CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study

Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical ca...
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Autor*in:	Xiaoting Huang [verfasserIn] Wei Liu [verfasserIn] Chunshan Liu [verfasserIn] Jijie Hu [verfasserIn] Baiyao Wang [verfasserIn] Anbang Ren [verfasserIn] Xiaona Huang [verfasserIn] Yawei Yuan [verfasserIn] Jinquan Liu [verfasserIn] Mingyi Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	CMTM6 cervical cancer proliferation migration MAPK signaling

Übergeordnetes Werk:	In: Frontiers in Molecular Biosciences - Frontiers Media S.A., 2015, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmolb.2022.983410

Katalog-ID:	DOAJ024893013

Internformat


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520			\|a Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer.
650		4	\|a CMTM6
650		4	\|a cervical cancer
650		4	\|a proliferation
650		4	\|a migration
650		4	\|a MAPK signaling
653		0	\|a Biology (General)
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700	0		\|a Chunshan Liu \|e verfasserin \|4 aut
700	0		\|a Jijie Hu \|e verfasserin \|4 aut
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700	0		\|a Jinquan Liu \|e verfasserin \|4 aut
700	0		\|a Jinquan Liu \|e verfasserin \|4 aut
700	0		\|a Mingyi Li \|e verfasserin \|4 aut
700	0		\|a Mingyi Li \|e verfasserin \|4 aut
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author_variant	x h xh x h xh w l wl w l wl c l cl c l cl j h jh b w bw b w bw a r ar a r ar x h xh y y yy y y yy j l jl j l jl m l ml m l ml
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allfields	10.3389/fmolb.2022.983410 doi (DE-627)DOAJ024893013 (DE-599)DOAJ0ac50742d3f64d65bbfbbc186834590b DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoting Huang verfasserin aut CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer. CMTM6 cervical cancer proliferation migration MAPK signaling Biology (General) Xiaoting Huang verfasserin aut Wei Liu verfasserin aut Wei Liu verfasserin aut Chunshan Liu verfasserin aut Chunshan Liu verfasserin aut Jijie Hu verfasserin aut Baiyao Wang verfasserin aut Baiyao Wang verfasserin aut Anbang Ren verfasserin aut Anbang Ren verfasserin aut Xiaona Huang verfasserin aut Yawei Yuan verfasserin aut Yawei Yuan verfasserin aut Jinquan Liu verfasserin aut Jinquan Liu verfasserin aut Mingyi Li verfasserin aut Mingyi Li verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 9(2022) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:9 year:2022 https://doi.org/10.3389/fmolb.2022.983410 kostenfrei https://doaj.org/article/0ac50742d3f64d65bbfbbc186834590b kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2022.983410/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
spelling	10.3389/fmolb.2022.983410 doi (DE-627)DOAJ024893013 (DE-599)DOAJ0ac50742d3f64d65bbfbbc186834590b DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoting Huang verfasserin aut CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer. CMTM6 cervical cancer proliferation migration MAPK signaling Biology (General) Xiaoting Huang verfasserin aut Wei Liu verfasserin aut Wei Liu verfasserin aut Chunshan Liu verfasserin aut Chunshan Liu verfasserin aut Jijie Hu verfasserin aut Baiyao Wang verfasserin aut Baiyao Wang verfasserin aut Anbang Ren verfasserin aut Anbang Ren verfasserin aut Xiaona Huang verfasserin aut Yawei Yuan verfasserin aut Yawei Yuan verfasserin aut Jinquan Liu verfasserin aut Jinquan Liu verfasserin aut Mingyi Li verfasserin aut Mingyi Li verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 9(2022) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:9 year:2022 https://doi.org/10.3389/fmolb.2022.983410 kostenfrei https://doaj.org/article/0ac50742d3f64d65bbfbbc186834590b kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2022.983410/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfields_unstemmed	10.3389/fmolb.2022.983410 doi (DE-627)DOAJ024893013 (DE-599)DOAJ0ac50742d3f64d65bbfbbc186834590b DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoting Huang verfasserin aut CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer. CMTM6 cervical cancer proliferation migration MAPK signaling Biology (General) Xiaoting Huang verfasserin aut Wei Liu verfasserin aut Wei Liu verfasserin aut Chunshan Liu verfasserin aut Chunshan Liu verfasserin aut Jijie Hu verfasserin aut Baiyao Wang verfasserin aut Baiyao Wang verfasserin aut Anbang Ren verfasserin aut Anbang Ren verfasserin aut Xiaona Huang verfasserin aut Yawei Yuan verfasserin aut Yawei Yuan verfasserin aut Jinquan Liu verfasserin aut Jinquan Liu verfasserin aut Mingyi Li verfasserin aut Mingyi Li verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 9(2022) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:9 year:2022 https://doi.org/10.3389/fmolb.2022.983410 kostenfrei https://doaj.org/article/0ac50742d3f64d65bbfbbc186834590b kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2022.983410/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsGer	10.3389/fmolb.2022.983410 doi (DE-627)DOAJ024893013 (DE-599)DOAJ0ac50742d3f64d65bbfbbc186834590b DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoting Huang verfasserin aut CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer. CMTM6 cervical cancer proliferation migration MAPK signaling Biology (General) Xiaoting Huang verfasserin aut Wei Liu verfasserin aut Wei Liu verfasserin aut Chunshan Liu verfasserin aut Chunshan Liu verfasserin aut Jijie Hu verfasserin aut Baiyao Wang verfasserin aut Baiyao Wang verfasserin aut Anbang Ren verfasserin aut Anbang Ren verfasserin aut Xiaona Huang verfasserin aut Yawei Yuan verfasserin aut Yawei Yuan verfasserin aut Jinquan Liu verfasserin aut Jinquan Liu verfasserin aut Mingyi Li verfasserin aut Mingyi Li verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 9(2022) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:9 year:2022 https://doi.org/10.3389/fmolb.2022.983410 kostenfrei https://doaj.org/article/0ac50742d3f64d65bbfbbc186834590b kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2022.983410/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsSound	10.3389/fmolb.2022.983410 doi (DE-627)DOAJ024893013 (DE-599)DOAJ0ac50742d3f64d65bbfbbc186834590b DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoting Huang verfasserin aut CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer. CMTM6 cervical cancer proliferation migration MAPK signaling Biology (General) Xiaoting Huang verfasserin aut Wei Liu verfasserin aut Wei Liu verfasserin aut Chunshan Liu verfasserin aut Chunshan Liu verfasserin aut Jijie Hu verfasserin aut Baiyao Wang verfasserin aut Baiyao Wang verfasserin aut Anbang Ren verfasserin aut Anbang Ren verfasserin aut Xiaona Huang verfasserin aut Yawei Yuan verfasserin aut Yawei Yuan verfasserin aut Jinquan Liu verfasserin aut Jinquan Liu verfasserin aut Mingyi Li verfasserin aut Mingyi Li verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 9(2022) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:9 year:2022 https://doi.org/10.3389/fmolb.2022.983410 kostenfrei https://doaj.org/article/0ac50742d3f64d65bbfbbc186834590b kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2022.983410/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
language	English
source	In Frontiers in Molecular Biosciences 9(2022) volume:9 year:2022
sourceStr	In Frontiers in Molecular Biosciences 9(2022) volume:9 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CMTM6 cervical cancer proliferation migration MAPK signaling Biology (General)
isfreeaccess_bool	true
container_title	Frontiers in Molecular Biosciences
authorswithroles_txt_mv	Xiaoting Huang @@aut@@ Wei Liu @@aut@@ Chunshan Liu @@aut@@ Jijie Hu @@aut@@ Baiyao Wang @@aut@@ Anbang Ren @@aut@@ Xiaona Huang @@aut@@ Yawei Yuan @@aut@@ Jinquan Liu @@aut@@ Mingyi Li @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	820039691
id	DOAJ024893013
language_de	englisch
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callnumber-first	Q - Science
author	Xiaoting Huang
spellingShingle	Xiaoting Huang misc QH301-705.5 misc CMTM6 misc cervical cancer misc proliferation misc migration misc MAPK signaling misc Biology (General) CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study
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topic_title	QH301-705.5 CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study CMTM6 cervical cancer proliferation migration MAPK signaling
topic	misc QH301-705.5 misc CMTM6 misc cervical cancer misc proliferation misc migration misc MAPK signaling misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc CMTM6 misc cervical cancer misc proliferation misc migration misc MAPK signaling misc Biology (General)
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title	CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study
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title_full	CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study
author_sort	Xiaoting Huang
journal	Frontiers in Molecular Biosciences
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author_browse	Xiaoting Huang Wei Liu Chunshan Liu Jijie Hu Baiyao Wang Anbang Ren Xiaona Huang Yawei Yuan Jinquan Liu Mingyi Li
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title_sort	cmtm6 as a candidate risk gene for cervical cancer: comprehensive bioinformatics study
callnumber	QH301-705.5
title_auth	CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study
abstract	Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer.
abstractGer	Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer.
abstract_unstemmed	Background: CKLF like MARVEL transmembrane domain containing 6 (CMTM6) is an important programmed cell death 1 ligand 1 regulator (PD-L1). CMTM6 was reported as an important regulator of PD-L1 by promoting PD-L1 expression in tumor cells against T cells. However, the function of CMTM6 in cervical cancer is not well characterized. In addition, the role of CMTM6 in the induction of epithelial-mesenchymal transition (EMT) in the context of cervical cancer is unknown.Methods: In this study, we evaluated the role of CMTM6, including gene expression analysis, miRNA target regulation, and methylation characteristic, using multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database. The expression of CMTM6 in cervical cancer tissues and non-cancerous adjacent tissues was assessed using immunohistochemistry. In vitro and in vivo function experiments were performed to explore the effects of CMTM6 on growth and metastasis of cervical cancer.Results: Human cervical cancer tissues showed higher expression of CMTM6 than the adjacent non-cancerous tissues. In vitro assays showed that CMTM6 promoted cervical cancer cell invasion, migration, proliferation, and epithelial-mesenchymal transition via activation of mitogen-activated protein kinase (MAPK) c-jun N-terminal kinase (JNK)/p38 signaling pathway. We identified transcription factors (TFs), miRNAs, and immune cells that may interact with CMTM6.Conclusion: These results indicate that CMTM6 is a potential therapeutic target in the context of cervical cancer.
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title_short	CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study
url	https://doi.org/10.3389/fmolb.2022.983410 https://doaj.org/article/0ac50742d3f64d65bbfbbc186834590b https://www.frontiersin.org/articles/10.3389/fmolb.2022.983410/full https://doaj.org/toc/2296-889X
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author2	Xiaoting Huang Wei Liu Chunshan Liu Jijie Hu Baiyao Wang Anbang Ren Xiaona Huang Yawei Yuan Jinquan Liu Mingyi Li
author2Str	Xiaoting Huang Wei Liu Chunshan Liu Jijie Hu Baiyao Wang Anbang Ren Xiaona Huang Yawei Yuan Jinquan Liu Mingyi Li
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up_date	2024-07-04T00:47:37.222Z
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