Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial
Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wan...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hu S [verfasserIn] Wang M [verfasserIn] Li S [verfasserIn] Zhou W [verfasserIn] Zhang Y [verfasserIn] Shi H [verfasserIn] Ye P [verfasserIn] Sun J [verfasserIn] Liu F [verfasserIn] Zhang W [verfasserIn] Zheng L [verfasserIn] Hou Q [verfasserIn] Wang Y [verfasserIn] Sun W [verfasserIn] Chen Y [verfasserIn] Lu Z [verfasserIn] Ji Z [verfasserIn] Liao L [verfasserIn] Lv X [verfasserIn] Wang X [verfasserIn] Yang H [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: Drug Design, Development and Therapy - Dove Medical Press, 2008, (2022), Seite 2695-2705 |
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| Übergeordnetes Werk: |
year:2022 ; pages:2695-2705 |
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DOAJ024247847 |
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| 245 | 1 | 0 | |a Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial |
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| 520 | |a Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation | ||
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(DE-627)DOAJ024247847 (DE-599)DOAJ12bb61a3b47342bfb1c8fa0161bcb6d8 DE-627 ger DE-627 rakwb eng RM1-950 Hu S verfasserin aut Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation lidocaine propofol gastroscopy elderly patient sedation Therapeutics. Pharmacology Wang M verfasserin aut Li S verfasserin aut Zhou W verfasserin aut Zhang Y verfasserin aut Shi H verfasserin aut Ye P verfasserin aut Sun J verfasserin aut Liu F verfasserin aut Zhang W verfasserin aut Zheng L verfasserin aut Hou Q verfasserin aut Wang Y verfasserin aut Sun W verfasserin aut Chen Y verfasserin aut Lu Z verfasserin aut Ji Z verfasserin aut Liao L verfasserin aut Lv X verfasserin aut Wang Y verfasserin aut Wang X verfasserin aut Yang H verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2022), Seite 2695-2705 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2022 pages:2695-2705 https://doaj.org/article/12bb61a3b47342bfb1c8fa0161bcb6d8 kostenfrei https://www.dovepress.com/intravenous-lidocaine-significantly-reduces-the-propofol-dose-in-elder-peer-reviewed-fulltext-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2695-2705 |
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(DE-627)DOAJ024247847 (DE-599)DOAJ12bb61a3b47342bfb1c8fa0161bcb6d8 DE-627 ger DE-627 rakwb eng RM1-950 Hu S verfasserin aut Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation lidocaine propofol gastroscopy elderly patient sedation Therapeutics. Pharmacology Wang M verfasserin aut Li S verfasserin aut Zhou W verfasserin aut Zhang Y verfasserin aut Shi H verfasserin aut Ye P verfasserin aut Sun J verfasserin aut Liu F verfasserin aut Zhang W verfasserin aut Zheng L verfasserin aut Hou Q verfasserin aut Wang Y verfasserin aut Sun W verfasserin aut Chen Y verfasserin aut Lu Z verfasserin aut Ji Z verfasserin aut Liao L verfasserin aut Lv X verfasserin aut Wang Y verfasserin aut Wang X verfasserin aut Yang H verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2022), Seite 2695-2705 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2022 pages:2695-2705 https://doaj.org/article/12bb61a3b47342bfb1c8fa0161bcb6d8 kostenfrei https://www.dovepress.com/intravenous-lidocaine-significantly-reduces-the-propofol-dose-in-elder-peer-reviewed-fulltext-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2695-2705 |
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(DE-627)DOAJ024247847 (DE-599)DOAJ12bb61a3b47342bfb1c8fa0161bcb6d8 DE-627 ger DE-627 rakwb eng RM1-950 Hu S verfasserin aut Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation lidocaine propofol gastroscopy elderly patient sedation Therapeutics. Pharmacology Wang M verfasserin aut Li S verfasserin aut Zhou W verfasserin aut Zhang Y verfasserin aut Shi H verfasserin aut Ye P verfasserin aut Sun J verfasserin aut Liu F verfasserin aut Zhang W verfasserin aut Zheng L verfasserin aut Hou Q verfasserin aut Wang Y verfasserin aut Sun W verfasserin aut Chen Y verfasserin aut Lu Z verfasserin aut Ji Z verfasserin aut Liao L verfasserin aut Lv X verfasserin aut Wang Y verfasserin aut Wang X verfasserin aut Yang H verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2022), Seite 2695-2705 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2022 pages:2695-2705 https://doaj.org/article/12bb61a3b47342bfb1c8fa0161bcb6d8 kostenfrei https://www.dovepress.com/intravenous-lidocaine-significantly-reduces-the-propofol-dose-in-elder-peer-reviewed-fulltext-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2695-2705 |
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(DE-627)DOAJ024247847 (DE-599)DOAJ12bb61a3b47342bfb1c8fa0161bcb6d8 DE-627 ger DE-627 rakwb eng RM1-950 Hu S verfasserin aut Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation lidocaine propofol gastroscopy elderly patient sedation Therapeutics. Pharmacology Wang M verfasserin aut Li S verfasserin aut Zhou W verfasserin aut Zhang Y verfasserin aut Shi H verfasserin aut Ye P verfasserin aut Sun J verfasserin aut Liu F verfasserin aut Zhang W verfasserin aut Zheng L verfasserin aut Hou Q verfasserin aut Wang Y verfasserin aut Sun W verfasserin aut Chen Y verfasserin aut Lu Z verfasserin aut Ji Z verfasserin aut Liao L verfasserin aut Lv X verfasserin aut Wang Y verfasserin aut Wang X verfasserin aut Yang H verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2022), Seite 2695-2705 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2022 pages:2695-2705 https://doaj.org/article/12bb61a3b47342bfb1c8fa0161bcb6d8 kostenfrei https://www.dovepress.com/intravenous-lidocaine-significantly-reduces-the-propofol-dose-in-elder-peer-reviewed-fulltext-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2695-2705 |
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(DE-627)DOAJ024247847 (DE-599)DOAJ12bb61a3b47342bfb1c8fa0161bcb6d8 DE-627 ger DE-627 rakwb eng RM1-950 Hu S verfasserin aut Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation lidocaine propofol gastroscopy elderly patient sedation Therapeutics. Pharmacology Wang M verfasserin aut Li S verfasserin aut Zhou W verfasserin aut Zhang Y verfasserin aut Shi H verfasserin aut Ye P verfasserin aut Sun J verfasserin aut Liu F verfasserin aut Zhang W verfasserin aut Zheng L verfasserin aut Hou Q verfasserin aut Wang Y verfasserin aut Sun W verfasserin aut Chen Y verfasserin aut Lu Z verfasserin aut Ji Z verfasserin aut Liao L verfasserin aut Lv X verfasserin aut Wang Y verfasserin aut Wang X verfasserin aut Yang H verfasserin aut In Drug Design, Development and Therapy Dove Medical Press, 2008 (2022), Seite 2695-2705 (DE-627)578533138 (DE-600)2451346-5 11778881 nnns year:2022 pages:2695-2705 https://doaj.org/article/12bb61a3b47342bfb1c8fa0161bcb6d8 kostenfrei https://www.dovepress.com/intravenous-lidocaine-significantly-reduces-the-propofol-dose-in-elder-peer-reviewed-fulltext-article-DDDT kostenfrei https://doaj.org/toc/1177-8881 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 2695-2705 |
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Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lidocaine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">propofol</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gastroscopy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">elderly patient</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sedation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. 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RM1-950 Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial lidocaine propofol gastroscopy elderly patient sedation |
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Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial |
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intravenous lidocaine significantly reduces the propofol dose in elderly patients undergoing gastroscopy: a randomized controlled trial |
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Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial |
| abstract |
Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation |
| abstractGer |
Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation |
| abstract_unstemmed |
Song Hu,1– 3,* Mingxia Wang,2,3,* Siyu Li,2,* Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ024247847</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230307073300.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ024247847</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ12bb61a3b47342bfb1c8fa0161bcb6d8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Hu S</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Song Hu,1– 3,&ast; Mingxia Wang,2,3,&ast; Siyu Li,2,&ast; Wenyu Zhou,3 Yi Zhang,2 Haobing Shi,2 Pengcheng Ye,2 Jixiong Sun,2 Feng Liu,2 Wei Zhang,2 Li Zheng,3 Qianhao Hou,2 Yue Wang,2 Weixin Sun,2 Yuanli Chen,2 Zhenzhen Lu,4 Zhonghua Ji,2 Lijun Liao,2 Xin Lv,3 Yinglin Wang,2 Xiangrui Wang,2 Hao Yang2,3 1Graduate School, Wannan Medical College, Wuhu, 241002, People’s Republic of China; 2Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 4Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hao Yang; Xiangrui Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, People’s Republic of China, Email yanghaozunyisina.com; wangxiangruirjyy@sina.comObjective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients.Methods: We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. Subjects were randomly assigned to the lidocaine group (Group L, n=70), who received IV 1.5 mg kg− 1 lidocaine followed by a continuous infusion of 4 mg kg− 1 h− 1 lidocaine, or the normal saline group (Group N, n=70), who received an equal volume of saline in the same way.Results: IV lidocaine reduced the total and maintenance propofol dose in Group L (p< 0.001), with no significant effect on the induction dose. The incidence of intraoperative hypoxia (p=0.035), emergency airway management events (p=0.005), duration of gastroscopy (p< 0.05), consciousness recovery time (p< 0.001), and postoperative pain (p=0.009) were all reduced in Group L. Patient (p=0.025) and gastroscopist (p=0.031) satisfaction was higher in Group L. Intraoperative hemodynamic parameters, the respiratory rate, the incidence of sedation-related events and anesthesiologist satisfaction were similar between the two groups.Conclusion: IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction.Keywords: lidocaine, propofol, gastroscopy, elderly patient, sedation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lidocaine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">propofol</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gastroscopy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">elderly patient</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sedation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. 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