Current and emerging therapies in multiple sclerosis: a systematic review

Multiple sclerosis (MS) is a potentially disabling chronic autoimmune neurological disease that mainly affects young adults. Our understanding of the pathophysiology of MS has significantly advanced in the past quarter of a century. This has led to the development of many disease-modifying therapies...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Wanda Castro-Borrero [verfasserIn] Donna Graves [verfasserIn] Teresa C. Frohman [verfasserIn] Angela Bates Flores [verfasserIn] Paula Hardeman [verfasserIn] Diana Logan [verfasserIn] Megan Orchard [verfasserIn] Benjamin Greenberg [verfasserIn] Elliot M. Frohman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Übergeordnetes Werk:	In: Therapeutic Advances in Neurological Disorders - SAGE Publishing, 2018, 5(2012)
Übergeordnetes Werk:	volume:5 ; year:2012

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1177/1756285612450936

Katalog-ID:	DOAJ024871966

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authorswithroles_txt_mv	Wanda Castro-Borrero @@aut@@ Donna Graves @@aut@@ Teresa C. Frohman @@aut@@ Angela Bates Flores @@aut@@ Paula Hardeman @@aut@@ Diana Logan @@aut@@ Megan Orchard @@aut@@ Benjamin Greenberg @@aut@@ Elliot M. Frohman @@aut@@
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topic_title	RC346-429 Current and emerging therapies in multiple sclerosis: a systematic review
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title	Current and emerging therapies in multiple sclerosis: a systematic review
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title_auth	Current and emerging therapies in multiple sclerosis: a systematic review
abstract	Multiple sclerosis (MS) is a potentially disabling chronic autoimmune neurological disease that mainly affects young adults. Our understanding of the pathophysiology of MS has significantly advanced in the past quarter of a century. This has led to the development of many disease-modifying therapies (DMTs) that prevent exacerbations and new lesions in patients with relapsing remitting MS (RRMS). So far there is no drug available that can completely halt the neurodegenerative changes associated with the disease. It is the purpose of this review to provide concise information regarding mechanism of action, indications, side effects and safety of Food and Drug Administration and European Medicines Agency approved agents for MS, emerging therapies, and drugs that can be considered for off-label use in MS.
abstractGer	Multiple sclerosis (MS) is a potentially disabling chronic autoimmune neurological disease that mainly affects young adults. Our understanding of the pathophysiology of MS has significantly advanced in the past quarter of a century. This has led to the development of many disease-modifying therapies (DMTs) that prevent exacerbations and new lesions in patients with relapsing remitting MS (RRMS). So far there is no drug available that can completely halt the neurodegenerative changes associated with the disease. It is the purpose of this review to provide concise information regarding mechanism of action, indications, side effects and safety of Food and Drug Administration and European Medicines Agency approved agents for MS, emerging therapies, and drugs that can be considered for off-label use in MS.
abstract_unstemmed	Multiple sclerosis (MS) is a potentially disabling chronic autoimmune neurological disease that mainly affects young adults. Our understanding of the pathophysiology of MS has significantly advanced in the past quarter of a century. This has led to the development of many disease-modifying therapies (DMTs) that prevent exacerbations and new lesions in patients with relapsing remitting MS (RRMS). So far there is no drug available that can completely halt the neurodegenerative changes associated with the disease. It is the purpose of this review to provide concise information regarding mechanism of action, indications, side effects and safety of Food and Drug Administration and European Medicines Agency approved agents for MS, emerging therapies, and drugs that can be considered for off-label use in MS.
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title_short	Current and emerging therapies in multiple sclerosis: a systematic review
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