Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma

Blood plasma from patients is a powerful resource for diagnosing infectious disease due to it having many genetic materials as well as being relatively easy to obtain. Thus, various biosensors have been investigated for diagnosing diseases in blood plasma. However, there are no optimized and validat...
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Autor*in:	Bonhan Koo [verfasserIn] Choong Eun Jin [verfasserIn] Moonsuk Bae [verfasserIn] Yoon Ok Jang [verfasserIn] Ji Yeun Kim [verfasserIn] Sung-Han Kim [verfasserIn] Yong Shin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	blood plasma infectious diseases biomolecular sensors silicon microring resonator acute Q fever

Übergeordnetes Werk:	In: Micromachines - MDPI AG, 2010, 10(2019), 7, p 427
Übergeordnetes Werk:	volume:10 ; year:2019 ; number:7, p 427

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/mi10070427

Katalog-ID:	DOAJ024460877

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language	English
source	In Micromachines 10(2019), 7, p 427 volume:10 year:2019 number:7, p 427
sourceStr	In Micromachines 10(2019), 7, p 427 volume:10 year:2019 number:7, p 427
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	blood plasma infectious diseases biomolecular sensors silicon microring resonator acute Q fever Mechanical engineering and machinery
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container_title	Micromachines
authorswithroles_txt_mv	Bonhan Koo @@aut@@ Choong Eun Jin @@aut@@ Moonsuk Bae @@aut@@ Yoon Ok Jang @@aut@@ Ji Yeun Kim @@aut@@ Sung-Han Kim @@aut@@ Yong Shin @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
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callnumber-first	T - Technology
author	Bonhan Koo
spellingShingle	Bonhan Koo misc TJ1-1570 misc blood plasma misc infectious diseases misc biomolecular sensors misc silicon microring resonator misc acute Q fever misc Mechanical engineering and machinery Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma
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topic_title	TJ1-1570 Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma blood plasma infectious diseases biomolecular sensors silicon microring resonator acute Q fever
topic	misc TJ1-1570 misc blood plasma misc infectious diseases misc biomolecular sensors misc silicon microring resonator misc acute Q fever misc Mechanical engineering and machinery
topic_unstemmed	misc TJ1-1570 misc blood plasma misc infectious diseases misc biomolecular sensors misc silicon microring resonator misc acute Q fever misc Mechanical engineering and machinery
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title	Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma
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title_full	Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma
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author_browse	Bonhan Koo Choong Eun Jin Moonsuk Bae Yoon Ok Jang Ji Yeun Kim Sung-Han Kim Yong Shin
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title_sort	detection of <i<coxiella burnetii</i< using silicon microring resonator in patient blood plasma
callnumber	TJ1-1570
title_auth	Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma
abstract	Blood plasma from patients is a powerful resource for diagnosing infectious disease due to it having many genetic materials as well as being relatively easy to obtain. Thus, various biosensors have been investigated for diagnosing diseases in blood plasma. However, there are no optimized and validated sensors for clinical use due to the low sensitivity, complexity, and difficulties of removing the inhibitors from plasma samples. In this study, we described a silicon microring resonator sensor used to detect <i<Coxiella burnetii</i< from the blood plasma of Q-fever patients in a label-free, real-time manner. Q-fever is an infectious disease caused by <i<Coxiella burnetii</i< via direct contact or inhalation aerosols. We validated this biosensor in the blood plasma of 35 clinical samples (including 16 Q fever samples infected with <i<Coxiella burnetii</i< and 19 samples infected with other febrile diseases. The biosensors are capable of rapid (10 min), highly sensitive (87.5%), and specific (89.5%) detection in plasma samples compared to the use of the conventional method.
abstractGer	Blood plasma from patients is a powerful resource for diagnosing infectious disease due to it having many genetic materials as well as being relatively easy to obtain. Thus, various biosensors have been investigated for diagnosing diseases in blood plasma. However, there are no optimized and validated sensors for clinical use due to the low sensitivity, complexity, and difficulties of removing the inhibitors from plasma samples. In this study, we described a silicon microring resonator sensor used to detect <i<Coxiella burnetii</i< from the blood plasma of Q-fever patients in a label-free, real-time manner. Q-fever is an infectious disease caused by <i<Coxiella burnetii</i< via direct contact or inhalation aerosols. We validated this biosensor in the blood plasma of 35 clinical samples (including 16 Q fever samples infected with <i<Coxiella burnetii</i< and 19 samples infected with other febrile diseases. The biosensors are capable of rapid (10 min), highly sensitive (87.5%), and specific (89.5%) detection in plasma samples compared to the use of the conventional method.
abstract_unstemmed	Blood plasma from patients is a powerful resource for diagnosing infectious disease due to it having many genetic materials as well as being relatively easy to obtain. Thus, various biosensors have been investigated for diagnosing diseases in blood plasma. However, there are no optimized and validated sensors for clinical use due to the low sensitivity, complexity, and difficulties of removing the inhibitors from plasma samples. In this study, we described a silicon microring resonator sensor used to detect <i<Coxiella burnetii</i< from the blood plasma of Q-fever patients in a label-free, real-time manner. Q-fever is an infectious disease caused by <i<Coxiella burnetii</i< via direct contact or inhalation aerosols. We validated this biosensor in the blood plasma of 35 clinical samples (including 16 Q fever samples infected with <i<Coxiella burnetii</i< and 19 samples infected with other febrile diseases. The biosensors are capable of rapid (10 min), highly sensitive (87.5%), and specific (89.5%) detection in plasma samples compared to the use of the conventional method.
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title_short	Detection of <i<Coxiella burnetii</i< Using Silicon Microring Resonator in Patient Blood Plasma
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