Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study

Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral...
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Autor*in:	Lasse S. Madsen [verfasserIn] Rune B. Nielsen [verfasserIn] Peter Parbo [verfasserIn] Rola Ismail [verfasserIn] Irene K. Mikkelsen [verfasserIn] Hanne Gottrup [verfasserIn] Leif Østergaard [verfasserIn] David J. Brooks [verfasserIn] Simon F. Eskildsen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Alzheimer’s disease Mild cognitive impairment Capillary dysfunction Magnetic resonance imaging Perfusion

Übergeordnetes Werk:	In: Aging Brain - Elsevier, 2021, 2(2022), Seite 100035-
Übergeordnetes Werk:	volume:2 ; year:2022 ; pages:100035-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nbas.2022.100035

Katalog-ID:	DOAJ025052772

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520			\|a Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD.
650		4	\|a Alzheimer’s disease
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allfields_unstemmed	10.1016/j.nbas.2022.100035 doi (DE-627)DOAJ025052772 (DE-599)DOAJ7c197089d395425ab1fc07797aaaeb63 DE-627 ger DE-627 rakwb eng RC321-571 Lasse S. Madsen verfasserin aut Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD. Alzheimer’s disease Mild cognitive impairment Capillary dysfunction Magnetic resonance imaging Perfusion Neurosciences. Biological psychiatry. Neuropsychiatry Rune B. Nielsen verfasserin aut Peter Parbo verfasserin aut Rola Ismail verfasserin aut Irene K. Mikkelsen verfasserin aut Hanne Gottrup verfasserin aut Leif Østergaard verfasserin aut David J. Brooks verfasserin aut Simon F. Eskildsen verfasserin aut In Aging Brain Elsevier, 2021 2(2022), Seite 100035- (DE-627)1757069569 25899589 nnns volume:2 year:2022 pages:100035- https://doi.org/10.1016/j.nbas.2022.100035 kostenfrei https://doaj.org/article/7c197089d395425ab1fc07797aaaeb63 kostenfrei http://www.sciencedirect.com/science/article/pii/S258995892200007X kostenfrei https://doaj.org/toc/2589-9589 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100035-
allfieldsGer	10.1016/j.nbas.2022.100035 doi (DE-627)DOAJ025052772 (DE-599)DOAJ7c197089d395425ab1fc07797aaaeb63 DE-627 ger DE-627 rakwb eng RC321-571 Lasse S. Madsen verfasserin aut Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD. Alzheimer’s disease Mild cognitive impairment Capillary dysfunction Magnetic resonance imaging Perfusion Neurosciences. Biological psychiatry. Neuropsychiatry Rune B. Nielsen verfasserin aut Peter Parbo verfasserin aut Rola Ismail verfasserin aut Irene K. Mikkelsen verfasserin aut Hanne Gottrup verfasserin aut Leif Østergaard verfasserin aut David J. Brooks verfasserin aut Simon F. Eskildsen verfasserin aut In Aging Brain Elsevier, 2021 2(2022), Seite 100035- (DE-627)1757069569 25899589 nnns volume:2 year:2022 pages:100035- https://doi.org/10.1016/j.nbas.2022.100035 kostenfrei https://doaj.org/article/7c197089d395425ab1fc07797aaaeb63 kostenfrei http://www.sciencedirect.com/science/article/pii/S258995892200007X kostenfrei https://doaj.org/toc/2589-9589 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100035-
allfieldsSound	10.1016/j.nbas.2022.100035 doi (DE-627)DOAJ025052772 (DE-599)DOAJ7c197089d395425ab1fc07797aaaeb63 DE-627 ger DE-627 rakwb eng RC321-571 Lasse S. Madsen verfasserin aut Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD. Alzheimer’s disease Mild cognitive impairment Capillary dysfunction Magnetic resonance imaging Perfusion Neurosciences. Biological psychiatry. Neuropsychiatry Rune B. Nielsen verfasserin aut Peter Parbo verfasserin aut Rola Ismail verfasserin aut Irene K. Mikkelsen verfasserin aut Hanne Gottrup verfasserin aut Leif Østergaard verfasserin aut David J. Brooks verfasserin aut Simon F. Eskildsen verfasserin aut In Aging Brain Elsevier, 2021 2(2022), Seite 100035- (DE-627)1757069569 25899589 nnns volume:2 year:2022 pages:100035- https://doi.org/10.1016/j.nbas.2022.100035 kostenfrei https://doaj.org/article/7c197089d395425ab1fc07797aaaeb63 kostenfrei http://www.sciencedirect.com/science/article/pii/S258995892200007X kostenfrei https://doaj.org/toc/2589-9589 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2022 100035-
language	English
source	In Aging Brain 2(2022), Seite 100035- volume:2 year:2022 pages:100035-
sourceStr	In Aging Brain 2(2022), Seite 100035- volume:2 year:2022 pages:100035-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Alzheimer’s disease Mild cognitive impairment Capillary dysfunction Magnetic resonance imaging Perfusion Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Aging Brain
authorswithroles_txt_mv	Lasse S. Madsen @@aut@@ Rune B. Nielsen @@aut@@ Peter Parbo @@aut@@ Rola Ismail @@aut@@ Irene K. Mikkelsen @@aut@@ Hanne Gottrup @@aut@@ Leif Østergaard @@aut@@ David J. Brooks @@aut@@ Simon F. Eskildsen @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	1757069569
id	DOAJ025052772
language_de	englisch
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callnumber-first	R - Medicine
author	Lasse S. Madsen
spellingShingle	Lasse S. Madsen misc RC321-571 misc Alzheimer’s disease misc Mild cognitive impairment misc Capillary dysfunction misc Magnetic resonance imaging misc Perfusion misc Neurosciences. Biological psychiatry. Neuropsychiatry Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
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topic_title	RC321-571 Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study Alzheimer’s disease Mild cognitive impairment Capillary dysfunction Magnetic resonance imaging Perfusion
topic	misc RC321-571 misc Alzheimer’s disease misc Mild cognitive impairment misc Capillary dysfunction misc Magnetic resonance imaging misc Perfusion misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Alzheimer’s disease misc Mild cognitive impairment misc Capillary dysfunction misc Magnetic resonance imaging misc Perfusion misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
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title_full	Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
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title_sort	capillary function progressively deteriorates in prodromal alzheimer’s disease: a longitudinal mri perfusion study
callnumber	RC321-571
title_auth	Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
abstract	Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD.
abstractGer	Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD.
abstract_unstemmed	Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD.
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title_short	Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
url	https://doi.org/10.1016/j.nbas.2022.100035 https://doaj.org/article/7c197089d395425ab1fc07797aaaeb63 http://www.sciencedirect.com/science/article/pii/S258995892200007X https://doaj.org/toc/2589-9589
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Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study

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