Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients

Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS)...
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Autor*in:	Joosep Paats [verfasserIn] Annika Adoberg [verfasserIn] Jürgen Arund [verfasserIn] Annemieke Dhondt [verfasserIn] Anders Fernström [verfasserIn] Ivo Fridolin [verfasserIn] Griet Glorieux [verfasserIn] Liisi Leis [verfasserIn] Merike Luman [verfasserIn] Emilio Gonzalez-Parra [verfasserIn] Vanessa Maria Perez-Gomez [verfasserIn] Kristjan Pilt [verfasserIn] Didier Sanchez-Ospina [verfasserIn] Mårten Segelmark [verfasserIn] Fredrik Uhlin [verfasserIn] Alberto Arduan Ortiz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 4, p 1522
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:4, p 1522

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms21041522

Katalog-ID:	DOAJ024719625

Internformat


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520			\|a Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses.
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allfields	10.3390/ijms21041522 doi (DE-627)DOAJ024719625 (DE-599)DOAJ1554936fe3bb425c9da2975ecc8fe0c1 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Joosep Paats verfasserin aut Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses. uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration Biology (General) Chemistry Annika Adoberg verfasserin aut Jürgen Arund verfasserin aut Annemieke Dhondt verfasserin aut Anders Fernström verfasserin aut Ivo Fridolin verfasserin aut Griet Glorieux verfasserin aut Liisi Leis verfasserin aut Merike Luman verfasserin aut Emilio Gonzalez-Parra verfasserin aut Vanessa Maria Perez-Gomez verfasserin aut Kristjan Pilt verfasserin aut Didier Sanchez-Ospina verfasserin aut Mårten Segelmark verfasserin aut Fredrik Uhlin verfasserin aut Alberto Arduan Ortiz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 4, p 1522 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:4, p 1522 https://doi.org/10.3390/ijms21041522 kostenfrei https://doaj.org/article/1554936fe3bb425c9da2975ecc8fe0c1 kostenfrei https://www.mdpi.com/1422-0067/21/4/1522 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 4, p 1522
spelling	10.3390/ijms21041522 doi (DE-627)DOAJ024719625 (DE-599)DOAJ1554936fe3bb425c9da2975ecc8fe0c1 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Joosep Paats verfasserin aut Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses. uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration Biology (General) Chemistry Annika Adoberg verfasserin aut Jürgen Arund verfasserin aut Annemieke Dhondt verfasserin aut Anders Fernström verfasserin aut Ivo Fridolin verfasserin aut Griet Glorieux verfasserin aut Liisi Leis verfasserin aut Merike Luman verfasserin aut Emilio Gonzalez-Parra verfasserin aut Vanessa Maria Perez-Gomez verfasserin aut Kristjan Pilt verfasserin aut Didier Sanchez-Ospina verfasserin aut Mårten Segelmark verfasserin aut Fredrik Uhlin verfasserin aut Alberto Arduan Ortiz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 4, p 1522 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:4, p 1522 https://doi.org/10.3390/ijms21041522 kostenfrei https://doaj.org/article/1554936fe3bb425c9da2975ecc8fe0c1 kostenfrei https://www.mdpi.com/1422-0067/21/4/1522 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 4, p 1522
allfields_unstemmed	10.3390/ijms21041522 doi (DE-627)DOAJ024719625 (DE-599)DOAJ1554936fe3bb425c9da2975ecc8fe0c1 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Joosep Paats verfasserin aut Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses. uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration Biology (General) Chemistry Annika Adoberg verfasserin aut Jürgen Arund verfasserin aut Annemieke Dhondt verfasserin aut Anders Fernström verfasserin aut Ivo Fridolin verfasserin aut Griet Glorieux verfasserin aut Liisi Leis verfasserin aut Merike Luman verfasserin aut Emilio Gonzalez-Parra verfasserin aut Vanessa Maria Perez-Gomez verfasserin aut Kristjan Pilt verfasserin aut Didier Sanchez-Ospina verfasserin aut Mårten Segelmark verfasserin aut Fredrik Uhlin verfasserin aut Alberto Arduan Ortiz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 4, p 1522 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:4, p 1522 https://doi.org/10.3390/ijms21041522 kostenfrei https://doaj.org/article/1554936fe3bb425c9da2975ecc8fe0c1 kostenfrei https://www.mdpi.com/1422-0067/21/4/1522 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 4, p 1522
allfieldsGer	10.3390/ijms21041522 doi (DE-627)DOAJ024719625 (DE-599)DOAJ1554936fe3bb425c9da2975ecc8fe0c1 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Joosep Paats verfasserin aut Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses. uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration Biology (General) Chemistry Annika Adoberg verfasserin aut Jürgen Arund verfasserin aut Annemieke Dhondt verfasserin aut Anders Fernström verfasserin aut Ivo Fridolin verfasserin aut Griet Glorieux verfasserin aut Liisi Leis verfasserin aut Merike Luman verfasserin aut Emilio Gonzalez-Parra verfasserin aut Vanessa Maria Perez-Gomez verfasserin aut Kristjan Pilt verfasserin aut Didier Sanchez-Ospina verfasserin aut Mårten Segelmark verfasserin aut Fredrik Uhlin verfasserin aut Alberto Arduan Ortiz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 4, p 1522 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:4, p 1522 https://doi.org/10.3390/ijms21041522 kostenfrei https://doaj.org/article/1554936fe3bb425c9da2975ecc8fe0c1 kostenfrei https://www.mdpi.com/1422-0067/21/4/1522 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 4, p 1522
allfieldsSound	10.3390/ijms21041522 doi (DE-627)DOAJ024719625 (DE-599)DOAJ1554936fe3bb425c9da2975ecc8fe0c1 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Joosep Paats verfasserin aut Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses. uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration Biology (General) Chemistry Annika Adoberg verfasserin aut Jürgen Arund verfasserin aut Annemieke Dhondt verfasserin aut Anders Fernström verfasserin aut Ivo Fridolin verfasserin aut Griet Glorieux verfasserin aut Liisi Leis verfasserin aut Merike Luman verfasserin aut Emilio Gonzalez-Parra verfasserin aut Vanessa Maria Perez-Gomez verfasserin aut Kristjan Pilt verfasserin aut Didier Sanchez-Ospina verfasserin aut Mårten Segelmark verfasserin aut Fredrik Uhlin verfasserin aut Alberto Arduan Ortiz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 4, p 1522 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:4, p 1522 https://doi.org/10.3390/ijms21041522 kostenfrei https://doaj.org/article/1554936fe3bb425c9da2975ecc8fe0c1 kostenfrei https://www.mdpi.com/1422-0067/21/4/1522 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 4, p 1522
language	English
source	In International Journal of Molecular Sciences 21(2020), 4, p 1522 volume:21 year:2020 number:4, p 1522
sourceStr	In International Journal of Molecular Sciences 21(2020), 4, p 1522 volume:21 year:2020 number:4, p 1522
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Joosep Paats @@aut@@ Annika Adoberg @@aut@@ Jürgen Arund @@aut@@ Annemieke Dhondt @@aut@@ Anders Fernström @@aut@@ Ivo Fridolin @@aut@@ Griet Glorieux @@aut@@ Liisi Leis @@aut@@ Merike Luman @@aut@@ Emilio Gonzalez-Parra @@aut@@ Vanessa Maria Perez-Gomez @@aut@@ Kristjan Pilt @@aut@@ Didier Sanchez-Ospina @@aut@@ Mårten Segelmark @@aut@@ Fredrik Uhlin @@aut@@ Alberto Arduan Ortiz @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ024719625
language_de	englisch
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callnumber-first	Q - Science
author	Joosep Paats
spellingShingle	Joosep Paats misc QH301-705.5 misc QD1-999 misc uremic toxins misc tryptophan misc tryptophan-derived uremic toxins misc indoxyl sulfate misc indole-3 acetic acid misc end-stage kidney disease misc chronic kidney disease misc haemodialysis misc haemodiafiltration misc Biology (General) misc Chemistry Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients
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topic_title	QH301-705.5 QD1-999 Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients uremic toxins tryptophan tryptophan-derived uremic toxins indoxyl sulfate indole-3 acetic acid end-stage kidney disease chronic kidney disease haemodialysis haemodiafiltration
topic	misc QH301-705.5 misc QD1-999 misc uremic toxins misc tryptophan misc tryptophan-derived uremic toxins misc indoxyl sulfate misc indole-3 acetic acid misc end-stage kidney disease misc chronic kidney disease misc haemodialysis misc haemodiafiltration misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc uremic toxins misc tryptophan misc tryptophan-derived uremic toxins misc indoxyl sulfate misc indole-3 acetic acid misc end-stage kidney disease misc chronic kidney disease misc haemodialysis misc haemodiafiltration misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc uremic toxins misc tryptophan misc tryptophan-derived uremic toxins misc indoxyl sulfate misc indole-3 acetic acid misc end-stage kidney disease misc chronic kidney disease misc haemodialysis misc haemodiafiltration misc Biology (General) misc Chemistry
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title	Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients
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title_full	Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients
author_sort	Joosep Paats
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author_browse	Joosep Paats Annika Adoberg Jürgen Arund Annemieke Dhondt Anders Fernström Ivo Fridolin Griet Glorieux Liisi Leis Merike Luman Emilio Gonzalez-Parra Vanessa Maria Perez-Gomez Kristjan Pilt Didier Sanchez-Ospina Mårten Segelmark Fredrik Uhlin Alberto Arduan Ortiz
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title_sort	serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in eskd patients
callnumber	QH301-705.5
title_auth	Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients
abstract	Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses.
abstractGer	Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses.
abstract_unstemmed	Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, −0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (−72%, −39%, −43%, respectively), serum tryptophan levels increased, resulting in negative RR (−8%) towards the end of the dialysis session (<i<p</i< < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (<i<p</i< < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses.
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title_short	Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients
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