A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011

<p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs)...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yu Bin [verfasserIn] Wang Zhen [verfasserIn] Dong Jianing [verfasserIn] Wang Chu [verfasserIn] Gu Lina [verfasserIn] Sun Caijun [verfasserIn] Kong Wei [verfasserIn] Yu Xianghui [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine

Übergeordnetes Werk:	In: Virology Journal - BMC, 2004, 9(2012), 1, p 287
Übergeordnetes Werk:	volume:9 ; year:2012 ; number:1, p 287

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1743-422X-9-287

Katalog-ID:	DOAJ024475777

Internformat


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245	1	2	\|a A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011
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520			\|a <p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p<
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912			\|a GBV_ILN_2009
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912			\|a GBV_ILN_4323
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912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 9 \|j 2012 \|e 1, p 287

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author_variant	y b yb w z wz d j dj w c wc g l gl s c sc k w kw y x yx
matchkey_str	article:1743422X:2012----::srlgcluvyfuaaeoiusrtp2n5icltnpdarcou
hierarchy_sort_str	2012
callnumber-subject-code	RC
publishDate	2012
allfields	10.1186/1743-422X-9-287 doi (DE-627)DOAJ024475777 (DE-599)DOAJf4c92f69b4514327bc277d046bc3c2a2 DE-627 ger DE-627 rakwb eng RC109-216 Yu Bin verfasserin aut A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p< Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine Infectious and parasitic diseases Wang Zhen verfasserin aut Dong Jianing verfasserin aut Wang Chu verfasserin aut Gu Lina verfasserin aut Sun Caijun verfasserin aut Kong Wei verfasserin aut Yu Xianghui verfasserin aut In Virology Journal BMC, 2004 9(2012), 1, p 287 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:9 year:2012 number:1, p 287 https://doi.org/10.1186/1743-422X-9-287 kostenfrei https://doaj.org/article/f4c92f69b4514327bc277d046bc3c2a2 kostenfrei http://www.virologyj.com/content/9/1/287 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2012 1, p 287
spelling	10.1186/1743-422X-9-287 doi (DE-627)DOAJ024475777 (DE-599)DOAJf4c92f69b4514327bc277d046bc3c2a2 DE-627 ger DE-627 rakwb eng RC109-216 Yu Bin verfasserin aut A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p< Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine Infectious and parasitic diseases Wang Zhen verfasserin aut Dong Jianing verfasserin aut Wang Chu verfasserin aut Gu Lina verfasserin aut Sun Caijun verfasserin aut Kong Wei verfasserin aut Yu Xianghui verfasserin aut In Virology Journal BMC, 2004 9(2012), 1, p 287 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:9 year:2012 number:1, p 287 https://doi.org/10.1186/1743-422X-9-287 kostenfrei https://doaj.org/article/f4c92f69b4514327bc277d046bc3c2a2 kostenfrei http://www.virologyj.com/content/9/1/287 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2012 1, p 287
allfields_unstemmed	10.1186/1743-422X-9-287 doi (DE-627)DOAJ024475777 (DE-599)DOAJf4c92f69b4514327bc277d046bc3c2a2 DE-627 ger DE-627 rakwb eng RC109-216 Yu Bin verfasserin aut A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p< Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine Infectious and parasitic diseases Wang Zhen verfasserin aut Dong Jianing verfasserin aut Wang Chu verfasserin aut Gu Lina verfasserin aut Sun Caijun verfasserin aut Kong Wei verfasserin aut Yu Xianghui verfasserin aut In Virology Journal BMC, 2004 9(2012), 1, p 287 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:9 year:2012 number:1, p 287 https://doi.org/10.1186/1743-422X-9-287 kostenfrei https://doaj.org/article/f4c92f69b4514327bc277d046bc3c2a2 kostenfrei http://www.virologyj.com/content/9/1/287 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2012 1, p 287
allfieldsGer	10.1186/1743-422X-9-287 doi (DE-627)DOAJ024475777 (DE-599)DOAJf4c92f69b4514327bc277d046bc3c2a2 DE-627 ger DE-627 rakwb eng RC109-216 Yu Bin verfasserin aut A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p< Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine Infectious and parasitic diseases Wang Zhen verfasserin aut Dong Jianing verfasserin aut Wang Chu verfasserin aut Gu Lina verfasserin aut Sun Caijun verfasserin aut Kong Wei verfasserin aut Yu Xianghui verfasserin aut In Virology Journal BMC, 2004 9(2012), 1, p 287 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:9 year:2012 number:1, p 287 https://doi.org/10.1186/1743-422X-9-287 kostenfrei https://doaj.org/article/f4c92f69b4514327bc277d046bc3c2a2 kostenfrei http://www.virologyj.com/content/9/1/287 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2012 1, p 287
allfieldsSound	10.1186/1743-422X-9-287 doi (DE-627)DOAJ024475777 (DE-599)DOAJf4c92f69b4514327bc277d046bc3c2a2 DE-627 ger DE-627 rakwb eng RC109-216 Yu Bin verfasserin aut A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p< Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine Infectious and parasitic diseases Wang Zhen verfasserin aut Dong Jianing verfasserin aut Wang Chu verfasserin aut Gu Lina verfasserin aut Sun Caijun verfasserin aut Kong Wei verfasserin aut Yu Xianghui verfasserin aut In Virology Journal BMC, 2004 9(2012), 1, p 287 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:9 year:2012 number:1, p 287 https://doi.org/10.1186/1743-422X-9-287 kostenfrei https://doaj.org/article/f4c92f69b4514327bc277d046bc3c2a2 kostenfrei http://www.virologyj.com/content/9/1/287 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2012 1, p 287
language	English
source	In Virology Journal 9(2012), 1, p 287 volume:9 year:2012 number:1, p 287
sourceStr	In Virology Journal 9(2012), 1, p 287 volume:9 year:2012 number:1, p 287
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine Infectious and parasitic diseases
isfreeaccess_bool	true
container_title	Virology Journal
authorswithroles_txt_mv	Yu Bin @@aut@@ Wang Zhen @@aut@@ Dong Jianing @@aut@@ Wang Chu @@aut@@ Gu Lina @@aut@@ Sun Caijun @@aut@@ Kong Wei @@aut@@ Yu Xianghui @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	394165004
id	DOAJ024475777
language_de	englisch
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callnumber-first	R - Medicine
author	Yu Bin
spellingShingle	Yu Bin misc RC109-216 misc Adenovirus misc Seroprevalence misc Neutralizing antibodies misc HIV vaccine misc Infectious and parasitic diseases A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011
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topic_title	RC109-216 A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011 Adenovirus Seroprevalence Neutralizing antibodies HIV vaccine
topic	misc RC109-216 misc Adenovirus misc Seroprevalence misc Neutralizing antibodies misc HIV vaccine misc Infectious and parasitic diseases
topic_unstemmed	misc RC109-216 misc Adenovirus misc Seroprevalence misc Neutralizing antibodies misc HIV vaccine misc Infectious and parasitic diseases
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title	A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011
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title_full	A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011
author_sort	Yu Bin
journal	Virology Journal
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author_browse	Yu Bin Wang Zhen Dong Jianing Wang Chu Gu Lina Sun Caijun Kong Wei Yu Xianghui
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title_sort	serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in changchun, china, 2011
callnumber	RC109-216
title_auth	A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011
abstract	<p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Efficacy of recombinant adenovirus serotype 5 (rAd5) vaccine vectors for human immunodeficiency virus type 1 (HIV-1) and other pathogens have been shown to be limited by high titers of pre-existing Ad5 neutralizing antibodies (NAbs) in the developing world.</p< <p<Results</p< <p<Using a secreted embryonic alkaline phosphatase (SEAP) neutralization assay, 50% serum neutralization titers against rAd2 and rAd5 vectors were measured in samples from 274 infants and young children in northeast China. The pediatric population was found to be 59.6% and 43.3% seropositive for rAd2 and rAd5, respectively. Of all participants, 44.9% had moderate and high (< 200) and 25.6% had high (<1000) Ad2 NAb titers, compared with the corresponding rates of 26.6% and 9.3% against Ad5. Marked age-dependent increases in NAb titers to both Ad serotypes were observed across five age groups, with the exception of infants in the 0-6-month group commonly having relatively high titers due to pre-existing maternal antibodies.</p< <p<Conclusions</p< <p<Our data suggest that Ad-based therapies may be suitible for children in the 7-12-month age range in this region.</p<
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title_short	A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011
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A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, 2011

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