Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?

Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced microsurgical techniques, the recovery of function is limited by an inherently slow rate of axonal regeneration. In particular, a time-dependent deterioration in the ability of the distal stump to supp...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Liam A. McMorrow [verfasserIn] Adrian Kosalko [verfasserIn] Daniel Robinson [verfasserIn] Alberto Saiani [verfasserIn] Adam J. Reid [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	peripheral nerve injury Schwann cells peripheral nerve regeneration nerve injury c-Jun chronic Schwann cell denervation

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 12(2022), 8, p 1128
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:8, p 1128

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom12081128

Katalog-ID:	DOAJ024427322

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allfieldsSound	10.3390/biom12081128 doi (DE-627)DOAJ024427322 (DE-599)DOAJ58fd989167614ab68f3875637939dee4 DE-627 ger DE-627 rakwb eng QR1-502 Liam A. McMorrow verfasserin aut Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced microsurgical techniques, the recovery of function is limited by an inherently slow rate of axonal regeneration. In particular, a time-dependent deterioration in the ability of the distal stump to support axonal growth is a major determinant to the failure of reinnervation. Schwann cells (SC) are crucial in the orchestration of nerve regeneration; their plasticity permits the adoption of a repair phenotype following nerve injury. The repair SC modulates the initial immune response, directs myelin clearance, provides neurotrophic support and remodels the distal nerve. These functions are critical for regeneration; yet the repair phenotype is unstable in the setting of chronic denervation. This phenotypic instability accounts for the deteriorating regenerative support offered by the distal nerve stump. Over the past 10 years, our understanding of the cellular machinery behind this repair phenotype, in particular the role of c-Jun, has increased exponentially, creating opportunities for therapeutic intervention. This review will cover the activation of the repair phenotype in SC, the effects of chronic denervation on SC and current strategies to ‘hack’ these cellular pathways toward supporting more prolonged periods of neural regeneration. peripheral nerve injury Schwann cells peripheral nerve regeneration nerve injury c-Jun chronic Schwann cell denervation Microbiology Adrian Kosalko verfasserin aut Daniel Robinson verfasserin aut Alberto Saiani verfasserin aut Adam J. Reid verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 8, p 1128 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:8, p 1128 https://doi.org/10.3390/biom12081128 kostenfrei https://doaj.org/article/58fd989167614ab68f3875637939dee4 kostenfrei https://www.mdpi.com/2218-273X/12/8/1128 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8, p 1128
language	English
source	In Biomolecules 12(2022), 8, p 1128 volume:12 year:2022 number:8, p 1128
sourceStr	In Biomolecules 12(2022), 8, p 1128 volume:12 year:2022 number:8, p 1128
format_phy_str_mv	Article
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topic_facet	peripheral nerve injury Schwann cells peripheral nerve regeneration nerve injury c-Jun chronic Schwann cell denervation Microbiology
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container_title	Biomolecules
authorswithroles_txt_mv	Liam A. McMorrow @@aut@@ Adrian Kosalko @@aut@@ Daniel Robinson @@aut@@ Alberto Saiani @@aut@@ Adam J. Reid @@aut@@
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McMorrow</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Outcomes for patients following major peripheral nerve injury are extremely poor. 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callnumber-first	Q - Science
author	Liam A. McMorrow
spellingShingle	Liam A. McMorrow misc QR1-502 misc peripheral nerve injury misc Schwann cells misc peripheral nerve regeneration misc nerve injury misc c-Jun misc chronic Schwann cell denervation misc Microbiology Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?
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topic_title	QR1-502 Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target? peripheral nerve injury Schwann cells peripheral nerve regeneration nerve injury c-Jun chronic Schwann cell denervation
topic	misc QR1-502 misc peripheral nerve injury misc Schwann cells misc peripheral nerve regeneration misc nerve injury misc c-Jun misc chronic Schwann cell denervation misc Microbiology
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title	Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?
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title_full	Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?
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title_auth	Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?
abstract	Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced microsurgical techniques, the recovery of function is limited by an inherently slow rate of axonal regeneration. In particular, a time-dependent deterioration in the ability of the distal stump to support axonal growth is a major determinant to the failure of reinnervation. Schwann cells (SC) are crucial in the orchestration of nerve regeneration; their plasticity permits the adoption of a repair phenotype following nerve injury. The repair SC modulates the initial immune response, directs myelin clearance, provides neurotrophic support and remodels the distal nerve. These functions are critical for regeneration; yet the repair phenotype is unstable in the setting of chronic denervation. This phenotypic instability accounts for the deteriorating regenerative support offered by the distal nerve stump. Over the past 10 years, our understanding of the cellular machinery behind this repair phenotype, in particular the role of c-Jun, has increased exponentially, creating opportunities for therapeutic intervention. This review will cover the activation of the repair phenotype in SC, the effects of chronic denervation on SC and current strategies to ‘hack’ these cellular pathways toward supporting more prolonged periods of neural regeneration.
abstractGer	Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced microsurgical techniques, the recovery of function is limited by an inherently slow rate of axonal regeneration. In particular, a time-dependent deterioration in the ability of the distal stump to support axonal growth is a major determinant to the failure of reinnervation. Schwann cells (SC) are crucial in the orchestration of nerve regeneration; their plasticity permits the adoption of a repair phenotype following nerve injury. The repair SC modulates the initial immune response, directs myelin clearance, provides neurotrophic support and remodels the distal nerve. These functions are critical for regeneration; yet the repair phenotype is unstable in the setting of chronic denervation. This phenotypic instability accounts for the deteriorating regenerative support offered by the distal nerve stump. Over the past 10 years, our understanding of the cellular machinery behind this repair phenotype, in particular the role of c-Jun, has increased exponentially, creating opportunities for therapeutic intervention. This review will cover the activation of the repair phenotype in SC, the effects of chronic denervation on SC and current strategies to ‘hack’ these cellular pathways toward supporting more prolonged periods of neural regeneration.
abstract_unstemmed	Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced microsurgical techniques, the recovery of function is limited by an inherently slow rate of axonal regeneration. In particular, a time-dependent deterioration in the ability of the distal stump to support axonal growth is a major determinant to the failure of reinnervation. Schwann cells (SC) are crucial in the orchestration of nerve regeneration; their plasticity permits the adoption of a repair phenotype following nerve injury. The repair SC modulates the initial immune response, directs myelin clearance, provides neurotrophic support and remodels the distal nerve. These functions are critical for regeneration; yet the repair phenotype is unstable in the setting of chronic denervation. This phenotypic instability accounts for the deteriorating regenerative support offered by the distal nerve stump. Over the past 10 years, our understanding of the cellular machinery behind this repair phenotype, in particular the role of c-Jun, has increased exponentially, creating opportunities for therapeutic intervention. This review will cover the activation of the repair phenotype in SC, the effects of chronic denervation on SC and current strategies to ‘hack’ these cellular pathways toward supporting more prolonged periods of neural regeneration.
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title_short	Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?
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