Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus?
Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucid...
Ausführliche Beschreibung
Autor*in: |
Youn Hee Cho [verfasserIn] Bong Min Ko [verfasserIn] Shin Hee Kim [verfasserIn] Yu Sik Myung [verfasserIn] Jong Hyo Choi [verfasserIn] Jae Pil Han [verfasserIn] Su Jin Hong [verfasserIn] Seong Ran Jeon [verfasserIn] Hyun Gun Kim [verfasserIn] Jin Oh Kim [verfasserIn] Moon Sung Lee [verfasserIn] |
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E-Artikel |
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Englisch |
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2014 |
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In: Intestinal Research - Korean Association for the Study of Intestinal Diseases, 2017, 12(2014), 2, Seite 139-145 |
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Übergeordnetes Werk: |
volume:12 ; year:2014 ; number:2 ; pages:139-145 |
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Link aufrufen |
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DOI / URN: |
10.5217/ir.2014.12.2.139 |
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Katalog-ID: |
DOAJ024931527 |
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520 | |a Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. | ||
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10.5217/ir.2014.12.2.139 doi (DE-627)DOAJ024931527 (DE-599)DOAJ2e7d983f7afb43ec8ae840b2f95efbce DE-627 ger DE-627 rakwb eng RC799-869 Youn Hee Cho verfasserin aut Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. Colon adenoma Adenoma detection rate Polyp detection rate Metformin Diabetes mellitus, type 2 Medicine R Diseases of the digestive system. Gastroenterology Bong Min Ko verfasserin aut Shin Hee Kim verfasserin aut Yu Sik Myung verfasserin aut Jong Hyo Choi verfasserin aut Jae Pil Han verfasserin aut Su Jin Hong verfasserin aut Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jin Oh Kim verfasserin aut Moon Sung Lee verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 12(2014), 2, Seite 139-145 (DE-627)1696048168 22881956 nnns volume:12 year:2014 number:2 pages:139-145 https://doi.org/10.5217/ir.2014.12.2.139 kostenfrei https://doaj.org/article/2e7d983f7afb43ec8ae840b2f95efbce kostenfrei http://www.irjournal.org/upload/pdf/ir-12-139.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 2 139-145 |
spelling |
10.5217/ir.2014.12.2.139 doi (DE-627)DOAJ024931527 (DE-599)DOAJ2e7d983f7afb43ec8ae840b2f95efbce DE-627 ger DE-627 rakwb eng RC799-869 Youn Hee Cho verfasserin aut Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. Colon adenoma Adenoma detection rate Polyp detection rate Metformin Diabetes mellitus, type 2 Medicine R Diseases of the digestive system. Gastroenterology Bong Min Ko verfasserin aut Shin Hee Kim verfasserin aut Yu Sik Myung verfasserin aut Jong Hyo Choi verfasserin aut Jae Pil Han verfasserin aut Su Jin Hong verfasserin aut Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jin Oh Kim verfasserin aut Moon Sung Lee verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 12(2014), 2, Seite 139-145 (DE-627)1696048168 22881956 nnns volume:12 year:2014 number:2 pages:139-145 https://doi.org/10.5217/ir.2014.12.2.139 kostenfrei https://doaj.org/article/2e7d983f7afb43ec8ae840b2f95efbce kostenfrei http://www.irjournal.org/upload/pdf/ir-12-139.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 2 139-145 |
allfields_unstemmed |
10.5217/ir.2014.12.2.139 doi (DE-627)DOAJ024931527 (DE-599)DOAJ2e7d983f7afb43ec8ae840b2f95efbce DE-627 ger DE-627 rakwb eng RC799-869 Youn Hee Cho verfasserin aut Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. Colon adenoma Adenoma detection rate Polyp detection rate Metformin Diabetes mellitus, type 2 Medicine R Diseases of the digestive system. Gastroenterology Bong Min Ko verfasserin aut Shin Hee Kim verfasserin aut Yu Sik Myung verfasserin aut Jong Hyo Choi verfasserin aut Jae Pil Han verfasserin aut Su Jin Hong verfasserin aut Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jin Oh Kim verfasserin aut Moon Sung Lee verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 12(2014), 2, Seite 139-145 (DE-627)1696048168 22881956 nnns volume:12 year:2014 number:2 pages:139-145 https://doi.org/10.5217/ir.2014.12.2.139 kostenfrei https://doaj.org/article/2e7d983f7afb43ec8ae840b2f95efbce kostenfrei http://www.irjournal.org/upload/pdf/ir-12-139.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 2 139-145 |
allfieldsGer |
10.5217/ir.2014.12.2.139 doi (DE-627)DOAJ024931527 (DE-599)DOAJ2e7d983f7afb43ec8ae840b2f95efbce DE-627 ger DE-627 rakwb eng RC799-869 Youn Hee Cho verfasserin aut Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. Colon adenoma Adenoma detection rate Polyp detection rate Metformin Diabetes mellitus, type 2 Medicine R Diseases of the digestive system. Gastroenterology Bong Min Ko verfasserin aut Shin Hee Kim verfasserin aut Yu Sik Myung verfasserin aut Jong Hyo Choi verfasserin aut Jae Pil Han verfasserin aut Su Jin Hong verfasserin aut Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jin Oh Kim verfasserin aut Moon Sung Lee verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 12(2014), 2, Seite 139-145 (DE-627)1696048168 22881956 nnns volume:12 year:2014 number:2 pages:139-145 https://doi.org/10.5217/ir.2014.12.2.139 kostenfrei https://doaj.org/article/2e7d983f7afb43ec8ae840b2f95efbce kostenfrei http://www.irjournal.org/upload/pdf/ir-12-139.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 2 139-145 |
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10.5217/ir.2014.12.2.139 doi (DE-627)DOAJ024931527 (DE-599)DOAJ2e7d983f7afb43ec8ae840b2f95efbce DE-627 ger DE-627 rakwb eng RC799-869 Youn Hee Cho verfasserin aut Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. Colon adenoma Adenoma detection rate Polyp detection rate Metformin Diabetes mellitus, type 2 Medicine R Diseases of the digestive system. Gastroenterology Bong Min Ko verfasserin aut Shin Hee Kim verfasserin aut Yu Sik Myung verfasserin aut Jong Hyo Choi verfasserin aut Jae Pil Han verfasserin aut Su Jin Hong verfasserin aut Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jin Oh Kim verfasserin aut Moon Sung Lee verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 12(2014), 2, Seite 139-145 (DE-627)1696048168 22881956 nnns volume:12 year:2014 number:2 pages:139-145 https://doi.org/10.5217/ir.2014.12.2.139 kostenfrei https://doaj.org/article/2e7d983f7afb43ec8ae840b2f95efbce kostenfrei http://www.irjournal.org/upload/pdf/ir-12-139.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 2 139-145 |
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does metformin affect the incidence of colonic polyps and adenomas in patients with type 2 diabetes mellitus? |
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RC799-869 |
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Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? |
abstract |
Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. |
abstractGer |
Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. |
abstract_unstemmed |
Background/AimsColorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associated with a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the development of colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomas in patients with type 2 DM.MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May 2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metformin use and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the two groups were analyzed retrospectively.ResultsThe Colorectal polyp detection rate was lower in the metformin group than in the non-meformin group (39.4% vs. 62.4%, P<0.01). Colorectal adenoma detection rate was significantly lower in the metformin group than in the non-metformin group (15.2% vs. 20.5%, P<0.01). Fewer advanced adenomas were detected in the metformin group than in the non-metformin group (12.2% vs. 22%, P<0.01). Multivariate analysis identified age, sex, Body mass index and metformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreased adenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P=0.03).ConclusionsIn patients with type 2 DM, metformin reduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the prevention of CRC in patients with type 2 DM. |
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Does Metformin Affect The Incidence of Colonic Polyps and Adenomas in Patients with Type 2 Diabetes Mellitus? |
url |
https://doi.org/10.5217/ir.2014.12.2.139 https://doaj.org/article/2e7d983f7afb43ec8ae840b2f95efbce http://www.irjournal.org/upload/pdf/ir-12-139.pdf https://doaj.org/toc/1598-9100 https://doaj.org/toc/2288-1956 |
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Bong Min Ko Shin Hee Kim Yu Sik Myung Jong Hyo Choi Jae Pil Han Su Jin Hong Seong Ran Jeon Hyun Gun Kim Jin Oh Kim Moon Sung Lee |
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Bong Min Ko Shin Hee Kim Yu Sik Myung Jong Hyo Choi Jae Pil Han Su Jin Hong Seong Ran Jeon Hyun Gun Kim Jin Oh Kim Moon Sung Lee |
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up_date |
2024-07-04T00:56:42.693Z |
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