Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning

It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the othe...
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Autor*in:	Juan D. Navarro-López [verfasserIn] Ana Contreras [verfasserIn] Katia Touyarot [verfasserIn] Ana I. Herrero [verfasserIn] César Venero [verfasserIn] Karine Cambon [verfasserIn] Agnés Gruart [verfasserIn] José M. Delgado-García [verfasserIn] Carmen Sandi [verfasserIn] Lydia Jiménez-Díaz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus

Übergeordnetes Werk:	In: Frontiers in Neuroanatomy - Frontiers Media S.A., 2008, 16(2022)
Übergeordnetes Werk:	volume:16 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnana.2022.1082701

Katalog-ID:	DOAJ02465079X

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allfields	10.3389/fnana.2022.1082701 doi (DE-627)DOAJ02465079X (DE-599)DOAJdea8ecb30a5e4f0883072926674a01df DE-627 ger DE-627 rakwb eng RC321-571 QM1-695 Juan D. Navarro-López verfasserin aut Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation. classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Human anatomy Ana Contreras verfasserin aut Katia Touyarot verfasserin aut Ana I. Herrero verfasserin aut César Venero verfasserin aut Karine Cambon verfasserin aut Agnés Gruart verfasserin aut José M. Delgado-García verfasserin aut Carmen Sandi verfasserin aut Lydia Jiménez-Díaz verfasserin aut In Frontiers in Neuroanatomy Frontiers Media S.A., 2008 16(2022) (DE-627)579826465 (DE-600)2452969-2 16625129 nnns volume:16 year:2022 https://doi.org/10.3389/fnana.2022.1082701 kostenfrei https://doaj.org/article/dea8ecb30a5e4f0883072926674a01df kostenfrei https://www.frontiersin.org/articles/10.3389/fnana.2022.1082701/full kostenfrei https://doaj.org/toc/1662-5129 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022
spelling	10.3389/fnana.2022.1082701 doi (DE-627)DOAJ02465079X (DE-599)DOAJdea8ecb30a5e4f0883072926674a01df DE-627 ger DE-627 rakwb eng RC321-571 QM1-695 Juan D. Navarro-López verfasserin aut Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation. classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Human anatomy Ana Contreras verfasserin aut Katia Touyarot verfasserin aut Ana I. Herrero verfasserin aut César Venero verfasserin aut Karine Cambon verfasserin aut Agnés Gruart verfasserin aut José M. Delgado-García verfasserin aut Carmen Sandi verfasserin aut Lydia Jiménez-Díaz verfasserin aut In Frontiers in Neuroanatomy Frontiers Media S.A., 2008 16(2022) (DE-627)579826465 (DE-600)2452969-2 16625129 nnns volume:16 year:2022 https://doi.org/10.3389/fnana.2022.1082701 kostenfrei https://doaj.org/article/dea8ecb30a5e4f0883072926674a01df kostenfrei https://www.frontiersin.org/articles/10.3389/fnana.2022.1082701/full kostenfrei https://doaj.org/toc/1662-5129 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022
allfields_unstemmed	10.3389/fnana.2022.1082701 doi (DE-627)DOAJ02465079X (DE-599)DOAJdea8ecb30a5e4f0883072926674a01df DE-627 ger DE-627 rakwb eng RC321-571 QM1-695 Juan D. Navarro-López verfasserin aut Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation. classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Human anatomy Ana Contreras verfasserin aut Katia Touyarot verfasserin aut Ana I. Herrero verfasserin aut César Venero verfasserin aut Karine Cambon verfasserin aut Agnés Gruart verfasserin aut José M. Delgado-García verfasserin aut Carmen Sandi verfasserin aut Lydia Jiménez-Díaz verfasserin aut In Frontiers in Neuroanatomy Frontiers Media S.A., 2008 16(2022) (DE-627)579826465 (DE-600)2452969-2 16625129 nnns volume:16 year:2022 https://doi.org/10.3389/fnana.2022.1082701 kostenfrei https://doaj.org/article/dea8ecb30a5e4f0883072926674a01df kostenfrei https://www.frontiersin.org/articles/10.3389/fnana.2022.1082701/full kostenfrei https://doaj.org/toc/1662-5129 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022
allfieldsGer	10.3389/fnana.2022.1082701 doi (DE-627)DOAJ02465079X (DE-599)DOAJdea8ecb30a5e4f0883072926674a01df DE-627 ger DE-627 rakwb eng RC321-571 QM1-695 Juan D. Navarro-López verfasserin aut Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation. classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Human anatomy Ana Contreras verfasserin aut Katia Touyarot verfasserin aut Ana I. Herrero verfasserin aut César Venero verfasserin aut Karine Cambon verfasserin aut Agnés Gruart verfasserin aut José M. Delgado-García verfasserin aut Carmen Sandi verfasserin aut Lydia Jiménez-Díaz verfasserin aut In Frontiers in Neuroanatomy Frontiers Media S.A., 2008 16(2022) (DE-627)579826465 (DE-600)2452969-2 16625129 nnns volume:16 year:2022 https://doi.org/10.3389/fnana.2022.1082701 kostenfrei https://doaj.org/article/dea8ecb30a5e4f0883072926674a01df kostenfrei https://www.frontiersin.org/articles/10.3389/fnana.2022.1082701/full kostenfrei https://doaj.org/toc/1662-5129 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022
allfieldsSound	10.3389/fnana.2022.1082701 doi (DE-627)DOAJ02465079X (DE-599)DOAJdea8ecb30a5e4f0883072926674a01df DE-627 ger DE-627 rakwb eng RC321-571 QM1-695 Juan D. Navarro-López verfasserin aut Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation. classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Human anatomy Ana Contreras verfasserin aut Katia Touyarot verfasserin aut Ana I. Herrero verfasserin aut César Venero verfasserin aut Karine Cambon verfasserin aut Agnés Gruart verfasserin aut José M. Delgado-García verfasserin aut Carmen Sandi verfasserin aut Lydia Jiménez-Díaz verfasserin aut In Frontiers in Neuroanatomy Frontiers Media S.A., 2008 16(2022) (DE-627)579826465 (DE-600)2452969-2 16625129 nnns volume:16 year:2022 https://doi.org/10.3389/fnana.2022.1082701 kostenfrei https://doaj.org/article/dea8ecb30a5e4f0883072926674a01df kostenfrei https://www.frontiersin.org/articles/10.3389/fnana.2022.1082701/full kostenfrei https://doaj.org/toc/1662-5129 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2022
language	English
source	In Frontiers in Neuroanatomy 16(2022) volume:16 year:2022
sourceStr	In Frontiers in Neuroanatomy 16(2022) volume:16 year:2022
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institution	findex.gbv.de
topic_facet	classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Human anatomy
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container_title	Frontiers in Neuroanatomy
authorswithroles_txt_mv	Juan D. Navarro-López @@aut@@ Ana Contreras @@aut@@ Katia Touyarot @@aut@@ Ana I. Herrero @@aut@@ César Venero @@aut@@ Karine Cambon @@aut@@ Agnés Gruart @@aut@@ José M. Delgado-García @@aut@@ Carmen Sandi @@aut@@ Lydia Jiménez-Díaz @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Juan D. Navarro-López
spellingShingle	Juan D. Navarro-López misc RC321-571 misc QM1-695 misc classical eyeblink conditioning misc synaptosomes misc L1 misc NCAM misc PSA-NCAM misc hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Human anatomy Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
authorStr	Juan D. Navarro-López
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topic_title	RC321-571 QM1-695 Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning classical eyeblink conditioning synaptosomes L1 NCAM PSA-NCAM hippocampus
topic	misc RC321-571 misc QM1-695 misc classical eyeblink conditioning misc synaptosomes misc L1 misc NCAM misc PSA-NCAM misc hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Human anatomy
topic_unstemmed	misc RC321-571 misc QM1-695 misc classical eyeblink conditioning misc synaptosomes misc L1 misc NCAM misc PSA-NCAM misc hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Human anatomy
topic_browse	misc RC321-571 misc QM1-695 misc classical eyeblink conditioning misc synaptosomes misc L1 misc NCAM misc PSA-NCAM misc hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Human anatomy
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title	Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
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title_full	Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
author_sort	Juan D. Navarro-López
journal	Frontiers in Neuroanatomy
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author_browse	Juan D. Navarro-López Ana Contreras Katia Touyarot Ana I. Herrero César Venero Karine Cambon Agnés Gruart José M. Delgado-García Carmen Sandi Lydia Jiménez-Díaz
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author-letter	Juan D. Navarro-López
doi_str_mv	10.3389/fnana.2022.1082701
author2-role	verfasserin
title_sort	acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
callnumber	RC321-571
title_auth	Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
abstract	It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation.
abstractGer	It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation.
abstract_unstemmed	It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation.
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title_short	Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
url	https://doi.org/10.3389/fnana.2022.1082701 https://doaj.org/article/dea8ecb30a5e4f0883072926674a01df https://www.frontiersin.org/articles/10.3389/fnana.2022.1082701/full https://doaj.org/toc/1662-5129
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author2	Ana Contreras Katia Touyarot Ana I. Herrero César Venero Karine Cambon Agnés Gruart José M. Delgado-García Carmen Sandi Lydia Jiménez-Díaz
author2Str	Ana Contreras Katia Touyarot Ana I. Herrero César Venero Karine Cambon Agnés Gruart José M. Delgado-García Carmen Sandi Lydia Jiménez-Díaz
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up_date	2024-07-03T23:51:39.912Z
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