserin aut Kine Ndiaye verfasserin aut Louise Fortes verfasserin aut Ousseynou Ndiaye verfasserin aut Maguette Fall verfasserin aut Assietou Gaye verfasserin aut Daye Ka verfasserin aut Moussa Seydi verfasserin aut Gilles Wandeler verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1614 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1614 https://doi.org/10.3390/v14081614 kostenfrei https://doaj.org/article/bbc9cd418b1e4c47b7170f247afbdc9b kostenfrei https://www.mdpi.com/1999-4915/14/8/1614 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1614
allfieldsGer	10.3390/v14081614 doi (DE-627)DOAJ024130591 (DE-599)DOAJbbc9cd418b1e4c47b7170f247afbdc9b DE-627 ger DE-627 rakwb eng QR1-502 Adrià Ramírez Mena verfasserin aut Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters. hepatitis B liver fibrosis HIV hepatitis B viral load Senegal Microbiology Ndeye Fatou Ngom verfasserin aut Judicaël Tine verfasserin aut Kine Ndiaye verfasserin aut Louise Fortes verfasserin aut Ousseynou Ndiaye verfasserin aut Maguette Fall verfasserin aut Assietou Gaye verfasserin aut Daye Ka verfasserin aut Moussa Seydi verfasserin aut Gilles Wandeler verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1614 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1614 https://doi.org/10.3390/v14081614 kostenfrei https://doaj.org/article/bbc9cd418b1e4c47b7170f247afbdc9b kostenfrei https://www.mdpi.com/1999-4915/14/8/1614 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1614
allfieldsSound	10.3390/v14081614 doi (DE-627)DOAJ024130591 (DE-599)DOAJbbc9cd418b1e4c47b7170f247afbdc9b DE-627 ger DE-627 rakwb eng QR1-502 Adrià Ramírez Mena verfasserin aut Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters. hepatitis B liver fibrosis HIV hepatitis B viral load Senegal Microbiology Ndeye Fatou Ngom verfasserin aut Judicaël Tine verfasserin aut Kine Ndiaye verfasserin aut Louise Fortes verfasserin aut Ousseynou Ndiaye verfasserin aut Maguette Fall verfasserin aut Assietou Gaye verfasserin aut Daye Ka verfasserin aut Moussa Seydi verfasserin aut Gilles Wandeler verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1614 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1614 https://doi.org/10.3390/v14081614 kostenfrei https://doaj.org/article/bbc9cd418b1e4c47b7170f247afbdc9b kostenfrei https://www.mdpi.com/1999-4915/14/8/1614 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1614
language	English
source	In Viruses 14(2022), 8, p 1614 volume:14 year:2022 number:8, p 1614
sourceStr	In Viruses 14(2022), 8, p 1614 volume:14 year:2022 number:8, p 1614
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hepatitis B liver fibrosis HIV hepatitis B viral load Senegal Microbiology
isfreeaccess_bool	true
container_title	Viruses
authorswithroles_txt_mv	Adrià Ramírez Mena @@aut@@ Ndeye Fatou Ngom @@aut@@ Judicaël Tine @@aut@@ Kine Ndiaye @@aut@@ Louise Fortes @@aut@@ Ousseynou Ndiaye @@aut@@ Maguette Fall @@aut@@ Assietou Gaye @@aut@@ Daye Ka @@aut@@ Moussa Seydi @@aut@@ Gilles Wandeler @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	609775871
id	DOAJ024130591
language_de	englisch
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callnumber-first	Q - Science
author	Adrià Ramírez Mena
spellingShingle	Adrià Ramírez Mena misc QR1-502 misc hepatitis B misc liver fibrosis misc HIV misc hepatitis B viral load misc Senegal misc Microbiology Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal
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topic_title	QR1-502 Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal hepatitis B liver fibrosis HIV hepatitis B viral load Senegal
topic	misc QR1-502 misc hepatitis B misc liver fibrosis misc HIV misc hepatitis B viral load misc Senegal misc Microbiology
topic_unstemmed	misc QR1-502 misc hepatitis B misc liver fibrosis misc HIV misc hepatitis B viral load misc Senegal misc Microbiology
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title	Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal
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title_full	Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal
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author_browse	Adrià Ramírez Mena Ndeye Fatou Ngom Judicaël Tine Kine Ndiaye Louise Fortes Ousseynou Ndiaye Maguette Fall Assietou Gaye Daye Ka Moussa Seydi Gilles Wandeler
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title_sort	prevalence and predictors of liver fibrosis in people living with hepatitis b in senegal
callnumber	QR1-502
title_auth	Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal
abstract	Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.
abstractGer	Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.
abstract_unstemmed	Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (<i<p</i< = 0.07). An HBV viral load < 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.
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container_issue	8, p 1614
title_short	Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal
url	https://doi.org/10.3390/v14081614 https://doaj.org/article/bbc9cd418b1e4c47b7170f247afbdc9b https://www.mdpi.com/1999-4915/14/8/1614 https://doaj.org/toc/1999-4915
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