Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial

Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and per...
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Gespeichert in:

Autor*in:	Robert Hüneburg [verfasserIn] Guido Kukuk [verfasserIn] Jacob Nattermann [verfasserIn] Christoph Endler [verfasserIn] Arndt-Hendrik Penner [verfasserIn] Karsten Wolter [verfasserIn] Hans Schild [verfasserIn] Christian Strassburg [verfasserIn] Tilman Sauerbruch [verfasserIn] Volker Schmitz [verfasserIn] Winfried Willinek [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: Endoscopy International Open - Georg Thieme Verlag KG, 2014, 04(2016), 02, Seite E164-E169
Übergeordnetes Werk:	volume:04 ; year:2016 ; number:02 ; pages:E164-E169

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1055/s-0041-111501

Katalog-ID:	DOAJ024870935

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520			\|a Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes.
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allfields	10.1055/s-0041-111501 doi (DE-627)DOAJ024870935 (DE-599)DOAJ4365da0ed5194e7db94142425e4e1297 DE-627 ger DE-627 rakwb eng RC799-869 Robert Hüneburg verfasserin aut Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes. Diseases of the digestive system. Gastroenterology Guido Kukuk verfasserin aut Jacob Nattermann verfasserin aut Christoph Endler verfasserin aut Arndt-Hendrik Penner verfasserin aut Karsten Wolter verfasserin aut Hans Schild verfasserin aut Christian Strassburg verfasserin aut Tilman Sauerbruch verfasserin aut Volker Schmitz verfasserin aut Winfried Willinek verfasserin aut In Endoscopy International Open Georg Thieme Verlag KG, 2014 04(2016), 02, Seite E164-E169 (DE-627)780383214 (DE-600)2761052-4 21969736 nnns volume:04 year:2016 number:02 pages:E164-E169 https://doi.org/10.1055/s-0041-111501 kostenfrei https://doaj.org/article/4365da0ed5194e7db94142425e4e1297 kostenfrei http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-111501 kostenfrei https://doaj.org/toc/2364-3722 Journal toc kostenfrei https://doaj.org/toc/2196-9736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2016 02 E164-E169
spelling	10.1055/s-0041-111501 doi (DE-627)DOAJ024870935 (DE-599)DOAJ4365da0ed5194e7db94142425e4e1297 DE-627 ger DE-627 rakwb eng RC799-869 Robert Hüneburg verfasserin aut Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes. Diseases of the digestive system. Gastroenterology Guido Kukuk verfasserin aut Jacob Nattermann verfasserin aut Christoph Endler verfasserin aut Arndt-Hendrik Penner verfasserin aut Karsten Wolter verfasserin aut Hans Schild verfasserin aut Christian Strassburg verfasserin aut Tilman Sauerbruch verfasserin aut Volker Schmitz verfasserin aut Winfried Willinek verfasserin aut In Endoscopy International Open Georg Thieme Verlag KG, 2014 04(2016), 02, Seite E164-E169 (DE-627)780383214 (DE-600)2761052-4 21969736 nnns volume:04 year:2016 number:02 pages:E164-E169 https://doi.org/10.1055/s-0041-111501 kostenfrei https://doaj.org/article/4365da0ed5194e7db94142425e4e1297 kostenfrei http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-111501 kostenfrei https://doaj.org/toc/2364-3722 Journal toc kostenfrei https://doaj.org/toc/2196-9736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2016 02 E164-E169
allfields_unstemmed	10.1055/s-0041-111501 doi (DE-627)DOAJ024870935 (DE-599)DOAJ4365da0ed5194e7db94142425e4e1297 DE-627 ger DE-627 rakwb eng RC799-869 Robert Hüneburg verfasserin aut Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes. Diseases of the digestive system. Gastroenterology Guido Kukuk verfasserin aut Jacob Nattermann verfasserin aut Christoph Endler verfasserin aut Arndt-Hendrik Penner verfasserin aut Karsten Wolter verfasserin aut Hans Schild verfasserin aut Christian Strassburg verfasserin aut Tilman Sauerbruch verfasserin aut Volker Schmitz verfasserin aut Winfried Willinek verfasserin aut In Endoscopy International Open Georg Thieme Verlag KG, 2014 04(2016), 02, Seite E164-E169 (DE-627)780383214 (DE-600)2761052-4 21969736 nnns volume:04 year:2016 number:02 pages:E164-E169 https://doi.org/10.1055/s-0041-111501 kostenfrei https://doaj.org/article/4365da0ed5194e7db94142425e4e1297 kostenfrei http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-111501 kostenfrei https://doaj.org/toc/2364-3722 Journal toc kostenfrei https://doaj.org/toc/2196-9736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2016 02 E164-E169
allfieldsGer	10.1055/s-0041-111501 doi (DE-627)DOAJ024870935 (DE-599)DOAJ4365da0ed5194e7db94142425e4e1297 DE-627 ger DE-627 rakwb eng RC799-869 Robert Hüneburg verfasserin aut Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes. Diseases of the digestive system. Gastroenterology Guido Kukuk verfasserin aut Jacob Nattermann verfasserin aut Christoph Endler verfasserin aut Arndt-Hendrik Penner verfasserin aut Karsten Wolter verfasserin aut Hans Schild verfasserin aut Christian Strassburg verfasserin aut Tilman Sauerbruch verfasserin aut Volker Schmitz verfasserin aut Winfried Willinek verfasserin aut In Endoscopy International Open Georg Thieme Verlag KG, 2014 04(2016), 02, Seite E164-E169 (DE-627)780383214 (DE-600)2761052-4 21969736 nnns volume:04 year:2016 number:02 pages:E164-E169 https://doi.org/10.1055/s-0041-111501 kostenfrei https://doaj.org/article/4365da0ed5194e7db94142425e4e1297 kostenfrei http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-111501 kostenfrei https://doaj.org/toc/2364-3722 Journal toc kostenfrei https://doaj.org/toc/2196-9736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2016 02 E164-E169
allfieldsSound	10.1055/s-0041-111501 doi (DE-627)DOAJ024870935 (DE-599)DOAJ4365da0ed5194e7db94142425e4e1297 DE-627 ger DE-627 rakwb eng RC799-869 Robert Hüneburg verfasserin aut Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes. Diseases of the digestive system. Gastroenterology Guido Kukuk verfasserin aut Jacob Nattermann verfasserin aut Christoph Endler verfasserin aut Arndt-Hendrik Penner verfasserin aut Karsten Wolter verfasserin aut Hans Schild verfasserin aut Christian Strassburg verfasserin aut Tilman Sauerbruch verfasserin aut Volker Schmitz verfasserin aut Winfried Willinek verfasserin aut In Endoscopy International Open Georg Thieme Verlag KG, 2014 04(2016), 02, Seite E164-E169 (DE-627)780383214 (DE-600)2761052-4 21969736 nnns volume:04 year:2016 number:02 pages:E164-E169 https://doi.org/10.1055/s-0041-111501 kostenfrei https://doaj.org/article/4365da0ed5194e7db94142425e4e1297 kostenfrei http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-111501 kostenfrei https://doaj.org/toc/2364-3722 Journal toc kostenfrei https://doaj.org/toc/2196-9736 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 04 2016 02 E164-E169
language	English
source	In Endoscopy International Open 04(2016), 02, Seite E164-E169 volume:04 year:2016 number:02 pages:E164-E169
sourceStr	In Endoscopy International Open 04(2016), 02, Seite E164-E169 volume:04 year:2016 number:02 pages:E164-E169
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the digestive system. Gastroenterology
isfreeaccess_bool	true
container_title	Endoscopy International Open
authorswithroles_txt_mv	Robert Hüneburg @@aut@@ Guido Kukuk @@aut@@ Jacob Nattermann @@aut@@ Christoph Endler @@aut@@ Arndt-Hendrik Penner @@aut@@ Karsten Wolter @@aut@@ Hans Schild @@aut@@ Christian Strassburg @@aut@@ Tilman Sauerbruch @@aut@@ Volker Schmitz @@aut@@ Winfried Willinek @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	780383214
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author	Robert Hüneburg
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topic_title	RC799-869 Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
topic	misc RC799-869 misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc Diseases of the digestive system. Gastroenterology
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title	Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
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title_full	Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
author_sort	Robert Hüneburg
journal	Endoscopy International Open
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author_browse	Robert Hüneburg Guido Kukuk Jacob Nattermann Christoph Endler Arndt-Hendrik Penner Karsten Wolter Hans Schild Christian Strassburg Tilman Sauerbruch Volker Schmitz Winfried Willinek
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title_sort	colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
callnumber	RC799-869
title_auth	Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
abstract	Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes.
abstractGer	Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes.
abstract_unstemmed	Background and study aims: Colorectal cancer (CRC) is one of the most common cancers worldwide, and several efforts have been made to reduce its occurrence or severity. Although colonoscopy is considered the gold standard in CRC prevention, it has its disadvantages: missed lesions, bleeding, and perforation. Furthermore, a high number of patients undergo this procedure even though no polyps are detected. Therefore, an initial screening examination may be warranted. Our aim was to compare the adenoma detection rate of magnetic resonance colonography (MRC) with that of optical colonoscopy. Patients and methods: A total of 25 patients with an intermediate risk for CRC (17 men, 8 women; mean age 57.6, standard deviation 11) underwent MRC with a 3.0-tesla magnet, followed by colonoscopy. The endoscopist was initially blinded to the results of MRC and unblinded immediately after examining the distal rectum. Following endoscopic excision, the size, anatomical localization, and appearance of all polyps were described according to the Paris classification. Results: A total of 93 lesions were detected during colonoscopy. These included a malignant infiltration of the transverse colon due to gastric cancer in 1 patient, 28 adenomas in 10 patients, 19 hyperplastic polyps in 9 patients, and 45 non-neoplastic lesions. In 5 patients, no lesion was detected. MRC detected significantly fewer lesions: 1 adenoma (P = 0.001) and 1 hyperplastic polyp (P = 0.004). The malignant infiltration was seen with both modalities. Of the 28 adenomas, 23 (82 %) were 5 mm or smaller; only 4 adenomas 10 mm or larger (14 %) were detected. Conclusion: MRC does not detect adenomas sufficiently independently of the location of the lesion. Even advanced lesions were missed. Therefore, colonoscopy should still be considered the current gold standard, even for diagnostic purposes.
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container_issue	02
title_short	Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial
url	https://doi.org/10.1055/s-0041-111501 https://doaj.org/article/4365da0ed5194e7db94142425e4e1297 http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-111501 https://doaj.org/toc/2364-3722 https://doaj.org/toc/2196-9736
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author2	Guido Kukuk Jacob Nattermann Christoph Endler Arndt-Hendrik Penner Karsten Wolter Hans Schild Christian Strassburg Tilman Sauerbruch Volker Schmitz Winfried Willinek
author2Str	Guido Kukuk Jacob Nattermann Christoph Endler Arndt-Hendrik Penner Karsten Wolter Hans Schild Christian Strassburg Tilman Sauerbruch Volker Schmitz Winfried Willinek
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