The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery

<p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung inju...
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Autor*in:	Engels Gerwin E [verfasserIn] Gu Y John [verfasserIn] van Oeveren Willem [verfasserIn] Rakhorst Gerhard [verfasserIn] Mariani Massimo A [verfasserIn] Erasmus Michiel E [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG

Übergeordnetes Werk:	In: Journal of Cardiothoracic Surgery - BMC, 2006, 8(2013), 1, p 4
Übergeordnetes Werk:	volume:8 ; year:2013 ; number:1, p 4

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1749-8090-8-4

Katalog-ID:	DOAJ025068377

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520			\|a <p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p<
650		4	\|a Clara cell 16 kD protein
650		4	\|a Surfactant protein D
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author_variant	e g e ege g y j gyj v o w vow r g rg m m a mma e m e eme
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allfields	10.1186/1749-8090-8-4 doi (DE-627)DOAJ025068377 (DE-599)DOAJd1d49ac19cc443c5beabd9c4db001863 DE-627 ger DE-627 rakwb eng RD1-811 RD78.3-87.3 Engels Gerwin E verfasserin aut The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p< Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG Surgery Anesthesiology Gu Y John verfasserin aut van Oeveren Willem verfasserin aut Rakhorst Gerhard verfasserin aut Mariani Massimo A verfasserin aut Erasmus Michiel E verfasserin aut In Journal of Cardiothoracic Surgery BMC, 2006 8(2013), 1, p 4 (DE-627)509401260 (DE-600)2227224-0 17498090 nnns volume:8 year:2013 number:1, p 4 https://doi.org/10.1186/1749-8090-8-4 kostenfrei https://doaj.org/article/d1d49ac19cc443c5beabd9c4db001863 kostenfrei http://www.cardiothoracicsurgery.org/content/8/1/4 kostenfrei https://doaj.org/toc/1749-8090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 1, p 4
spelling	10.1186/1749-8090-8-4 doi (DE-627)DOAJ025068377 (DE-599)DOAJd1d49ac19cc443c5beabd9c4db001863 DE-627 ger DE-627 rakwb eng RD1-811 RD78.3-87.3 Engels Gerwin E verfasserin aut The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p< Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG Surgery Anesthesiology Gu Y John verfasserin aut van Oeveren Willem verfasserin aut Rakhorst Gerhard verfasserin aut Mariani Massimo A verfasserin aut Erasmus Michiel E verfasserin aut In Journal of Cardiothoracic Surgery BMC, 2006 8(2013), 1, p 4 (DE-627)509401260 (DE-600)2227224-0 17498090 nnns volume:8 year:2013 number:1, p 4 https://doi.org/10.1186/1749-8090-8-4 kostenfrei https://doaj.org/article/d1d49ac19cc443c5beabd9c4db001863 kostenfrei http://www.cardiothoracicsurgery.org/content/8/1/4 kostenfrei https://doaj.org/toc/1749-8090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 1, p 4
allfields_unstemmed	10.1186/1749-8090-8-4 doi (DE-627)DOAJ025068377 (DE-599)DOAJd1d49ac19cc443c5beabd9c4db001863 DE-627 ger DE-627 rakwb eng RD1-811 RD78.3-87.3 Engels Gerwin E verfasserin aut The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p< Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG Surgery Anesthesiology Gu Y John verfasserin aut van Oeveren Willem verfasserin aut Rakhorst Gerhard verfasserin aut Mariani Massimo A verfasserin aut Erasmus Michiel E verfasserin aut In Journal of Cardiothoracic Surgery BMC, 2006 8(2013), 1, p 4 (DE-627)509401260 (DE-600)2227224-0 17498090 nnns volume:8 year:2013 number:1, p 4 https://doi.org/10.1186/1749-8090-8-4 kostenfrei https://doaj.org/article/d1d49ac19cc443c5beabd9c4db001863 kostenfrei http://www.cardiothoracicsurgery.org/content/8/1/4 kostenfrei https://doaj.org/toc/1749-8090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 1, p 4
allfieldsGer	10.1186/1749-8090-8-4 doi (DE-627)DOAJ025068377 (DE-599)DOAJd1d49ac19cc443c5beabd9c4db001863 DE-627 ger DE-627 rakwb eng RD1-811 RD78.3-87.3 Engels Gerwin E verfasserin aut The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p< Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG Surgery Anesthesiology Gu Y John verfasserin aut van Oeveren Willem verfasserin aut Rakhorst Gerhard verfasserin aut Mariani Massimo A verfasserin aut Erasmus Michiel E verfasserin aut In Journal of Cardiothoracic Surgery BMC, 2006 8(2013), 1, p 4 (DE-627)509401260 (DE-600)2227224-0 17498090 nnns volume:8 year:2013 number:1, p 4 https://doi.org/10.1186/1749-8090-8-4 kostenfrei https://doaj.org/article/d1d49ac19cc443c5beabd9c4db001863 kostenfrei http://www.cardiothoracicsurgery.org/content/8/1/4 kostenfrei https://doaj.org/toc/1749-8090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 1, p 4
allfieldsSound	10.1186/1749-8090-8-4 doi (DE-627)DOAJ025068377 (DE-599)DOAJd1d49ac19cc443c5beabd9c4db001863 DE-627 ger DE-627 rakwb eng RD1-811 RD78.3-87.3 Engels Gerwin E verfasserin aut The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p< Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG Surgery Anesthesiology Gu Y John verfasserin aut van Oeveren Willem verfasserin aut Rakhorst Gerhard verfasserin aut Mariani Massimo A verfasserin aut Erasmus Michiel E verfasserin aut In Journal of Cardiothoracic Surgery BMC, 2006 8(2013), 1, p 4 (DE-627)509401260 (DE-600)2227224-0 17498090 nnns volume:8 year:2013 number:1, p 4 https://doi.org/10.1186/1749-8090-8-4 kostenfrei https://doaj.org/article/d1d49ac19cc443c5beabd9c4db001863 kostenfrei http://www.cardiothoracicsurgery.org/content/8/1/4 kostenfrei https://doaj.org/toc/1749-8090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 1, p 4
language	English
source	In Journal of Cardiothoracic Surgery 8(2013), 1, p 4 volume:8 year:2013 number:1, p 4
sourceStr	In Journal of Cardiothoracic Surgery 8(2013), 1, p 4 volume:8 year:2013 number:1, p 4
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG Surgery Anesthesiology
isfreeaccess_bool	true
container_title	Journal of Cardiothoracic Surgery
authorswithroles_txt_mv	Engels Gerwin E @@aut@@ Gu Y John @@aut@@ van Oeveren Willem @@aut@@ Rakhorst Gerhard @@aut@@ Mariani Massimo A @@aut@@ Erasmus Michiel E @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	509401260
id	DOAJ025068377
language_de	englisch
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Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. 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callnumber-first	R - Medicine
author	Engels Gerwin E
spellingShingle	Engels Gerwin E misc RD1-811 misc RD78.3-87.3 misc Clara cell 16 kD protein misc Surfactant protein D misc Cardiopulmonary bypass misc Off-pump misc CABG misc Surgery misc Anesthesiology The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery
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topic_title	RD1-811 RD78.3-87.3 The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery Clara cell 16 kD protein Surfactant protein D Cardiopulmonary bypass Off-pump CABG
topic	misc RD1-811 misc RD78.3-87.3 misc Clara cell 16 kD protein misc Surfactant protein D misc Cardiopulmonary bypass misc Off-pump misc CABG misc Surgery misc Anesthesiology
topic_unstemmed	misc RD1-811 misc RD78.3-87.3 misc Clara cell 16 kD protein misc Surfactant protein D misc Cardiopulmonary bypass misc Off-pump misc CABG misc Surgery misc Anesthesiology
topic_browse	misc RD1-811 misc RD78.3-87.3 misc Clara cell 16 kD protein misc Surfactant protein D misc Cardiopulmonary bypass misc Off-pump misc CABG misc Surgery misc Anesthesiology
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title	The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery
ctrlnum	(DE-627)DOAJ025068377 (DE-599)DOAJd1d49ac19cc443c5beabd9c4db001863
title_full	The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery
author_sort	Engels Gerwin E
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author_browse	Engels Gerwin E Gu Y John van Oeveren Willem Rakhorst Gerhard Mariani Massimo A Erasmus Michiel E
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author-letter	Engels Gerwin E
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title_sort	utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery
callnumber	RD1-811
title_auth	The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery
abstract	<p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Despite continuous improvements in materials and perfusion techniques, cardiac surgery still causes lung injury and a delay of pulmonary recovery. Currently, there is no gold standard for quantifying cardiac surgery induced lung injury and dysfunction. Adding objective measures, such as plasma biomarkers, could be of great use here. In this study the utility of lung epithelium specific proteins as biomarkers for lung dysfunction was evaluated.</p< <p<Methods</p< <p<Serial measurements of plasma concentrations of Clara cell 16 kD (CC16) protein, Surfactant protein D (SP-D), Elastase and Myeloperoxidase were performed on blood samples from 40 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass (CABG, n = 20) or without cardiopulmonary bypass (OPCAB, n = 20).</p< <p<Results</p< <p<The increase of SP-D and CC16 between pre-operative concentrations and concentrations at the end of cardiopulmonary bypass, correlated with the Aa-O<sub<2</sub< gradient at 1 hour on the ICU (R<sub<s</sub< = 0.409, <it<p</it< = .016 and R<sub<s</sub< = 0.343, <it<p</it< = .043, respectively).</p< <p<Furthermore, SP-D and CC16 were higher in CABG than in OPCAB at the end of surgery [8.96 vs. 4.91 ng/mL, <it<p</it< = .042 and 92 vs. 113%, <it<p</it< = .007, respectively]. After 24 h both biomarkers returned to their baseline values.</p< <p<Conclusions</p< <p<Our results show that increases in plasma of SP-D and CC16 correlate with clinical lung injury after coronary artery bypass surgery. Therefore, lung epithelium specific proteins seem to be a useful biomarker for measuring lung injury in the setting of cardiac surgery.</p<
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title_short	The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery
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The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery

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