Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review

<i<Alternaria</i< spp. have emerged as opportunistic pathogens particularly in immunosuppressed patients. A case of a breakthrough acute invasive fungal rhinosinusitis (AIFRS), caused by <i<Alternaria alternata</i<, is reported in a patient with acute lymphoblastic leukemia (...
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Autor*in:	Giorgos Tyrellis [verfasserIn] Maria Siopi [verfasserIn] Danai Leventakou [verfasserIn] Alexander Delides [verfasserIn] Pavlos Maragkoudakis [verfasserIn] George Korres [verfasserIn] Christina Apostolopoulou [verfasserIn] Alina-Roxani Gouloumi [verfasserIn] Vasiliki Pappa [verfasserIn] Spyros Pournaras [verfasserIn] Ioannis Panayiotides [verfasserIn] Joseph Meletiadis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	invasive necrotizing rhinosinusitis breakthrough

Übergeordnetes Werk:	In: Journal of Fungi - MDPI AG, 2015, 8(2022), 8, p 879
Übergeordnetes Werk:	volume:8 ; year:2022 ; number:8, p 879

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jof8080879

Katalog-ID:	DOAJ024428736

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callnumber-first	Q - Science
author	Giorgos Tyrellis
spellingShingle	Giorgos Tyrellis misc QH301-705.5 misc invasive necrotizing rhinosinusitis misc <i<Alternaria</i< spp. misc breakthrough misc Biology (General) Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review
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topic_title	QH301-705.5 Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review invasive necrotizing rhinosinusitis <i<Alternaria</i< spp breakthrough
topic	misc QH301-705.5 misc invasive necrotizing rhinosinusitis misc <i<Alternaria</i< spp. misc breakthrough misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc invasive necrotizing rhinosinusitis misc <i<Alternaria</i< spp. misc breakthrough misc Biology (General)
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title	Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review
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title_full	Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review
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author_browse	Giorgos Tyrellis Maria Siopi Danai Leventakou Alexander Delides Pavlos Maragkoudakis George Korres Christina Apostolopoulou Alina-Roxani Gouloumi Vasiliki Pappa Spyros Pournaras Ioannis Panayiotides Joseph Meletiadis
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title_sort	breakthrough acute necrotizing invasive fungal rhinosinusitis by <i<alternaria</i<<i<alternata</i< in a patient with acute lymphoblastic leukemia on anidulafungin therapy and case-based literature review
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title_auth	Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review
abstract	<i<Alternaria</i< spp. have emerged as opportunistic pathogens particularly in immunosuppressed patients. A case of a breakthrough acute invasive fungal rhinosinusitis (AIFRS), caused by <i<Alternaria alternata</i<, is reported in a patient with acute lymphoblastic leukemia (ALL) on anidulafungin therapy, who was successfully treated with liposomal amphotericin B and surgical intervention. To date, 20 cases of AIFRS due to <i<Alternaria</i< spp. have been described, 19 in the USA and 1 in Chile, making this case report the first case of AIFRS due to <i<Alternaria</i< in Europe. The patients had median (range) age 25 (2–56) years (65% female), almost all of them (19/20) with hematological diseases and severe neutropenia (8–41 days pre-infection). Amphotericin B was the most frequently used antifungal agent, either alone or in combination. In all of the cases, systemic antifungal therapy was combined with surgery. Despite stabilization or improvement of the AIFRS, mortality was 38% (5 days to 8 months post-surgical debridement) due to their underlying disease or other infections without sign of AIFRS at autopsy.
abstractGer	<i<Alternaria</i< spp. have emerged as opportunistic pathogens particularly in immunosuppressed patients. A case of a breakthrough acute invasive fungal rhinosinusitis (AIFRS), caused by <i<Alternaria alternata</i<, is reported in a patient with acute lymphoblastic leukemia (ALL) on anidulafungin therapy, who was successfully treated with liposomal amphotericin B and surgical intervention. To date, 20 cases of AIFRS due to <i<Alternaria</i< spp. have been described, 19 in the USA and 1 in Chile, making this case report the first case of AIFRS due to <i<Alternaria</i< in Europe. The patients had median (range) age 25 (2–56) years (65% female), almost all of them (19/20) with hematological diseases and severe neutropenia (8–41 days pre-infection). Amphotericin B was the most frequently used antifungal agent, either alone or in combination. In all of the cases, systemic antifungal therapy was combined with surgery. Despite stabilization or improvement of the AIFRS, mortality was 38% (5 days to 8 months post-surgical debridement) due to their underlying disease or other infections without sign of AIFRS at autopsy.
abstract_unstemmed	<i<Alternaria</i< spp. have emerged as opportunistic pathogens particularly in immunosuppressed patients. A case of a breakthrough acute invasive fungal rhinosinusitis (AIFRS), caused by <i<Alternaria alternata</i<, is reported in a patient with acute lymphoblastic leukemia (ALL) on anidulafungin therapy, who was successfully treated with liposomal amphotericin B and surgical intervention. To date, 20 cases of AIFRS due to <i<Alternaria</i< spp. have been described, 19 in the USA and 1 in Chile, making this case report the first case of AIFRS due to <i<Alternaria</i< in Europe. The patients had median (range) age 25 (2–56) years (65% female), almost all of them (19/20) with hematological diseases and severe neutropenia (8–41 days pre-infection). Amphotericin B was the most frequently used antifungal agent, either alone or in combination. In all of the cases, systemic antifungal therapy was combined with surgery. Despite stabilization or improvement of the AIFRS, mortality was 38% (5 days to 8 months post-surgical debridement) due to their underlying disease or other infections without sign of AIFRS at autopsy.
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container_issue	8, p 879
title_short	Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review
url	https://doi.org/10.3390/jof8080879 https://doaj.org/article/7116064545a444c9a385f2ba15e76d22 https://www.mdpi.com/2309-608X/8/8/879 https://doaj.org/toc/2309-608X
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author2	Maria Siopi Danai Leventakou Alexander Delides Pavlos Maragkoudakis George Korres Christina Apostolopoulou Alina-Roxani Gouloumi Vasiliki Pappa Spyros Pournaras Ioannis Panayiotides Joseph Meletiadis
author2Str	Maria Siopi Danai Leventakou Alexander Delides Pavlos Maragkoudakis George Korres Christina Apostolopoulou Alina-Roxani Gouloumi Vasiliki Pappa Spyros Pournaras Ioannis Panayiotides Joseph Meletiadis
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up_date	2024-07-03T22:52:09.931Z
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Breakthrough Acute Necrotizing Invasive Fungal Rhinosinusitis by <i<Alternaria</i<<i<alternata</i< in a Patient with Acute Lymphoblastic Leukemia on Anidulafungin Therapy and Case-Based Literature Review

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