Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia

Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rather Izhar Ul Haq [verfasserIn] Oveas Rafiq Parray [verfasserIn] Qurat Ul Ain Nazir [verfasserIn] Riyaz Ahmed Bhat [verfasserIn] Showkat Ahmad Shah [verfasserIn] Majid Shafi Kawoosa [verfasserIn] Ali A. Rabaan [verfasserIn] Mohammed Aljeldah [verfasserIn] Basim R. Al Shammari [verfasserIn] Mohammed S. Almogbel [verfasserIn] Nada Alharbi [verfasserIn] Reem Alrashoudi [verfasserIn] Amal A. Sabour [verfasserIn] Rana A. Alaeq [verfasserIn] Maha A. Alshiekheid [verfasserIn] Saleh A. Alshamrani [verfasserIn] Aqel Albutti [verfasserIn] Ameen S.S. Alwashmi [verfasserIn] Kuldeep Dhama [verfasserIn] Mohd. Iqbal Yatoo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 10(2022), 8, p 1634
Übergeordnetes Werk:	volume:10 ; year:2022 ; number:8, p 1634

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms10081634

Katalog-ID:	DOAJ024451932

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245	1	0	\|a Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia
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spelling	10.3390/microorganisms10081634 doi (DE-627)DOAJ024451932 (DE-599)DOAJ75b1b8b7d8bd44f6906d3aeceb98aaac DE-627 ger DE-627 rakwb eng QH301-705.5 Rather Izhar Ul Haq verfasserin aut Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions. antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit Biology (General) Oveas Rafiq Parray verfasserin aut Qurat Ul Ain Nazir verfasserin aut Riyaz Ahmed Bhat verfasserin aut Showkat Ahmad Shah verfasserin aut Majid Shafi Kawoosa verfasserin aut Ali A. Rabaan verfasserin aut Mohammed Aljeldah verfasserin aut Basim R. Al Shammari verfasserin aut Mohammed S. Almogbel verfasserin aut Nada Alharbi verfasserin aut Reem Alrashoudi verfasserin aut Amal A. Sabour verfasserin aut Rana A. Alaeq verfasserin aut Maha A. Alshiekheid verfasserin aut Saleh A. Alshamrani verfasserin aut Aqel Albutti verfasserin aut Ameen S.S. Alwashmi verfasserin aut Kuldeep Dhama verfasserin aut Mohd. Iqbal Yatoo verfasserin aut In Microorganisms MDPI AG, 2013 10(2022), 8, p 1634 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:10 year:2022 number:8, p 1634 https://doi.org/10.3390/microorganisms10081634 kostenfrei https://doaj.org/article/75b1b8b7d8bd44f6906d3aeceb98aaac kostenfrei https://www.mdpi.com/2076-2607/10/8/1634 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 8, p 1634
allfields_unstemmed	10.3390/microorganisms10081634 doi (DE-627)DOAJ024451932 (DE-599)DOAJ75b1b8b7d8bd44f6906d3aeceb98aaac DE-627 ger DE-627 rakwb eng QH301-705.5 Rather Izhar Ul Haq verfasserin aut Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions. antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit Biology (General) Oveas Rafiq Parray verfasserin aut Qurat Ul Ain Nazir verfasserin aut Riyaz Ahmed Bhat verfasserin aut Showkat Ahmad Shah verfasserin aut Majid Shafi Kawoosa verfasserin aut Ali A. Rabaan verfasserin aut Mohammed Aljeldah verfasserin aut Basim R. Al Shammari verfasserin aut Mohammed S. Almogbel verfasserin aut Nada Alharbi verfasserin aut Reem Alrashoudi verfasserin aut Amal A. Sabour verfasserin aut Rana A. Alaeq verfasserin aut Maha A. Alshiekheid verfasserin aut Saleh A. Alshamrani verfasserin aut Aqel Albutti verfasserin aut Ameen S.S. Alwashmi verfasserin aut Kuldeep Dhama verfasserin aut Mohd. Iqbal Yatoo verfasserin aut In Microorganisms MDPI AG, 2013 10(2022), 8, p 1634 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:10 year:2022 number:8, p 1634 https://doi.org/10.3390/microorganisms10081634 kostenfrei https://doaj.org/article/75b1b8b7d8bd44f6906d3aeceb98aaac kostenfrei https://www.mdpi.com/2076-2607/10/8/1634 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 8, p 1634
allfieldsGer	10.3390/microorganisms10081634 doi (DE-627)DOAJ024451932 (DE-599)DOAJ75b1b8b7d8bd44f6906d3aeceb98aaac DE-627 ger DE-627 rakwb eng QH301-705.5 Rather Izhar Ul Haq verfasserin aut Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions. antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit Biology (General) Oveas Rafiq Parray verfasserin aut Qurat Ul Ain Nazir verfasserin aut Riyaz Ahmed Bhat verfasserin aut Showkat Ahmad Shah verfasserin aut Majid Shafi Kawoosa verfasserin aut Ali A. Rabaan verfasserin aut Mohammed Aljeldah verfasserin aut Basim R. Al Shammari verfasserin aut Mohammed S. Almogbel verfasserin aut Nada Alharbi verfasserin aut Reem Alrashoudi verfasserin aut Amal A. Sabour verfasserin aut Rana A. Alaeq verfasserin aut Maha A. Alshiekheid verfasserin aut Saleh A. Alshamrani verfasserin aut Aqel Albutti verfasserin aut Ameen S.S. Alwashmi verfasserin aut Kuldeep Dhama verfasserin aut Mohd. Iqbal Yatoo verfasserin aut In Microorganisms MDPI AG, 2013 10(2022), 8, p 1634 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:10 year:2022 number:8, p 1634 https://doi.org/10.3390/microorganisms10081634 kostenfrei https://doaj.org/article/75b1b8b7d8bd44f6906d3aeceb98aaac kostenfrei https://www.mdpi.com/2076-2607/10/8/1634 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 8, p 1634
allfieldsSound	10.3390/microorganisms10081634 doi (DE-627)DOAJ024451932 (DE-599)DOAJ75b1b8b7d8bd44f6906d3aeceb98aaac DE-627 ger DE-627 rakwb eng QH301-705.5 Rather Izhar Ul Haq verfasserin aut Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions. antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit Biology (General) Oveas Rafiq Parray verfasserin aut Qurat Ul Ain Nazir verfasserin aut Riyaz Ahmed Bhat verfasserin aut Showkat Ahmad Shah verfasserin aut Majid Shafi Kawoosa verfasserin aut Ali A. Rabaan verfasserin aut Mohammed Aljeldah verfasserin aut Basim R. Al Shammari verfasserin aut Mohammed S. Almogbel verfasserin aut Nada Alharbi verfasserin aut Reem Alrashoudi verfasserin aut Amal A. Sabour verfasserin aut Rana A. Alaeq verfasserin aut Maha A. Alshiekheid verfasserin aut Saleh A. Alshamrani verfasserin aut Aqel Albutti verfasserin aut Ameen S.S. Alwashmi verfasserin aut Kuldeep Dhama verfasserin aut Mohd. Iqbal Yatoo verfasserin aut In Microorganisms MDPI AG, 2013 10(2022), 8, p 1634 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:10 year:2022 number:8, p 1634 https://doi.org/10.3390/microorganisms10081634 kostenfrei https://doaj.org/article/75b1b8b7d8bd44f6906d3aeceb98aaac kostenfrei https://www.mdpi.com/2076-2607/10/8/1634 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 8, p 1634
language	English
source	In Microorganisms 10(2022), 8, p 1634 volume:10 year:2022 number:8, p 1634
sourceStr	In Microorganisms 10(2022), 8, p 1634 volume:10 year:2022 number:8, p 1634
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit Biology (General)
isfreeaccess_bool	true
container_title	Microorganisms
authorswithroles_txt_mv	Rather Izhar Ul Haq @@aut@@ Oveas Rafiq Parray @@aut@@ Qurat Ul Ain Nazir @@aut@@ Riyaz Ahmed Bhat @@aut@@ Showkat Ahmad Shah @@aut@@ Majid Shafi Kawoosa @@aut@@ Ali A. Rabaan @@aut@@ Mohammed Aljeldah @@aut@@ Basim R. Al Shammari @@aut@@ Mohammed S. Almogbel @@aut@@ Nada Alharbi @@aut@@ Reem Alrashoudi @@aut@@ Amal A. Sabour @@aut@@ Rana A. Alaeq @@aut@@ Maha A. Alshiekheid @@aut@@ Saleh A. Alshamrani @@aut@@ Aqel Albutti @@aut@@ Ameen S.S. Alwashmi @@aut@@ Kuldeep Dhama @@aut@@ Mohd. Iqbal Yatoo @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	750370696
id	DOAJ024451932
language_de	englisch
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The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. 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callnumber-first	Q - Science
author	Rather Izhar Ul Haq
spellingShingle	Rather Izhar Ul Haq misc QH301-705.5 misc antigen misc contagious caprine pleuropneumonia misc immunity misc mycoplasma misc oxidative stress misc rabbit misc Biology (General) Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia
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topic_title	QH301-705.5 Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia antigen contagious caprine pleuropneumonia immunity mycoplasma oxidative stress rabbit
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title	Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia
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title_full	Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia
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author_browse	Rather Izhar Ul Haq Oveas Rafiq Parray Qurat Ul Ain Nazir Riyaz Ahmed Bhat Showkat Ahmad Shah Majid Shafi Kawoosa Ali A. Rabaan Mohammed Aljeldah Basim R. Al Shammari Mohammed S. Almogbel Nada Alharbi Reem Alrashoudi Amal A. Sabour Rana A. Alaeq Maha A. Alshiekheid Saleh A. Alshamrani Aqel Albutti Ameen S.S. Alwashmi Kuldeep Dhama Mohd. Iqbal Yatoo
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title_sort	immune and oxidative response against sonicated antigen of <i<mycoplasma capricolum subspecies capripneumonia</i<—a causative agent of contagious caprine pleuropneumonia
callnumber	QH301-705.5
title_auth	Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia
abstract	Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions.
abstractGer	Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions.
abstract_unstemmed	Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of <i<Mycoplasma capricolum subsp. capripneumonia</i< in male Angora rabbits (1 year old, 2 kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (<i<p</i< < 0.05) increase in vaccinated groups compared to the healthy group on most of the intervals. TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. This study concludes that the saponin-adjuvanted and-sonicated antigen induces comparatively higher immune response than montanide but is associated with oxidative and inflammatory reactions.
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title_short	Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia
url	https://doi.org/10.3390/microorganisms10081634 https://doaj.org/article/75b1b8b7d8bd44f6906d3aeceb98aaac https://www.mdpi.com/2076-2607/10/8/1634 https://doaj.org/toc/2076-2607
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up_date	2024-07-03T22:59:19.724Z
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TNF-α levels were significantly (<i<p</i< < 0.05) higher in the Group 2 than the Group 1 at all the time intervals and more comparable to Group 4 than Group 3. IL-10 levels were significantly (<i<p</i< < 0.05) higher in vaccinated groups compared to the healthy group on days 14, 21, and 28, but were lower in Group 3 than in Group 2 and Group 4. More hypersensitivity as inflammation and histopathological cellular infiltration in the ear was produced in Group 2 and Group 4 than in Group 3. IgG levels were significantly (<i<p</i< < 0.05) higher in Group 2 and Group 4 than in Group 3 on days 14 and 21. Antibody titers were comparatively higher in Group 4, followed by Group 2 and 3, than Group 1. Significantly (<i<p</i< < 0.05) higher oxidant and lower antioxidant values were noted in Group 2 and 4 compared to Group 3 and Group 1 on most of the intervals. The TLC and antibody titer showed increasing trend throughout the trial, whereas TNF-α, IgG, L, M and E started decreasing from day 14, and IL-10, N and B started decreasing from day 21. 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Immune and Oxidative Response against Sonicated Antigen of <i<Mycoplasma capricolum subspecies capripneumonia</i<—A Causative Agent of Contagious Caprine Pleuropneumonia

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