The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy

The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiothera...
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Autor*in:	Łukasz Kuncman [verfasserIn] Magdalena Orzechowska [verfasserIn] Konrad Stawiski [verfasserIn] Michał Masłowski [verfasserIn] Magdalena Ciążyńska [verfasserIn] Leszek Gottwald [verfasserIn] Tomasz Milecki [verfasserIn] Jacek Fijuth [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 16, p 3844
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:16, p 3844

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14163844

Katalog-ID:	DOAJ024215058

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allfields	10.3390/cancers14163844 doi (DE-627)DOAJ024215058 (DE-599)DOAJbe793fd219514c929d82f4c8acfe7cfa DE-627 ger DE-627 rakwb eng RC254-282 Łukasz Kuncman verfasserin aut The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred. chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magdalena Orzechowska verfasserin aut Konrad Stawiski verfasserin aut Michał Masłowski verfasserin aut Magdalena Ciążyńska verfasserin aut Leszek Gottwald verfasserin aut Tomasz Milecki verfasserin aut Jacek Fijuth verfasserin aut In Cancers MDPI AG, 2010 14(2022), 16, p 3844 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:16, p 3844 https://doi.org/10.3390/cancers14163844 kostenfrei https://doaj.org/article/be793fd219514c929d82f4c8acfe7cfa kostenfrei https://www.mdpi.com/2072-6694/14/16/3844 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 16, p 3844
spelling	10.3390/cancers14163844 doi (DE-627)DOAJ024215058 (DE-599)DOAJbe793fd219514c929d82f4c8acfe7cfa DE-627 ger DE-627 rakwb eng RC254-282 Łukasz Kuncman verfasserin aut The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred. chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magdalena Orzechowska verfasserin aut Konrad Stawiski verfasserin aut Michał Masłowski verfasserin aut Magdalena Ciążyńska verfasserin aut Leszek Gottwald verfasserin aut Tomasz Milecki verfasserin aut Jacek Fijuth verfasserin aut In Cancers MDPI AG, 2010 14(2022), 16, p 3844 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:16, p 3844 https://doi.org/10.3390/cancers14163844 kostenfrei https://doaj.org/article/be793fd219514c929d82f4c8acfe7cfa kostenfrei https://www.mdpi.com/2072-6694/14/16/3844 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 16, p 3844
allfields_unstemmed	10.3390/cancers14163844 doi (DE-627)DOAJ024215058 (DE-599)DOAJbe793fd219514c929d82f4c8acfe7cfa DE-627 ger DE-627 rakwb eng RC254-282 Łukasz Kuncman verfasserin aut The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred. chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magdalena Orzechowska verfasserin aut Konrad Stawiski verfasserin aut Michał Masłowski verfasserin aut Magdalena Ciążyńska verfasserin aut Leszek Gottwald verfasserin aut Tomasz Milecki verfasserin aut Jacek Fijuth verfasserin aut In Cancers MDPI AG, 2010 14(2022), 16, p 3844 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:16, p 3844 https://doi.org/10.3390/cancers14163844 kostenfrei https://doaj.org/article/be793fd219514c929d82f4c8acfe7cfa kostenfrei https://www.mdpi.com/2072-6694/14/16/3844 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 16, p 3844
allfieldsGer	10.3390/cancers14163844 doi (DE-627)DOAJ024215058 (DE-599)DOAJbe793fd219514c929d82f4c8acfe7cfa DE-627 ger DE-627 rakwb eng RC254-282 Łukasz Kuncman verfasserin aut The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred. chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magdalena Orzechowska verfasserin aut Konrad Stawiski verfasserin aut Michał Masłowski verfasserin aut Magdalena Ciążyńska verfasserin aut Leszek Gottwald verfasserin aut Tomasz Milecki verfasserin aut Jacek Fijuth verfasserin aut In Cancers MDPI AG, 2010 14(2022), 16, p 3844 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:16, p 3844 https://doi.org/10.3390/cancers14163844 kostenfrei https://doaj.org/article/be793fd219514c929d82f4c8acfe7cfa kostenfrei https://www.mdpi.com/2072-6694/14/16/3844 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 16, p 3844
allfieldsSound	10.3390/cancers14163844 doi (DE-627)DOAJ024215058 (DE-599)DOAJbe793fd219514c929d82f4c8acfe7cfa DE-627 ger DE-627 rakwb eng RC254-282 Łukasz Kuncman verfasserin aut The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred. chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magdalena Orzechowska verfasserin aut Konrad Stawiski verfasserin aut Michał Masłowski verfasserin aut Magdalena Ciążyńska verfasserin aut Leszek Gottwald verfasserin aut Tomasz Milecki verfasserin aut Jacek Fijuth verfasserin aut In Cancers MDPI AG, 2010 14(2022), 16, p 3844 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:16, p 3844 https://doi.org/10.3390/cancers14163844 kostenfrei https://doaj.org/article/be793fd219514c929d82f4c8acfe7cfa kostenfrei https://www.mdpi.com/2072-6694/14/16/3844 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 16, p 3844
language	English
source	In Cancers 14(2022), 16, p 3844 volume:14 year:2022 number:16, p 3844
sourceStr	In Cancers 14(2022), 16, p 3844 volume:14 year:2022 number:16, p 3844
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
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publishDateDaySort_date	2022-01-01T00:00:00Z
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author	Łukasz Kuncman
spellingShingle	Łukasz Kuncman misc RC254-282 misc chemoradiotherapy misc immunotherapy misc radiotherapy misc FMS-related tyrosine kinase 3 ligand (Flt-3L) misc dendric cells misc active bone marrow misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy
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issn	20726694
topic_title	RC254-282 The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy chemoradiotherapy immunotherapy radiotherapy FMS-related tyrosine kinase 3 ligand (Flt-3L) dendric cells active bone marrow
topic	misc RC254-282 misc chemoradiotherapy misc immunotherapy misc radiotherapy misc FMS-related tyrosine kinase 3 ligand (Flt-3L) misc dendric cells misc active bone marrow misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc chemoradiotherapy misc immunotherapy misc radiotherapy misc FMS-related tyrosine kinase 3 ligand (Flt-3L) misc dendric cells misc active bone marrow misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc chemoradiotherapy misc immunotherapy misc radiotherapy misc FMS-related tyrosine kinase 3 ligand (Flt-3L) misc dendric cells misc active bone marrow misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy
ctrlnum	(DE-627)DOAJ024215058 (DE-599)DOAJbe793fd219514c929d82f4c8acfe7cfa
title_full	The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy
author_sort	Łukasz Kuncman
journal	Cancers
journalStr	Cancers
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author_browse	Łukasz Kuncman Magdalena Orzechowska Konrad Stawiski Michał Masłowski Magdalena Ciążyńska Leszek Gottwald Tomasz Milecki Jacek Fijuth
container_volume	14
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Łukasz Kuncman
doi_str_mv	10.3390/cancers14163844
author2-role	verfasserin
title_sort	kinetics of fms-related tyrosine kinase 3 ligand (flt-3l) during chemoradiotherapy suggests a potential gain from the earlier initiation of immunotherapy
callnumber	RC254-282
title_auth	The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy
abstract	The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred.
abstractGer	The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred.
abstract_unstemmed	The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (<i<p</i< < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred.
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container_issue	16, p 3844
title_short	The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy
url	https://doi.org/10.3390/cancers14163844 https://doaj.org/article/be793fd219514c929d82f4c8acfe7cfa https://www.mdpi.com/2072-6694/14/16/3844 https://doaj.org/toc/2072-6694
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author2	Magdalena Orzechowska Konrad Stawiski Michał Masłowski Magdalena Ciążyńska Leszek Gottwald Tomasz Milecki Jacek Fijuth
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up_date	2024-07-03T21:49:11.966Z
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